Cleveland Clinic

Enspire DBS Therapy focuses on restoring motor function for stroke survivors through proprietary deep brain stimulation (DBS) therapy combined with physical rehabilitation. It aims to accelerate post-stroke recovery by mediating the effects of stimulation and rehabilitation.

MediView, LLC is a medical device company based in Cleveland, Ohio, that specializes in developing augmented reality surgical navigation systems aimed at enhancing surgical processes for healthcare providers. Founded in 2017, the company focuses on creating advanced technologies for surgical navigation, particularly for the ablation and biopsy of cancerous tumors. MediView's flagship product, MediView, utilizes real-time, fused-holographic visualization to enable surgeons to navigate procedures with greater accuracy and efficacy. This innovative approach allows for enhanced examination of patients through augmented reality 3D visualization, facilitating improved surgical outcomes and supporting remote collaboration among healthcare professionals.

Centerline Biomedical, Inc. is a Cleveland, Ohio-based company founded in 2014 that specializes in developing advanced surgical navigation technologies. The company focuses on an Intra-Operative Positioning System, which utilizes non-x-ray based three-dimensional GPS technology to enhance the precision of endovascular procedures and minimize radiation exposure for both patients and medical staff. Centerline's innovative system aids surgeons in navigating complex three-dimensional vascular anatomy, thereby improving surgical outcomes in interventional vascular procedures. The technology is rooted in advancements made at the Cleveland Clinic, reflecting a commitment to enhancing the safety and effectiveness of minimally invasive surgeries.

Cleveland Diagnostics is a commercial-stage company based in Cleveland, Ohio, focused on developing and commercializing innovative cancer diagnostic tests. Founded in 2013, the company specializes in creating non-invasive screening tools for various cancers, including prostate, breast, ovarian, lung, and certain neurological diseases. Their portfolio includes blood-based tests designed to enhance early detection and improve patient outcomes. Cleveland Diagnostics employs a proprietary solvent interaction analysis technology that examines protein biomarkers at a structural level, offering more precise insights into disease processes and enhancing test specificity. The company has established strategic collaborations with industry partners, such as Genomic Health, to advance its diagnostic capabilities.

Advanced NanoTherapies, Inc. is a biotechnology company focused on developing innovative medical devices utilizing Sirolimus and biodegradable functionalized nanoparticle technology for the treatment of atherosclerosis and related conditions, including coronary artery disease and peripheral artery disease. Founded in 2018, the company is headquartered in Cleveland, Ohio. Advanced NanoTherapies aims to enhance drug delivery through its proprietary platform, which improves medication uptake and retention at the cellular level. This technology provides clinicians with safer treatment options for patients suffering from cardiovascular and endovascular diseases.