Canaan Partners

ThirtyFiveBio is a biotechnology company developing novel genetically and pharmacologically validated protein modulators for treating severe gastrointestinal diseases.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Autobahn Therapeutics develops brain-targeting, small molecule therapies for central nervous system disorders. Its lead program ABX-002 is a thyroid hormone receptor beta agonist being developed as an adjunctive treatment for mood disorders, including major depressive disorder and bipolar depression. The company emphasizes precision tuning of CNS exposure, validated clinical and biologic targets, and biomarker-guided development across neuropsychiatry, neurodegeneration, and neuroinflammation to address high unmet medical needs and improve patient outcomes.

Catalym GmbH, established in Munich, Germany in 2016, is a biotechnology company dedicated to developing innovative immunotherapies for cancer patients. The company focuses on neutralizing GDF-15, a central regulator of the immune system in the tumor microenvironment, aiming to demonstrate clinical proof-of-concept across multiple solid tumor indications with its lead program CTL-002. Catalym's mission is to transform cancer patients' lives by engaging their own immune systems and improving treatment options.

Grey Wolf Therapeutics is a biotechnology company based in Oxford, United Kingdom, focused on developing innovative immunotherapies for oncology. Founded in 2017, the company aims to enhance the visibility of non-responsive tumors to the immune system by directly modifying tumor cells. Its approach involves targeting endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 within the antigen presentation pathway, which increases the neoantigen repertoire on tumor cells. This strategy is designed to improve the effectiveness of immunotherapy in treating cancer. Grey Wolf collaborates with leading academic and commercial partners to advance its drug discovery initiatives and deliver clinical candidates against well-validated targets in the field of immuno-oncology.

Qlaris Bio is a clinical-stage biotechnology company based in Wellesley, Massachusetts, founded in 2017. The company specializes in developing innovative therapies for serious and debilitating ophthalmic diseases, with a focus on addressing episcleral venous pressure (EVP), a significant component of intraocular pressure (IOP). Qlaris Bio's lead therapy, QLS-101, aims to reduce IOP, thereby mitigating the risk of blindness in conditions such as Primary Open Angle Glaucoma and Normal Tension Glaucoma. The company also targets other high unmet need conditions related to disturbances in intraocular pressure, including a progressive pediatric rare disease with limited effective therapies.

Alterome Therapeutics is a precision oncology biotechnology company focused on developing alteration-specific therapeutics to target high-value, validated oncogenic drivers. It employs structure-guided drug discovery and advanced computational chemistry to create small-molecule therapies that selectively address oncogenic alterations, with the aim of improving patient outcomes in cancer.

Founded in 2011, Acesion Pharma is a Danish biotech company dedicated to developing safe and tolerable treatments for atrial fibrillation (AF), the most common cardiac arrhythmia. The company focuses on inhibiting specific ion channels in heart cells to regulate the heart's rhythm and prevent AF recurrence.

Diligent Robotics develops hospital service robots and related AI software to assist clinical and nursing staff with logistical tasks, enabling more time for direct patient care. Its flagship robot, Moxi, operates in hospital environments to handle routine duties and collaborate with humans, supported by AI-based software that enables safe interaction and adaptation to human workflows. Founded in 2017 and based in Austin, Texas, the company seeks to improve patient satisfaction, quality of care, and safety by augmenting healthcare teams with robotic assistance.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

Aer Therapeutics is a clinical-stage biopharmaceutical company focused on developing innovative treatments for respiratory diseases characterized by excess mucus and mucus plugs. Its primary focus lies in addressing significant unmet needs in conditions such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and asthma.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Grey Wolf Therapeutics is a biotechnology company based in Oxford, United Kingdom, focused on developing innovative immunotherapies for oncology. Founded in 2017, the company aims to enhance the visibility of non-responsive tumors to the immune system by directly modifying tumor cells. Its approach involves targeting endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 within the antigen presentation pathway, which increases the neoantigen repertoire on tumor cells. This strategy is designed to improve the effectiveness of immunotherapy in treating cancer. Grey Wolf collaborates with leading academic and commercial partners to advance its drug discovery initiatives and deliver clinical candidates against well-validated targets in the field of immuno-oncology.

Normunity is a biotechnology company that develops precision immuno‑oncology medicines, termed immune normalizers, designed to restore the body’s natural immune response against cancer. Leveraging a partnership with Dr. Lieping Chen’s laboratory at Yale School of Medicine, the company focuses on newly discovered mechanisms of immune disruption, such as the exclusion of T‑cells from immune‑sensitive tumors and other barriers to normal immune function. Its pipeline includes programs targeting these mechanisms to enable clinicians to treat cancer by reactivating the patient’s own immunity. Normunity operates from offices in Boston, Massachusetts, and West Haven, Connecticut.

Theia is a pioneering personalized health service tailored specifically for mothers, offering a comprehensive platform that connects them with a network of vetted healthcare professionals. Designed to support women from preconception through early childhood, Theia provides both remote and in-person consultations, ensuring access to holistic care at every stage of motherhood. The platform utilizes data to deliver timely content and advice related to pregnancy, while also facilitating communication with a diverse team of specialists, including psychologists, doctors, and nurses. Theia's commitment to personalized care is underscored by its focus on understanding and respecting each woman's individual needs throughout her journey into motherhood.

Rondo Therapeutics is a biopharmaceutical company based in Hayward, California, specializing in the discovery and development of innovative bispecific antibodies aimed at activating the immune system to combat cancer. Founded in 2021, the company focuses on creating cancer immunotherapies specifically for solid tumor types that do not respond to existing immune checkpoint inhibitors. By addressing areas of unmet medical need, Rondo Therapeutics aims to advance novel therapeutic options for patients facing challenging cancer diagnoses.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

Day One Biopharmaceuticals is a clinical-stage biotechnology company focused on developing targeted therapies for genetically defined cancers across all ages, with an initial emphasis on pediatric patients. The company aims to bring effective cancer treatments to families by advancing therapies that can benefit both children and adults, prioritizing programs that can progress to the market rapidly. Day One pursues licensing or acquisition of promising products from research institutions and industry partners to expand its pipeline. Its lead candidate, DAY101, is an oral, brain-penetrant, highly selective type II pan-RAF kinase inhibitor designed to target cancers driven by the RAF signaling pathway. By applying insights from childhood cancer biology, the company seeks to address unmet needs in oncology and broaden access to precision therapies.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Mate Fertility is a technology-driven fertility clinic founded in 2020 and based in Los Angeles, California. The company aims to make parenthood more accessible by providing comprehensive fertility services at affordable prices. It operates a platform that connects patients to fertility clinics and offers telemedicine options for various treatments and therapies. By delivering end-to-end fertility services, Mate Fertility ensures that patients receive expert guidance and care throughout their fertility journey, making the process more comfortable and manageable.

Stargazer Pharmaceuticals Inc. is a biopharmaceutical company based in Boston, Massachusetts, founded in 2018. It specializes in developing and manufacturing therapies specifically for rare eye diseases. The company is particularly focused on addressing Stargardt's disease, a juvenile retinal degeneration condition for which there are currently no available treatments. By concentrating on these rare diseases, Stargazer Pharmaceuticals aims to provide healthcare professionals with innovative therapeutic options for patients suffering from such conditions. The company is currently operating in stealth mode as it advances its research and development efforts.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Synthekine Inc. is a biotechnology company based in Menlo Park, California, specializing in the development of engineered cytokine therapies and immunotherapies aimed at treating cancer and autoimmune disorders. Founded in 2018, Synthekine utilizes advanced platform technologies, including engineered partial agonists and orthogonal cell therapies, to enhance the efficacy of cytokines while minimizing their toxic side effects. The company's innovative Synthekine Platform employs surrogate agonists instead of traditional mutant cytokines to create selective immunotherapies. Its product pipeline features candidates such as STK-009, an orthogonal ligand paired with SYNCAR-001, an orthogonal receptor-modified CAR-T therapy targeting CD-19. Additionally, Synthekine is developing STK-012, partial agonists of IL-2, and other novel immunotherapies that integrate cytokine receptors to initiate new signaling pathways without relying on wild-type cytokines.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

Day One Biopharmaceuticals is a clinical-stage biotechnology company focused on developing targeted therapies for genetically defined cancers across all ages, with an initial emphasis on pediatric patients. The company aims to bring effective cancer treatments to families by advancing therapies that can benefit both children and adults, prioritizing programs that can progress to the market rapidly. Day One pursues licensing or acquisition of promising products from research institutions and industry partners to expand its pipeline. Its lead candidate, DAY101, is an oral, brain-penetrant, highly selective type II pan-RAF kinase inhibitor designed to target cancers driven by the RAF signaling pathway. By applying insights from childhood cancer biology, the company seeks to address unmet needs in oncology and broaden access to precision therapies.

Grey Wolf Therapeutics is a biotechnology company based in Oxford, United Kingdom, focused on developing innovative immunotherapies for oncology. Founded in 2017, the company aims to enhance the visibility of non-responsive tumors to the immune system by directly modifying tumor cells. Its approach involves targeting endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 within the antigen presentation pathway, which increases the neoantigen repertoire on tumor cells. This strategy is designed to improve the effectiveness of immunotherapy in treating cancer. Grey Wolf collaborates with leading academic and commercial partners to advance its drug discovery initiatives and deliver clinical candidates against well-validated targets in the field of immuno-oncology.

Uniform Teeth is an orthodontics practice focused on delivering accessible and high-quality orthodontic care. The company operates dental clinics that utilize a modern approach to treatment, specializing in clear teeth aligners. These aligners are crafted from biocompatible, BPA-free plastic designed to fit snugly over the teeth at each stage of the orthodontic process. By prioritizing patient experience and innovative technology, Uniform Teeth aims to simplify the journey to achieving straightened teeth.

Intrepida Bio, Inc. is a biotechnology company focused on developing innovative cancer therapies that enhance the body’s innate immune response. Founded in 2016 and headquartered in San Diego, California, the company specializes in creating medicines that modulate the innate immune system to combat cancer and other diseases. Intrepida Bio is particularly engaged in the development of monoclonal antibodies aimed at novel targets such as BAG3 and its receptor IFITM-2, which are involved in establishing a tumor-friendly environment. Through its research efforts, Intrepida Bio aims to provide patients with effective treatment options to fight cancer.

Qlaris Bio is a clinical-stage biotechnology company based in Wellesley, Massachusetts, founded in 2017. The company specializes in developing innovative therapies for serious and debilitating ophthalmic diseases, with a focus on addressing episcleral venous pressure (EVP), a significant component of intraocular pressure (IOP). Qlaris Bio's lead therapy, QLS-101, aims to reduce IOP, thereby mitigating the risk of blindness in conditions such as Primary Open Angle Glaucoma and Normal Tension Glaucoma. The company also targets other high unmet need conditions related to disturbances in intraocular pressure, including a progressive pediatric rare disease with limited effective therapies.

nTopology, Inc. is an engineering software company founded in 2013 and headquartered in New York, New York. The company specializes in developing design software and tools aimed at optimizing manufacturing processes. Its flagship platform, nTopology, empowers engineers to create lightweight and optimized parts that meet specific functional requirements. The software includes features such as Lightweighting, Architected Materials, Topology Optimization, Additive Manufacturing, and Design Analysis, facilitating the integration of geometry and simulation data into manufacturing-ready models. By streamlining workflows and enhancing team collaboration, nTopology serves a diverse range of industries, including aerospace and defense, medical, automotive, consumer products, and education.

Comet Therapeutics, established in 2018 and headquartered in Cambridge, Massachusetts, specializes in developing novel small-molecule treatments for various diseases, with a focus on orphan neurological disorders. The company's core technology is its CoEnzyme metabolism platform, which aims to restore dysregulated CoEnzyme A metabolism, thereby addressing significant unmet medical needs in these areas.

Roman is a men's health company that offers online diagnosis and discreet shipping of safe erectile dysfunctional medication. The company was launched in 2017 as a vertical of Ro, a healthcare technology company.

Hyalex Orthopaedics is a Lexington, Massachusetts-based medical device company founded in 2016 that develops and commercializes products using HYALEX materials, a synthetic polymer designed to mimic cartilage. The material aims to maintain low friction and low wear under the high loads encountered in human joints, potentially enabling replacement of arthritic cartilage while sparing healthy bone. Products are in the development stage and have not been approved for use in humans by regulatory agencies.

Founded in 1985, Commonwealth Labs operates a specialized diagnostic laboratory based in San Francisco. It offers advanced tests for functional gastrointestinal disorders, serving healthcare providers.

Grey Wolf Therapeutics is a biotechnology company based in Oxford, United Kingdom, focused on developing innovative immunotherapies for oncology. Founded in 2017, the company aims to enhance the visibility of non-responsive tumors to the immune system by directly modifying tumor cells. Its approach involves targeting endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 within the antigen presentation pathway, which increases the neoantigen repertoire on tumor cells. This strategy is designed to improve the effectiveness of immunotherapy in treating cancer. Grey Wolf collaborates with leading academic and commercial partners to advance its drug discovery initiatives and deliver clinical candidates against well-validated targets in the field of immuno-oncology.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

PACT Pharma, Inc. is a biotechnology company focused on developing personalized cell-based therapies for cancer treatment. The company specializes in neoantigen-specific adoptive T-cell therapies aimed at solid tumors. Its innovative platform utilizes bioinformatics to analyze patients' tumor and normal DNA and RNA, identifying candidate neoantigen peptides that stimulate robust antitumor T-cell responses. By pinpointing neo-epitopes unique to each patient's cancer, PACT Pharma enables the engineering of autologous T cells that specifically target and eradicate tumors expressing these neo-antigens. Founded in 2016 and headquartered in South San Francisco, California, PACT Pharma is dedicated to advancing personalized medicine in oncology.

Rallybio is a clinical-stage biopharmaceutical company focused on developing therapies for severe and rare diseases. Its programs cover hematology, immuno-inflammation, maternal-fetal health and metabolic disorders, with a lead candidate aimed at preventing fetal and neonatal alloimmune thrombocytopenia, a life-threatening condition that can cause bleeding in fetuses and newborns. Founded in 2018 and based in New Haven, Connecticut, Rallybio develops therapies across antibodies, small molecules and engineered proteins to address unmet needs in rare diseases. Guided by experienced biopharma leadership, the company emphasizes translating biology into transformative therapies for underserved patients.

Arvinas, Inc. is a clinical-stage biopharmaceutical company based in New Haven, Connecticut, that specializes in the discovery, development, and commercialization of innovative therapies aimed at degrading disease-causing proteins. The company's lead product candidates include ARV-110, a proteolysis targeting chimera (PROTAC) currently in phase I clinical trials for metastatic castration-resistant prostate cancer, and ARV-471, which targets the estrogen receptor for patients with metastatic ER-positive/HER2-negative breast cancer. In addition to these, Arvinas is developing various other PROTACs aimed at degrading clinically relevant androgen receptor mutations and treatments for neurodegenerative diseases, including tauopathies. The company has established collaborations with prominent pharmaceutical firms such as Pfizer Inc., Genentech, and Bayer AG, enhancing its research capabilities and reach within the biopharmaceutical landscape. Founded in 2015, Arvinas aims to improve patient outcomes by eliminating harmful proteins from the body through its proprietary technology.

Genome Medical operates a platform that connects individuals and healthcare providers with genetic specialists. It offers virtual genetic care services, including clinical consultations for various health areas like cancer, cardiology, and reproductive health. The company uses its Genome Care Delivery technology to facilitate efficient genetic assessments and personalized treatment plans.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

Hyalex Orthopaedics is a Lexington, Massachusetts-based medical device company founded in 2016 that develops and commercializes products using HYALEX materials, a synthetic polymer designed to mimic cartilage. The material aims to maintain low friction and low wear under the high loads encountered in human joints, potentially enabling replacement of arthritic cartilage while sparing healthy bone. Products are in the development stage and have not been approved for use in humans by regulatory agencies.

Genome Medical operates a platform that connects individuals and healthcare providers with genetic specialists. It offers virtual genetic care services, including clinical consultations for various health areas like cancer, cardiology, and reproductive health. The company uses its Genome Care Delivery technology to facilitate efficient genetic assessments and personalized treatment plans.

Onkos Surgical Inc. is a privately-held company based in Parsippany, New Jersey, focused on providing advanced technologies and solutions for surgical oncologists. Founded in 2014, Onkos Surgical is dedicated to transforming the treatment of musculoskeletal cancers and complex orthopedic conditions. The company offers innovative products such as GenVie, a magnesium bone scaffolding technology, and the ELEOS Proximal Tibia, a 3D printed limb salvage replacement. By leveraging cutting-edge techniques in virtual surgical planning, 3D modeling and printing, and personalized surgical planning, Onkos Surgical aims to enhance patient outcomes and improve the overall experience for both patients and healthcare professionals.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

Abyrx, Inc. is a medical device company based in Irvington, New York, specializing in the development, manufacture, and distribution of therapeutic devices for surgical procedures. Founded in 2013, Abyrx offers a range of products, including resorbable hemostatic bone putties and applicator devices designed to stop bone bleeding and facilitate bone healing. The company's technology platforms not only support the re-approximation of bone surfaces but also enable the targeted delivery of drugs to bone. Abyrx's innovative solutions are utilized across various surgical fields, including orthopedic, cranial, maxillofacial, trauma, cardiothoracic, and spine surgeries, promoting efficient recovery for patients.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

Chrono Therapeutics Inc. is a pharmaceutical company based in Hayward, California, focused on revolutionizing drug delivery and addiction management. Founded in 2003, the company specializes in the development of SmartStop, a digital nicotine replacement therapy that employs a wearable device to deliver programmable, transdermal drug therapy. This innovative system is designed to tailor the timing and dosage of nicotine while providing real-time behavioral support to help users manage addiction and smoking cessation effectively. Chrono Therapeutics aims to address the challenges associated with smoking addiction through its advanced technology, which seeks to achieve optimal clinical outcomes and improve the overall quality of life for users. The company's leadership team brings extensive experience in product development, research and development, and navigating regulatory pathways, positioning Chrono Therapeutics as a key player in the smoking cessation market.

Ambra Health is a medical data and image management company that provides a cloud-based platform for healthcare providers. The platform is designed to enhance imaging innovation by offering secure and easy access to medical images, facilitating internal adoption, and strengthening collaboration among healthcare organizations. With its intuitive and flexible design, Ambra's solutions enable health systems, radiology practices, and clinical research organizations to improve workflows related to imaging and patient care. The company's technology aims to make medical images and data accessible from anywhere, significantly enhancing operational efficiency and business outcomes within the healthcare sector.

Founded in 2014, Tizona Therapeutics is a biopharmaceutical company based in South San Francisco, California. It specializes in developing immunotherapies for cancer and autoimmune diseases, with a focus on understanding the role of regulatory T cells in various tumors.

NextCure, Inc. is a clinical-stage biopharmaceutical company based in Beltsville, Maryland, that focuses on discovering and developing novel immunomedicines aimed at treating cancer and other immune-related diseases by restoring normal immune function. Its lead product candidate, NC318, is currently undergoing Phase 2 clinical trials for advanced or metastatic solid tumors. Additionally, NextCure is developing NC410, designed to inhibit immune suppression through the modulation of a specific immune receptor. The company is also advancing other product candidates, including LNCB74, an antibody-drug conjugate targeting B7-H4, and is exploring additional immunomodulatory molecules in preclinical stages. NextCure has established collaborations with Yale University for licensing and with Eli Lilly and Company for research and development. Founded in 2015, the company leverages proprietary platforms to identify biologically relevant targets in its pursuit of first-in-class immunotherapy solutions.

MID has developed the FloShield system, a franchise of products that substantially improve visualization during laparoscopic surgery. During laparoscopic surgery, it is common for condensation to form on the end of the laparoscope obscuring vision. It is also common for debris from the ultrasonic scalpel, cautery, or even blood products themselves to degrade the surgical view. Most commonly, surgeons will need to remove the laparoscope for manual cleaning. It was founded in 2006 and headquartered in Columbus, Ohio.

Arvinas, Inc. is a clinical-stage biopharmaceutical company based in New Haven, Connecticut, that specializes in the discovery, development, and commercialization of innovative therapies aimed at degrading disease-causing proteins. The company's lead product candidates include ARV-110, a proteolysis targeting chimera (PROTAC) currently in phase I clinical trials for metastatic castration-resistant prostate cancer, and ARV-471, which targets the estrogen receptor for patients with metastatic ER-positive/HER2-negative breast cancer. In addition to these, Arvinas is developing various other PROTACs aimed at degrading clinically relevant androgen receptor mutations and treatments for neurodegenerative diseases, including tauopathies. The company has established collaborations with prominent pharmaceutical firms such as Pfizer Inc., Genentech, and Bayer AG, enhancing its research capabilities and reach within the biopharmaceutical landscape. Founded in 2015, Arvinas aims to improve patient outcomes by eliminating harmful proteins from the body through its proprietary technology.

Antiva Biosciences, Inc. is a biopharmaceutical company based in South San Francisco, California, focused on developing antiviral therapies for human papillomavirus (HPV) infections. Established in 2012, the company aims to prevent cancer by treating precancerous lesions associated with HPV. Antiva's innovative approach includes localized therapeutics and small molecule antivirals that target HPV and other viral infections. The company is currently conducting clinical trials for high-grade anal intraepithelial neoplasias and high-grade cervical intraepithelial neoplasias. Through its medicinal chemistry platform, Antiva strives to enhance health outcomes for patients affected by HPV-related diseases and other viral infections.

CytomX Therapeutics is a clinical-stage oncology-focused biopharmaceutical company that develops proteolytically-activated antibodies based on its Probody technology platform. Probody therapeutics are designed to be activated by the tumor microenvironment, enabling targeted cancer immunotherapies with reduced activity in healthy tissues. The company advances antibody and antibody-drug conjugate programs such as CX-072 (PD-L1), CX-2009 (CD166-targeted PDC), BMS-986249 (CTLA-4 Probody), CX-2029 (CD71-targeted PDC), and BMS-986288 (CTLA-4 Probody) in clinical research, and maintains collaborations with AbbVie, Amgen, Bristol-Myers Squibb, ImmunoGen, Pfizer, and Astellas to develop Probody therapeutics. Founded in 2008 and headquartered in South San Francisco, the company aims to improve the precision and safety of antibody-based therapies for cancer and inflammatory diseases.

Founded in 2014, Vivace Therapeutics is a biotechnology company based in the San Francisco Bay Area. It focuses on discovering and developing cancer therapeutics by targeting novel pathways, with a particular emphasis on the Hippo pathway which controls tissue regeneration and organ size.

LQ3 Pharmaceuticals, Inc. is a healthcare company based in Morrisville, North Carolina, specializing in the development of oral health therapies. Established in 2013, the company employs advanced PRINT (Particle Replication In Non-Wetting Templates) technology to research and create innovative solutions for various oral health issues. By focusing on this niche within the pharmaceutical sector, LQ3 Pharmaceuticals aims to enhance the dental industry through the application of cutting-edge technology and effective therapeutic products.

ALDEA Pharmaceuticals, Inc. is a biotechnology company focused on developing small-molecule modulators of the aldehyde dehydrogenase (ALDH) enzyme superfamily. Founded in 2008 and headquartered in Redwood City, California, the company aims to address diseases associated with aldehyde metabolism dysfunction, which can range from acute alcohol toxicity to rare conditions such as Fanconi anemia. ALDEA's proprietary technology offers new product opportunities targeting a variety of therapeutic areas, including the development of ALDH activator compounds that enhance the detoxification of harmful aldehydes like acetaldehyde. These advancements are intended to alleviate acute symptoms and mitigate long-term tissue damage and cancer risk related to alcohol consumption and other toxic aldehyde-related diseases.

Dermira, Inc. is a biopharmaceutical company that specializes in developing and commercializing therapies for dermatologic diseases, primarily targeting the U.S. market. Founded in 2010 and headquartered in Menlo Park, California, Dermira offers QBREXZA, a topical treatment for primary axillary hyperhidrosis in patients aged nine and older. The company is also advancing its pipeline with lebrikizumab, a monoclonal antibody currently in Phase IIb trials for moderate-to-severe atopic dermatitis, alongside several other early-stage research initiatives in dermatology. Dermira has established strategic partnerships for the development and commercialization of its products, including agreements with Maruho Co., Ltd., F. Hoffmann-La Roche Ltd, Genentech, Inc., and UCB Pharma S.A. Notably, Dermira was previously known as Skintelligence, Inc. before rebranding in September 2011. As of early 2020, Dermira operates as a subsidiary of Eli Lilly and Company.

Ambra Health is a medical data and image management company that provides a cloud-based platform for healthcare providers. The platform is designed to enhance imaging innovation by offering secure and easy access to medical images, facilitating internal adoption, and strengthening collaboration among healthcare organizations. With its intuitive and flexible design, Ambra's solutions enable health systems, radiology practices, and clinical research organizations to improve workflows related to imaging and patient care. The company's technology aims to make medical images and data accessible from anywhere, significantly enhancing operational efficiency and business outcomes within the healthcare sector.

MID has developed the FloShield system, a franchise of products that substantially improve visualization during laparoscopic surgery. During laparoscopic surgery, it is common for condensation to form on the end of the laparoscope obscuring vision. It is also common for debris from the ultrasonic scalpel, cautery, or even blood products themselves to degrade the surgical view. Most commonly, surgeons will need to remove the laparoscope for manual cleaning. It was founded in 2006 and headquartered in Columbus, Ohio.

Chrono Therapeutics Inc. is a pharmaceutical company based in Hayward, California, focused on revolutionizing drug delivery and addiction management. Founded in 2003, the company specializes in the development of SmartStop, a digital nicotine replacement therapy that employs a wearable device to deliver programmable, transdermal drug therapy. This innovative system is designed to tailor the timing and dosage of nicotine while providing real-time behavioral support to help users manage addiction and smoking cessation effectively. Chrono Therapeutics aims to address the challenges associated with smoking addiction through its advanced technology, which seeks to achieve optimal clinical outcomes and improve the overall quality of life for users. The company's leadership team brings extensive experience in product development, research and development, and navigating regulatory pathways, positioning Chrono Therapeutics as a key player in the smoking cessation market.

Transcend Medical, Inc. is an ophthalmic device company based in Menlo Park, California, focused on developing innovative medical devices for the treatment of glaucoma, a leading cause of irreversible blindness in adults. Founded in 2005, Transcend Medical emerged from ForSight Labs, an incubator dedicated to ophthalmic innovations. The company's flagship product, the CyPass Micro-Stent, is a micro-invasive device designed to be implanted during routine cataract surgery to reduce intraocular pressure. Additionally, Transcend Medical offers the Vold Gonio Lens for use in micro-invasive glaucoma surgeries and provides clinical trial services. The CyPass Micro-Stent received its CE mark in 2008 and has been undergoing evaluation in various clinical studies, including the COMPASS multi-center trial, to assess its effectiveness and safety in treating glaucoma. As of 2016, Transcend Medical operates as a subsidiary of Alcon Holdings, Inc.

Envisia Therapeutics Inc. is a company focused on discovering and developing innovative therapies for ophthalmic medical needs. Founded in 2013 and based in Durham, North Carolina, the company utilizes its proprietary Particle Replication In Non-Wetting Templates (PRINT) technology to create a range of particle-based therapies. Envisia is particularly known for its lead product, ENV515, a prostaglandin analogue designed to deliver sustained intraocular pressure reduction for extended periods. In addition to this, the company is developing glaucoma drug therapies that leverage PRINT particle therapeutics to improve drug delivery and efficacy while addressing common barriers faced by existing ocular treatments. As the demand for more effective ocular therapeutics continues to grow, Envisia aims to enhance patient outcomes and convenience in the management of ocular diseases.

Arvinas, Inc. is a clinical-stage biopharmaceutical company based in New Haven, Connecticut, that specializes in the discovery, development, and commercialization of innovative therapies aimed at degrading disease-causing proteins. The company's lead product candidates include ARV-110, a proteolysis targeting chimera (PROTAC) currently in phase I clinical trials for metastatic castration-resistant prostate cancer, and ARV-471, which targets the estrogen receptor for patients with metastatic ER-positive/HER2-negative breast cancer. In addition to these, Arvinas is developing various other PROTACs aimed at degrading clinically relevant androgen receptor mutations and treatments for neurodegenerative diseases, including tauopathies. The company has established collaborations with prominent pharmaceutical firms such as Pfizer Inc., Genentech, and Bayer AG, enhancing its research capabilities and reach within the biopharmaceutical landscape. Founded in 2015, Arvinas aims to improve patient outcomes by eliminating harmful proteins from the body through its proprietary technology.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

MID has developed the FloShield system, a franchise of products that substantially improve visualization during laparoscopic surgery. During laparoscopic surgery, it is common for condensation to form on the end of the laparoscope obscuring vision. It is also common for debris from the ultrasonic scalpel, cautery, or even blood products themselves to degrade the surgical view. Most commonly, surgeons will need to remove the laparoscope for manual cleaning. It was founded in 2006 and headquartered in Columbus, Ohio.

Dermira, Inc. is a biopharmaceutical company that specializes in developing and commercializing therapies for dermatologic diseases, primarily targeting the U.S. market. Founded in 2010 and headquartered in Menlo Park, California, Dermira offers QBREXZA, a topical treatment for primary axillary hyperhidrosis in patients aged nine and older. The company is also advancing its pipeline with lebrikizumab, a monoclonal antibody currently in Phase IIb trials for moderate-to-severe atopic dermatitis, alongside several other early-stage research initiatives in dermatology. Dermira has established strategic partnerships for the development and commercialization of its products, including agreements with Maruho Co., Ltd., F. Hoffmann-La Roche Ltd, Genentech, Inc., and UCB Pharma S.A. Notably, Dermira was previously known as Skintelligence, Inc. before rebranding in September 2011. As of early 2020, Dermira operates as a subsidiary of Eli Lilly and Company.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

AtheroMed, Inc. is a medical device company based in Menlo Park, California, which specializes in developing catheter-based treatments for peripheral arterial disease (PAD). Founded in 2006, AtheroMed's innovative systems address a range of vessel sizes, from small arteries at the ankle to larger ones above the knee. The company aims to improve patient outcomes through its targeted therapies, facilitating more effective treatment options for individuals suffering from PAD.

ALDEA Pharmaceuticals, Inc. is a biotechnology company focused on developing small-molecule modulators of the aldehyde dehydrogenase (ALDH) enzyme superfamily. Founded in 2008 and headquartered in Redwood City, California, the company aims to address diseases associated with aldehyde metabolism dysfunction, which can range from acute alcohol toxicity to rare conditions such as Fanconi anemia. ALDEA's proprietary technology offers new product opportunities targeting a variety of therapeutic areas, including the development of ALDH activator compounds that enhance the detoxification of harmful aldehydes like acetaldehyde. These advancements are intended to alleviate acute symptoms and mitigate long-term tissue damage and cancer risk related to alcohol consumption and other toxic aldehyde-related diseases.

Theraclone Sciences, Inc. is a discovery-stage biotechnology company based in Seattle, Washington, focused on developing novel therapeutic antibodies for cancer and infectious diseases. The company employs its proprietary In-Situ Therapeutic Antibody Rescue technology to rapidly identify and test human antibodies with exceptional biological functions. Theraclone's pipeline includes TCN-032, a recombinant human monoclonal antibody aimed at treating patients hospitalized with severe influenza, along with several preclinical and clinical programs targeting unmet medical needs such as triple-negative breast cancer, infectious disease-associated cancers, and multidrug-resistant bacteria. Founded in 2004 and originally known as Spaltudaq Corporation until its rebranding in 2009, Theraclone leverages the natural immune responses of human subjects to discover rare monoclonal antibodies that could lead to effective therapeutic interventions.

MID has developed the FloShield system, a franchise of products that substantially improve visualization during laparoscopic surgery. During laparoscopic surgery, it is common for condensation to form on the end of the laparoscope obscuring vision. It is also common for debris from the ultrasonic scalpel, cautery, or even blood products themselves to degrade the surgical view. Most commonly, surgeons will need to remove the laparoscope for manual cleaning. It was founded in 2006 and headquartered in Columbus, Ohio.

Novira Therapeutics is a clinical‑stage biopharmaceutical company that discovers and develops oral antiviral drugs targeting the capsid of hepatitis B virus and human immunodeficiency virus. Its pipeline focuses on first‑in‑class capsid inhibitors that can be used alone or with existing therapies, aiming to overcome limitations of current polymerase inhibitors and drug‑resistant HIV strains. The company was founded in 2006 as Molecmo Nanobiotechnologies and is headquartered in Doylestown, Pennsylvania. It has pursued partnerships and collaborations to advance its candidates toward clinical evaluation.

Marinus Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics for rare seizure disorders and neuropsychiatric conditions. The company's lead product candidate, ganaxolone, functions as an allosteric modulator of GABAA receptors and is being developed in both intravenous and oral formulations for use in various patient populations, including adults and children. Ganaxolone is targeted for multiple indications, such as status epilepticus, cyclin dependent kinase like 5 deficiency disorder, PCDH19-related epilepsy, tuberous sclerosis complex, postpartum depression, and treatment-resistant depression. Marinus Pharmaceuticals emphasizes collaboration with healthcare professionals and partners to enhance patient care and improve the lives of those affected by these conditions. Founded in 2003 and headquartered in Radnor, Pennsylvania, the company is committed to advancing its therapeutic offerings through rigorous scientific research and development.

Labrys Biologics Inc. is a biotechnology company dedicated to developing innovative treatments for chronic migraines. The company has acquired worldwide rights to RN-307 from Pfizer Inc., an antibody specifically designed to address chronic migraine conditions. In addition to RN-307, Labrys Biologics is advancing its lead candidate, LBR-101, which is an anti-CGRP monoclonal antibody aimed at the prevention of chronic and high-frequency migraines. Through these targeted therapies, Labrys Biologics seeks to provide effective solutions for individuals suffering from debilitating migraine conditions.

Labrys Biologics Inc. is a biotechnology company dedicated to developing innovative treatments for chronic migraines. The company has acquired worldwide rights to RN-307 from Pfizer Inc., an antibody specifically designed to address chronic migraine conditions. In addition to RN-307, Labrys Biologics is advancing its lead candidate, LBR-101, which is an anti-CGRP monoclonal antibody aimed at the prevention of chronic and high-frequency migraines. Through these targeted therapies, Labrys Biologics seeks to provide effective solutions for individuals suffering from debilitating migraine conditions.

CytomX Therapeutics is a clinical-stage oncology-focused biopharmaceutical company that develops proteolytically-activated antibodies based on its Probody technology platform. Probody therapeutics are designed to be activated by the tumor microenvironment, enabling targeted cancer immunotherapies with reduced activity in healthy tissues. The company advances antibody and antibody-drug conjugate programs such as CX-072 (PD-L1), CX-2009 (CD166-targeted PDC), BMS-986249 (CTLA-4 Probody), CX-2029 (CD71-targeted PDC), and BMS-986288 (CTLA-4 Probody) in clinical research, and maintains collaborations with AbbVie, Amgen, Bristol-Myers Squibb, ImmunoGen, Pfizer, and Astellas to develop Probody therapeutics. Founded in 2008 and headquartered in South San Francisco, the company aims to improve the precision and safety of antibody-based therapies for cancer and inflammatory diseases.

Ambra Health is a medical data and image management company that provides a cloud-based platform for healthcare providers. The platform is designed to enhance imaging innovation by offering secure and easy access to medical images, facilitating internal adoption, and strengthening collaboration among healthcare organizations. With its intuitive and flexible design, Ambra's solutions enable health systems, radiology practices, and clinical research organizations to improve workflows related to imaging and patient care. The company's technology aims to make medical images and data accessible from anywhere, significantly enhancing operational efficiency and business outcomes within the healthcare sector.

ALDEA Pharmaceuticals, Inc. is a biotechnology company focused on developing small-molecule modulators of the aldehyde dehydrogenase (ALDH) enzyme superfamily. Founded in 2008 and headquartered in Redwood City, California, the company aims to address diseases associated with aldehyde metabolism dysfunction, which can range from acute alcohol toxicity to rare conditions such as Fanconi anemia. ALDEA's proprietary technology offers new product opportunities targeting a variety of therapeutic areas, including the development of ALDH activator compounds that enhance the detoxification of harmful aldehydes like acetaldehyde. These advancements are intended to alleviate acute symptoms and mitigate long-term tissue damage and cancer risk related to alcohol consumption and other toxic aldehyde-related diseases.

Relievant Medsystems, Inc. is a medical device company focused on developing innovative solutions for chronic axial low back pain. Founded in 2004 and headquartered in Minneapolis, Minnesota, with a development office in Sunnyvale, California, the company has created the Intracept System. This minimally invasive procedure specifically targets the basivertebral nerve, providing relief by blocking pain signal transmission. The Intracept System offers patients a low-risk therapy option aimed at alleviating chronic vertebrogenic low back pain.

AtheroMed, Inc. is a medical device company based in Menlo Park, California, which specializes in developing catheter-based treatments for peripheral arterial disease (PAD). Founded in 2006, AtheroMed's innovative systems address a range of vessel sizes, from small arteries at the ankle to larger ones above the knee. The company aims to improve patient outcomes through its targeted therapies, facilitating more effective treatment options for individuals suffering from PAD.

Transcend Medical, Inc. is an ophthalmic device company based in Menlo Park, California, focused on developing innovative medical devices for the treatment of glaucoma, a leading cause of irreversible blindness in adults. Founded in 2005, Transcend Medical emerged from ForSight Labs, an incubator dedicated to ophthalmic innovations. The company's flagship product, the CyPass Micro-Stent, is a micro-invasive device designed to be implanted during routine cataract surgery to reduce intraocular pressure. Additionally, Transcend Medical offers the Vold Gonio Lens for use in micro-invasive glaucoma surgeries and provides clinical trial services. The CyPass Micro-Stent received its CE mark in 2008 and has been undergoing evaluation in various clinical studies, including the COMPASS multi-center trial, to assess its effectiveness and safety in treating glaucoma. As of 2016, Transcend Medical operates as a subsidiary of Alcon Holdings, Inc.

Founded in 2008, Elevation Pharmaceuticals is developing a pipeline of improved aerosol drug products for COPD patients. There founding team has a successful track record starting companies and building dedicated teams to develop new drug products that improve patients' lives. At Elevation, they have a disciplined approach to strategic decision-making that helps us stay focused on the path with the highest probability of success. They are executing our drug development plans with passion, integrity, and a high sense of urgency in order to meet the needs and expectations of our stakeholders -- employees, investors, partners, and patients.

Theraclone Sciences, Inc. is a discovery-stage biotechnology company based in Seattle, Washington, focused on developing novel therapeutic antibodies for cancer and infectious diseases. The company employs its proprietary In-Situ Therapeutic Antibody Rescue technology to rapidly identify and test human antibodies with exceptional biological functions. Theraclone's pipeline includes TCN-032, a recombinant human monoclonal antibody aimed at treating patients hospitalized with severe influenza, along with several preclinical and clinical programs targeting unmet medical needs such as triple-negative breast cancer, infectious disease-associated cancers, and multidrug-resistant bacteria. Founded in 2004 and originally known as Spaltudaq Corporation until its rebranding in 2009, Theraclone leverages the natural immune responses of human subjects to discover rare monoclonal antibodies that could lead to effective therapeutic interventions.

Dermira, Inc. is a biopharmaceutical company that specializes in developing and commercializing therapies for dermatologic diseases, primarily targeting the U.S. market. Founded in 2010 and headquartered in Menlo Park, California, Dermira offers QBREXZA, a topical treatment for primary axillary hyperhidrosis in patients aged nine and older. The company is also advancing its pipeline with lebrikizumab, a monoclonal antibody currently in Phase IIb trials for moderate-to-severe atopic dermatitis, alongside several other early-stage research initiatives in dermatology. Dermira has established strategic partnerships for the development and commercialization of its products, including agreements with Maruho Co., Ltd., F. Hoffmann-La Roche Ltd, Genentech, Inc., and UCB Pharma S.A. Notably, Dermira was previously known as Skintelligence, Inc. before rebranding in September 2011. As of early 2020, Dermira operates as a subsidiary of Eli Lilly and Company.

Founded in 2008, Elevation Pharmaceuticals is developing a pipeline of improved aerosol drug products for COPD patients. There founding team has a successful track record starting companies and building dedicated teams to develop new drug products that improve patients' lives. At Elevation, they have a disciplined approach to strategic decision-making that helps us stay focused on the path with the highest probability of success. They are executing our drug development plans with passion, integrity, and a high sense of urgency in order to meet the needs and expectations of our stakeholders -- employees, investors, partners, and patients.

Transcend Medical, Inc. is an ophthalmic device company based in Menlo Park, California, focused on developing innovative medical devices for the treatment of glaucoma, a leading cause of irreversible blindness in adults. Founded in 2005, Transcend Medical emerged from ForSight Labs, an incubator dedicated to ophthalmic innovations. The company's flagship product, the CyPass Micro-Stent, is a micro-invasive device designed to be implanted during routine cataract surgery to reduce intraocular pressure. Additionally, Transcend Medical offers the Vold Gonio Lens for use in micro-invasive glaucoma surgeries and provides clinical trial services. The CyPass Micro-Stent received its CE mark in 2008 and has been undergoing evaluation in various clinical studies, including the COMPASS multi-center trial, to assess its effectiveness and safety in treating glaucoma. As of 2016, Transcend Medical operates as a subsidiary of Alcon Holdings, Inc.

Chimerix, Inc. is a biopharmaceutical company based in Durham, North Carolina, focused on the development of innovative medicines for patients with cancer and serious viral infections. The company is advancing several clinical-stage programs, including dociparstat sodium (DSTAT), a glycosaminoglycan compound aimed at improving outcomes for patients with acute myeloid leukemia during chemotherapy. Another key candidate is brincidofovir (BCV), an antiviral drug being developed as a medical countermeasure for smallpox. Chimerix also leads the development of CMX001, a broad-spectrum antiviral agent targeting life-threatening double-stranded DNA viral infections, currently undergoing multiple clinical studies for use in immunocompromised patients. Additionally, CMX157, an antiviral compound with activity against HIV and hepatitis B, is in development, addressing challenges posed by existing therapies. The company collaborates with various organizations for research and commercialization, deriving revenue from licensing agreements and royalties. Founded in 2000, Chimerix is committed to transforming patient care through its advanced therapeutic candidates.

Ambra Health is a medical data and image management company that provides a cloud-based platform for healthcare providers. The platform is designed to enhance imaging innovation by offering secure and easy access to medical images, facilitating internal adoption, and strengthening collaboration among healthcare organizations. With its intuitive and flexible design, Ambra's solutions enable health systems, radiology practices, and clinical research organizations to improve workflows related to imaging and patient care. The company's technology aims to make medical images and data accessible from anywhere, significantly enhancing operational efficiency and business outcomes within the healthcare sector.

Tobira Therapeutics, Inc. is a biotechnology company based in Princeton, New Jersey, focused on the research, development, and commercialization of antiviral compounds aimed at addressing life-threatening infectious diseases. Founded in 2006, the company specializes in developing TBR-652 and TBR-220 antagonists specifically for the treatment of HIV/AIDS and hepatitis, along with other related infectious conditions. Through its innovative approach, Tobira Therapeutics seeks to provide effective therapies for patients suffering from these serious health challenges.

ReVision Optics, Inc. is a company that specializes in designing, manufacturing, and delivering implantable products aimed at treating presbyopia, a condition associated with the natural aging process that affects near vision. The company's flagship product, the PRESBYLENS Corneal Inlay, offers a patented refractive surgery solution that enhances visual acuity for individuals experiencing age-related vision loss. Founded in 1996 and based in Lake Forest, California, ReVision Optics serves ophthalmology professionals, providing them with advanced technology to improve patient outcomes. Originally established as IntraLens Vision, Inc., the company rebranded to its current name in 2005, reflecting its focus on innovative optical solutions.

Theraclone Sciences, Inc. is a discovery-stage biotechnology company based in Seattle, Washington, focused on developing novel therapeutic antibodies for cancer and infectious diseases. The company employs its proprietary In-Situ Therapeutic Antibody Rescue technology to rapidly identify and test human antibodies with exceptional biological functions. Theraclone's pipeline includes TCN-032, a recombinant human monoclonal antibody aimed at treating patients hospitalized with severe influenza, along with several preclinical and clinical programs targeting unmet medical needs such as triple-negative breast cancer, infectious disease-associated cancers, and multidrug-resistant bacteria. Founded in 2004 and originally known as Spaltudaq Corporation until its rebranding in 2009, Theraclone leverages the natural immune responses of human subjects to discover rare monoclonal antibodies that could lead to effective therapeutic interventions.

Founded in 2008, Elevation Pharmaceuticals is developing a pipeline of improved aerosol drug products for COPD patients. There founding team has a successful track record starting companies and building dedicated teams to develop new drug products that improve patients' lives. At Elevation, they have a disciplined approach to strategic decision-making that helps us stay focused on the path with the highest probability of success. They are executing our drug development plans with passion, integrity, and a high sense of urgency in order to meet the needs and expectations of our stakeholders -- employees, investors, partners, and patients.

ORTHOCON is a medical therapeutics company focused on developing innovative absorbable products specifically for orthopedic and spine surgeries. The company specializes in creating implantable products that effectively address bone bleeding, which is a common challenge in surgical procedures. Among its offerings is the HEMASORB Absorbable Bone Hemostat Matrix, a ready-to-use, biocompatible, water-resistant, and absorbable putty designed to halt bleeding when applied to damaged or cut bone. ORTHOCON's commitment to enhancing surgical outcomes is reflected in its development and manufacturing processes aimed at providing effective solutions for healthcare professionals in the field of orthopedics.

Coapt Systems, Inc. specializes in the design, development, and manufacture of bio-absorbable implants used in soft tissue fixation during facial cosmetic surgery. The company offers a range of products, including the ENDOTINE Forehead 3.0 and ENDOTINE Triple 3.0, which are designed for brow fixation, along with ENDOTINE Midface ST 4.5 for midface suspension. Other offerings include the ENDOTINE Ribbon and various surgical tools such as manual surgical drills and incisionless dissectors for precise application. Coapt's implants are utilized in procedures like forehead lifts, brow lifts, and midface and neck suspensions, catering to the needs of plastic surgeons in enhancing patient outcomes.

Chimerix, Inc. is a biopharmaceutical company based in Durham, North Carolina, focused on the development of innovative medicines for patients with cancer and serious viral infections. The company is advancing several clinical-stage programs, including dociparstat sodium (DSTAT), a glycosaminoglycan compound aimed at improving outcomes for patients with acute myeloid leukemia during chemotherapy. Another key candidate is brincidofovir (BCV), an antiviral drug being developed as a medical countermeasure for smallpox. Chimerix also leads the development of CMX001, a broad-spectrum antiviral agent targeting life-threatening double-stranded DNA viral infections, currently undergoing multiple clinical studies for use in immunocompromised patients. Additionally, CMX157, an antiviral compound with activity against HIV and hepatitis B, is in development, addressing challenges posed by existing therapies. The company collaborates with various organizations for research and commercialization, deriving revenue from licensing agreements and royalties. Founded in 2000, Chimerix is committed to transforming patient care through its advanced therapeutic candidates.