IndieBio

Capro-X is an ag-tech company focused on sustainability in the dairy industry. It develops fermentation bioprocess technology to convert acid whey, a dairy waste stream, into valuable products such as bio-oils, biofuels, and bioplastics, while producing clean water. The WheyAway treatment uses naturally occurring, non-GMO microbes to upgrade dairy waste on site at the point of generation. By upcycling acid from dairy waste, Capro-X helps dairy producers reduce waste and improve sustainability and yield over time. Founded in 2017 and based in Ithaca, New York, Capro-X serves dairy processors seeking to turn waste streams into value.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

Ten63 Therapeutics, Inc. is a biotechnology company based in Chapel Hill, North Carolina, focused on developing potent therapeutics for medically validated yet undruggable targets. Founded in 2017, the company utilizes its innovative platform, COPPER, which combines machine learning-based computational chemistry with advanced physical modeling to explore an extensive chemical space. This approach allows Ten63 Therapeutics to discover novel drug candidates for some of the most lethal diseases by employing proprietary algorithms for scaffold redesign and optimizing chemical design. By integrating these technologies, the company aims to produce durable therapies and improve drug resistance prediction, ultimately addressing challenges in drug development for previously intractable targets.

Founded in 2023, AlkaLi Labs is a biotechnology company based in San Francisco. It specializes in recovering critical minerals like lithium and cobalt from industrial waste streams using bioengineering solutions.

Quorum Earth, based in Brooklyn, New York, is a pioneering agricultural technology company. It specializes in the development of innovative, eco-friendly pesticides, harnessing the power of the fungal kingdom to create products that are safe for the planet and effective in controlling pests. Currently, the company operates in stealth mode.

Synplexity is a biotechnology company located in New Castle, Delaware, specializing in mutational scanning and multiplexed gene synthesis through advanced artificial intelligence technology. The company operates a large-scale gene synthesis and proteomics discovery platform that utilizes microdroplets as microreactors. This innovative approach allows for the efficient creation of multiplex gene libraries, which have applications across various sectors, including therapeutics, biomanufacturing, agriculture, and climate systems. Synplexity aims to drive advancements in healthcare and other industries through its cutting-edge genetic technologies.

Founded in 2022 and headquartered in Berkeley, California, Laguna Bio develops a drug discovery platform designed to selectively activate and expand the innate immune system against cancer. The company focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of bispecific antibody drugs.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Capro-X is an ag-tech company focused on sustainability in the dairy industry. It develops fermentation bioprocess technology to convert acid whey, a dairy waste stream, into valuable products such as bio-oils, biofuels, and bioplastics, while producing clean water. The WheyAway treatment uses naturally occurring, non-GMO microbes to upgrade dairy waste on site at the point of generation. By upcycling acid from dairy waste, Capro-X helps dairy producers reduce waste and improve sustainability and yield over time. Founded in 2017 and based in Ithaca, New York, Capro-X serves dairy processors seeking to turn waste streams into value.

CellCrine focuses on discovering enzymes that transform cell culture for the cell-based meats industry. CellCrine was founded in 2021and was headquartered in United, States.

Melio is a healthcare company based in Santa Clara, California, specializing in blood testing technology aimed at detecting prevalent infections. The company has developed a comprehensive blood test platform that identifies common pathogens responsible for bloodstream infections. Utilizing a patented melting technique followed by detailed analysis, Melio's technology enables quick and accurate identification of blood-based pathogens. This innovation allows healthcare providers to deliver timely and targeted treatment, addressing the urgent need for effective therapies while also contributing to the fight against antibiotic resistance.

Helex is a biotechnology company developing genomic medicines for kidney-related diseases. It leverages its own genomics data, bioinformatics, and an intelligent data-driven platform to design, verify, and deliver therapy-specific gRNAs, with a focus on non-viral targeted delivery and genome editing for renal indications. The company's platform uses data-driven deep-learning models and high-throughput sequencing data from CRISPR edits in human cell lines to generate reliable predictions and validate them in-house. By combining these capabilities, Helex aims to accelerate CRISPR-based drug research and the development of cell and gene therapies for kidney conditions, offering precise and scalable renal therapeutics.

Finless Foods is a biotechnology company that uses cellular agriculture to develop cell-cultured seafood products as sustainable alternatives for human consumption. It grows marine-animal cells to create seafood substitutes, including bluefin tuna, with the goal of offering responsibly produced options that support ocean health and reduce overfishing. Founded in 2017 and based in Emeryville, California, the company concentrates on expanding dietary choices while addressing environmental impacts of traditional seafood.

California Cultured is a food company that uses cellular agriculture to produce cocoa and coffee, with the aim of delivering sustainable, lab-grown ingredients. Its cocoa is described as less bitter and requiring less sugar to achieve flavor, enabling premium quality products with a smaller environmental footprint. The company seeks to address social and environmental concerns linked to traditional cocoa production by avoiding practices such as slavery, deforestation, and child labor. California Cultured was founded in 2020 and is based in Davis, California.

VIA BioFuels is a biotechnology research company based in Houston, Texas, founded in 2023. The company specializes in the development of proprietary engineered yeast strains, specifically S. cerevisiae, which produce aromatic 3-methyl anisole (3-MA) from conventional ethanol feedstocks. VIA BioFuels’ technology is designed to be scalable, utilizing existing ethanol production methods and infrastructure. The high-purity 3-MA produced can be transformed into various valuable compounds, enhancing the market potential of the output and allowing consumers to substitute traditional fuels without blending restrictions.

AquaLith Advanced Materials specializes in the development of innovative lithium-ion battery materials. The company has secured exclusive rights to a portfolio of patents from the University of Maryland, which focus on advancements made by researchers in the field of chemical and materials engineering. AquaLith's technology includes an ultra-high energy cathode, a novel silicon anode, and a non-flammable aqueous electrolyte, all designed to enhance the performance of lithium-ion batteries. This technology addresses key challenges such as efficiency in low temperatures, faster charging times, and improved safety by reducing fire risks associated with short circuits. The company's materials aim to provide high energy density while being cost-effective and abundant, ultimately benefiting consumer electronics and other applications in need of reliable battery solutions.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

Founded in 2013, ZymoChem develops eco-friendly chemical production processes using engineered microbes. These processes convert renewable feedstocks like sugars into industrial chemicals, minimizing carbon loss and enabling cost-competitive bio-based manufacturing.

Chronus Health develops a portable diagnostic device for delivering point-of-care lab results in minutes. Its device enables real-time diagnosis at the point-of-care, improving time to care and patient outcomes.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

BioAesthetics develops tissue-engineered nipple-areolar complex grafts to support breast reconstruction after mastectomy. The graft is designed as a scaffold for the patient's own cells to populate and regenerate the nipple and areola during reconstruction, aiming to improve cosmetic and reconstructive outcomes. The company originated as a Tulane University spin-out and was founded in 2015.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

California Cultured is a food company that uses cellular agriculture to produce cocoa and coffee, with the aim of delivering sustainable, lab-grown ingredients. Its cocoa is described as less bitter and requiring less sugar to achieve flavor, enabling premium quality products with a smaller environmental footprint. The company seeks to address social and environmental concerns linked to traditional cocoa production by avoiding practices such as slavery, deforestation, and child labor. California Cultured was founded in 2020 and is based in Davis, California.

VIA BioFuels is a biotechnology research company based in Houston, Texas, founded in 2023. The company specializes in the development of proprietary engineered yeast strains, specifically S. cerevisiae, which produce aromatic 3-methyl anisole (3-MA) from conventional ethanol feedstocks. VIA BioFuels’ technology is designed to be scalable, utilizing existing ethanol production methods and infrastructure. The high-purity 3-MA produced can be transformed into various valuable compounds, enhancing the market potential of the output and allowing consumers to substitute traditional fuels without blending restrictions.

Pannex Therapeutics is a New York-based biopharmaceutical company focused on developing innovative cancer therapies. It specializes in Pannexin 1 channel blockers, a novel class of drugs designed to inhibit multiple pathways, preventing cancer cell growth, metastasis, and survival.

Founded in 2023, AlkaLi Labs is a biotechnology company based in San Francisco. It specializes in recovering critical minerals like lithium and cobalt from industrial waste streams using bioengineering solutions.

Protogenix develops a platform technology to replace the mammalian cell system for manufacturing complex proteins. The decentralized plug-and-play platform enables high-yield production at greater speed and lower cost, helping food and pharmaceutical producers access sustainably produced, safe protein ingredients while aiming to reduce the carbon footprint of animal agriculture.

Geltor designs and produces animal-free collagen and other bioactive proteins for beauty, wellness, and nutrition applications. Founded in 2015, the company uses proprietary AI to create customized proteins tailored to specific industry needs.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

BiomeSense develops an integrated hardware, software, and data platform to scale microbiome data collection and analysis for clinical research. The company integrates at-home monitoring of the gut microbiome through its GutLab smart-bathroom system with the MetaBiome time-series analytics platform to connect microbiome changes with clinical outcomes in real time. Its platform supports large-scale, densely longitudinal datasets to discover, validate, and commercialize microbiome biomarkers, enabling clinicians to apply microbiome insights to improve human health. Founded in 2018 and based in Chicago, BiomeSense seeks to advance precision medicine by providing end-to-end microbiome measurement and analytics.

Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.

Founded in 2019, Aja Labs is a biotechnology company based in San Francisco. It specializes in producing biodegradable fiber derived from plants, designed to resemble human hair for use in hair extensions. This innovative approach aims to replace plastic-based fibers and reduce the reliance on chemical-heavy synthetics or human hair.

BioROSA Technologies Inc. is a biotechnology company focused on developing diagnostic tools for Autism Spectrum Disorders (ASD). Founded in 2018 and headquartered in Belmont, Massachusetts, the company specializes in creating biologically-based blood tests that assist clinicians in identifying individuals at risk for ASD. By utilizing machine learning to analyze biological data, BioROSA Technologies aims to provide reliable and accurate diagnoses, facilitating early detection and timely treatment. Additionally, the company's technology supports therapeutic trials by evaluating pharmacodynamics and patient stratification, thereby enhancing the overall standard of care for ASD.

Pneuma is a biotechnology company based in New York, USA. It develops sustainable products through innovative biological processes.

Harmony is a biotechnology startup that creates human breast milk protein-based infant nutrition designed to help human babies thrive. It is the world’s first dairy-free, allergen-free and environmentally friendly infant nutrition. Harmony Baby Nutrition was established in 2018 and is based in Boston, MA.

OneSkin is a biotechnology company focused on skin aging and longevity that develops testing platforms and consumer products. It uses animal-free three-dimensional human skin models to evaluate the safety and efficacy of cosmetic ingredients and anti-aging compounds, supporting research and validation for the cosmetic and ingredient supplier industries. The company has developed a proprietary peptide, OS-01, intended to reduce skin biological age by decreasing the accumulation of aged cells, improving cellular repair, and strengthening the epidermal barrier. Its consumer offering includes a vegan topical product based on OS-01 designed for all skin types, marketed through its website. The business combines in vitro testing services with product development to address root causes of skin aging and support proper skin cell function.

Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

Protogenix develops a platform technology to replace the mammalian cell system for manufacturing complex proteins. The decentralized plug-and-play platform enables high-yield production at greater speed and lower cost, helping food and pharmaceutical producers access sustainably produced, safe protein ingredients while aiming to reduce the carbon footprint of animal agriculture.

Helex is a biotechnology company developing genomic medicines for kidney-related diseases. It leverages its own genomics data, bioinformatics, and an intelligent data-driven platform to design, verify, and deliver therapy-specific gRNAs, with a focus on non-viral targeted delivery and genome editing for renal indications. The company's platform uses data-driven deep-learning models and high-throughput sequencing data from CRISPR edits in human cell lines to generate reliable predictions and validate them in-house. By combining these capabilities, Helex aims to accelerate CRISPR-based drug research and the development of cell and gene therapies for kidney conditions, offering precise and scalable renal therapeutics.

Wayfinder Biosciences is a biotechnology company focused on developing orally available small molecule drugs that modulate RNA targets linked to cancer and neurodegenerative diseases. The company uses a proprietary platform that combines high-throughput screening, computational modeling, and machine learning with unique datasets to discover RNA-targeting compounds with potency and selectivity for traditionally inaccessible targets. Its approach includes RNA biosensor technologies that render target molecules detectable, aiding discovery and evaluation. Founded in 2021 and based in Seattle, Wayfinder aims to accelerate development of therapies for undruggable targets by enabling rapid screening and optimization of RNA-targeting small molecules.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Intrinsic Medicine, Inc. is a clinical-stage company based in Des Moines, Washington, focused on researching and developing innovative medicines for patients. Formerly known as Lupa Bio, the company specializes in the development of prebiotic drugs aimed at treating various human diseases. Its flagship products, Human Identical Milk Oligosaccharides (HiMOs), are engineered to remain stable in stomach acid and resist degradation in the upper gastrointestinal tract. This unique formulation allows patients to enhance gut health and modulate immune responses effectively. As a venture-backed entity, Intrinsic Medicine operates with a technical and operational platform designed to bring significant medical advancements to patients in an efficient and ethical manner.

Founded in 2022 and headquartered in Berkeley, California, Laguna Bio develops a drug discovery platform designed to selectively activate and expand the innate immune system against cancer. The company focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of bispecific antibody drugs.

CellCrine focuses on discovering enzymes that transform cell culture for the cell-based meats industry. CellCrine was founded in 2021and was headquartered in United, States.

Edge Foods is a New York City-based company that addresses the scaling challenges faced by the cultured meat sector. The company has developed a platform technology designed to produce high-performing and affordable growth factors and recombinant proteins. This innovative approach allows for the creation of tasty and cost-effective meat alternatives that cater to health-conscious consumers, ensuring that meat lovers can enjoy their favorite foods while promoting sustainability and environmental responsibility.

Melio is a healthcare company based in Santa Clara, California, specializing in blood testing technology aimed at detecting prevalent infections. The company has developed a comprehensive blood test platform that identifies common pathogens responsible for bloodstream infections. Utilizing a patented melting technique followed by detailed analysis, Melio's technology enables quick and accurate identification of blood-based pathogens. This innovation allows healthcare providers to deliver timely and targeted treatment, addressing the urgent need for effective therapies while also contributing to the fight against antibiotic resistance.

Prellis Biologics is a biotechnology company based in San Francisco, founded in 2016, focused on bioprinting vascularized human tissues and organs for drug development, disease modeling, and transplantation. Its platform enables rapid, high-resolution printing of tissues and organoids, including lymph node models, to reproduce human immune responses. This capability supports antibody discovery, immunogenicity assessment, and tumor–immune studies, aiming to accelerate early-stage drug discovery and translational pharmacology while advancing the development of tissue and organ therapies.

SyntheX specializes in drug discovery using synthetic biology platforms. It identifies protein interaction modulators and enables functional protein degradation, focusing on unique mechanisms for cancer and rare disease treatments.

BioLumen is a nutritional technology company that develops a patented dietary fiber technology platform that reduces the negative effect of a diet heavy in processed foods. BioLumen's technology is composed of insoluble dietary fiber matrix covered with a blend of food ingredients created from the latest drug delivery system research. The company's product, a nutraceutical, focuses on high risk individuals with prediabetes to help manage blood sugar levels, protect their liver from excess sugar and feed their gut microbiome, delivering health benefits. BioLumen was founded on 2018 and is headquartered in San Francisco, California.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Pannex Therapeutics is a New York-based biopharmaceutical company focused on developing innovative cancer therapies. It specializes in Pannexin 1 channel blockers, a novel class of drugs designed to inhibit multiple pathways, preventing cancer cell growth, metastasis, and survival.

Founded in 2019, Kalia Health is a biotechnology company based in Chapel Hill, North Carolina. It develops affordable and accessible home-based early detection tests to improve maternal health outcomes.

UPSIDE Foods, formerly known as Memphis Meats, is a cultivated meat company founded in 2015 and headquartered in Berkeley, California. The company specializes in producing real meat, poultry, and seafood directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach significantly reduces the resource consumption associated with traditional meat production, requiring less water, land, and energy. UPSIDE Foods aims to offer consumers clean, humane, and sustainable meat products, such as beef meatballs, chicken, and duck, all grown in controlled environments. The company is led by Dr. Uma Valeti, who is committed to transforming the food industry with healthier and environmentally friendly alternatives to conventional meat.

Tesarakt is a New York City-based company founded in 2022 that specializes in developing predictive artificial intelligence technology for brain care. The company focuses on enhancing neuro-diagnosis by employing advanced artificial intelligence and machine learning techniques. Tesarakt utilizes a comprehensive database of conventional MRI scans to improve the predictive capabilities of medical professionals, enabling earlier detection of neurological disorders such as Parkinson's disease and Alzheimer's disease, often before the onset of initial symptoms. Through its innovative approach, Tesarakt aims to transform the way neurological conditions are diagnosed and managed.

Tesarakt is a New York City-based company founded in 2022 that specializes in developing predictive artificial intelligence technology for brain care. The company focuses on enhancing neuro-diagnosis by employing advanced artificial intelligence and machine learning techniques. Tesarakt utilizes a comprehensive database of conventional MRI scans to improve the predictive capabilities of medical professionals, enabling earlier detection of neurological disorders such as Parkinson's disease and Alzheimer's disease, often before the onset of initial symptoms. Through its innovative approach, Tesarakt aims to transform the way neurological conditions are diagnosed and managed.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Eachday is a Pittsburgh-based digital health management company focused on providing tools and evidence-based techniques for self-managing ADHD. The company offers an ADHD self-management application designed to assist users in effectively managing their daily lives. By tracking behaviors and interests, such as task completion, cognitive failures, and self-reported symptoms, Eachday creates personalized profiles that help users gain insights into their cognitive patterns. This approach enables individuals to visualize their time and develop structured routines, ultimately aiming to alleviate ADHD symptoms as they arise and lessen the cognitive burden associated with everyday activities.

Eachday is a Pittsburgh-based digital health management company focused on providing tools and evidence-based techniques for self-managing ADHD. The company offers an ADHD self-management application designed to assist users in effectively managing their daily lives. By tracking behaviors and interests, such as task completion, cognitive failures, and self-reported symptoms, Eachday creates personalized profiles that help users gain insights into their cognitive patterns. This approach enables individuals to visualize their time and develop structured routines, ultimately aiming to alleviate ADHD symptoms as they arise and lessen the cognitive burden associated with everyday activities.

Founded in 2020, Conan MedTech specializes in developing rapid point-of-care diagnostic tests for concussions. Its innovative technology enables sports medicine professionals and coaches to make informed decisions on the sideline during games, revolutionizing mild traumatic brain injury diagnosis.

Founded in 2020, Conan MedTech specializes in developing rapid point-of-care diagnostic tests for concussions. Its innovative technology enables sports medicine professionals and coaches to make informed decisions on the sideline during games, revolutionizing mild traumatic brain injury diagnosis.

Founded in 2019, Kalia Health is a biotechnology company based in Chapel Hill, North Carolina. It develops affordable and accessible home-based early detection tests to improve maternal health outcomes.

Finless Foods is a biotechnology company that uses cellular agriculture to develop cell-cultured seafood products as sustainable alternatives for human consumption. It grows marine-animal cells to create seafood substitutes, including bluefin tuna, with the goal of offering responsibly produced options that support ocean health and reduce overfishing. Founded in 2017 and based in Emeryville, California, the company concentrates on expanding dietary choices while addressing environmental impacts of traditional seafood.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Avisa Myko is a biotechnology company based in San Francisco, California. It specializes in the production of melanin, a natural pigment with applications in cosmetics, biomedicine, organic semiconductors, biosensors, and latex products. The company's patented technology enables large-scale production of soluble, affordable melanin, offering protection against ionizing radiation and contributing to better health and environmental sustainability.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Cellens is a medical device company based in Medford, Massachusetts, and is a spinoff from Tufts University, established in 2019. The company focuses on enhancing cancer detection through noninvasive screening methods. It has developed a cell surface scanning platform that utilizes atomic force microscopy imaging and machine learning to assist oncologists in the detection of bladder cancer. By analyzing physio-biomarkers on cell surfaces derived from urine samples, Cellens provides a diagnostic score that helps healthcare professionals minimize the need for invasive and costly procedures, thereby improving patient outcomes in bladder cancer diagnostics.

Cellens is a medical device company based in Medford, Massachusetts, and is a spinoff from Tufts University, established in 2019. The company focuses on enhancing cancer detection through noninvasive screening methods. It has developed a cell surface scanning platform that utilizes atomic force microscopy imaging and machine learning to assist oncologists in the detection of bladder cancer. By analyzing physio-biomarkers on cell surfaces derived from urine samples, Cellens provides a diagnostic score that helps healthcare professionals minimize the need for invasive and costly procedures, thereby improving patient outcomes in bladder cancer diagnostics.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Founded in 2013, ZymoChem develops eco-friendly chemical production processes using engineered microbes. These processes convert renewable feedstocks like sugars into industrial chemicals, minimizing carbon loss and enabling cost-competitive bio-based manufacturing.

Founded in 2015, Tidal Vision is a sustainable manufacturer based in Ferndale, Washington. It specializes in producing chitosan, a biodegradable biopolymer extracted from crab shells using a zero-waste process. The company offers consistent, high-quality chitosan at competitive prices, tailored for various industrial applications such as water treatment, textiles, and agriculture.

Founded in 2014, Lingrove specializes in manufacturing eco-friendly bio-composite materials. Utilizing a proprietary process, they produce high-performance natural fiber composites from plant-based fibers and resins, aiming to reduce deforestation and embodied carbon in industries such as commercial interiors, transportation, and construction.

Founded in 2018, New Culture is a food company based in San Francisco, California. It specializes in producing sustainable, animal-free cheese using microflora to create dairy proteins.

Sundial Foods develops plant-based meat alternatives designed to replicate the texture, appearance, and sensory experience of traditional meat using natural, plant-derived ingredients. The company aims to offer affordable, nutritious options for conscious consumers and to reduce meat consumption without relying on synthetic additives or heavily processed ingredients. Based in Berkeley, California, Sundial Foods was founded in 2019.

Prothegen is a biotechnology company located in Palo Alto, California, focused on developing innovative medicines that precisely regulate cell death. The company has created a platform aimed at delivering therapies that can either inhibit or promote ferroptosis, a form of regulated cell death. By targeting this mechanism, Prothegen seeks to provide effective therapeutics that can prevent unwanted cell death, thereby improving treatment options for various diseases.

Prothegen is a biotechnology company located in Palo Alto, California, focused on developing innovative medicines that precisely regulate cell death. The company has created a platform aimed at delivering therapies that can either inhibit or promote ferroptosis, a form of regulated cell death. By targeting this mechanism, Prothegen seeks to provide effective therapeutics that can prevent unwanted cell death, thereby improving treatment options for various diseases.

California Cultured is a food company that uses cellular agriculture to produce cocoa and coffee, with the aim of delivering sustainable, lab-grown ingredients. Its cocoa is described as less bitter and requiring less sugar to achieve flavor, enabling premium quality products with a smaller environmental footprint. The company seeks to address social and environmental concerns linked to traditional cocoa production by avoiding practices such as slavery, deforestation, and child labor. California Cultured was founded in 2020 and is based in Davis, California.

New Age Meats is a biotechnology company based in San Francisco, California, founded in 2017. The company specializes in producing cultivated meat through an innovative automated, data-driven platform that utilizes stem cell technology. By growing meat from animal cells instead of relying on traditional animal slaughter, New Age Meats aims to create healthier and more sustainable food options.

Indee Labs develops hardware and platform technologies for gene delivery to immune cells, with the aim of enabling the rapid development and scalable manufacture of gene-modified cell therapies, including CAR-T cells. The company focuses on non-viral delivery methods to introduce small molecules, nucleic acids, proteins, and gene-editing complexes into immune cells, supporting biopharmaceutical research and manufacturing while maintaining high cell viability and function. Its technology has progressed with collaboration from national facilities and through participation in biotech incubators and accelerators. Indee Labs maintains an international footprint, with an office in Sydney and lab space in Berkeley, reflecting its cross-regional development and manufacturing focus.

Khepra is a company based in San Francisco, California, that specializes in converting plastics and agricultural waste into renewable fuels and chemicals. Utilizing proprietary technology, Khepra employs ultrasonic methods, including frictive heating, cavitation, and acoustic pressure, to break down waste streams without extraction, thus preserving their integrity. This innovative, electrified process leverages excess renewable electricity, particularly from solar and wind sources, during periods of energy curtailment. By transforming waste into valuable resources, Khepra aims to support industries in adopting clean energy solutions and contribute to a sustainable future.

Helex is a biotechnology company developing genomic medicines for kidney-related diseases. It leverages its own genomics data, bioinformatics, and an intelligent data-driven platform to design, verify, and deliver therapy-specific gRNAs, with a focus on non-viral targeted delivery and genome editing for renal indications. The company's platform uses data-driven deep-learning models and high-throughput sequencing data from CRISPR edits in human cell lines to generate reliable predictions and validate them in-house. By combining these capabilities, Helex aims to accelerate CRISPR-based drug research and the development of cell and gene therapies for kidney conditions, offering precise and scalable renal therapeutics.

Helex is a biotechnology company developing genomic medicines for kidney-related diseases. It leverages its own genomics data, bioinformatics, and an intelligent data-driven platform to design, verify, and deliver therapy-specific gRNAs, with a focus on non-viral targeted delivery and genome editing for renal indications. The company's platform uses data-driven deep-learning models and high-throughput sequencing data from CRISPR edits in human cell lines to generate reliable predictions and validate them in-house. By combining these capabilities, Helex aims to accelerate CRISPR-based drug research and the development of cell and gene therapies for kidney conditions, offering precise and scalable renal therapeutics.

Finless Foods is a biotechnology company that uses cellular agriculture to develop cell-cultured seafood products as sustainable alternatives for human consumption. It grows marine-animal cells to create seafood substitutes, including bluefin tuna, with the goal of offering responsibly produced options that support ocean health and reduce overfishing. Founded in 2017 and based in Emeryville, California, the company concentrates on expanding dietary choices while addressing environmental impacts of traditional seafood.

Filtricine is a Santa Clara, California-based biotechnology company focused on cancer therapy through targeted nutrient depletion. The company develops approaches that remove nutrients critical to cancer cell growth, enabling exploitation of cancer-specific metabolic dependencies without traditional drug substances. Through a nutrient modulation platform, Filtricine aims to identify metabolic vulnerabilities in cancers and apply strategies to deprive tumor cells of essential nutrients, potentially slowing or stopping disease progression. Founded in 2017, Filtricine operates as a clinical-stage, venture-backed biotechnology company dedicated to developing therapies that spare normal cells while targeting cancer metabolism.

Founded in 2014, QuantumCyte develops an automated tissue dissection system that uses digital maps to isolate regions of interest containing informative biomarkers. This platform aims to improve cancer outcomes by enabling precise cellular data analysis for predicting drug efficacy.

Intrinsic Medicine, Inc. is a clinical-stage company based in Des Moines, Washington, focused on researching and developing innovative medicines for patients. Formerly known as Lupa Bio, the company specializes in the development of prebiotic drugs aimed at treating various human diseases. Its flagship products, Human Identical Milk Oligosaccharides (HiMOs), are engineered to remain stable in stomach acid and resist degradation in the upper gastrointestinal tract. This unique formulation allows patients to enhance gut health and modulate immune responses effectively. As a venture-backed entity, Intrinsic Medicine operates with a technical and operational platform designed to bring significant medical advancements to patients in an efficient and ethical manner.

JointechLabs develops point-of-care regenerative medicine devices that enable access to cell-based therapies in doctors' offices, hospitals, and clinics. Its closed-loop, disposable systems process human tissue to produce autologous fat grafts and fat-derived stem cells, simplifying personalized cell- and tissue-based treatments for orthopedic and aesthetic procedures. Core products include a system for processing adipose tissue and related kits designed for use at the point of care, with regional variants for the United States and international markets. The company aims to extend applications through a pipeline that covers biologic drugs and 3D bioprinted products to support orthopedic, wound healing, and plastic and reconstructive surgery. By focusing on safe, time-efficient workflows, JointechLabs seeks to reduce costs and improve accessibility to regenerative therapies in clinical settings.

Oralta is a United States-based company specializing in the production of probiotic supplements aimed at improving oral health. The company manufactures FRESH BREATH, a line of chewable tablets designed to combat bad breath by targeting odor-producing bacteria. These probiotics work by restoring a healthy balance of beneficial bacteria in the mouth, effectively eliminating the harmful germs responsible for unpleasant odors. In addition to addressing bad breath, Oralta's products also focus on broader oral health issues, such as tooth decay and gum disease. By inactivating the byproducts of these harmful bacteria, Oralta supports sustainable oral hygiene practices, allowing users to maintain their overall dental well-being.

Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.

Sundial Foods develops plant-based meat alternatives designed to replicate the texture, appearance, and sensory experience of traditional meat using natural, plant-derived ingredients. The company aims to offer affordable, nutritious options for conscious consumers and to reduce meat consumption without relying on synthetic additives or heavily processed ingredients. Based in Berkeley, California, Sundial Foods was founded in 2019.

Sundial Foods develops plant-based meat alternatives designed to replicate the texture, appearance, and sensory experience of traditional meat using natural, plant-derived ingredients. The company aims to offer affordable, nutritious options for conscious consumers and to reduce meat consumption without relying on synthetic additives or heavily processed ingredients. Based in Berkeley, California, Sundial Foods was founded in 2019.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative gene therapy treatments for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes advanced oral lipid nanoparticle technology to deliver mRNA and plasmid DNA directly to intestinal stem cells. This approach aims to address the root causes of gastrointestinal diseases, including Familial Adenomatous Polyposis (FAP), a hereditary condition that can lead to colorectal cancer and often necessitates invasive surgical interventions. DNALite's therapies seek to transform protein biologics into oral drugs, allowing for more effective and less invasive treatment options.

Founded in 2020, Prolific Machines is a San Francisco-based biotech company dedicated to revolutionizing cell production for a sustainable future. It combines advanced technologies to enable large-scale cell manufacturing, aiming to improve therapeutic protein production for biotechnology and pharmaceutical companies.