DCVC

Radiant is a clean energy startup based in Los Angeles, California, that specializes in the development of portable nuclear microreactors. Founded in 2019, the company aims to provide an alternative to fossil fuels through its innovative microreactor technology. Designed to fit within a shipping container, these reactors can be easily transported by air, ship, or road, making them suitable for both military and commercial applications. The Kaleidos microreactor, in particular, is notable for offering a zero-emissions power source, ideal for remote locations and critical power needs.

Unspun, Inc., founded in 2015 and based in San Francisco, California, specializes in the development of a platform that creates customized jeans using advanced body scanning technology, fit algorithms, and additive manufacturing. The company aims to address environmental concerns by reducing global carbon emissions through automated and localized manufacturing processes. Unspun’s innovative approach not only eliminates pattern-cutting waste and unsold inventory but also allows for the production of jeans in under ten minutes in a zero-waste manner. Their technology is showcased through the unspun.io platform, which provides digital customization solutions for various apparel brands. With a mission to make fashion more sustainable, Unspun is positioned at the intersection of robotics and digital apparel, striving to transform the industry with its unique approach to on-demand manufacturing.

Fervo Energy, founded in 2017 and based in San Francisco, California, specializes in the development and commercialization of next-generation geothermal power technology. The company focuses on owning, developing, and operating geothermal assets to generate clean, carbon-free energy in new locations. By leveraging innovations in geoscience, Fervo Energy aims to accelerate the transition to a sustainable energy future, positioning itself as a key player in the evolution of the electric grid. Its proprietary technology serves as a dispatchable foundation for achieving a fully clean energy system, enabling clients to enhance productivity and scalability in energy production.

Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company focuses on the discovery and development of medicines targeting cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational methods and machine learning to identify and pharmacologically target new binding pockets on proteins, facilitating the development of small-molecule drugs. By enhancing the accessibility of these proteins, Frontier Medicines aims to provide effective treatments that can redefine the management of debilitating diseases.

Unlearn.AI, Inc. is a biotechnology company that specializes in developing software tools for clinical research, focusing on improving diagnosis and treatment processes. Based in San Francisco, the company offers solutions such as Clinical Trial Design, which helps define inclusion criteria, endpoints, and study sizes; Synthetic Control Arms, which reduce or eliminate the necessity for concurrent control groups; and Subgroup Analysis, which identifies specific patient subgroups within trial results. Unlearn.AI has pioneered the TwinRCT solution, a digital twin service that leverages machine learning to enhance the efficiency and success rates of clinical trials. This innovative approach creates a prognostic digital twin for each patient, allowing for more precise estimations of treatment effects based on historical data. By integrating machine learning and biostatistics, Unlearn.AI aims to accelerate the clinical trial process, benefiting both patients and pharmaceutical sponsors.

CH4 Global Inc. is a holding company focused on producing seaweed bio-products aimed at reducing methane emissions from livestock. Founded in 2019 and based in San Francisco, California, the company specializes in Asparagopsis armata, a seaweed supplement that can significantly lower methane emissions from ruminant animals such as cows, goats, sheep, and deer. Operating through subsidiaries in the United States, Australia, New Zealand, and the Pacific, CH4 Global seeks to address climate change by providing innovative solutions that leverage proven science and technology in aquaculture. The company targets a large-scale impact on greenhouse gas emissions, with its feed additives designed for feedlot cattle serving as the cornerstone of its product line. By mitigating enteric methane emissions, CH4 Global not only contributes to environmental sustainability but also offers farmers and food producers potential benefits such as carbon credits and enhanced market prices for their products.

Verdigris Technologies, Inc. specializes in software solutions for electricity monitoring and management in commercial facilities. The company offers the Verdigris Energy Tracker, which identifies operational inefficiencies, automates building management, and predicts demand peaks while detecting equipment failures. Its cloud-based system employs wireless hardware to transmit electricity consumption data from devices, facilitating smarter facility operations and enhancing energy efficiency. Additionally, Verdigris Building.AI serves as an analytics platform for enterprise facilities managers, providing insights into power usage per device and optimizing operations to increase uptime and reduce energy costs. By leveraging artificial intelligence and real-time monitoring, Verdigris aims to improve energy efficiency in large buildings, making them smarter and more connected. Founded in 2010, the company is headquartered in Moffett Field, California.

Demox Labs, founded in 2021 and based in Walnut Creek, California, specializes in developing a decentralized oracle protocol that connects smart contracts to various off-chain data sources. The company aims to bridge the gap between web2 and web3, enabling the integration of online data into smart contract development. Its platform transforms any website into an oracle, facilitating efficient data relay across different blockchain networks. Additionally, Demox Labs focuses on creating privacy-preserving wallets for web3 applications, enhancing security for users while improving the overall global payment structure.

Mythic Inc. is a technology company that designs and develops silicon chips and artificial intelligence processing units (IPUs) for a wide range of applications, from consumer electronics and wearables to autonomous vehicles and robotic drones. Founded in 2012 and headquartered in Redwood City, California, with an additional office in Austin, Texas, Mythic specializes in analog matrix processors that utilize unique compute-in-memory technology. Their products, including the M1076 Analog Matrix Processor and various PCIe and M.2 cards, integrate AI capabilities directly into compact chips, enabling desktop-level processing power in smaller devices. The company emphasizes its expertise in neural networks, processor architecture, and software design to deliver efficient AI solutions while maintaining performance, power efficiency, and accuracy in real-world environments.

Verdant Robotics, Inc. specializes in developing artificial intelligence-based robotic solutions for agriculture. Established in 2018 and headquartered in Hayward, California, the company focuses on enhancing grower profits through advanced technology that digitally maps farms and tracks plant health over time. Its flagship product, the Model B Smart Sprayer, significantly reduces labor costs by over 50% and input costs by 96%, while providing efficient weed and thinning services for various crop types, including organic and no-till fields. Utilizing proprietary targeting technology and a precise spraying system, Verdant Robotics enables micro-fertilization and nutrient delivery, leading to notable increases in crop yields. By integrating robotics, computer vision, and machine learning, Verdant empowers farmers to maximize productivity and efficiency in food production.

Novome Biotechnologies, Inc. is a biotechnology company that focuses on engineering bacteria from the human gut to develop innovative treatments for chronic diseases. Its proprietary platform, which allows for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs), is designed to provide sustained therapeutic effects. Novome's lead preclinical program targets hyperoxaluria by developing a therapeutic strain of bacteria that degrades oxalate, thereby preventing kidney stone formation. The company aims to leverage its synthetic biology tools to expand its applications into additional health conditions, enhancing its ability to deliver precise therapeutic activities through engineered gut microbiota. Founded in 2015, Novome is headquartered in South San Francisco, California.

Fervo Energy, founded in 2017 and based in San Francisco, California, specializes in the development and commercialization of next-generation geothermal power technology. The company focuses on owning, developing, and operating geothermal assets to generate clean, carbon-free energy in new locations. By leveraging innovations in geoscience, Fervo Energy aims to accelerate the transition to a sustainable energy future, positioning itself as a key player in the evolution of the electric grid. Its proprietary technology serves as a dispatchable foundation for achieving a fully clean energy system, enabling clients to enhance productivity and scalability in energy production.

Capella Space is a commercial satellite imaging company based in San Francisco, California, founded in 2016. It operates a constellation of small satellites equipped with synthetic aperture radar (SAR) technology, capable of providing high-resolution Earth observation imagery at 50 centimeters. This technology allows for continuous monitoring of the Earth's surface, regardless of weather conditions, including clouds, smoke, and darkness. Capella Space's services support various industries, including maritime domain awareness, agriculture, infrastructure monitoring, and disaster response. The company aims to enhance decision-making related to commerce, conservation, and security by delivering timely and flexible geospatial data. Its capabilities are particularly valuable for applications involving economic activity estimation, urban planning, and search and rescue operations.

Unlearn.AI, Inc. is a biotechnology company that specializes in developing software tools for clinical research, focusing on improving diagnosis and treatment processes. Based in San Francisco, the company offers solutions such as Clinical Trial Design, which helps define inclusion criteria, endpoints, and study sizes; Synthetic Control Arms, which reduce or eliminate the necessity for concurrent control groups; and Subgroup Analysis, which identifies specific patient subgroups within trial results. Unlearn.AI has pioneered the TwinRCT solution, a digital twin service that leverages machine learning to enhance the efficiency and success rates of clinical trials. This innovative approach creates a prognostic digital twin for each patient, allowing for more precise estimations of treatment effects based on historical data. By integrating machine learning and biostatistics, Unlearn.AI aims to accelerate the clinical trial process, benefiting both patients and pharmaceutical sponsors.

Brimstone is a company that has developed a carbon-negative process for producing ordinary Portland cement and supplementary cementitious material. Founded in 2019 and based in Oakland, California, Brimstone's innovative technology employs carbon-free calcium silicate rock instead of traditional limestone, resulting in a product that matches the performance of conventional materials while remaining cost-competitive at scale. This advancement aims to provide the construction industry with a cleaner and more sustainable alternative to traditional cement production methods.

Kettle Inc. is an innovative company that has developed an online risk analysis platform for the insurance industry, focusing on reinsurance solutions amid the challenges posed by climate change. Founded in 2020 and based in Kensington, California, Kettle utilizes advanced deep learning algorithms to analyze over seven billion lines of satellite, weather, and ground truth data. By employing Swarm Neural Networks, the platform identifies patterns that enhance predictive accuracy, ultimately helping insurers manage and balance their risk portfolios. Kettle's technology aims to reduce loss ratios by enabling more effective underwriting of catastrophic risks, positioning the company as a key player in the evolving landscape of climate-related insurance.

Jupiter Intelligence, Inc. is a company that specializes in climate risk analytics, providing tools and platforms that deliver weather and climate data, trend visualizations, forecasts, and risk assessments. Its ClimateScore Intelligence Platform utilizes cloud computing to integrate various prediction models, processing data from numerous ground-based and satellite sensors. Jupiter also offers specific products like FloodScore, which aids users in preparing for potential flooding linked to climate change, and HeatScore, designed to help organizations anticipate and mitigate the impacts of extreme temperatures. Founded in 2017 and based in San Mateo, California, Jupiter Intelligence transforms complex climate science into actionable insights, enabling businesses to assess physical risks, comply with regulations, and address reputational concerns related to climate change.

CH4 Global Inc. is a holding company focused on producing seaweed bio-products aimed at reducing methane emissions from livestock. Founded in 2019 and based in San Francisco, California, the company specializes in Asparagopsis armata, a seaweed supplement that can significantly lower methane emissions from ruminant animals such as cows, goats, sheep, and deer. Operating through subsidiaries in the United States, Australia, New Zealand, and the Pacific, CH4 Global seeks to address climate change by providing innovative solutions that leverage proven science and technology in aquaculture. The company targets a large-scale impact on greenhouse gas emissions, with its feed additives designed for feedlot cattle serving as the cornerstone of its product line. By mitigating enteric methane emissions, CH4 Global not only contributes to environmental sustainability but also offers farmers and food producers potential benefits such as carbon credits and enhanced market prices for their products.

CodeSee is a company based in San Francisco, California, that specializes in cloud-based data visualization software aimed at enhancing code comprehension. Founded in 2019, CodeSee's platform provides developers and development teams with tools to continuously grasp their codebase throughout the development process. By mapping the relationships between code and functionality, the software facilitates better understanding and management of complex code structures, ultimately aiding in more efficient software development.

GenEdit Inc., founded in 2016 and based in Berkeley, California, focuses on advancing gene therapy through its innovative genome editing tools, particularly the CRISPR/Cas9 system. The company aims to address the challenges associated with gene therapy delivery by utilizing its proprietary NanoGalaxy™ platform, which systematically screens a library of nanoparticles to enhance the safety and efficiency of delivering genetic material to target tissues. GenEdit's technology is designed to facilitate therapeutic gene editing, offering a solution that is easier, faster, and more accurate than traditional methods. This positions GenEdit to potentially enable the treatment of previously incurable genetic diseases, significantly contributing to the future of non-viral, gene editing-based therapeutics.

Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company focuses on the discovery and development of medicines targeting cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational methods and machine learning to identify and pharmacologically target new binding pockets on proteins, facilitating the development of small-molecule drugs. By enhancing the accessibility of these proteins, Frontier Medicines aims to provide effective treatments that can redefine the management of debilitating diseases.

Pivot Bio is improving and using a deep understanding of the microbiome to advance crop nutrition. They believe that microbes can deliver nutrients, protect against pests, and improve crop quality better than chemical fertilizers and pesticides. They leverage engineering principles and data science to map the dynamics of the plant microbiome and evolve beneficial traits. Their team thrives on collaboration and communication as they seek to create revolutionary fertilizers that transform food supply and improves the planet. Pivot Bio's proprietary ON Technology harnesses the power of naturally occurring microbes to provide more nutrients to crops. It’s a smart, sustainable way for farmers to improve yield as they work to help feed the world’s growing population. Their current efforts are focused on enabling microbes to fix and supply more nitrogen to corn. Pivot Bio was founded in 2010 and is headquartered in Berkeley, California, United States.

Stemson Therapeutics, LLC is a cell therapy company based in La Jolla, California, focused on addressing hair loss by restoring natural hair through innovative treatments. Founded in 2018, the company utilizes a proprietary process that employs induced pluripotent stem cells (iPSC) to generate new dermal papilla, the essential cells needed for hair follicle regeneration. Its flagship product, the Stemson solution, combines engineered cells with a unique tissue engineering approach to create a sustainable supply of new hair follicles for patients. By providing effective solutions for individuals experiencing hair loss, Stemson Therapeutics aims to alleviate the emotional and social challenges associated with this condition.

Plexium, Inc. is a biotechnology company based in San Diego, California, that specializes in developing targeted protein degradation therapies aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium utilizes a platform that identifies small molecules capable of modulating E3 ligases, which play a crucial role in protein degradation. This platform includes the DELPhe screening technology, designed for high-content readouts from cell-based assays. By harnessing E3 ligases, Plexium's approach enables selective targeting of various cancers, including small cell lung and breast tumors. The company's innovative research extends beyond existing therapies, exploring new drug-like protein degraders and molecular glues to enhance treatment options for cancer and inflammatory diseases.

Deepcell, Inc. is a biotechnology company based in Mountain View, California, that specializes in providing advanced diagnostic solutions through its innovative microfluidic imaging platform. Founded in 2015, the company focuses on delivering non-invasive tests with diagnostic-level accuracy, enabling researchers and clinicians to gain insights at the single-cell level. Deepcell's technology employs artificial intelligence to analyze and classify cells based on their morphological features, isolating viable cells for various applications in translational research, diagnostic testing, and therapeutics. By utilizing ordinary blood samples, Deepcell enhances the understanding of genetic health without the need for invasive procedures, thereby improving the diagnosis and treatment of diseases.

Subtle Medical, Inc. is a healthcare technology company based in Menlo Park, California, that specializes in developing AI-powered medical imaging software for clinical imaging centers and hospitals. Founded in 2017, the company offers products such as SubtleMR and SubtlePET, both of which are FDA cleared and CE marked. These technologies enhance image quality in magnetic resonance imaging (MRI) and positron emission tomography (PET) exams by reducing noise and increasing sharpness, ultimately improving workflow efficiency while ensuring patient safety. Subtle Medical also features SubtleGAD, a technology recognized by the Radiological Society of North America, which aims to make imaging exams safer. The company employs a vendor-agnostic AI infrastructure that integrates seamlessly with existing scanners, allowing imaging providers to serve more patients effectively by enhancing image acquisition without disrupting their current workflow. Through its innovations, Subtle Medical seeks to improve the quality, value, and accessibility of medical imaging while significantly lowering costs and radiation exposure.

Carbon Health is a technology-driven healthcare company founded in 2015 and headquartered in San Francisco, California. It provides a comprehensive primary care experience through a mobile application that allows users to manage their treatment plans, prescriptions, and lab reports in one place. The company emphasizes convenience and accessibility, offering omnichannel care through various platforms, including clinics, pop-up sites, and virtual consultations. Additionally, Carbon Health has developed a coronavirus assessment tool and has implemented COVID-19 testing services in California, further expanding its commitment to accessible healthcare.

Zymergen, Inc. is a biotechnology company based in Emeryville, California, established in 2013, with additional offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan. The company focuses on researching, developing, and manufacturing microbes for a variety of sectors, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. Zymergen employs a platform that integrates automation, machine learning, and genomics to enhance the optimization of microbial strains, improve existing production processes, and bridge the gap between lab and commercial manufacturing. Additionally, the company offers services for new product development, leveraging its expertise to engineer novel molecules from microbes, thereby harnessing the potential of biological innovation to create advanced materials and products across multiple industries.

Auransa Inc., founded in 2014 and based in Palo Alto, California, is a clinical stage drug development company focused on creating innovative treatments for challenging diseases, including cancer, autoimmune, and neurological disorders. Utilizing a proprietary artificial intelligence platform, Auransa analyzes extensive genomic data from human disease tissues to study molecular subtypes of diseases. This approach allows the company to predict potential drug compounds and identify targets tailored for specific patient populations. Currently, Auransa's internal drug pipeline features a first-in-class investigational new drug for cancer that is undergoing clinical trials. The company actively collaborates with various partners in the biopharma sector to advance its drug development efforts.

Atomwise, Inc. is a biotechnology company based in San Francisco that specializes in using deep learning artificial intelligence for small molecule drug discovery. Founded in 2012, Atomwise developed the AtomNet platform, which enables virtual screening of molecules by predicting the binding of small molecules to proteins through a statistical approach that leverages experimental affinity measurements and protein structures. The company focuses on addressing over 600 unique disease targets and has established partnerships with more than 250 organizations, including pharmaceutical and biotechnology firms. Atomwise's technology has been recognized for its ability to unlock previously undruggable targets, and the company has raised significant funding to support its mission of accelerating drug discovery and development.

Rigetti Computing is a full-stack quantum computing company that designs and manufactures quantum-integrated circuits, deploying them in low-temperature environments. The company develops proprietary control systems to execute quantum logic operations and has created software to integrate its quantum systems with existing cloud infrastructure. Rigetti's innovations include the industry's first multi-chip quantum processor, which enables scalability in quantum computing systems. The company focuses on practical applications of quantum computing, particularly in computational chemistry and machine learning, and offers the Forest platform, a comprehensive programming and execution environment for quantum and classical computing. Most of its revenue is generated from the United States.

Caption Health, Inc. is a technology company that specializes in artificial intelligence-driven software solutions for ultrasound examinations. Founded in 2013 and headquartered in Brisbane, California, the company offers Caption AI, a system designed to assist healthcare providers in acquiring and interpreting ultrasound images. This software provides real-time guidance during exams, automates quality assessments, and facilitates the interpretation of ultrasound results, enabling practitioners to capture high-quality diagnostic images more efficiently. As the adoption of the Caption AI platform grows, Caption Health plans to enhance its technology and expand its clinical capabilities, aiming to integrate its solutions into a wider range of healthcare settings.

Carbon Health is a technology-driven healthcare company founded in 2015 and headquartered in San Francisco, California. It provides a comprehensive primary care experience through a mobile application that allows users to manage their treatment plans, prescriptions, and lab reports in one place. The company emphasizes convenience and accessibility, offering omnichannel care through various platforms, including clinics, pop-up sites, and virtual consultations. Additionally, Carbon Health has developed a coronavirus assessment tool and has implemented COVID-19 testing services in California, further expanding its commitment to accessible healthcare.

Pivot Bio is improving and using a deep understanding of the microbiome to advance crop nutrition. They believe that microbes can deliver nutrients, protect against pests, and improve crop quality better than chemical fertilizers and pesticides. They leverage engineering principles and data science to map the dynamics of the plant microbiome and evolve beneficial traits. Their team thrives on collaboration and communication as they seek to create revolutionary fertilizers that transform food supply and improves the planet. Pivot Bio's proprietary ON Technology harnesses the power of naturally occurring microbes to provide more nutrients to crops. It’s a smart, sustainable way for farmers to improve yield as they work to help feed the world’s growing population. Their current efforts are focused on enabling microbes to fix and supply more nitrogen to corn. Pivot Bio was founded in 2010 and is headquartered in Berkeley, California, United States.

Unlearn.AI, Inc. is a biotechnology company that specializes in developing software tools for clinical research, focusing on improving diagnosis and treatment processes. Based in San Francisco, the company offers solutions such as Clinical Trial Design, which helps define inclusion criteria, endpoints, and study sizes; Synthetic Control Arms, which reduce or eliminate the necessity for concurrent control groups; and Subgroup Analysis, which identifies specific patient subgroups within trial results. Unlearn.AI has pioneered the TwinRCT solution, a digital twin service that leverages machine learning to enhance the efficiency and success rates of clinical trials. This innovative approach creates a prognostic digital twin for each patient, allowing for more precise estimations of treatment effects based on historical data. By integrating machine learning and biostatistics, Unlearn.AI aims to accelerate the clinical trial process, benefiting both patients and pharmaceutical sponsors.

Culture Biosciences, Inc. is a biomanufacturing company based in South San Francisco, California, that offers a cloud-based platform for scientists to conduct, monitor, and analyze bioreactor experiments. Founded in 2016, the company focuses on automating bioprocesses to help biotech firms optimize their manufacturing processes and expedite product development. By utilizing robotic sample handling and cloud data monitoring, Culture Biosciences enhances the efficiency of fermentation and bioreactor operations, allowing researchers to achieve results more rapidly than with traditional methods.

Novome Biotechnologies, Inc. is a biotechnology company that focuses on engineering bacteria from the human gut to develop innovative treatments for chronic diseases. Its proprietary platform, which allows for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs), is designed to provide sustained therapeutic effects. Novome's lead preclinical program targets hyperoxaluria by developing a therapeutic strain of bacteria that degrades oxalate, thereby preventing kidney stone formation. The company aims to leverage its synthetic biology tools to expand its applications into additional health conditions, enhancing its ability to deliver precise therapeutic activities through engineered gut microbiota. Founded in 2015, Novome is headquartered in South San Francisco, California.

Pyka, Inc. is a startup based in Oakland, California, that specializes in the development of autonomous electric aircraft for agricultural and cargo applications. Founded in 2016, the company focuses on creating innovative solutions that enhance safety, affordability, and accessibility in aviation. Pyka's aircraft are designed for precision spraying in agriculture, allowing for effective chemical application over diverse terrains while minimizing environmental impact. The technology incorporates advanced flight controllers and onboard sensors to ensure accuracy and efficiency in operations. Additionally, the aircraft can be utilized for cargo transportation, particularly in remote or challenging areas, showcasing their versatility. Through its commitment to sustainability and technological advancement, Pyka aims to transform traditional practices in crop protection and logistics.

Capella Space is a commercial satellite imaging company based in San Francisco, California, founded in 2016. It operates a constellation of small satellites equipped with synthetic aperture radar (SAR) technology, capable of providing high-resolution Earth observation imagery at 50 centimeters. This technology allows for continuous monitoring of the Earth's surface, regardless of weather conditions, including clouds, smoke, and darkness. Capella Space's services support various industries, including maritime domain awareness, agriculture, infrastructure monitoring, and disaster response. The company aims to enhance decision-making related to commerce, conservation, and security by delivering timely and flexible geospatial data. Its capabilities are particularly valuable for applications involving economic activity estimation, urban planning, and search and rescue operations.

X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, founded in 2018. The company specializes in addressing cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, Inc., X-37 focuses on discovering novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach aims to expedite the discovery and development of medicines, ultimately benefiting the healthcare sector and improving patient outcomes.

Plexium, Inc. is a biotechnology company based in San Diego, California, that specializes in developing targeted protein degradation therapies aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium utilizes a platform that identifies small molecules capable of modulating E3 ligases, which play a crucial role in protein degradation. This platform includes the DELPhe screening technology, designed for high-content readouts from cell-based assays. By harnessing E3 ligases, Plexium's approach enables selective targeting of various cancers, including small cell lung and breast tumors. The company's innovative research extends beyond existing therapies, exploring new drug-like protein degraders and molecular glues to enhance treatment options for cancer and inflammatory diseases.

Embark Trucks Inc. specializes in developing self-driving truck technology and highway autopilot systems aimed at enhancing commercial trucking efficiency. Founded in 2015 and based in San Francisco, the company designs artificial intelligence software specifically for long-haul transportation. Embark has achieved significant milestones in automated trucking, including successful cross-country drives and the ability to operate in challenging weather conditions such as rain and fog. The company has assembled a team of engineers with backgrounds from prominent organizations like Tesla, Google, Audi, and NASA, supported by a professional operations team that averages over a million miles of driving experience per member. Embark collaborates with carriers, truck manufacturers, and tier-one suppliers to provide operational savings and improve weight management and disturbance performance in freight and logistics services.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Lucira Health, Inc. is a medical technology company based in Emeryville, California, that specializes in the development and commercialization of innovative infectious disease test kits. Founded in 2013, the company focuses on creating accessible and user-friendly testing solutions, including a disposable COVID-19 test kit designed for home use. This kit provides centralized-laboratory-accurate molecular testing in a compact format that operates on two AA batteries. It connects consumers to treatment options through a mobile application and offers a dual testing capability to determine whether viral respiratory symptoms are caused by COVID-19 or influenza. Lucira Health aims to enhance the accessibility and efficiency of infectious disease diagnostics.

Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company focuses on the discovery and development of medicines targeting cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational methods and machine learning to identify and pharmacologically target new binding pockets on proteins, facilitating the development of small-molecule drugs. By enhancing the accessibility of these proteins, Frontier Medicines aims to provide effective treatments that can redefine the management of debilitating diseases.

Mythic Inc. is a technology company that designs and develops silicon chips and artificial intelligence processing units (IPUs) for a wide range of applications, from consumer electronics and wearables to autonomous vehicles and robotic drones. Founded in 2012 and headquartered in Redwood City, California, with an additional office in Austin, Texas, Mythic specializes in analog matrix processors that utilize unique compute-in-memory technology. Their products, including the M1076 Analog Matrix Processor and various PCIe and M.2 cards, integrate AI capabilities directly into compact chips, enabling desktop-level processing power in smaller devices. The company emphasizes its expertise in neural networks, processor architecture, and software design to deliver efficient AI solutions while maintaining performance, power efficiency, and accuracy in real-world environments.

Carbon Health is a technology-driven healthcare company founded in 2015 and headquartered in San Francisco, California. It provides a comprehensive primary care experience through a mobile application that allows users to manage their treatment plans, prescriptions, and lab reports in one place. The company emphasizes convenience and accessibility, offering omnichannel care through various platforms, including clinics, pop-up sites, and virtual consultations. Additionally, Carbon Health has developed a coronavirus assessment tool and has implemented COVID-19 testing services in California, further expanding its commitment to accessible healthcare.

Plexium, Inc. is a biotechnology company based in San Diego, California, that specializes in developing targeted protein degradation therapies aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium utilizes a platform that identifies small molecules capable of modulating E3 ligases, which play a crucial role in protein degradation. This platform includes the DELPhe screening technology, designed for high-content readouts from cell-based assays. By harnessing E3 ligases, Plexium's approach enables selective targeting of various cancers, including small cell lung and breast tumors. The company's innovative research extends beyond existing therapies, exploring new drug-like protein degraders and molecular glues to enhance treatment options for cancer and inflammatory diseases.

Jupiter Intelligence, Inc. is a company that specializes in climate risk analytics, providing tools and platforms that deliver weather and climate data, trend visualizations, forecasts, and risk assessments. Its ClimateScore Intelligence Platform utilizes cloud computing to integrate various prediction models, processing data from numerous ground-based and satellite sensors. Jupiter also offers specific products like FloodScore, which aids users in preparing for potential flooding linked to climate change, and HeatScore, designed to help organizations anticipate and mitigate the impacts of extreme temperatures. Founded in 2017 and based in San Mateo, California, Jupiter Intelligence transforms complex climate science into actionable insights, enabling businesses to assess physical risks, comply with regulations, and address reputational concerns related to climate change.

Lucira Health, Inc. is a medical technology company based in Emeryville, California, that specializes in the development and commercialization of innovative infectious disease test kits. Founded in 2013, the company focuses on creating accessible and user-friendly testing solutions, including a disposable COVID-19 test kit designed for home use. This kit provides centralized-laboratory-accurate molecular testing in a compact format that operates on two AA batteries. It connects consumers to treatment options through a mobile application and offers a dual testing capability to determine whether viral respiratory symptoms are caused by COVID-19 or influenza. Lucira Health aims to enhance the accessibility and efficiency of infectious disease diagnostics.

Unlearn.AI, Inc. is a biotechnology company that specializes in developing software tools for clinical research, focusing on improving diagnosis and treatment processes. Based in San Francisco, the company offers solutions such as Clinical Trial Design, which helps define inclusion criteria, endpoints, and study sizes; Synthetic Control Arms, which reduce or eliminate the necessity for concurrent control groups; and Subgroup Analysis, which identifies specific patient subgroups within trial results. Unlearn.AI has pioneered the TwinRCT solution, a digital twin service that leverages machine learning to enhance the efficiency and success rates of clinical trials. This innovative approach creates a prognostic digital twin for each patient, allowing for more precise estimations of treatment effects based on historical data. By integrating machine learning and biostatistics, Unlearn.AI aims to accelerate the clinical trial process, benefiting both patients and pharmaceutical sponsors.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Alation, Inc. is a provider of data intelligence solutions based in Redwood City, California, founded in 2012. The company specializes in an AI-driven platform that encompasses data search and discovery, data governance, data stewardship, analytics, and digital transformation. Alation's platform is recognized for its capabilities in the data catalog market, leveraging a Behavioral Analysis Engine and collaboration features to blend machine learning with human insight. This approach allows organizations to efficiently manage their data and metadata, facilitating self-service analytics and improving decision-making processes. By automating the capture of critical information regarding data usage and provenance, Alation supports businesses in navigating the complexities of data management and governance.

Zymergen, Inc. is a biotechnology company based in Emeryville, California, established in 2013, with additional offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan. The company focuses on researching, developing, and manufacturing microbes for a variety of sectors, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. Zymergen employs a platform that integrates automation, machine learning, and genomics to enhance the optimization of microbial strains, improve existing production processes, and bridge the gap between lab and commercial manufacturing. Additionally, the company offers services for new product development, leveraging its expertise to engineer novel molecules from microbes, thereby harnessing the potential of biological innovation to create advanced materials and products across multiple industries.

GenEdit Inc., founded in 2016 and based in Berkeley, California, focuses on advancing gene therapy through its innovative genome editing tools, particularly the CRISPR/Cas9 system. The company aims to address the challenges associated with gene therapy delivery by utilizing its proprietary NanoGalaxy™ platform, which systematically screens a library of nanoparticles to enhance the safety and efficiency of delivering genetic material to target tissues. GenEdit's technology is designed to facilitate therapeutic gene editing, offering a solution that is easier, faster, and more accurate than traditional methods. This positions GenEdit to potentially enable the treatment of previously incurable genetic diseases, significantly contributing to the future of non-viral, gene editing-based therapeutics.

X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, founded in 2018. The company specializes in addressing cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, Inc., X-37 focuses on discovering novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach aims to expedite the discovery and development of medicines, ultimately benefiting the healthcare sector and improving patient outcomes.

Pachyderm, Inc. is a software company that specializes in developing a data engineering platform focused on automating complex data pipelines. Founded in 2014 and based in San Francisco, California, Pachyderm's platform facilitates the creation of multi-stage, language-agnostic data workflows while ensuring reproducibility and traceability. Its features include data versioning and lineage tracking, which are essential for maintaining oversight throughout the machine learning development lifecycle. The software is available in several versions, including open-source and enterprise options, allowing users to implement scalable and sophisticated data transformations across various data types. By integrating tools for managing and tracking data, Pachyderm aims to make machine learning and artificial intelligence more accessible and efficient for enterprises.

Area 1 Security, Inc. is a cybersecurity company based in Redwood City, California, focused on eliminating targeted cyber-attacks, particularly those that are socially engineered. Founded in 2013 by experts from the NSA and MIT, the company develops the Area 1 Horizon, a cloud-based solution that identifies threat campaigns and attack delivery mechanisms. This technology provides advanced warning and helps prevent phishing attacks during their early stages, enhancing the cybersecurity posture of enterprises. Area 1 Security's solutions effectively eliminate various cyber-attack traffic vectors, including email, web, and networks, enabling organizations to proactively address potential threats. The company has raised a total of $25.5 million in funding from prominent investors, reinforcing its commitment to advancing cybersecurity measures.

Plexium, Inc. is a biotechnology company based in San Diego, California, that specializes in developing targeted protein degradation therapies aimed at treating cancer and neurodegenerative diseases. Founded in 2017, Plexium utilizes a platform that identifies small molecules capable of modulating E3 ligases, which play a crucial role in protein degradation. This platform includes the DELPhe screening technology, designed for high-content readouts from cell-based assays. By harnessing E3 ligases, Plexium's approach enables selective targeting of various cancers, including small cell lung and breast tumors. The company's innovative research extends beyond existing therapies, exploring new drug-like protein degraders and molecular glues to enhance treatment options for cancer and inflammatory diseases.

Capella Space is a commercial satellite imaging company based in San Francisco, California, founded in 2016. It operates a constellation of small satellites equipped with synthetic aperture radar (SAR) technology, capable of providing high-resolution Earth observation imagery at 50 centimeters. This technology allows for continuous monitoring of the Earth's surface, regardless of weather conditions, including clouds, smoke, and darkness. Capella Space's services support various industries, including maritime domain awareness, agriculture, infrastructure monitoring, and disaster response. The company aims to enhance decision-making related to commerce, conservation, and security by delivering timely and flexible geospatial data. Its capabilities are particularly valuable for applications involving economic activity estimation, urban planning, and search and rescue operations.

SCUBA is a collaborative decision intelligence platform providing in-the-moment decision intelligence and activation without compromising privacy. Global brands like Microsoft, McDonald's, Twitter, and Warner Bros trust SCUBA to gain in-the-moment insights across billions of touchpoints, fueling real-time experiences and growth. Founded by former Facebook executives and led by industry veterans from Kantar, Sonos, Splunk, and WarnerMedia.

Embark Trucks Inc. specializes in developing self-driving truck technology and highway autopilot systems aimed at enhancing commercial trucking efficiency. Founded in 2015 and based in San Francisco, the company designs artificial intelligence software specifically for long-haul transportation. Embark has achieved significant milestones in automated trucking, including successful cross-country drives and the ability to operate in challenging weather conditions such as rain and fog. The company has assembled a team of engineers with backgrounds from prominent organizations like Tesla, Google, Audi, and NASA, supported by a professional operations team that averages over a million miles of driving experience per member. Embark collaborates with carriers, truck manufacturers, and tier-one suppliers to provide operational savings and improve weight management and disturbance performance in freight and logistics services.

Vium, Inc. is a biotechnology company focused on transforming preclinical research and enhancing animal welfare through the development of digital biomarkers. Fully accredited by AAALAC International, Vium has received commendation for its commitment to the principles of humane animal research. The company's platform, known as Digital Vivarium and Vium Cloud, integrates advanced technologies such as computer vision, artificial intelligence, and machine learning to non-invasively capture and analyze physiological metrics and behaviors. This innovative approach provides researchers across biotechnology, pharmaceutical, and academic sectors with accurate data that facilitates better decision-making regarding which compounds to advance to clinical trials. Founded in 2013 and headquartered in San Mateo, California, Vium aims to accelerate the preclinical drug discovery and development pipeline while ensuring ethical standards in research practices.

Subtle Medical, Inc. is a healthcare technology company based in Menlo Park, California, that specializes in developing AI-powered medical imaging software for clinical imaging centers and hospitals. Founded in 2017, the company offers products such as SubtleMR and SubtlePET, both of which are FDA cleared and CE marked. These technologies enhance image quality in magnetic resonance imaging (MRI) and positron emission tomography (PET) exams by reducing noise and increasing sharpness, ultimately improving workflow efficiency while ensuring patient safety. Subtle Medical also features SubtleGAD, a technology recognized by the Radiological Society of North America, which aims to make imaging exams safer. The company employs a vendor-agnostic AI infrastructure that integrates seamlessly with existing scanners, allowing imaging providers to serve more patients effectively by enhancing image acquisition without disrupting their current workflow. Through its innovations, Subtle Medical seeks to improve the quality, value, and accessibility of medical imaging while significantly lowering costs and radiation exposure.

Mythic Inc. is a technology company that designs and develops silicon chips and artificial intelligence processing units (IPUs) for a wide range of applications, from consumer electronics and wearables to autonomous vehicles and robotic drones. Founded in 2012 and headquartered in Redwood City, California, with an additional office in Austin, Texas, Mythic specializes in analog matrix processors that utilize unique compute-in-memory technology. Their products, including the M1076 Analog Matrix Processor and various PCIe and M.2 cards, integrate AI capabilities directly into compact chips, enabling desktop-level processing power in smaller devices. The company emphasizes its expertise in neural networks, processor architecture, and software design to deliver efficient AI solutions while maintaining performance, power efficiency, and accuracy in real-world environments.

Atomwise, Inc. is a biotechnology company based in San Francisco that specializes in using deep learning artificial intelligence for small molecule drug discovery. Founded in 2012, Atomwise developed the AtomNet platform, which enables virtual screening of molecules by predicting the binding of small molecules to proteins through a statistical approach that leverages experimental affinity measurements and protein structures. The company focuses on addressing over 600 unique disease targets and has established partnerships with more than 250 organizations, including pharmaceutical and biotechnology firms. Atomwise's technology has been recognized for its ability to unlock previously undruggable targets, and the company has raised significant funding to support its mission of accelerating drug discovery and development.

Jupiter Intelligence, Inc. is a company that specializes in climate risk analytics, providing tools and platforms that deliver weather and climate data, trend visualizations, forecasts, and risk assessments. Its ClimateScore Intelligence Platform utilizes cloud computing to integrate various prediction models, processing data from numerous ground-based and satellite sensors. Jupiter also offers specific products like FloodScore, which aids users in preparing for potential flooding linked to climate change, and HeatScore, designed to help organizations anticipate and mitigate the impacts of extreme temperatures. Founded in 2017 and based in San Mateo, California, Jupiter Intelligence transforms complex climate science into actionable insights, enabling businesses to assess physical risks, comply with regulations, and address reputational concerns related to climate change.

Deepcell, Inc. is a biotechnology company based in Mountain View, California, that specializes in providing advanced diagnostic solutions through its innovative microfluidic imaging platform. Founded in 2015, the company focuses on delivering non-invasive tests with diagnostic-level accuracy, enabling researchers and clinicians to gain insights at the single-cell level. Deepcell's technology employs artificial intelligence to analyze and classify cells based on their morphological features, isolating viable cells for various applications in translational research, diagnostic testing, and therapeutics. By utilizing ordinary blood samples, Deepcell enhances the understanding of genetic health without the need for invasive procedures, thereby improving the diagnosis and treatment of diseases.

TigerGraph Inc. develops a graph analytics platform that facilitates advanced analytics and machine learning on connected data. Founded in 2012 and headquartered in Redwood City, California, the company also has offices in Shanghai, London, and Munich. Its platform features a distributed native graph database, enabling real-time graph updates and built-in parallel computation. TigerGraph's technology supports various applications, including fraud detection, anti-money laundering, customer 360 analysis, recommendations, and network analysis. By transforming complex data into a network of objects and relationships, the platform empowers enterprises to uncover hidden patterns and derive actionable insights, enhancing their relationship analysis capabilities.

Subtle Medical, Inc. is a healthcare technology company based in Menlo Park, California, that specializes in developing AI-powered medical imaging software for clinical imaging centers and hospitals. Founded in 2017, the company offers products such as SubtleMR and SubtlePET, both of which are FDA cleared and CE marked. These technologies enhance image quality in magnetic resonance imaging (MRI) and positron emission tomography (PET) exams by reducing noise and increasing sharpness, ultimately improving workflow efficiency while ensuring patient safety. Subtle Medical also features SubtleGAD, a technology recognized by the Radiological Society of North America, which aims to make imaging exams safer. The company employs a vendor-agnostic AI infrastructure that integrates seamlessly with existing scanners, allowing imaging providers to serve more patients effectively by enhancing image acquisition without disrupting their current workflow. Through its innovations, Subtle Medical seeks to improve the quality, value, and accessibility of medical imaging while significantly lowering costs and radiation exposure.

Unlearn.AI, Inc. is a biotechnology company that specializes in developing software tools for clinical research, focusing on improving diagnosis and treatment processes. Based in San Francisco, the company offers solutions such as Clinical Trial Design, which helps define inclusion criteria, endpoints, and study sizes; Synthetic Control Arms, which reduce or eliminate the necessity for concurrent control groups; and Subgroup Analysis, which identifies specific patient subgroups within trial results. Unlearn.AI has pioneered the TwinRCT solution, a digital twin service that leverages machine learning to enhance the efficiency and success rates of clinical trials. This innovative approach creates a prognostic digital twin for each patient, allowing for more precise estimations of treatment effects based on historical data. By integrating machine learning and biostatistics, Unlearn.AI aims to accelerate the clinical trial process, benefiting both patients and pharmaceutical sponsors.

Quilt Data, Inc. is a San Francisco-based company founded in 2015 that specializes in crowdsource data collection and organization services. The company operates a cloud-based platform designed to enhance data management for organizations, enabling faster, more collaborative, and trustworthy data interactions among all team members, not just data scientists. Quilt's platform facilitates the management of code, sharing, discovery, analytics, and insights, while also providing custom information development and personalized training. This approach allows organizations to make informed decisions more rapidly, improving their operational efficiency and competitive advantage in an increasingly data-driven environment.

Karius, Inc. is a life sciences company based in Redwood City, California, specializing in genomic insights for infectious diseases. The company offers a non-invasive blood test known as the Karius Test, which utilizes sequencing of microbial cell-free DNA to identify and quantify various pathogens, including bacteria, DNA viruses, fungi, and parasites. This test is particularly useful for diagnosing complicated pneumonia, infections in immunocompromised patients, and endocarditis. By mapping the microbial landscape of each patient from a single blood draw, Karius aims to assist clinicians in making rapid and informed treatment decisions. The company's laboratory is CLIA-certified and CAP-accredited, ensuring high standards in clinical laboratory testing. Additionally, Karius provides laboratory services for pathogen biomarker detection tailored to biopharmaceutical companies.

PerimeterX, Inc. is a cybersecurity company that specializes in developing solutions to prevent automated attacks and malicious web behavior. Founded in 2014 and headquartered in San Mateo, California, with additional locations in London, Miami, and a subsidiary in Tel Aviv, the company offers a suite of products aimed at protecting web infrastructure. Its flagship solutions, known as PerimeterX Bot Defender, provide real-time defenses against various types of bot attacks, including those targeting websites, mobile applications, and APIs. By leveraging behavioral analytics and advanced threat detection techniques, PerimeterX helps organizations in sectors such as e-commerce, travel, and media safeguard their digital assets from account abuse, web scraping, and marketing fraud. The company's innovative approach has garnered recognition, including being listed among the top cybersecurity startups and promising artificial intelligence firms.

Plenty Inc., founded in 2014 and based in South San Francisco, California, specializes in vertical farming, providing fresh and nutritious produce while minimizing environmental impact. The company employs innovative farming techniques that significantly reduce the water and land needed compared to traditional agriculture, and it operates without the use of pesticides or genetically modified organisms. By utilizing proprietary vertical farming systems that integrate engineering, software, and crop science, Plenty aims to deliver healthy food year-round while eliminating fertilizer runoff. Through its collective of growers, engineers, scientists, and food enthusiasts, Plenty is dedicated to enhancing the health of consumers and the planet.

Alation, Inc. is a provider of data intelligence solutions based in Redwood City, California, founded in 2012. The company specializes in an AI-driven platform that encompasses data search and discovery, data governance, data stewardship, analytics, and digital transformation. Alation's platform is recognized for its capabilities in the data catalog market, leveraging a Behavioral Analysis Engine and collaboration features to blend machine learning with human insight. This approach allows organizations to efficiently manage their data and metadata, facilitating self-service analytics and improving decision-making processes. By automating the capture of critical information regarding data usage and provenance, Alation supports businesses in navigating the complexities of data management and governance.

Embark Trucks Inc. specializes in developing self-driving truck technology and highway autopilot systems aimed at enhancing commercial trucking efficiency. Founded in 2015 and based in San Francisco, the company designs artificial intelligence software specifically for long-haul transportation. Embark has achieved significant milestones in automated trucking, including successful cross-country drives and the ability to operate in challenging weather conditions such as rain and fog. The company has assembled a team of engineers with backgrounds from prominent organizations like Tesla, Google, Audi, and NASA, supported by a professional operations team that averages over a million miles of driving experience per member. Embark collaborates with carriers, truck manufacturers, and tier-one suppliers to provide operational savings and improve weight management and disturbance performance in freight and logistics services.

Citrine Informatics, Inc. is a technology company that specializes in artificial intelligence and machine learning to enhance materials development. Founded in 2013 and headquartered in Redwood City, California, with an additional office in Pittsburgh, the company operates a platform that aggregates and analyzes extensive datasets related to materials, chemicals, and devices. This platform aims to streamline research and development, manufacturing, and supply chain processes for organizations involved in producing physical products. By employing data science and machine learning, Citrine Informatics accelerates the discovery of new materials and helps identify defects early in the research process, thereby improving product design and development efficiency across various sectors, including energy, aerospace, and electronics.

Illumio, Inc. is a cybersecurity company based in Sunnyvale, California, founded in 2012. It specializes in cloud-based security solutions designed to protect organizations from cyber threats and enhance operational resilience. The company's core offering is the Adaptive Security Platform, which includes tools for data center and cloud traffic security. Key components of this platform are the Illumination application traffic mapping tool, the Enforcement application nano-segmentation solution, and SecureConnect for data protection. Illumio's approach centers on Zero Trust principles, helping organizations visualize traffic flows and implement segmentation policies that limit lateral movement within multi-cloud and hybrid infrastructures. This capability is essential for safeguarding critical resources and preventing the spread of cyber attacks. Illumio serves a diverse clientele, including notable companies such as Plantronics, Yahoo, Creative Artists Agency, and NTT Innovation Institute, Inc.

Mythic Inc. is a technology company that designs and develops silicon chips and artificial intelligence processing units (IPUs) for a wide range of applications, from consumer electronics and wearables to autonomous vehicles and robotic drones. Founded in 2012 and headquartered in Redwood City, California, with an additional office in Austin, Texas, Mythic specializes in analog matrix processors that utilize unique compute-in-memory technology. Their products, including the M1076 Analog Matrix Processor and various PCIe and M.2 cards, integrate AI capabilities directly into compact chips, enabling desktop-level processing power in smaller devices. The company emphasizes its expertise in neural networks, processor architecture, and software design to deliver efficient AI solutions while maintaining performance, power efficiency, and accuracy in real-world environments.

Aporeto offers comprehensive cloud-native security for containers and microservices. It secures all workloads across any infrastructure with identity-based access control for a Zero Trust posture. Aporeto was founded in 2016 and is based in San Jose, California.

Honeycomb provides full-stack observability for modern engineering teams to understand, debug, and improve production systems. Honeycomb's customers rely on the product for fast incident response, system optimization, and delivering pain-free releases across the software engineering cycle that translates to happy devs and happy customers. Founded on the experience of debugging problems at the scale of millions of apps serving tens of millions of users, it helps every engineer to the instrument and queries the behavior of their system. The company was founded in 2016 and is based in San Francisco, California.

Rigetti Computing is a full-stack quantum computing company that designs and manufactures quantum-integrated circuits, deploying them in low-temperature environments. The company develops proprietary control systems to execute quantum logic operations and has created software to integrate its quantum systems with existing cloud infrastructure. Rigetti's innovations include the industry's first multi-chip quantum processor, which enables scalability in quantum computing systems. The company focuses on practical applications of quantum computing, particularly in computational chemistry and machine learning, and offers the Forest platform, a comprehensive programming and execution environment for quantum and classical computing. Most of its revenue is generated from the United States.

Freenome, Inc. is a biotechnology company based in South San Francisco, California, founded in 2014. It specializes in developing artificial intelligence-driven genomic solutions for the early detection of cancer. The company focuses on creating simple, non-invasive blood tests that can identify early-stage cancer and assist in treatment selection, thus enabling proactive disease management. Freenome’s multi-omics platform employs proprietary algorithms to enhance disease screening processes, aiming to facilitate timely interventions and improve treatment effectiveness. In addition to its diagnostic products, Freenome also offers clinical research services to support its mission of transforming cancer management through systematic early detection.

Caption Health, Inc. is a technology company that specializes in artificial intelligence-driven software solutions for ultrasound examinations. Founded in 2013 and headquartered in Brisbane, California, the company offers Caption AI, a system designed to assist healthcare providers in acquiring and interpreting ultrasound images. This software provides real-time guidance during exams, automates quality assessments, and facilitates the interpretation of ultrasound results, enabling practitioners to capture high-quality diagnostic images more efficiently. As the adoption of the Caption AI platform grows, Caption Health plans to enhance its technology and expand its clinical capabilities, aiming to integrate its solutions into a wider range of healthcare settings.

Cape Analytics, LLC is a technology company that specializes in an artificial intelligence-based geospatial imagery data platform designed for the insurance and reinsurance sectors in the United States. Founded in 2014 and based in Mountain View, California, the company employs deep learning and computer vision to provide instant property intelligence, allowing insurers and property stakeholders to obtain critical property attributes during the underwriting process. This platform offers the precision and detail typically associated with on-site inspections, but with the added benefits of speed and extensive coverage. By streamlining access to valuable property data, Cape Analytics enhances the efficiency of underwriting for real estate and insurance companies.

Capella Space is a commercial satellite imaging company based in San Francisco, California, founded in 2016. It operates a constellation of small satellites equipped with synthetic aperture radar (SAR) technology, capable of providing high-resolution Earth observation imagery at 50 centimeters. This technology allows for continuous monitoring of the Earth's surface, regardless of weather conditions, including clouds, smoke, and darkness. Capella Space's services support various industries, including maritime domain awareness, agriculture, infrastructure monitoring, and disaster response. The company aims to enhance decision-making related to commerce, conservation, and security by delivering timely and flexible geospatial data. Its capabilities are particularly valuable for applications involving economic activity estimation, urban planning, and search and rescue operations.

Zymergen, Inc. is a biotechnology company based in Emeryville, California, established in 2013, with additional offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan. The company focuses on researching, developing, and manufacturing microbes for a variety of sectors, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. Zymergen employs a platform that integrates automation, machine learning, and genomics to enhance the optimization of microbial strains, improve existing production processes, and bridge the gap between lab and commercial manufacturing. Additionally, the company offers services for new product development, leveraging its expertise to engineer novel molecules from microbes, thereby harnessing the potential of biological innovation to create advanced materials and products across multiple industries.

BlueTalon, Inc. specializes in data collaboration and unification technologies, offering solutions that enhance data-centric security for big data environments. The company's key products include the Control Your Data solution, the BlueTalon Virtual Database, and the BlueTalon Policy Engine, which collectively facilitate secure access and management of data across various platforms, including Hadoop, Spark, and SQL-based systems. These tools enable organizations to enforce precise user access controls, ensuring compliance and reducing security risks. BlueTalon's services allow users to access corporate data seamlessly across different departments and locations without the need for extensive modifications to existing databases or applications. Founded in 2013 and headquartered in Redwood City, California, BlueTalon has gained recognition for its innovative approach to data security, earning accolades such as being named a Gartner Cool Vendor in 2016. As of 2019, BlueTalon operates as a subsidiary of Microsoft Corporation, serving a wide range of clients, including Fortune 100 companies, that seek to enhance their visibility and control over sensitive data.

SigOpt, Inc. operates an advanced optimization platform designed to enhance the performance of machine learning models, A/B tests, and physical experiments. Founded in 2014 and based in San Francisco, California, the company offers a REST API that integrates seamlessly into existing machine learning workflows. SigOpt's platform employs a black-box optimization approach, allowing users to input parameter spaces and performance metrics without needing to share underlying data. By continuously analyzing model performance, SigOpt refines its suggestions for optimal hyper-parameter configurations, thereby accelerating the model development process and improving results in a cost-effective manner. As of late 2020, SigOpt functions as a subsidiary of Intel Corporation.

Flutterwave Inc. is a payments solutions provider that enables businesses globally to process transactions seamlessly. Founded in 2014 and headquartered in San Francisco, the company offers a range of services including Flutterwave Checkout for collecting payments via web and mobile platforms, and Flutterwave API for creating and managing virtual cards, which can be customized with spending limits. Its invoicing feature allows businesses to generate professional invoices, track payments, and manage transactions efficiently. Additionally, Flutterwave provides payment links that facilitate payment collection from customers worldwide. Serving various sectors such as gaming, events, transportation, and hospitality, Flutterwave aims to simplify the payment infrastructure for merchants and payment service providers by offering a comprehensive digital financial platform.

3Scan is turning tissue into bits by building robotic microscopy tools and software for large-scale sample analysis and 3D visualizations. Many diseases emerge only at a tissue level, such as cancer, heart disease, lung disease, stroke, Alzheimer's, and diabetes. 3Scan enables higher throughput, greater quantification, and broader image analysis than what is currently possible with traditional histopathology. 3Scan's data-driven approach is expanding our understanding of tissue biology and will lead to the discovery of new diagnostics and therapeutics. The company was founded in 2011 and is headquartered in San Francisco, California.

Gladly is a customer service platform that enables B2C companies to focus on people talking to people throughout a lifetime of naturally productive conversations. With Gladly, customers are at the center and brands can communicate with their customers seamlessly across any channel from voice, email, messaging, chat, and social media. Agents are empowered, customers feel known, and companies build love and loyalty through consistently positive experiences. Gladly is based in San Francisco and funded by Greylock Partners, GGV Capital, NEA, and JetBlue Ventures.

Rescale, Inc. is a company that specializes in developing and operating cloud-based platforms for scientific and engineering simulations. Its offerings include the ScaleX Pro platform for independent professionals and small to medium-sized businesses, and ScaleX Developer, which allows external application developers to integrate their software directly with Rescale’s systems. Additionally, the ScaleX Enterprise platform provides a comprehensive solution for enterprise-level simulation needs, managing on-premise high-performance computing resources and software licenses. Serving a diverse range of industries, including aerospace, automotive, and life sciences, Rescale facilitates more than 300 customers, from startups to large corporations, in accelerating their design processes and reducing time to market. Founded in 2011 and headquartered in San Francisco, Rescale also has offices in Tokyo, Munich, and Singapore, and it is supported by a variety of investors from the technology and venture capital sectors.

Agenovir Corporation is focused on the research and development of antiviral therapeutics aimed at tackling diseases linked to latent or persistent viral reservoirs. The company employs advanced nucleases, including CRISPR/Cas9 technology, to precisely target and disrupt viral DNA. Established in 2014 and headquartered in South San Francisco, California, Agenovir operates as a subsidiary of Vir Biotechnology, Inc. Its innovative approach seeks to create a new class of nuclease-based antiviral therapeutics that can effectively eliminate pathogenic viral genomes, thereby providing healthcare providers with tools to treat patients suffering from severe and persistent viral infections.

Capella Space is a commercial satellite imaging company based in San Francisco, California, founded in 2016. It operates a constellation of small satellites equipped with synthetic aperture radar (SAR) technology, capable of providing high-resolution Earth observation imagery at 50 centimeters. This technology allows for continuous monitoring of the Earth's surface, regardless of weather conditions, including clouds, smoke, and darkness. Capella Space's services support various industries, including maritime domain awareness, agriculture, infrastructure monitoring, and disaster response. The company aims to enhance decision-making related to commerce, conservation, and security by delivering timely and flexible geospatial data. Its capabilities are particularly valuable for applications involving economic activity estimation, urban planning, and search and rescue operations.

Haven builds software for commodity producers, traders, and their customers who need to save time managing complex international logistics. Its software automates trade, enables collaboration, and provides detailed visibility into a shipper’s supply chain. It was founded in 2014 and is based in San Francisco, California.

Nstream, founded in 2015 and based in California, specializes in advanced analytics software that processes edge data in real-time. The company's flagship product, SWIM EDX, transforms streaming data into actionable insights and predictions, addressing the complexities associated with big data. Nstream offers solutions tailored for a diverse range of clients, including original equipment manufacturers, service providers, enterprises, and Internet of Things (IoT) vendors. Its platform combines edge computing, machine learning, and self-training digital twins within a unique mesh architecture. Additionally, Nstream provides Swim Continuum, an open-core, enterprise-grade platform designed for building and managing continuous intelligence applications at scale. This platform enhances situational awareness and decision-making by delivering precise, relevant data through a stateful architecture that minimizes latency and optimizes performance for high-frequency data analytics. By integrating seamlessly with existing enterprise systems, Nstream enables organizations to improve productivity, reduce operational costs, and gain deeper insights into their business operations.

Verdigris Technologies, Inc. specializes in software solutions for electricity monitoring and management in commercial facilities. The company offers the Verdigris Energy Tracker, which identifies operational inefficiencies, automates building management, and predicts demand peaks while detecting equipment failures. Its cloud-based system employs wireless hardware to transmit electricity consumption data from devices, facilitating smarter facility operations and enhancing energy efficiency. Additionally, Verdigris Building.AI serves as an analytics platform for enterprise facilities managers, providing insights into power usage per device and optimizing operations to increase uptime and reduce energy costs. By leveraging artificial intelligence and real-time monitoring, Verdigris aims to improve energy efficiency in large buildings, making them smarter and more connected. Founded in 2010, the company is headquartered in Moffett Field, California.

Pivot Bio is improving and using a deep understanding of the microbiome to advance crop nutrition. They believe that microbes can deliver nutrients, protect against pests, and improve crop quality better than chemical fertilizers and pesticides. They leverage engineering principles and data science to map the dynamics of the plant microbiome and evolve beneficial traits. Their team thrives on collaboration and communication as they seek to create revolutionary fertilizers that transform food supply and improves the planet. Pivot Bio's proprietary ON Technology harnesses the power of naturally occurring microbes to provide more nutrients to crops. It’s a smart, sustainable way for farmers to improve yield as they work to help feed the world’s growing population. Their current efforts are focused on enabling microbes to fix and supply more nitrogen to corn. Pivot Bio was founded in 2010 and is headquartered in Berkeley, California, United States.