Janus Henderson Investors

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company based in Wilmette, Illinois, focused on developing proprietary therapeutics to improve outcomes for cancer patients. The company is advancing several key products, including Validive, a clonidine mucobuccal tablet in Phase III trials aimed at preventing severe oral mucositis caused by chemoradiotherapy in oropharyngeal cancer patients. Another significant compound is camsirubicin, a targeted analog of doxorubicin designed to treat soft tissue sarcoma while minimizing cardiac toxicity. Additionally, Monopar is developing MNPR-101, a humanized monoclonal antibody targeting advanced solid tumors, and MNPR-202, an early-stage analog for various cancers. Monopar collaborates with organizations such as Grupo Español de Investigación en Sarcomas and NorthStar Medical Radioisotopes, focusing on treatments for both cancer and severe COVID-19. Founded in 2014, the company emphasizes the development of orphan oncology compounds to extend life and enhance the quality of life for patients.

Monopar Therapeutics Inc. is a clinical-stage biopharmaceutical company based in Wilmette, Illinois, focused on developing proprietary therapeutics to improve outcomes for cancer patients. The company is advancing several key products, including Validive, a clonidine mucobuccal tablet in Phase III trials aimed at preventing severe oral mucositis caused by chemoradiotherapy in oropharyngeal cancer patients. Another significant compound is camsirubicin, a targeted analog of doxorubicin designed to treat soft tissue sarcoma while minimizing cardiac toxicity. Additionally, Monopar is developing MNPR-101, a humanized monoclonal antibody targeting advanced solid tumors, and MNPR-202, an early-stage analog for various cancers. Monopar collaborates with organizations such as Grupo Español de Investigación en Sarcomas and NorthStar Medical Radioisotopes, focusing on treatments for both cancer and severe COVID-19. Founded in 2014, the company emphasizes the development of orphan oncology compounds to extend life and enhance the quality of life for patients.

Victory Park Capital, established in 2007, is a global alternative investment firm headquartered in Chicago, with additional offices in New York, Los Angeles, and San Francisco. The firm specializes in asset-backed lending, providing financing solutions to small businesses, consumers, and real estate sectors. It invests in emerging and established companies across diverse industries, often serving as an alternative to traditional capital sources. Victory Park Capital leverages its extensive industry relationships, disciplined deal origination, and broad credit structuring expertise to create tailored financing solutions.

Loadsmart operates an online platform designed to streamline the process of booking trucks for shippers and carriers. The company's technology enables users to obtain real-time bookable rates instantly, facilitating efficient interactions between shippers and carriers. Loadsmart was founded in 2014 by Felipe Capella and Ricardo Salgado and is headquartered in Chicago, Illinois, with an additional office in New York, New York.

Xos Trucks Inc. is an electric mobility company specializing in the development of electric commercial vehicle fleets and battery-electric vehicle platforms. Founded in 2016 and based in North Hollywood, California, Xos focuses on medium- and heavy-duty vehicles designed for last-mile delivery routes, typically under 200 miles per day. The company aims to assist commercial fleets in transitioning from diesel to zero-emission electric vehicles, offering similar performance with lower operating costs. Xos Trucks also designs electrified armored vehicles and delivers its products to markets in Texas and Illinois, with plans to expand to Michigan and New Jersey. Leveraging proprietary technologies, Xos provides fleets with vehicles that are not only environmentally friendly but also more efficient and easier to maintain compared to traditional internal combustion engine vehicles.

Phathom Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Buffalo Grove, Illinois, focused on developing and commercializing innovative treatments for gastrointestinal diseases. Established in 2018 and launched in 2019, the company is advancing its lead drug candidate, vonoprazan, a potassium-competitive acid blocker (P-CAB) that effectively inhibits acid secretion in the stomach. Vonoprazan is currently undergoing Phase III clinical trials for the treatment of erosive gastroesophageal reflux disease and is also being studied in combination with antibiotics for the treatment of Helicobacter pylori infection. The company aims to address significant unmet medical needs in patients suffering from acid-related disorders and has assembled a team of experts in the gastrointestinal and pharmaceutical fields to drive its development efforts.