DCVC

Mainspring Energy, Inc. is a technology company based in Menlo Park, California, that specializes in developing linear generator technology for low carbon, dispatchable energy solutions. Founded in 2010 by three Stanford engineers, the company focuses on creating advanced prototypes that convert fuel into electricity through a unique, low-temperature reaction of air and fuel. This innovative approach allows Mainspring to offer generators that provide affordable, reliable electricity while significantly reducing carbon emissions compared to traditional electric grids. The company's mission is to address climate change and enhance energy accessibility, contributing to the development of net-zero carbon energy systems for the future.

Founded in 2017, Fervo Energy specializes in developing and operating geothermal assets using proprietary technology. Based in San Francisco, the company generates clean power through innovative geoscience methods, aiming to provide a dispatchable foundation for a 100% clean energy future.

Radiant is a clean energy startup based in Los Angeles, California, that specializes in the development of portable nuclear microreactors. Founded in 2019, the company aims to provide an alternative to fossil fuels for both military and commercial applications. Its flagship product, the Kaleidos microreactor, is designed to fit within a shipping container, allowing for transportation by air, ship, and road. This innovative microreactor serves as a zero-emissions power source, making it particularly suitable for remote locations and critical applications where traditional diesel generators are typically used.

Zap Energy, Inc. is a Seattle-based company that specializes in the design and manufacture of sheared-flow stabilized Z-Pinch fusion reactors for power generation. Founded in 2017, the company focuses on developing compact and scalable fusion technology that offers low-carbon, cost-effective, and flexible energy solutions. Unlike conventional fusion methods, Zap Energy's approach utilizes electric current to create magnetic fields that confine and compress plasma, enhancing the stability and efficiency of the fusion process. This innovative technology aims to provide sustainable energy while requiring less capital investment compared to traditional fusion systems.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Unspun, Inc. is a digital apparel company based in San Francisco, California, founded in 2015. It specializes in creating custom jeans tailored to individual consumers using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental challenges by minimizing pattern-cutting waste and unsold inventory, thus contributing to a reduction in global carbon emissions. Unspun's innovative approach enables on-demand production of jeans in under ten minutes, utilizing localized manufacturing processes designed to be zero-waste. Its technology has gained recognition, including being named one of TIME's Best Inventions of 2019, and supports a B2B platform that facilitates digital customization for major apparel brands.

Founded in 2017, Fervo Energy specializes in developing and operating geothermal assets using proprietary technology. Based in San Francisco, the company generates clean power through innovative geoscience methods, aiming to provide a dispatchable foundation for a 100% clean energy future.

Frontier Medicines Corporation, established in 2018 and headquartered in South San Francisco, California, is a pre-clinical stage biopharmaceutical company specializing in cancer research. The company employs chemoproteomics to discover and develop novel medicines targeting cancer-causing proteins. Frontier Medicines' innovative platform integrates advanced computational methods and machine learning algorithms to identify and pharmacologically target new binding pockets on proteins, thereby enabling small-molecule drug discovery and development for previously inaccessible targets.

Insight M specializes in developing innovative aerial monitoring technology focused on methane detection for the energy sector. Utilizing a combination of physical science expertise and advanced data analytics, the company surveys extensive areas and generates digital maps using optical and infrared wavelengths. This technology allows Insight M to meticulously scan pipelines and vast territories to pinpoint significant sources of gas loss. By facilitating comprehensive data collection about both the natural environment and human infrastructure, Insight M aims to enhance operational efficiency and safety within the oil and gas industry. Notably, the company carried out the first-ever basin-wide aerial survey for methane detection in the Permian Basin in 2019, underscoring its commitment to improving methane management practices.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

CH4 Global develops seaweed-based feed additives for ruminant animals to reduce methane emissions. Its primary product uses Asparagopsis seaweed as a supplement to lower enteric methane in cattle, goats, sheep, and other ruminants. The company aims to scale sustainable livestock production by offering solutions to farmers and food producers and by enabling potential access to carbon credits and premium prices for low-emission products. Describing itself as an aquaculture solutions provider, CH4 Global applies science and technology to grow seaweed for livestock use and relies on a team of scientists and business leaders to advance deployment worldwide.

Verdigris Technologies develops software solutions for real-time electricity monitoring in commercial facilities. Its key product, Verdigris Energy Tracker, identifies operational inefficiencies, automates building management, predicts and reduces peak demand, and detects equipment failures. The system uses wireless hardware to send device-level consumption data to the cloud, enabling smarter facility operations, energy efficiency, and property management.

Founded in 2021, Demox Labs specializes in developing a decentralized oracle protocol that connects smart contracts to off-chain data sources. Its platform bridges the gap between web2 and web3, unlocking online data for smart contract development.

Founded in 2012, Mythic specializes in designing and manufacturing AI-driven silicon chips and inference processors. Its innovative technology brings desktop GPU compute capabilities and neural networks to compact, energy-efficient devices, enabling AI deployment across various industries such as consumer electronics, wearables, and autonomous systems.

Fortem Technologies is a security technology company that develops AI-enabled airspace security and detect-and-avoid solutions to identify, classify, and manage drones and other unmanned aircraft. Its offerings include radar-based detection systems and AI-driven monitoring software, enabling real-time analysis of multiple sensors to support safe autonomous flight and BVLOS operations. Key products and capabilities include DAA-R10 and DAA-R20 radar-based detect-and-avoid systems, ThreatAware AI analysis engine, the F700 Patriot multi-rotor platform, and DroneHunter, an autonomous interceptor for perimeter intrusion detection and protection. The company serves defense, government, and commercial sectors and is based in Provo, Utah.

Verdant Robotics, Inc., founded in 2018 and based in Hayward, California, specializes in artificial intelligence-driven robotic solutions for agriculture. The company develops advanced technologies that enable farmers to digitally map their fields and monitor each plant's health over time. Verdant's flagship product, the Model B Smart Sprayer, significantly reduces labor costs by over 50% and input costs by up to 96% while providing precise weeding and thinning for various crop types. Utilizing proprietary Bullseye targeting technology and a Pinpoint Spray System, Verdant promotes micro-fertilization and nutrient delivery, enhancing crop yields and efficiency. By leveraging robotics, computer vision, and machine learning, Verdant Robotics empowers growers of all sizes to optimize production and improve profitability in the agricultural sector.

Novome Biotechnologies, Inc. is a biotechnology company specializing in the engineering of gut bacteria to create innovative therapies for chronic diseases. Established in 2015 and located in South San Francisco, California, Novome has developed a pioneering platform for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs). This platform allows for the precise delivery of therapeutic activities aimed at treating conditions such as hyperoxaluria, with a focus on creating a bacterial strain that can degrade oxalate to help prevent kidney stone formation. The company is also expanding its synthetic biology capabilities to explore additional therapeutic indications, aiming to improve long-term health outcomes for patients through its living therapeutics.

Founded in 2017, Fervo Energy specializes in developing and operating geothermal assets using proprietary technology. Based in San Francisco, the company generates clean power through innovative geoscience methods, aiming to provide a dispatchable foundation for a 100% clean energy future.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Zap Energy, Inc. is a Seattle-based company that specializes in the design and manufacture of sheared-flow stabilized Z-Pinch fusion reactors for power generation. Founded in 2017, the company focuses on developing compact and scalable fusion technology that offers low-carbon, cost-effective, and flexible energy solutions. Unlike conventional fusion methods, Zap Energy's approach utilizes electric current to create magnetic fields that confine and compress plasma, enhancing the stability and efficiency of the fusion process. This innovative technology aims to provide sustainable energy while requiring less capital investment compared to traditional fusion systems.

Capella Space is an information services company based in San Francisco that operates a constellation of small satellites equipped with synthetic aperture radar, delivering on-demand, high-resolution radar imagery of the Earth's surface. The SAR imagery can be acquired through clouds, smoke, fog, and darkness, enabling continuous global monitoring and rapid insight across industries. Capella's services support infrastructure monitoring, agriculture, disaster response, maritime domain awareness, city planning and mapping, and business intelligence, helping customers detect sub-meter surface changes, track economic activity, and monitor environmental and security-related conditions. Founded in 2016, Capella Space provides timely earth observation for commerce, conservation, and safety.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

Brimstone develops a carbon-negative process for producing ordinary portland cement and supplementary cementitious material. Its technology uses calcium silicate rock instead of limestone, delivering identical products at scale while significantly reducing CO2 emissions.

Founded in 2020, Kettle is a technology-driven reinsurer based in Bermuda. It employs proprietary deep learning algorithms to analyze vast amounts of satellite, weather, and ground truth data, enabling more accurate risk predictions and reducing loss ratios for insurance companies.

Jupiter Intelligence, Inc. is a technology company that specializes in climate risk analytics, providing tools and platforms to assess the impacts of weather and climate change. Founded in 2017 and based in San Mateo, California, Jupiter offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate various predictive models that process data from numerous ground-based and satellite sensors. The company's offerings include Jupiter FloodScore, which assists users in preparing for potential flooding, and Jupiter HeatScore, which predicts extreme temperatures to help organizations mitigate heat- and cold-related risks. By transforming complex climate science into actionable data, Jupiter enables businesses to proactively manage and disclose climate risks, helping them navigate the increasing frequency and severity of extreme weather events.

CH4 Global develops seaweed-based feed additives for ruminant animals to reduce methane emissions. Its primary product uses Asparagopsis seaweed as a supplement to lower enteric methane in cattle, goats, sheep, and other ruminants. The company aims to scale sustainable livestock production by offering solutions to farmers and food producers and by enabling potential access to carbon credits and premium prices for low-emission products. Describing itself as an aquaculture solutions provider, CH4 Global applies science and technology to grow seaweed for livestock use and relies on a team of scientists and business leaders to advance deployment worldwide.

CodeSee is a developer of cloud-based data visualization software aimed at enhancing code comprehension for developers and development teams. Founded in 2019 and based in San Francisco, California, the company provides tools that facilitate a continuous understanding of the codebase throughout the development process. Its software enables users to visualize how various elements of code and functionality are interconnected, thereby improving the overall workflow and efficiency of software development.

GenEdit Inc., established in 2016 and headquartered in Berkeley, California, specializes in developing innovative genome editing tools. The company's core technology is CRISPR/Cas9, which enables precise therapeutic gene editing. GenEdit has further advanced this field by creating the NanoGalaxy™ platform, a proprietary non-viral delivery system that efficiently transports CRISPR/Cas9 to target tissues, overcoming previous delivery challenges. This platform systematically screens a library of nanoparticles to ensure safer and more effective delivery, making therapeutic gene editing easier, faster, and more accurate than traditional methods. GenEdit's ultimate goal is to facilitate the cure of previously incurable genetic diseases by providing physicians with powerful tools for gene therapy.

SafelyYou, Inc. is a technology company based in Berkeley, California, founded in 2015, that specializes in artificial intelligence software designed for managed Alzheimer's care. The company focuses on fall prevention by utilizing a camera system installed in patients' rooms to detect falls in real time and alert caregivers. Its AI-enabled technology analyzes patterns and signs that may indicate a potential fall, allowing for proactive intervention. SafelyYou's solutions aim to enhance the safety and well-being of individuals with Alzheimer's and other forms of dementia, facilitating improved medication adherence, behavioral monitoring, and overall care management in skilled nursing facilities and assisted living communities. By reducing the frequency and impact of falls, SafelyYou contributes to lowering hospitalization rates among this vulnerable population.

Insight M specializes in developing innovative aerial monitoring technology focused on methane detection for the energy sector. Utilizing a combination of physical science expertise and advanced data analytics, the company surveys extensive areas and generates digital maps using optical and infrared wavelengths. This technology allows Insight M to meticulously scan pipelines and vast territories to pinpoint significant sources of gas loss. By facilitating comprehensive data collection about both the natural environment and human infrastructure, Insight M aims to enhance operational efficiency and safety within the oil and gas industry. Notably, the company carried out the first-ever basin-wide aerial survey for methane detection in the Permian Basin in 2019, underscoring its commitment to improving methane management practices.

Founded in 2010, Pivot Bio is a biotechnology company specializing in microbial nitrogen fertilizers. It harnesses naturally occurring microbes to provide nutrients to crops sustainably, aiming to reduce the need for petrochemical fertilizers and improve crop yield.

Frontier Medicines Corporation, established in 2018 and headquartered in South San Francisco, California, is a pre-clinical stage biopharmaceutical company specializing in cancer research. The company employs chemoproteomics to discover and develop novel medicines targeting cancer-causing proteins. Frontier Medicines' innovative platform integrates advanced computational methods and machine learning algorithms to identify and pharmacologically target new binding pockets on proteins, thereby enabling small-molecule drug discovery and development for previously inaccessible targets.

Stemson Therapeutics is a cell therapy company focused on restoring natural hair by generating new hair follicles. It uses induced pluripotent stem cells to create dermal papilla cells and combines them with a tissue engineering approach to produce a net new supply of hair follicles for patients experiencing hair loss. The company develops its proprietary methods to engineer cells capable of regenerating follicles, aiming to address emotional and social impact of hair loss. Founded in 2018, it is based in La Jolla, California.

Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Plexium, Inc. is a biotechnology company based in San Diego, California, specializing in the development of targeted protein degradation therapeutics aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium focuses on identifying E3 ligase modulating small molecules to create innovative therapies. The company has developed a screening platform known as DELPhe, which utilizes advanced techniques to miniaturize cell-based assays for high-content readouts. This platform enables the modulation of E3 ligases to selectively target various cancers, including small cell lung and breast tumors, while also inducing immune responses. By exploring next-generation drug candidates that extend beyond traditional approaches, Plexium is poised to uncover new therapeutic possibilities across a wide range of medical applications.

Deepcell, Inc. is a biotechnology company based in Mountain View, California, that specializes in single-cell analysis technology. Founded in 2015, the company has developed an AI-powered imaging and microfluidics platform that offers a non-invasive method for genetic testing with diagnostic-level accuracy. This platform enables researchers to classify and isolate viable cells based on their morphological characteristics, thus facilitating improved diagnosis and treatment of diseases. By providing detailed genetic health information through ordinary blood samples, Deepcell aims to enhance translational research, diagnostic testing, and therapeutic applications, ultimately reducing the need for invasive procedures in medical diagnostics.

Subtle Medical is a healthcare technology company that develops artificial‑intelligence software for magnetic resonance and positron emission tomography imaging. Its flagship products, SubtleMR and SubtlePET, are FDA‑cleared and CE‑marked tools that enhance image quality by reducing noise and sharpening detail, allowing scans to be performed faster and with lower radiation or contrast dose. The company’s deep‑learning algorithms integrate with any scanner without changing existing workflows, enabling imaging centers and hospitals to increase throughput and improve patient safety. Subtle Medical also offers a vendor‑agnostic AI platform that delivers analytics and support to clinical imaging providers. Founded in 2017 and headquartered in Menlo Park, California, the firm has received an NIH SBIR grant and an RSNA award for its GAD technology.

Carbon Health is a technology-enabled healthcare company that delivers primary and virtual care through a mobile app and a network of clinics. It provides omnichannel services, enabling patients to access care via clinics, pop-up sites, video visits, and a single platform for following treatment plans, managing prescriptions, and viewing lab results. The company has developed COVID-19 tools, including an assessment tool and testing in California. Founded in 2015 and headquartered in San Francisco, Carbon Health aims to provide convenient, accessible care from anywhere.

Zymergen, Inc. is a biotechnology company that focuses on researching, developing, and manufacturing microbes for various industries, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. Founded in 2013 and headquartered in Emeryville, California, Zymergen employs a platform that integrates automation, machine learning, and genomics to enhance the efficiency of microbial strain optimization and production processes. This technology enables the company to improve existing manufacturing strains and facilitates the development of new products by engineering novel molecules from microbes. With additional offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan, Zymergen aims to partner with nature to create innovative materials and products that deliver significant value across multiple sectors.

Auransa Inc. is a clinical stage drug development company founded in 2014 and based in Palo Alto, California. The company focuses on inventing novel drugs for challenging diseases, including cancer, autoimmune disorders, and neurological conditions, utilizing its proprietary AI-driven drug discovery platform. This platform enables Auransa to analyze extensive genomics data from human disease tissues, facilitating the study of molecular disease subtypes and the prediction of effective compounds and targets for specific patient populations. Auransa's current pipeline includes a first-in-class investigational new drug for cancer that is undergoing clinical trials. Additionally, the company collaborates with various partners in the biopharma industry to enhance its research and development efforts.

Atomwise, Inc. is a biotechnology company specializing in deep learning artificial intelligence technology for small molecule drug discovery. Based in San Francisco and founded in 2012, the company has developed AtomNet, a pioneering AI platform that facilitates virtual screening of molecules by predicting the binding of small molecules to proteins through a statistical analysis of experimental affinity measurements and protein structures. Atomwise is focused on addressing over 600 unique disease targets and has established collaborations with over 250 partners, including prominent pharmaceutical and biotechnology firms. By leveraging its advanced technology, Atomwise aims to revolutionize the drug discovery process and advance a pipeline of small-molecule drug candidates into preclinical studies. The company was previously known as Chematria, Inc. and rebranded to Atomwise, Inc. in 2015.

Caption Health, Inc. is a technology company specializing in artificial intelligence software designed to enhance the acquisition and interpretation of ultrasound exams. Its flagship product, Caption AI, serves as an AI-guided medical imaging acquisition system that assists healthcare providers by offering real-time guidance, automating quality assessments, and interpreting ultrasound images to ensure diagnostic accuracy. Founded in 2013 and headquartered in Brisbane, California, Caption Health was previously known as Bay Labs, Inc. The company aims to scale its commercial operations and further develop its AI technology platform, intending to broaden the application of Caption AI across various clinical settings as adoption increases among healthcare practitioners.

Proprio, Inc. is a healthcare technology company based in Seattle, Washington, that focuses on developing an advanced surgical navigation and imaging platform. Founded in 2016, the company utilizes machine learning, artificial intelligence, and mixed-reality user interfaces to enhance surgical accuracy and simplify workflows, ultimately improving patient outcomes. Proprio's innovative solutions aim to replace traditional surgical microscopes and navigation systems with a more integrated system that leverages networked camera arrays, depth-sensing technology, and computer graphics. By synthesizing data from multiple inputs, Proprio enables medical professionals to navigate complex anatomical structures in real-time 3D environments, fostering a shift in medicine that embraces modern technological advancements. The company's vision extends beyond mere replacement of existing tools; it seeks to transform the surgical landscape by integrating software and data-driven approaches, enhancing the collaboration between humans and machines in the operating room.

Carbon Health is a technology-enabled healthcare company that delivers primary and virtual care through a mobile app and a network of clinics. It provides omnichannel services, enabling patients to access care via clinics, pop-up sites, video visits, and a single platform for following treatment plans, managing prescriptions, and viewing lab results. The company has developed COVID-19 tools, including an assessment tool and testing in California. Founded in 2015 and headquartered in San Francisco, Carbon Health aims to provide convenient, accessible care from anywhere.

Founded in 2010, Pivot Bio is a biotechnology company specializing in microbial nitrogen fertilizers. It harnesses naturally occurring microbes to provide nutrients to crops sustainably, aiming to reduce the need for petrochemical fertilizers and improve crop yield.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

Culture Biosciences, Inc. is a biotechnology company based in South San Francisco, California, that offers an innovative biomanufacturing platform designed for scientists to efficiently run, monitor, and analyze bioreactor experiments through the cloud. Founded in 2016, the company specializes in developing automated bioreactors and fermentation tools that enable biotech companies to optimize their manufacturing processes. By leveraging robotic sample handling and cloud-based data monitoring and analysis, Culture Biosciences significantly accelerates the ability of scientists to manage bioreactor operations compared to traditional methods. This allows for faster product development and market readiness, streamlining the biomanufacturing workflow for its clients.

Novome Biotechnologies, Inc. is a biotechnology company specializing in the engineering of gut bacteria to create innovative therapies for chronic diseases. Established in 2015 and located in South San Francisco, California, Novome has developed a pioneering platform for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs). This platform allows for the precise delivery of therapeutic activities aimed at treating conditions such as hyperoxaluria, with a focus on creating a bacterial strain that can degrade oxalate to help prevent kidney stone formation. The company is also expanding its synthetic biology capabilities to explore additional therapeutic indications, aiming to improve long-term health outcomes for patients through its living therapeutics.

Pyka develops autonomous electric aircraft for agriculture and related applications, including crop-dusting and precision spraying on farms and potential cargo transport. The company designs and manufactures drones and aircraft with autonomous flight controllers and onboard sensors to enable safe, efficient operation over varied terrain. Its fully electric aircraft aim to reduce environmental impact while improving safety, affordability, and accessibility in aviation. Founded in 2016 and based in Oakland, California.

Capella Space is an information services company based in San Francisco that operates a constellation of small satellites equipped with synthetic aperture radar, delivering on-demand, high-resolution radar imagery of the Earth's surface. The SAR imagery can be acquired through clouds, smoke, fog, and darkness, enabling continuous global monitoring and rapid insight across industries. Capella's services support infrastructure monitoring, agriculture, disaster response, maritime domain awareness, city planning and mapping, and business intelligence, helping customers detect sub-meter surface changes, track economic activity, and monitor environmental and security-related conditions. Founded in 2016, Capella Space provides timely earth observation for commerce, conservation, and safety.

X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, established in 2018. The company specializes in addressing cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, Inc., X-37 focuses on discovering novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach aims to expedite the process of medicine discovery and development, thereby enhancing the healthcare sector's ability to deliver effective treatments to patients more efficiently.

Plexium, Inc. is a biotechnology company based in San Diego, California, specializing in the development of targeted protein degradation therapeutics aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium focuses on identifying E3 ligase modulating small molecules to create innovative therapies. The company has developed a screening platform known as DELPhe, which utilizes advanced techniques to miniaturize cell-based assays for high-content readouts. This platform enables the modulation of E3 ligases to selectively target various cancers, including small cell lung and breast tumors, while also inducing immune responses. By exploring next-generation drug candidates that extend beyond traditional approaches, Plexium is poised to uncover new therapeutic possibilities across a wide range of medical applications.

Embark Trucks Inc. is a technology company based in San Francisco, California, specializing in the development of self-driving truck technology for the commercial trucking industry. Founded in 2015, the company focuses on creating artificial intelligence software that enhances long-haul transportation efficiency. Embark has achieved significant milestones in automation, including successful cross-country drives and the ability to operate in various weather conditions such as rain and fog. The company employs a skilled team of engineers with backgrounds from leading organizations like Tesla, Google, Audi, and NASA, and its operations team has an impressive track record, averaging over a million miles per driver. By collaborating with trucking carriers, manufacturers, and suppliers, Embark aims to deliver operational savings and improve logistics for freight and transportation services.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Lucira Health, Inc. is a medical technology company that specializes in the development and commercialization of innovative infectious disease test kits. Founded in 2013 and based in Emeryville, California, Lucira has created a consumer-friendly, single-use testing platform that delivers centralized-laboratory-accurate molecular testing. Their flagship product is a disposable COVID-19 test kit that can be used at home, featuring a mobile application that connects users to treatment options. The kit is powered by two AA batteries and is compact enough to fit in the palm of a hand. Additionally, Lucira has developed a 2-in-1 lab testing solution that can determine if viral respiratory symptoms are due to COVID-19 or the flu, enhancing the accessibility and convenience of viral testing for consumers.

Frontier Medicines Corporation, established in 2018 and headquartered in South San Francisco, California, is a pre-clinical stage biopharmaceutical company specializing in cancer research. The company employs chemoproteomics to discover and develop novel medicines targeting cancer-causing proteins. Frontier Medicines' innovative platform integrates advanced computational methods and machine learning algorithms to identify and pharmacologically target new binding pockets on proteins, thereby enabling small-molecule drug discovery and development for previously inaccessible targets.

Founded in 2012, Mythic specializes in designing and manufacturing AI-driven silicon chips and inference processors. Its innovative technology brings desktop GPU compute capabilities and neural networks to compact, energy-efficient devices, enabling AI deployment across various industries such as consumer electronics, wearables, and autonomous systems.

Carbon Health is a technology-enabled healthcare company that delivers primary and virtual care through a mobile app and a network of clinics. It provides omnichannel services, enabling patients to access care via clinics, pop-up sites, video visits, and a single platform for following treatment plans, managing prescriptions, and viewing lab results. The company has developed COVID-19 tools, including an assessment tool and testing in California. Founded in 2015 and headquartered in San Francisco, Carbon Health aims to provide convenient, accessible care from anywhere.

Plexium, Inc. is a biotechnology company based in San Diego, California, specializing in the development of targeted protein degradation therapeutics aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium focuses on identifying E3 ligase modulating small molecules to create innovative therapies. The company has developed a screening platform known as DELPhe, which utilizes advanced techniques to miniaturize cell-based assays for high-content readouts. This platform enables the modulation of E3 ligases to selectively target various cancers, including small cell lung and breast tumors, while also inducing immune responses. By exploring next-generation drug candidates that extend beyond traditional approaches, Plexium is poised to uncover new therapeutic possibilities across a wide range of medical applications.

Jupiter Intelligence, Inc. is a technology company that specializes in climate risk analytics, providing tools and platforms to assess the impacts of weather and climate change. Founded in 2017 and based in San Mateo, California, Jupiter offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate various predictive models that process data from numerous ground-based and satellite sensors. The company's offerings include Jupiter FloodScore, which assists users in preparing for potential flooding, and Jupiter HeatScore, which predicts extreme temperatures to help organizations mitigate heat- and cold-related risks. By transforming complex climate science into actionable data, Jupiter enables businesses to proactively manage and disclose climate risks, helping them navigate the increasing frequency and severity of extreme weather events.

Lucira Health, Inc. is a medical technology company that specializes in the development and commercialization of innovative infectious disease test kits. Founded in 2013 and based in Emeryville, California, Lucira has created a consumer-friendly, single-use testing platform that delivers centralized-laboratory-accurate molecular testing. Their flagship product is a disposable COVID-19 test kit that can be used at home, featuring a mobile application that connects users to treatment options. The kit is powered by two AA batteries and is compact enough to fit in the palm of a hand. Additionally, Lucira has developed a 2-in-1 lab testing solution that can determine if viral respiratory symptoms are due to COVID-19 or the flu, enhancing the accessibility and convenience of viral testing for consumers.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Alation is a Redwood City, California-based provider of enterprise data intelligence platforms. Its flagship platform combines AI-driven data search and discovery with data governance, data stewardship, analytics, and digital transformation capabilities, along with privacy, risk, and compliance solutions. The platform supports metadata management and collaboration by linking data sources, usage, and lineage to guide self-service analytics and governance. By integrating machine learning with human insight, Alation helps organizations find the right data, understand its provenance, and govern its use, enabling faster, evidence-based decision making across teams.

Zymergen, Inc. is a biotechnology company that focuses on researching, developing, and manufacturing microbes for various industries, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. Founded in 2013 and headquartered in Emeryville, California, Zymergen employs a platform that integrates automation, machine learning, and genomics to enhance the efficiency of microbial strain optimization and production processes. This technology enables the company to improve existing manufacturing strains and facilitates the development of new products by engineering novel molecules from microbes. With additional offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan, Zymergen aims to partner with nature to create innovative materials and products that deliver significant value across multiple sectors.

GenEdit Inc., established in 2016 and headquartered in Berkeley, California, specializes in developing innovative genome editing tools. The company's core technology is CRISPR/Cas9, which enables precise therapeutic gene editing. GenEdit has further advanced this field by creating the NanoGalaxy™ platform, a proprietary non-viral delivery system that efficiently transports CRISPR/Cas9 to target tissues, overcoming previous delivery challenges. This platform systematically screens a library of nanoparticles to ensure safer and more effective delivery, making therapeutic gene editing easier, faster, and more accurate than traditional methods. GenEdit's ultimate goal is to facilitate the cure of previously incurable genetic diseases by providing physicians with powerful tools for gene therapy.

X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, established in 2018. The company specializes in addressing cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, Inc., X-37 focuses on discovering novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach aims to expedite the process of medicine discovery and development, thereby enhancing the healthcare sector's ability to deliver effective treatments to patients more efficiently.

Pachyderm, Inc., founded in 2014 and based in San Francisco, California, specializes in developing software for deploying and managing multi-stage, language-agnostic data pipelines. The company's platform provides data lineage to track the entire machine learning development lifecycle and supports end-to-end data science workflows. Pachyderm offers an enterprise-grade, open-source data science platform that ensures explainable, repeatable, and scalable ML/AI processes. Its solutions include version control for data, tools for building scalable pipelines, and support for any language, framework, or tool. The company provides a free, open-source version of its platform, as well as enterprise and hub versions tailored to specific needs.

Area 1 Security, Inc. is a cybersecurity company based in Redwood City, California, that specializes in eliminating targeted, socially engineered cyber-attacks. Founded in 2013 by experts from the NSA and MIT, the company develops the Area 1 Horizon, a cloud-based solution that identifies threat campaigns, attacker infrastructure, and attack delivery mechanisms. This product provides advanced warnings and effectively halts phishing attacks during their early stages, addressing multiple use cases such as attack visualization and preemption. By targeting various cyber-attack vectors, including email and web, Area 1 Security enhances the cybersecurity posture of enterprises and enables them to proactively combat threats.

Plexium, Inc. is a biotechnology company based in San Diego, California, specializing in the development of targeted protein degradation therapeutics aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium focuses on identifying E3 ligase modulating small molecules to create innovative therapies. The company has developed a screening platform known as DELPhe, which utilizes advanced techniques to miniaturize cell-based assays for high-content readouts. This platform enables the modulation of E3 ligases to selectively target various cancers, including small cell lung and breast tumors, while also inducing immune responses. By exploring next-generation drug candidates that extend beyond traditional approaches, Plexium is poised to uncover new therapeutic possibilities across a wide range of medical applications.

Capella Space is an information services company based in San Francisco that operates a constellation of small satellites equipped with synthetic aperture radar, delivering on-demand, high-resolution radar imagery of the Earth's surface. The SAR imagery can be acquired through clouds, smoke, fog, and darkness, enabling continuous global monitoring and rapid insight across industries. Capella's services support infrastructure monitoring, agriculture, disaster response, maritime domain awareness, city planning and mapping, and business intelligence, helping customers detect sub-meter surface changes, track economic activity, and monitor environmental and security-related conditions. Founded in 2016, Capella Space provides timely earth observation for commerce, conservation, and safety.

SCUBA Analytics develops a continuous intelligence platform that focuses on unifying customer experience management. Founded in 2013 and headquartered in Redwood City, California, with additional locations in Dallas and Bellevue, the company provides a solution that allows business intelligence and data science teams to make real-time decisions across various business silos. SCUBA's platform is designed for fast and scalable analysis of large datasets, enabling users to interpret billions of events in seconds. By employing a visual interface, the platform allows clients to conduct direct queries and explore essential business metrics such as growth, retention, conversion, and engagement, ultimately helping organizations understand customer behavior and improve product utilization.

Embark Trucks Inc. is a technology company based in San Francisco, California, specializing in the development of self-driving truck technology for the commercial trucking industry. Founded in 2015, the company focuses on creating artificial intelligence software that enhances long-haul transportation efficiency. Embark has achieved significant milestones in automation, including successful cross-country drives and the ability to operate in various weather conditions such as rain and fog. The company employs a skilled team of engineers with backgrounds from leading organizations like Tesla, Google, Audi, and NASA, and its operations team has an impressive track record, averaging over a million miles per driver. By collaborating with trucking carriers, manufacturers, and suppliers, Embark aims to deliver operational savings and improve logistics for freight and transportation services.

Vium, Inc. is a biotechnology company founded in 2013 and headquartered in San Mateo, California. It specializes in developing digital biomarkers aimed at enhancing preclinical research and animal welfare. The company is fully accredited by AAALAC International and has received significant commendation for its commitment to the principles of humane animal research. Vium's digital platform, known as Digital Vivarium and Vium Cloud, utilizes advanced technologies such as computer vision, artificial intelligence, and machine learning to non-invasively collect physiological metrics and behaviors. This innovative approach enables researchers and drug developers to gain improved insights into disease progression, thereby facilitating better decision-making regarding which compounds should progress to clinical trials. Its clientele includes a diverse array of biotechnology, pharmaceutical, and academic institutions, as well as novel therapeutic laboratories, all seeking more sensitive and accurate data for replicable studies.

Subtle Medical is a healthcare technology company that develops artificial‑intelligence software for magnetic resonance and positron emission tomography imaging. Its flagship products, SubtleMR and SubtlePET, are FDA‑cleared and CE‑marked tools that enhance image quality by reducing noise and sharpening detail, allowing scans to be performed faster and with lower radiation or contrast dose. The company’s deep‑learning algorithms integrate with any scanner without changing existing workflows, enabling imaging centers and hospitals to increase throughput and improve patient safety. Subtle Medical also offers a vendor‑agnostic AI platform that delivers analytics and support to clinical imaging providers. Founded in 2017 and headquartered in Menlo Park, California, the firm has received an NIH SBIR grant and an RSNA award for its GAD technology.

SingleStore is a data technology company that provides a distributed SQL database platform designed for real-time transactions and analytics. Its offerings include SingleStore DB, a distributed SQL database that can run on bare metal, in the cloud, or in hybrid deployments for operational analytics, and SingleStore Managed Service, a cloud database-as-a-service that provides analytics across a cloud of choice. The platform combines transactional and analytical processing in a single engine, supports real-time querying, multi-model data, and scalable ingestion, and aims to modernize data platforms, secure workloads, and support customer analytics across industries such as financial services, media and communications, energy and utilities, government, retail, and technology. Headquartered in San Francisco with additional offices, the company serves global enterprises by enabling real-time insights from data.

GitPrime, founded in 2015 and headquartered in Durango, Colorado, develops productivity analytics software tailored for developer teams. The company aggregates data from various sources such as git repositories, ticketing systems, and pull requests, transforming this information into understandable insights and reports. This helps engineering organizations map their initiatives to outcomes and adjust processes with confidence. GitPrime's platform integrates with popular code repositories like GitHub, GitLab, and BitBucket, providing timely and accurate data-driven answers for engineering leaders and stakeholders.

Founded in 2012, Mythic specializes in designing and manufacturing AI-driven silicon chips and inference processors. Its innovative technology brings desktop GPU compute capabilities and neural networks to compact, energy-efficient devices, enabling AI deployment across various industries such as consumer electronics, wearables, and autonomous systems.

Fortem Technologies is a security technology company that develops AI-enabled airspace security and detect-and-avoid solutions to identify, classify, and manage drones and other unmanned aircraft. Its offerings include radar-based detection systems and AI-driven monitoring software, enabling real-time analysis of multiple sensors to support safe autonomous flight and BVLOS operations. Key products and capabilities include DAA-R10 and DAA-R20 radar-based detect-and-avoid systems, ThreatAware AI analysis engine, the F700 Patriot multi-rotor platform, and DroneHunter, an autonomous interceptor for perimeter intrusion detection and protection. The company serves defense, government, and commercial sectors and is based in Provo, Utah.

Atomwise, Inc. is a biotechnology company specializing in deep learning artificial intelligence technology for small molecule drug discovery. Based in San Francisco and founded in 2012, the company has developed AtomNet, a pioneering AI platform that facilitates virtual screening of molecules by predicting the binding of small molecules to proteins through a statistical analysis of experimental affinity measurements and protein structures. Atomwise is focused on addressing over 600 unique disease targets and has established collaborations with over 250 partners, including prominent pharmaceutical and biotechnology firms. By leveraging its advanced technology, Atomwise aims to revolutionize the drug discovery process and advance a pipeline of small-molecule drug candidates into preclinical studies. The company was previously known as Chematria, Inc. and rebranded to Atomwise, Inc. in 2015.

Jupiter Intelligence, Inc. is a technology company that specializes in climate risk analytics, providing tools and platforms to assess the impacts of weather and climate change. Founded in 2017 and based in San Mateo, California, Jupiter offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate various predictive models that process data from numerous ground-based and satellite sensors. The company's offerings include Jupiter FloodScore, which assists users in preparing for potential flooding, and Jupiter HeatScore, which predicts extreme temperatures to help organizations mitigate heat- and cold-related risks. By transforming complex climate science into actionable data, Jupiter enables businesses to proactively manage and disclose climate risks, helping them navigate the increasing frequency and severity of extreme weather events.

Founded in 2016, Akash Systems specializes in developing advanced satellite technologies. The company is renowned for its innovative use of gallium nitride (GaN)-on-Diamond composite material, which enhances energy efficiency and reduces the size and weight of satellite transmitters and CubeSats. Headquartered in San Francisco, CA.

Vathys, Inc. is a manufacturer of deep learning processor chips, established in 2016 and headquartered in Portland, Oregon. Originally founded as Ingemini, LLC, the company rebranded in January 2018. Vathys focuses on developing innovative processor architectures specifically designed for deep learning applications. Its technology aims to address computing challenges by minimizing data movement, thereby reducing computational loads and lowering power consumption. This unique approach allows Vathys to offer advanced solutions that cater to the growing demands of deep learning, positioning the company as a key player in the semiconductor industry.

Deepcell, Inc. is a biotechnology company based in Mountain View, California, that specializes in single-cell analysis technology. Founded in 2015, the company has developed an AI-powered imaging and microfluidics platform that offers a non-invasive method for genetic testing with diagnostic-level accuracy. This platform enables researchers to classify and isolate viable cells based on their morphological characteristics, thus facilitating improved diagnosis and treatment of diseases. By providing detailed genetic health information through ordinary blood samples, Deepcell aims to enhance translational research, diagnostic testing, and therapeutic applications, ultimately reducing the need for invasive procedures in medical diagnostics.

Recursion Pharmaceuticals is a clinical-stage biotechnology company that aims to radically improve patients’ lives by decoding biology through the integration of biology, chemistry, automation, data science, and engineering to industrialize drug discovery. The company operates a large-scale drug discovery platform built around Recursion OS, an infrastructure layer and a Map of proprietary biological and chemical data, supported by software tools and machine learning to explore biology beyond human bias and identify new therapeutic opportunities. Its platform includes ReChem for selecting and designing compounds, ReScreen and ReScreenRun for planning and automating large-scale experiments, and ReRun, ReAnalyze, and RePredict for digital signatures, data analysis, and predictive modeling of drug relationships. Founded in 2013, the company is based in Salt Lake City, Utah.

TigerGraph Inc. is a technology company that specializes in graph analytics and databases. Founded in 2012 and headquartered in Redwood City, California, with additional offices in Shanghai, London, and Munich, the company offers a platform that combines native graph storage and computing with real-time updates. This platform is designed to facilitate advanced analytics and machine learning on connected data, enabling applications such as fraud detection, anti-money laundering, entity resolution, and cybersecurity. TigerGraph's technology allows enterprises to transform complex data into a network of objects and relationships, uncovering hidden patterns and actionable insights. The company's tools support ad-hoc and interactive analytics, making it a vital resource for organizations seeking to enhance their relationship analysis capabilities.

Subtle Medical is a healthcare technology company that develops artificial‑intelligence software for magnetic resonance and positron emission tomography imaging. Its flagship products, SubtleMR and SubtlePET, are FDA‑cleared and CE‑marked tools that enhance image quality by reducing noise and sharpening detail, allowing scans to be performed faster and with lower radiation or contrast dose. The company’s deep‑learning algorithms integrate with any scanner without changing existing workflows, enabling imaging centers and hospitals to increase throughput and improve patient safety. Subtle Medical also offers a vendor‑agnostic AI platform that delivers analytics and support to clinical imaging providers. Founded in 2017 and headquartered in Menlo Park, California, the firm has received an NIH SBIR grant and an RSNA award for its GAD technology.

Founded in 2015, Quilt Data operates a platform that facilitates collaborative data management. It enables organizations to work with data more efficiently, making informed decisions faster and enhancing overall success.

Unlearn.AI, Inc. is a biotechnology company based in San Francisco, California, that specializes in developing innovative software tools for clinical research. Established in 2017, Unlearn.AI focuses on enhancing clinical trials through its unique digital twin technology, known as TwinRCT. This approach utilizes machine learning to create prognostic digital twins for individual patients, allowing for more accurate estimations of treatment effects while reducing the number of participants needed. The company also offers services for Clinical Trial Design, which helps determine inclusion criteria, endpoints, and study sizes, as well as Synthetic Control Arms that can minimize or eliminate the need for concurrent control groups. Additionally, Unlearn.AI provides Subgroup Analysis to identify and analyze specific patient subgroups within trial results. By integrating expertise from pharmaceuticals, medical technology, and machine learning, Unlearn.AI aims to transform clinical trials to improve outcomes for both patients and sponsors.

Freenome, Inc. is an artificial intelligence genomics biotech company based in South San Francisco, California, founded in 2014. The company focuses on developing accurate, accessible, and non-invasive blood tests for the early detection of cancer and treatment selection. Utilizing a proprietary multi-omics platform, Freenome employs advanced algorithms to analyze cell-free genomic data, which aids in identifying early-stage cancers and other diseases. This innovative approach aims to transform disease management by enabling timely interventions and proactive treatment strategies. In addition to its diagnostic solutions, Freenome also offers clinical research services to further advance cancer detection and management.

Pyka develops autonomous electric aircraft for agriculture and related applications, including crop-dusting and precision spraying on farms and potential cargo transport. The company designs and manufactures drones and aircraft with autonomous flight controllers and onboard sensors to enable safe, efficient operation over varied terrain. Its fully electric aircraft aim to reduce environmental impact while improving safety, affordability, and accessibility in aviation. Founded in 2016 and based in Oakland, California.

Molecular Assemblies, Inc. is a San Diego-based company that specializes in enzymatic DNA synthesis technology, aimed at creating DNA-based products across various industries. Founded in 2013, the company has developed a proprietary method that allows for the reliable, affordable, and sustainable production of long, high-quality, sequence-specific DNA. This innovative technology is designed to support advancements in industrial synthetic biology, personalized therapeutics, precision diagnostics, and has potential applications in information storage and nanotechnology. With a strong executive and scientific team, as well as a robust intellectual property portfolio, Molecular Assemblies is positioned to enhance the capabilities of researchers and contribute to the evolution of DNA-based applications.

Karius is a life sciences company that develops genomic insights for infectious diseases. Its core offering, the Karius Test, is a non-invasive blood test that sequences microbial cell-free DNA to identify and quantify pathogens—including bacteria, DNA viruses, fungi, and parasites—for use in complicated pneumonia, infections in immunocompromised patients, and endocarditis. The company also provides laboratory services for pathogen biomarker detection for biopharmaceutical research and development. Founded in 2014, Karius is headquartered in Redwood City, California, with an additional office in Menlo Park, California. The laboratory operations are CLIA-certified and CAP-accredited, enabling high-complexity clinical testing. By mapping a patient’s microbial landscape from a single blood draw, Karius aims to support rapid, informed treatment decisions.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Insight Engines, Inc. is a cybersecurity company based in San Francisco, California, founded in 2015. It specializes in developing innovative products that leverage natural language understanding to enhance cybersecurity investigations. The company's primary offering, the Insight Engines Cyber Security Investigator for Splunk, allows security teams to conduct investigations and threat hunting using plain English, significantly reducing the time required to analyze data. By transforming complex machine data into accessible insights, Insight Engines empowers organizations, including major players in healthcare, finance, and government sectors, to quickly detect, investigate, and visualize cyber threats. The platform also provides timely recommendations and insights into potential use cases for data stored in log systems, facilitating more effective decision-making for security analysts. As a subsidiary of Mr Buzz Inc, LLC, Insight Engines continues to focus on making cybersecurity investigations more efficient and user-friendly.

Plenty is a vertical farming company that operates indoor vertical farms to grow fresh, nutritious produce with far lower water and land use than conventional farming. Founded in 2014 and headquartered in South San Francisco, California, Plenty uses proprietary systems that combine engineering, software and crop science to deliver year-round crops without GMOs or pesticides and with minimal fertilizer runoff.

Embark Trucks Inc. is a technology company based in San Francisco, California, specializing in the development of self-driving truck technology for the commercial trucking industry. Founded in 2015, the company focuses on creating artificial intelligence software that enhances long-haul transportation efficiency. Embark has achieved significant milestones in automation, including successful cross-country drives and the ability to operate in various weather conditions such as rain and fog. The company employs a skilled team of engineers with backgrounds from leading organizations like Tesla, Google, Audi, and NASA, and its operations team has an impressive track record, averaging over a million miles per driver. By collaborating with trucking carriers, manufacturers, and suppliers, Embark aims to deliver operational savings and improve logistics for freight and transportation services.

Alation is a Redwood City, California-based provider of enterprise data intelligence platforms. Its flagship platform combines AI-driven data search and discovery with data governance, data stewardship, analytics, and digital transformation capabilities, along with privacy, risk, and compliance solutions. The platform supports metadata management and collaboration by linking data sources, usage, and lineage to guide self-service analytics and governance. By integrating machine learning with human insight, Alation helps organizations find the right data, understand its provenance, and govern its use, enabling faster, evidence-based decision making across teams.

Dark Inc. is a technology company founded in 2017 and based in San Francisco, California. The company specializes in developing a new programming language that is closely integrated with its own editor and compiler, as well as providing platform-as-a-service (PaaS) solutions. Dark's offerings enable engineers to build distributed applications using high-level programming primitives, streamlining the development process. By combining a holistic programming language with hosted infrastructure, Dark aims to simplify the complexities associated with application development and enhance the efficiency of software engineering.

Buoyant Inc., established in 2015 and based in San Francisco, specializes in developing open-source software to enhance the performance, reliability, and security of cloud-native applications. The company's flagship product is Linkerd, an open-source network proxy designed for service mesh deployment, facilitating efficient management, control, and monitoring of service-to-service communication within applications. Buoyant's team comprises senior ex-Twitter infrastructure engineers aiming to provide advanced capabilities to various companies, as they previously helped conquer Twitter's "Fail Whale" issue. The company is well-funded and backed by prominent investors.