Creative Destruction Lab (CDL)

Tidal Medical specializes in developing advanced digital health technologies for remote monitoring of chronic heart and lung conditions. Their innovative portable imaging system accurately assesses pulmonary artery pressure, matching the precision of invasive methods like PA catheters.

Nanochon is developing an implantable, 3D-printed cartilage implant designed to replace damaged cartilage and promote new tissue growth in joints, with a focus on knee damage. The device combines 3D printing and a novel nanomaterial to enable on-demand, cost-effective solutions intended to restore joint function and improve outcomes for young and active patients.

Liberum Biotech is a biotechnology company focused on advancing protein manufacturing through proprietary molecular and hardware technologies. Its platform facilitates the rapid production of enzymes, therapeutics, and laboratory reagents, enabling clients to enhance speed and scalability while significantly reducing costs. By leveraging its innovative protein synthesizers, Liberum aims to democratize access to synthetic biology, ultimately transforming existing biologics manufacturing practices and making these technologies more accessible to a broader range of users.

Aquark Technologies specializes in developing compact cold-atom quantum devices, including atomic clocks, sensors, and navigation systems. Utilizing proprietary research from the University of Southampton, they miniaturize these systems using unique laser geometry.

GuideStar Medical Devices is a medical technology startup that specializes in manufacturing innovative medical devices. Its flagship product is a novel device designed to enhance the safety of epidural procedures, reducing the risk of accidental dural puncture. This innovation aims to improve patient satisfaction and deliver cost savings for healthcare providers.

Pathkeeper Surgical develops a medical device that enhances surgical accuracy in spine procedures through an advanced 3D camera system. This system provides real-time navigation by tracking the patient's spine and the surgeon's instruments independently, ensuring precise surgical guidance with sub-millimeter accuracy. Utilizing proprietary technology, the camera integrates images with pre-surgery CT scans, allowing continuous adjustment of the anatomical map to reflect both spinal movement and surgeon manipulation. By leveraging artificial intelligence, Pathkeeper Surgical aims to make navigation-guided surgeries accessible in any operating room, regardless of size, thereby improving outcomes for both patients and surgeons. The innovative solution offers a radiation-free approach to spine surgery, enhancing safety and effectiveness in the operating room.

Total Flow Cannula is a novel, specialized tubing that ensures blood flow to a patient’s leg during extracorporeal circulation procedures. The new design enables surgeons to pursue preventive treatment or implement an immediate rescue strategy without additional devices or surgical procedures.

AWE Technologies specializes in developing wave-based, non-invasive sensor technologies. They use a range of wave energies, from acoustics to electromagnetics, to characterize, measure, and manipulate objects and fluids. Their core technologies include acoustic resonance spectroscopy, swept frequency acoustic interferometry, and acoustic manipulation, serving diverse industries such as biomedical, environmental, energy, and manufacturing.

Hyivy Health specializes in innovative pelvic rehabilitation solutions. Its flagship product is an intelligent device designed for women experiencing pelvic health complications, offering quantifiable data tracking and three different therapies to enhance recovery and comfort.

Nia Therapeutics, Inc. is a company focused on developing precision neurostimulation therapies aimed at treating memory impairment, particularly in patients with traumatic brain injury. Founded in 2016, Nia Therapeutics is based in Radnor, Pennsylvania. The company's innovative approach involves utilizing neurostimulation devices that interpret complex brain activity related to memory function. By providing personalized therapy through deep-brain stimulation, Nia Therapeutics aims to enhance memory restoration and improve cognitive outcomes for affected individuals.

PionEar Technologies is a medical device company focused on developing innovative solutions for ear and hearing disorders. The company specializes in a minimally invasive tympanostomy tube designed to prevent cellular and bacterial adhesion while enhancing drug delivery to the middle and inner ears. This technology aims to modernize the treatment of chronic ear infections and hearing loss, enabling healthcare providers to deliver more effective treatment options for patients. Through its advancements, PionEar Technologies seeks to improve care and outcomes in ear health.

QV Bioelectronics develops an innovative electric field therapy implant, GRACE, designed to extend the lives of brain tumor patients while maintaining their quality of life. This first-of-its-kind device targets glioblastoma, a cancer with poor outcomes, by slowing tumor growth and sparing healthy tissue.

SynchroPET is a medical imaging company that develops compact, multiuse positron emission tomography scanners for preclinical and clinical research. Its product line includes PET/MRI systems for comprehensive animal studies, the portable Mini-PET for workstation mobility, RatCAP for small-animal imaging without restricting movement, and Wrist PET Detector for noninvasive wrist imaging in clinical settings. The company aims to provide versatile, quantitative PET solutions that enhance disease research and improve diagnostic and treatment assessment. Based in Stony Brook, New York, SynchroPET focuses on enabling more efficient, accurate imaging across laboratory and clinical environments.

NanoTess is a company focused on commercializing nanotechnology solutions to address health-related needs. It develops advanced wound care products, including formulations based on solid-state heterogeneous biocatalysts that optimize natural wound healing, reduce inflammation, and provide broad-spectrum antimicrobial protection within a protective matrix, enabling healthcare providers to manage acute and chronic wounds more effectively and improve patient outcomes.

HEARTio is a Pittsburgh-based startup founded in 2018 that specializes in digital diagnostics for heart health. The company leverages artificial intelligence to enhance the capabilities of electrocardiograms (ECGs), allowing emergency providers to detect heart abnormalities more swiftly and accurately than traditional methods. By developing deep learning algorithms, HEARTio aims to improve individualized predictions of arterial stenosis, thereby aiding medical professionals in assessing patient risk and making informed decisions about admission or discharge.

Modality.AI, Inc. is a healthcare technology company based in San Francisco, California, founded in 2018. It specializes in AI-powered solutions that enhance the efficiency of clinical trials for neurological and mental health therapies. The company's platform utilizes conversational AI to engage patients through naturalistic spoken interaction, allowing for continuous health assessments anytime and anywhere. By analyzing multimodal data, including audio-visual biomarkers, Modality.AI provides objective measures that correlate with clinical outcomes. This innovative approach enables pharmaceutical companies to conduct self-driven assessments and improve the monitoring of health conditions, ultimately facilitating more effective clinical trials.

Neurolytic Healthcare Ltd. is a medical technology company based in Oxford, United Kingdom, specializing in the design, development, and manufacture of digital and genomic-based diagnostic tools and medical devices for migraine and related neurological disorders. Founded in 2016, the company focuses on personalized medicine by integrating genetic and biomarker data to enhance diagnosis and assist clinicians in determining optimal treatment strategies. Its product offerings include a diagnostic support tool, a pharmacogenetic test, and a mobile application designed to predict migraine events. By leveraging artificial intelligence, Neurolytic Healthcare aims to provide genomics-driven diagnostics and personalized treatment recommendations, helping patients find effective treatments while minimizing side effects and reducing the trial-and-error approach often associated with neurological care.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

DeepSpin GmbH, founded in 2019 and based in Berlin, Germany, specializes in the development of an innovative artificial intelligence-powered magnetic resonance imaging (MRI) system. The company's technology aims to significantly reduce the cost, size, and weight of traditional MRI machines, thereby enhancing accessibility to medical imaging for patients worldwide. By utilizing generative topological design for its hardware and deep learning techniques for image processing, DeepSpin's MRI system seeks to make advanced medical imaging available in a variety of previously underserved healthcare settings. This approach not only aims to improve patient care but also to democratize access to essential medical diagnostics globally.

Dynami Battery Corp is a technology company focused on developing customized battery solutions tailored to specific product designs rather than adapting products to fit standard battery sizes. Founded in March 2017 and headquartered in Buenos Aires, Argentina, with an office in Washington, DC, Dynami specializes in creating batteries for a variety of applications, including the Internet of Things (IoT), wearable technology, sensors, and medical devices. The company utilizes regional resources and advanced engineering to develop proprietary battery technologies and manufacturing processes. Dynami's innovations offer scalable, cost-effective solutions, enabling industries such as electric vehicles, aerospace, and consumer electronics to benefit from fast-charging batteries with extended lifecycles.

Leiden Measurement Technology is a research and development company that specializes in creating high-end scientific instruments. It employs advanced techniques such as microfluidics, optics, spectroscopy, and chemical extraction to design devices for diverse scientific applications. These include space exploration, water analysis, environmental monitoring, and biomedical research, enabling precise data collection in challenging and remote conditions.

Renaissance Fusion develops magnetic confinement fusion technologies for affordable electricity generation and net-zero emission goals. It specializes in constructing highly efficient stellarators using High Temperature Superconducting magnets, aiming to enable businesses to contribute to a sustainable energy future.

Rehabtronics specializes in developing medical devices aimed at aiding recovery from neurological issues such as stroke and spinal cord injury. Their product suite includes intermittent electrical stimulation technology designed to reduce pressure and enable patients to recover through simple, effective treatments.

Granville Biomedical is a health tech company that designs anatomical models and simulations to support healthcare training, patient education, and device demonstration. Through research and development in mechanical, simulation, and biological testing, it produces anatomically accurate models and medical devices used for hands-on learning. The company's offerings include women's health simulations and biocompatible devices that enable private practitioners and sexual health educators to rehearse and demonstrate procedures, as well as a novel nasopharyngeal swab for nasal specimen collection. The focus is on creating realistic tools that enhance training effectiveness and patient engagement.

Cipher Skin Inc. is a technology company based in Denver, Colorado, founded in 2014. The company specializes in wearable technology that utilizes innovative mesh sensors to conform to the human body, enabling precise measurement and monitoring of vital data. Cipher Skin's platform captures three-dimensional motion data and biosignals, such as heart rate and oxygen saturation, without the need for cameras or bulky equipment. This technology provides actionable insights that can be trusted, allowing physical therapists and trainers to develop safe and effective programs by accurately assessing complex movements, particularly in the upper limbs. Through its advancements, Cipher Skin aims to create the largest and most accurate data DNA platform of the physical world.

Founded in 2018, Brink Bionics specializes in developing advanced prosthetic technologies. Its flagship product is the Axo Hand, a six-degree-of-freedom myoelectric hand prosthesis designed for adults with below-elbow limb differences.

BreatheSuite develops an inhaler attachment that connects to a smartphone via Bluetooth. It provides real-time feedback on inhalation technique and medication dosage for asthma and COPD patients, ensuring proper usage and symptom control.

Reach Orthopaedics develops a patent-approved orthopedic shoulder implant designed to treat massive irreparable rotator cuff tears. The device aims to restore shoulder function and reduce chronic pain by correcting joint imbalances and lowering the risk of progressive osteoarthritis. Founded by orthopaedic surgeons, the company targets patients across ages and seeks to streamline recovery through a design intended to shorten surgery duration and improve outcomes.

PulseMedica is a medical device company based in Edmonton. It develops non-invasive, automated image-guided laser treatments for vitreoretinal diseases using 3D computer vision and femtosecond laser technology.

Emagix develops a diagnostic image analysis platform that focuses on vascular health and integrity in the retina and MRI images. Utilizing advanced algorithm-based analytics technology, the company aims to enhance the detection of vascular pathology. Emagix's software significantly reduces the time needed to capture images while accurately identifying and quantifying critical information within those images. This capability enables healthcare professionals to conduct early diagnoses and assess the efficacy of follow-up treatments, ultimately leading to improved patient care and reduced clinical costs.

Per Vices is a developer of software-defined radio technology that enables software developers to create applications that interact with diverse wireless signals and devices. The company's innovative platform supports a wide variety of applications across multiple sectors, including defense, aerospace, telecommunications, and medical industries. Per Vices' technology boasts features such as instantaneous bandwidth, custom channels, and advanced data backhaul processors. By addressing the critical needs for various functions, Per Vices enables its clients to develop and economically integrate systems essential for mission-critical operations.

Ring Rescue is a medical device manufacturing company specializing in solutions for stuck ring removal. Their flagship product, the Ring Rescue Kit, comprises two primary tools: the Compression Device, a non-invasive solution that temporarily reduces finger swelling to enable ring removal, and the Dolphin Ring Cutter, an FDA-registered, electric ring cutter designed to safely cut through various ring metals, including titanium and tungsten carbide. The Dolphin Ring Cutter is CSA certified and features a slow-rotation micro-abrasive cutting disc with real-time feedback, minimizing heat generation and finger burn risk. The company aims to elevate the standard of care for stuck ring removal, replacing outdated and unsafe methods with their efficient and safe solutions.

PanThera CryoSolutions designs and manufactures cryopreservation solutions and systems to preserve cells, tissues, and small molecules used in clinical research. The company develops patented ice recrystallization inhibitors that minimize ice crystal formation during freezing, enabling less costly storage and transportation methods and reducing reliance on liquid nitrogen in certain cell therapies. Its products aim to maintain cellular function after extended frozen storage, reduce toxicity, enhance stability, and improve post-thaw performance, helping researchers and clinicians preserve biological material more efficiently. Through scientific expertise, PanThera CryoSolutions supports reliable, scalable cryopreservation that underpins medical research, drug development, and therapeutic applications by enabling safer and more economical cryogenic storage.

ProbiusDx Inc. is a manufacturer of portable diagnostic devices that utilize an electronic sensing platform to analyze multiple target proteins in real time. Founded in 2015 and headquartered in El Cerrito, California, the company focuses on providing diagnostic technology for the detection and monitoring of blood concentrations. This innovative approach allows healthcare professionals to make informed decisions regarding appropriate therapies for patients in critical care settings. ProbiusDx aims to enhance patient outcomes through its advanced diagnostic solutions.

SiDx is a health services provider based in Seattle, Washington, specializing in modernizing blood group testing. Founded in 2017, the company has developed a medical device that utilizes micro-sensors on a silicon chip, which are interrogated by laser to detect reactions to various compounds. This innovative diagnostic platform enables healthcare professionals to obtain test results during patient visits, significantly speeding up the care process and reducing associated costs. By enhancing the efficiency of blood testing, SiDx aims to improve patient care and streamline healthcare services.

FluoretiQ is a medical device company developing rapid bacterial detection systems to enable early diagnosis and targeted treatment of infections. Its technology combines proprietary nanomaterials and optical sensing with advances in glycan chemistry and quantum optics to identify bacterial pathogens quickly, enabling clinicians to prescribe effective antibiotics on the same day. The company has developed a rapid diagnostic platform designed for easy use in primary care and hospital settings, with the goal of improving diagnostic speed and antibiotic selection. Founded in 2017, the company is based in Bristol, United Kingdom.

Sonus Microsystems specializes in the development of innovative ultrasound transducers, crafted from polymer materials. They offer customizable linear and matrix array transducers, primarily for consumer ultrasound applications. Their technology, distinguished by its size, flexibility, and customizability, expands the possibilities of ultrasound imaging, surpassing traditional piezoelectric or silicon-based transducers. Notably, Sonus Microsystems is developing a wearable cardiac ultrasound imaging device, harnessing advanced polymer micro-electromechanical systems transducers and AI-driven analysis. This device aims to facilitate real-time cardiac insights, enabling timely interventions for patients with cardiovascular conditions and enhancing diagnostic precision in remote monitoring scenarios.

Front Line Medical Technologies is the developer of a medical device intended to lower the barriers to bleeding control and resuscitation worldwide. The device provides a life-saving tool to control truncal hemorrhaging, which enables patients to survive emergency situations.

Revolve Surgical is a Toronto, Ontario-headquartered company developing a robotic surgery platform designed to enable robotic procedures across a broader range of operating rooms and to advance value-based care. The hybrid manual-robotic system eliminates teleoperation and seeks to reduce the size, cost, and training required by current robotic devices, expanding access to robotic surgery for patients. The technology targets abdominal surgeries performed outside traditional hospital settings, aiming to bring the benefits of surgical robotics to more care settings in the United States.

QSM Diagnostics develops point-of-care diagnostics for identifying bacterial infections, with a focus on veterinary applications. The company specializes in electrochemical sensors and disposable sensor-based devices that rapidly detect target bacteria at infection sites, such as ear infections caused by Pseudomonas aeruginosa in dogs. Founded in 2014 as a Northeastern University spin-out, QSM Diagnostics brings together extensive experience in sensor development and medical device commercialization to provide practical diagnostic solutions for animal care.

Epineuron Technologies, Inc. is a medical device company based in Hamilton, Canada, established in 2016. It specializes in developing innovative treatment strategies for peripheral nerve injuries through bioelectronic medicine. The company focuses on creating a suite of surgical solutions aimed at enhancing the repair and regeneration of peripheral nerves. Epineuron's flagship product is an electroceutical device that delivers targeted electrical stimulation to accelerate the natural healing processes of injured nerves. By leveraging this technology, Epineuron aims to set a new standard of care in the field of nerve injury treatment, aspiring to become a leader in bioelectronic nerve care.

aDolus Technology develops a cybersecurity platform designed to enhance the security of industrial and medical systems. The company's innovative solution generates Software Bills of Materials (SBOMs) from software binaries, allowing for the analysis of vulnerabilities, malware, and obsolescence within software components. By providing a risk score for software used in regulated and sensitive industries, aDolus enables organizations to detect counterfeit components and assess third-party risks, thereby safeguarding critical infrastructure. With a growing database of 32 million records and a vendor-agnostic approach, aDolus is positioned to address the urgent need for security solutions in a rapidly expanding market, particularly for the Internet of Things (IoT) and Industrial Control Systems (ICS). As the security landscape evolves with increasing regulatory demands and the proliferation of connected devices, aDolus aims to capitalize on significant opportunities across various sectors, including energy, transportation, medical, and defense.

CellFE Inc. is a biotechnology company based in San Carlos, California, established in 2017. It specializes in the development of a microfluidics-based device designed to deliver gene-editing molecules into human cells. This innovative platform enhances the manufacturing and development of cell therapies by utilizing rapid cell compression techniques that facilitate the uptake of therapeutic molecules from surrounding fluids. By enabling the transport of hard-to-deliver molecules, CellFE aims to improve the effectiveness of treatments for various disorders, supporting medical researchers in their efforts to advance patient care and outcomes.

Aufero Medical is a medical device company that develops a catheter stabilizer designed to counteract heart motion during catheter ablation procedures. The device stabilizes the contact force at the catheter tip against a moving heart, enabling more consistent lesion formation during energy delivery. By improving stability and reproducibility of the ablation, the company aims to enhance procedural outcomes, reduce procedure variability, and lower the incidence of repeat treatments and associated healthcare costs. The technology targets a critical step in treating cardiac arrhythmias by enabling physicians to deliver more precise ablation therapy with potentially better patient outcomes.

Swiftsure Innovations provides registered nurses with the tools required to improve patient outcomes. It develops a medical device that enhances oral care for patients on life support with the aim of decreasing the incidence of ventilator-acquired pneumonia, length of mechanical ventilation, and length of hospital stay. Creative Destruction Labs supports the company.

KataPilla develops a wound-dressing solution that provides healthcare practitioners with real-time medical data to remotely monitor swelling, temperature, and wound discharge in post-operative patients, decreasing the risk of complications.

FluidAI is a medical technology company focused on post-operative care, combining artificial intelligence with in-body data to improve patient monitoring. The company develops a smart catheter system that enables proactive post-operative care by detecting complications at onset and delivering critical health data to healthcare providers ahead of time.

Coloursmith Labs Inc. is an optical filtering technology company based in Halifax, Canada, founded in 2018. The company specializes in developing advanced optical filters for contact lenses, designed to enhance color saturation and assist individuals with color vision deficiencies. By focusing on innovative materials and the principles of light and optics, Coloursmith Labs aims to create products that offer protection from harmful light while addressing chromatic applications. Their mission centers on integrating science and creativity to expand the potential of human vision, thereby improving the quality of life for their users.

Quthero is focused on developing innovative solutions for post-surgical scarring prevention through a patented gel technology. This gel is designed to restore moisture and mechanical properties of wounds, facilitating effective healing while minimizing scarring, redness, and bruising. By promoting full epithelial restoration, Quthero's products aim to accelerate the closure of skin wounds, thereby reducing the complications and risks associated with slow healing. Their approach targets both cosmetic and medical applications, providing a comprehensive solution for individuals undergoing skin procedures or surgeries.

Founded in 2013, Aluna develops a portable spirometry device paired with an interactive iPhone game. Its health platform helps users track asthma symptoms, monitor medication, and provides real-time data sharing with doctors for personalized treatment plans.

Zilia is a medtech company developing a non-invasive platform that uses imaging, spectroscopy and artificial intelligence to quantify biomarkers in the eye. The technology leverages the eye’s optical properties and its link to the vascular system and brain to enable early detection and monitoring of ocular and systemic health conditions. Its first product, Zilia Ocular, is a retinal camera designed to quantify oxygen saturation, a key biomarker in diseases such as glaucoma, diabetic retinopathy and age-related macular degeneration. By delivering actionable data on the eye’s metabolic activity, Zilia aims to improve prevention, diagnosis and management of these conditions.

Imeka Solutions Inc., established in 2011 and based in Sherbrooke, Canada, specializes in medical image processing services. It provides advanced MRI-based techniques such as diffusion tensor imaging, tractography, and free water imaging to clients including neurologists, clinicians, and pharmaceutical researchers. Imeka's platform leverages deep learning algorithms and high-resolution MRI structures to quantify and understand brain connectivity, particularly white matter, aiding in neuroinflammation and demyelination research.

Prime Discoveries develops microbiome testing, discovery, and diagnostics, leveraging a technology platform that integrates automation, machine learning, and computational biology to enable rapid, scalable solutions for microbiome research and pathogen diagnostics. Founded in 2017 and based in New York, the company serves healthcare and agricultural industries with novel diagnostics and testing services designed to deliver results quickly with minimal lab infrastructure, often under 1 hour, using US-developed assays. The company focuses on cost-effective, automatable assays that address emerging pathogens such as Covid, flu, STIs, and drug-resistant microbes, supporting researchers, clinicians, and public health efforts.

Fluid Biomed is a medical device start-up specializing in the development of an innovative implantable dissolving stent aimed at treating brain aneurysms. Founded by a team of neurosurgeons, the company focuses on enhancing patient outcomes by offering a bio-absorbable polymer-based flow-diverting stent that gently redirects blood flow to facilitate the healing of weakened blood vessels. This advanced medical device is designed to minimize the need for invasive procedures, allowing physicians to efficiently and effectively treat patients while reducing the risk of stroke. Through its pioneering approach, Fluid Biomed is poised to contribute significantly to the field of neurosurgery and improve the quality of care for individuals with brain aneurysms.

Sonic Incytes Medical Corp develops handheld ultrasound solutions for point-of-care assessment and monitoring of chronic liver diseases. It uses quantitative ultrasound and elastography with artificial intelligence to provide deeper measurements, larger tissue samples, and single-probe operation without recalibrations, enabling guidance for diagnostics and procedures. The devices assess liver stiffness, attenuation, and fat fraction to support diagnosis and management of liver health. The company was incorporated in 2012 and is based in Vancouver, Canada.

16 Bit Inc. is a Toronto-based company that develops medical image analysis systems, focusing on artificial intelligence software designed to enhance diagnostic capabilities for healthcare professionals. The company is working on a triaging algorithm specifically for breast cancer screening, as well as systems for neurological emergency detection and pediatric bone age assessment. By creating trusted AI software as a medical device, 16 Bit aims to improve the quality, efficiency, and accessibility of healthcare, ultimately assisting physicians and radiologists in interpreting medical images more effectively.

Nimble Science Ltd. is a digital health company focused on revolutionizing gastrointestinal (GI) health through its innovative SIMBA capsule technology. This end-to-end platform facilitates multi-omic mapping of the GI tract, allowing for the passive sampling of small bowel luminal fluid. By leveraging this advanced sampling method, Nimble Science provides precision datasets that offer valuable insights into GI health, thereby transforming the diagnosis and treatment of gastrointestinal conditions. The company's approach enables healthcare providers to directly sample and analyze targeted regions of the GI tract, marking a significant advancement in the understanding and management of GI health.

Leap Biosystems is a Canadian company that specializes in developing innovative next-generation medical technologies and astronaut medical training platforms. Their mission is to support upcoming human space exploration initiatives by providing advanced healthcare solutions designed for remote environments. The company combines clinical medicine with space exploration technologies, enabling clients to access remote medical procedure guidance technology.

Forcen develops and manufactures force-sensing film for various industries, including surgical robotics, industrial robotics, and aerospace. Its film can be integrated into parts or assemblies of devices in these sectors, providing real-time force feedback. Founded in 2015, the company is headquartered in Toronto, Canada.

Voyage Biomedical is a California-based medical device company focused on protecting the brain during acute cerebrovascular and cardiac events. It develops the Voyage Brain Cooling System, a device designed to rapidly and selectively cool the brain to limit brain injury from cerebral ischemia during ischemic stroke and to support brain protection during cardiac arrest, enabling healthcare teams to deliver definitive care. Founded in 2018 and headquartered in Emeryville, Voyage Biomedical aims to provide life-changing solutions where conventional options are limited.

Iterate Labs is a developer of a smart wearable device used to track relevant hand and wrist actions for workplace safety. Its device is a smart glove that collects and analyzes biomechanics data to alert workers and managers of injury risk and fatigue that enable health and safety officers to monitor and prevent workplace injuries through sensors and data analytics.

Synex Medical is a company focused on advancing health monitoring technology through non-invasive blood testing. It has developed a portable device that utilizes a miniaturized magnetic resonance system to measure blood metabolites without the need for skin penetration. This innovative approach employs only magnets and radio waves, ensuring no adverse health effects for users. By accurately measuring critical metabolites such as glucose, lactate, and ketones, Synex Medical's technology empowers individuals to monitor their health proactively and make informed decisions about their well-being.

Journeys Metabolic is a digital therapeutic platform that extends metabolic care from the clinic into the home. Its interoperable program is designed to address obesity and insulin resistance-related conditions by enabling health systems and accountable care organizations to transition toward value-based or fee-for-outcomes models with reduced provider burden. Grounded in several years of behavior modification, the physician-developed program integrates AI-enabled precision pathways, education through computer vision-enabled food analysis, and a proprietary biomarker of fat oxidation (Biosense) to guide nutritional interventions. The platform is HITRUST and EHR interoperable, supporting shared savings optimization across metabolic diseases and nutrition-related disorders. The approach emphasizes sustained lifestyle changes delivered over multi-month periods and aims to improve overall health outcomes while simplifying care delivery for clinicians and care teams.

Cogwear is a brain technology company focused on assisting individuals who experience anxiety and depression. The company is developing an advanced wearable device that transcends existing products by integrating cognitive and emotional insights with physical measurements. This innovation aims to enhance human health, safety, and performance. Cogwear utilizes AI-powered algorithms to provide users with real-time access to clinical-grade cognitive and emotional data in various environments. Its wearables are equipped with mobile electroencephalogram (EEG) sensors and machine learning technology, allowing for the accurate measurement and interpretation of brainwave activity. The proprietary dry EEG sensors are designed for comfort and precision, enabling users to track their brain activity through a secure application and shareable dashboard.

SaluTech is a medical technology company specializing in the development of a conductive biomaterial (CBM) for treating atrial fibrillation, a common heart rhythm disorder. Their innovative, non-toxic, biocompatible, and long-lasting nano-membrane is designed to reduce and potentially eliminate arrhythmia, providing a safe and effective solution for healthcare professionals.

Kheiron Medical Technologies is a London-based medical technology company that develops Mia, an AI-powered mammography screening tool designed to help radiologists detect breast cancer. The system combines deep learning with radiology insights to improve detection efficiency, consistency, and accuracy across imaging workflows. Incorporated in 2016 and formerly known as Maesterai, the company maintains an international presence with offices in London, San Francisco, Budapest, and Amsterdam, aiming to advance precision radiology and improve outcomes for cancer patients.

Founded in Ottawa, Canada in 2015, eMurmur is a digital health company specializing in the detection, analysis, and classification of heart murmurs using machine learning. Its platform enables remote recording and analysis of auscultation sounds, facilitating screening, monitoring, diagnosis, and consultation for heart health.

Ravata Solutions develops a medical device platform for gene delivery used to create custom transgenic animal models and support production-scale embryo engineering. Founded in 2016 and based in Davis, California, the company targets pre-clinical research by enabling faster creation of transgenic organisms and improving embryo viability for disease modeling and fertility applications. The technology is designed to streamline model development for drug efficacy studies and medical genetics research, helping researchers accelerate timelines while enhancing the reliability of embryo production and genetic modification processes.

SafKan Health, founded in 2016 and based in Tucson, Arizona, specializes in the development and manufacturing of automated ear cleaning devices for clinical applications. Its flagship product, OtoSet, is the first automated ear cleaning device to receive FDA clearance, addressing the needs of the 35 million Americans affected by impacted earwax, a common cause of conductive hearing loss. OtoSet offers a hygienic and mess-free solution for earwax removal, featuring disposable ear tips and waste containers. The device is designed to perform both bilateral and unilateral procedures, allowing for effective removal of mild to severe earwax impactions, thereby providing patients with a safe and efficient tool for ear care.

Zennea Technologies is a medical device company based in Surrey, Canada, specializing in the development of therapeutic wearables aimed at reducing snoring and improving overall health through enhanced sleep quality. The company's flagship product, ZENS, is a comfortable and discreet sleep wearable that targets the root cause of snoring, thereby assisting individuals with chronic snoring and mild obstructive sleep apnea. Zennea conducts clinical trials to validate the efficacy of its device, which not only helps reduce snoring but also tracks sleep quality, providing valuable insights for users to make informed decisions about their health and sleep habits.

InnoVein, Inc. is a medical device company established in 2015 and based in San Carlos, California. The company specializes in developing implantable valves designed to regulate blood flow in the veins, particularly for elderly patients suffering from venous insufficiency disease. InnoVein aims to address the challenges associated with this condition through innovative cardiac and arterial solutions, contributing to improved health outcomes for affected individuals.

Cosm Medical is a health-tech startup developing a software-enabled medical device platform to improve the lives of women affected by pelvic floor disorders. The company's digital platform personalizes care for pelvic health issues, utilizing AI-powered cloud software and 3D printing technology to create customized gynecological prosthetics.

Human in Motion Robotics develops a lower-body wearable exoskeleton system for rehabilitation and personal mobility. The exoskeleton uses miniaturized, versatile joints for the hip, knee, and ankle to help users walk more naturally and maintain balance in challenging conditions such as uphill, downhill, turning, and stairs without external assistance. Designed for mobility support and motion augmentation, the system also offers potential in robotic rehabilitation and related fields, including gaming and medical applications. The company targets paralyzed or physically disabled users, aiming to restore walking capability and reduce reliance on assistive devices or caregivers.

Systolik Digital Health is a medical device manufacturer providing solutions for cardiologists.

Orpyx Medical Technologies Inc. is a Calgary-based company that develops innovative mobility sensor devices aimed at supporting diabetic patients in maintaining their mobility. Founded in 2010, the company offers several key products, including the Orpyx SI sensory insoles, which are designed to manage and prevent diabetic foot ulcers and limb loss by capturing real-time data related to pressure, temperature, and movement. Additionally, Orpyx provides Kinetyx, a mobile in-shoe pressure management system that collects clinical plantar pressure data for various applications, including sports medicine and therapeutic use. Another notable product is SurroGait Rx, which assists multiple sclerosis patients in improving their mobility and balance. Orpyx Medical Technologies emphasizes the importance of prevention in healthcare and collaborates with global stakeholders to promote sustainable health solutions.

Awake Labs develops a healthcare platform designed to improve care for individuals with cognitive or developmental disabilities by measuring stress and strong emotions in real-time. The system includes a smartwatch app that monitors physiological and emotional states, a mobile app that notifies caregivers of concerns, and a clinical dashboard for care teams to review data and tailor care plans. The platform aims to reduce incidents such as self-injury and injuries to staff, lower hospitalizations, and lessen caregiver burnout while supporting greater independence and reduced anxiety for users.

InnoVein, Inc. is a medical device company established in 2015 and based in San Carlos, California. The company specializes in developing implantable valves designed to regulate blood flow in the veins, particularly for elderly patients suffering from venous insufficiency disease. InnoVein aims to address the challenges associated with this condition through innovative cardiac and arterial solutions, contributing to improved health outcomes for affected individuals.

Correlia Biosystems develops microscale protein measurement platforms that enable rapid, multiplexed quantification of biomolecules for proteomics and pharmaceutical research. Building on microarray-inspired technology, it provides tools for large protein panels, including cytokines and post-translational modifications, with speed and automation to shorten timelines and lower costs. Its SimpleScan technology supports applications from point-of-care diagnostics to proteomics, offering inexpensive, fast, and customizable protein measurements. The company is a UC Berkeley spinoff founded in 2013 and is based in Berkeley, California.

See-Through Scientific is a developer of innovative holographic microscopy systems that enhance the optimization of scattered light fields while maintaining minimal hardware complexity. The company specializes in creating small modules that can be integrated into both advanced microscopy systems and resource-limited environments. This versatility allows researchers and industry professionals to utilize holographic technology as a digital microscopy alternative, facilitating applications such as viable cell counting and the isolation of rare particles. By providing accessible and efficient solutions, See-Through Scientific aims to advance the capabilities of microscopy across various scientific and industrial sectors.

True Positive Medical Devices specializes in the development of advanced imaging software analytics and medical devices aimed at enhancing brain health assessment. The company's innovative technologies focus on creating sensitive and quantitative biomarkers that diagnose and predict the progression of traumatic brain diseases, including Alzheimer's and Parkinson's. By measuring the size, shape, and appearance of brain regions, True Positive MD's devices enable healthcare professionals to evaluate brain health more accurately and identify early signs of injury. This approach aims to revolutionize how brain health readings are conducted, ultimately improving patient outcomes through timely and precise diagnostics.

Noze specializes in digital odor perception technology, aiming to replicate the human sense of smell digitally. Utilizing advanced machine learning and an innovative sensor based on NASA technology, Noze detects and identifies odors with precision. Their primary goal is to improve patient outcomes by enabling real-time disease detection through breath-based biomarkers at any point-of-care.

ODS Medical Inc. is a Montreal-based medical device company established in 2015, specializing in the design and manufacture of advanced diagnostic tools for cancer detection. The company's flagship product is an exclusive Raman spectroscopy system that enables real-time identification of tissue abnormalities across various clinical settings. By integrating innovative optical probes with sophisticated software powered by machine learning algorithms, ODS Medical aims to enhance the capabilities of physicians, allowing for critical decision-making with high sensitivity, specificity, and accuracy. Through its commitment to developing and commercializing cutting-edge technology, ODS Medical strives to revolutionize the diagnostic landscape in oncology.

Optina Diagnostics is a diagnostics company focusing on retinal imaging and artificial intelligence to provide non-invasive tests that detect signs of neurodegenerative and ocular diseases. By analyzing retinal images, it identifies biomarkers associated with Alzheimer's disease, as well as eye conditions like age-related macular degeneration and diabetic retinopathy, enabling clinicians to assess brain health and disease risk early. The platform aims to support timely diagnosis and treatment decisions with a simple eye exam.

Neuraura is a medical device company developing a wearable bioelectronic therapy that uses proprietary micro-electrodes to address polycystic ovary syndrome (PCOS) and related metabolic health concerns. The device aims to augment the body's natural processes and provide a practical, accessible treatment option for PCOS and insulin resistance. Initial market entry targets pelvic pain indications with regulatory clearance pursued under the FDA 510(k) pathway, followed by expanded clinical evidence and claims related to insulin resistance and other PCOS aspects. In the long term, Neuraura is exploring premium, reimbursed device offerings for metabolic conditions such as prediabetes and diabetes. The technology centers on personalized bioelectronic medicine delivered via a wearable device that clinicians can use to support women's reproductive and metabolic health.

Trexo Robotics develops robotic mobility devices for individuals with physical impairments. Their flagship product is designed specifically for children, aiming to enhance walking mobility through repetitive motion therapy and user-centric design.

Elucid Labs Inc. is a MedTech company based in Waterloo, Canada, focused on the early detection and diagnosis of skin cancer through innovative imaging technology. Established in 2016, the company has developed a proprietary imaging device that analyzes the molecular composition of skin lesions at various depths, creating a unique fingerprint for each mole or lesion. This technology leverages augmented intelligence to convert the molecular data into actionable clinical insights, aiding dermatologists in making more informed and timely decisions. By enabling earlier detection of skin cancer, Elucid Labs' solution aims to reduce treatment costs and minimize the number of unnecessary biopsies performed annually.

Plantiga Technologies Inc. is a Vancouver-based company that specializes in biometric sensing technology for footwear. Founded in 2006, it focuses on human movement intelligence, offering deep insights into health through the analysis of movement patterns. The company's platform aims to optimize health, prevent injuries, and monitor recovery by detecting changes in functional movement that are often imperceptible to the naked eye. Plantiga's innovative foot-strike analytics technology combines the rigor of human performance analysis with the immediacy of wearable devices, allowing users to evaluate athletic performance, health, and productivity effectively.

Founded in 2016, MIMOSA Diagnostics develops a handheld device that uses near-infrared light to accurately assess tissue health. This non-invasive tool enables patients or caregivers to monitor foot health, particularly for diabetes management, and aids clinicians in making informed treatment decisions.

ICSPI Corp. is a Canadian company, founded in 2007 and based in Waterloo, that specializes in the design and manufacture of advanced nanoscale imaging tools. The company utilizes a CMOS-MEMS technology platform to produce innovative scanning probe instruments, including its flagship nGauge Atomic Force Microscope (AFM). ICSPI's products cater to educational, research, and industrial applications, offering solutions that miniaturize and simplify the operation of nanoscale metrology instruments. Their product line includes various AFM models and components, which are aimed at enhancing the development of future materials and devices. Through its cutting-edge technology, ICSPI is committed to transforming the landscape of nanoscale imaging and measurement.

HelpWear develops a waterproof wearable device that monitors heart activity, detects heart attacks, and sends real-time alerts to medical facilities. Incorporated in 2015, the company is based in Toronto, Canada.

Acorn Biolabs, Inc. is a biotechnology company based in Toronto, Canada, founded in 2017. It specializes in providing a take-home service for the cryopreservation of human cells, focusing on young cell preservation to facilitate future regenerative medical treatments. The company employs a non-invasive, follicle-based cell collection method, allowing individuals to collect and preserve their healthy young cells for potential use in gene therapies, stem cell therapeutics, tissue engineering, and organ regeneration. Acorn Biolabs offers its services directly to consumers, with options for at-home and in-clinic cell collection. The company also has established partnerships with a network of clinics and pharmacies across Canada to enhance accessibility to its innovative services.

Sensassure is a Toronto-based company that specializes in developing innovative technologies for incontinence care in seniors. Founded in 2013, the company has created the SmartPatch, a wearable sensor that attaches to the outside of adult briefs. This device provides caregivers with valuable insights into when a resident may experience an episode of incontinence, facilitating timely and personalized care. By enabling communities to better manage incontinence, Sensassure's technology helps reduce costs associated with briefs and laundry, while also preserving the dignity and skin integrity of newly admitted residents. Through its impact-driven approach, Sensassure aims to enhance the quality of life for elder citizens.

Innovere Medical specializes in developing wireless peripheral devices for Magnetic Resonance Imaging (MRI) applications. Their primary product is an interactive TV designed to operate within MRI scanners, providing clear audio signals and reducing noise, thereby enhancing patient comfort and communication between healthcare providers.

AccSys Diagnostics manufactures a point-of-care medical diagnostic device designed to enhance healthcare delivery standards. This device employs enzyme immunoassay and nucleic acid detection technologies to accurately test for various infectious diseases such as HIV, Ebola, and Hepatitis. It enables healthcare professionals to receive rapid results, facilitating more informed treatment decisions.

Nymi Inc. is a Toronto-based company that specializes in developing wearable biometric devices, particularly the Nymi Band, which authentically identifies users through their unique electrocardiogram using proprietary HeartID technology. Founded in 2011 and originally named Bionym Inc., the company rebranded in December 2014. Nymi offers a mobile application for Android that activates its wearable bands, which are sold online. The company's focus extends to creating a connected worker platform that enhances workplace integration by improving health and safety, enterprise security, data integrity, and productivity across various industries, including life sciences, healthcare, manufacturing, and finance. Nymi's innovative approach facilitates digital transformation by connecting employees with their digital networks in a secure and user-friendly manner. The company has been recognized as one of the Best Workplaces in Canada for small organizations in 2019.