Bpifrance

MSInsight is a bioinformatics startup specializing in the development of diagnostic and treatment response prediction solutions for microsatellite instability (MSI) cancers. The company offers a platform that utilizes next-generation sequencing data to analyze MSI status, a crucial biomarker in oncology. By providing actionable insights on this biomarker, MSInsight enables healthcare professionals to make informed decisions about patient care, particularly concerning treatment options such as immunotherapy. The focus on diagnostic and prognostic biomarkers of treatment response enhances the ability to improve overall patient outcomes in the oncology market.

GenSight Biologics S.A. is a clinical-stage biotechnology company based in Paris, France, focused on the discovery and development of gene therapies for retinal degenerative diseases and neurodegenerative disorders of the central nervous system. Founded in 2012, the company utilizes innovative technologies, including mitochondrial targeting sequences and optogenetics, to develop treatments that aim to preserve or restore vision in patients with severe vision impairments. Its lead product candidates include GS010, an AAV2-based gene therapy that is currently undergoing Phase III clinical trials for Leber hereditary optic neuropathy caused by mutations in the ND4 gene, and GS030, which is in Phase I/II trials for retinitis pigmentosa and geographic atrophy associated with dry age-related macular degeneration. GenSight Biologics is also advancing other product candidates in preclinical development targeting various ophthalmic and neurodegenerative conditions.

BiPER Therapeutics is a biotechnology company focused on developing and commercializing innovative therapeutic solutions. The company specializes in creating drugs that target critical proteins involved in the metabolism of cancer cells, aiming to overcome treatment resistance and enhance cancer cell survival. Their primary focus is on providing effective treatments for gastrointestinal cancers.

Vetbiolix is a veterinary biotechnology company dedicated to developing innovative therapeutic solutions for dogs and cats. The company focuses on the clinical development of first-in-class drug candidates aimed at treating and preventing diseases affecting pets, including periodontitis, osteoarthritis, and gut motility disorders. By prioritizing the creation of effective treatments for common health issues, Vetbiolix aims to enhance the quality of life for pets and their owners.

Orakl Oncology specializes in expediting cancer drug discovery by employing advanced biology and AI-driven analysis. It maintains a unique collection of patient tumor avatars, integrating biological and clinical data, to create realistic tumor models that mimic real-life drug responses. By mining multi-modal experimental data and combining it with deep patient data, Orakl enables oncology companies to identify relevant targets and develop more effective treatments at an accelerated pace.

Vaxinano is a biotechnology company founded in 2016, focused on the preclinical and pharmaceutical development of vaccines and drug delivery systems for both humans and animals. Building on 25 years of research and clinical trials led by Pr Didier Betbeder, Vaxinano specializes in creating prophylactic and therapeutic vaccines for infectious diseases. The company employs safe-by-design nanoparticles that adhere to green chemistry principles, facilitating the development of drugs targeting active biomolecules, proteins, and antigens. This innovative approach enables medical researchers to create new vaccines aimed at addressing untreated viral, bacterial, and parasitic diseases.

Okomera is a biotech start-up focused on enhancing access to more effective, precision-based cancer therapies. The company has pioneered the automation and miniaturization of individualized tumor biopsy research, developing advanced medical technologies that leverage microfluidic 3D cellular assays. These innovative technologies enable the prediction of patient-specific responses to cancer treatments by automating relevant biopsy testing. In this process, tumor cells are cultivated within thousands of microfluidic droplets and exposed to numerous conditions simultaneously. This approach allows healthcare providers to expedite the development and delivery of modern cancer therapies, ultimately improving treatment outcomes for patients.

Vetbiolix is a veterinary biotechnology company dedicated to developing innovative therapeutic solutions for dogs and cats. The company focuses on the clinical development of first-in-class drug candidates aimed at treating and preventing diseases affecting pets, including periodontitis, osteoarthritis, and gut motility disorders. By prioritizing the creation of effective treatments for common health issues, Vetbiolix aims to enhance the quality of life for pets and their owners.

UroMems is a medical device company dedicated to addressing specific clinical needs related to urinary conditions that significantly impact patients' quality of life. The company specializes in the design, development, and commercialization of active implantable medical devices. Its innovative approach aims to enhance existing surgical treatments by minimizing associated side effects and ensuring that patients receive appropriate care promptly. Through its commitment to improving treatment options, UroMems seeks to benefit a wide range of patients facing urinary health challenges.

StarkAge Therapeutics is a discovery-stage biotechnology company focused on improving the quality of life for patients through innovative treatments. The company specializes in developing a platform that utilizes immunotherapy combined with cancer therapy to target and deplete senescent cells associated with age-related diseases. Its research and development efforts are aimed at addressing conditions such as idiopathic pulmonary fibrosis, neurodegenerative diseases, and metabolic dysfunctions, including hepatic fibroses. By leveraging its unique approach, StarkAge Therapeutics seeks to provide effective therapeutic options for managing these challenging health issues.

Biodol Therapeutics SAS is a biotechnology company based in Clapiers, France, established in 2015. The company focuses on developing innovative compounds for the treatment of chronic pain, specifically targeting the Receptor Tyrosine Kinase (RTK) FLT3, which plays a critical role in triggering and sustaining chronic neuropathic pain. Biodol Therapeutics' research indicates that inhibiting FLT3 can enhance the effectiveness of opioids, potentially reducing their risk of addiction and contributing to solutions for the opioid crisis. By creating extracellular inhibitors of the FLT3 receptor, the company aims to alleviate pain hypersensitivity, allodynia, and spontaneous pain while preserving normal nervous system function. Through academic partnerships, Biodol Therapeutics continues to advance its understanding of pain mechanisms and develop its proprietary therapeutic approaches.

MaaT Pharma, based in Lyon, France, is a clinical-stage biotechnology company founded in 2014 that specializes in the development of microbiome-based therapies aimed at treating diseases associated with gut microbiota imbalance. The company focuses on improving survival outcomes in patients with life-threatening conditions, particularly cancers and Graft-versus-Host Disease, a serious complication following allogeneic stem cell transplantation. MaaT Pharma has demonstrated proof of concept in acute myeloid leukemia patients and is actively expanding its pipeline to enhance outcomes in immunotherapy for solid tumors. Central to its research efforts is the GutPrint® platform, which facilitates the evaluation of drug candidates, identification of novel disease targets, and discovery of biomarkers related to microbiome-associated conditions.

Hephaistos Pharma is a biotechnology firm dedicated to advancing oncology treatments through innovative immunotherapy solutions. The company focuses on developing next-generation therapies that utilize active and non-specific immuno-stimulants, which enhance the efficacy of existing antibodies and transform cold tumors into hot targets for the immune system. By addressing unmet medical needs, Hephaistos Pharma aims to provide effective treatment options for patients with incurable cancers. Their platform is designed to stimulate immune responses, thereby improving the overall efficiency of immunotherapy. The firm also offers an online inquiry form on its website for further engagement.

May Health is a healthcare company focused on addressing infertility related to Polycystic Ovary Syndrome (PCOS). The company has developed an innovative, minimally invasive procedure aimed at restoring ovulation in women with PCOS. This one-time treatment is performed transvaginally under ultrasound guidance, allowing for its execution in a clinical setting without the need for general anesthesia. May Health's approach seeks to provide patients with a more natural pregnancy experience by assisting the body to ovulate as it would naturally, thereby offering a less medicalized alternative to traditional fertility treatments.

Klineo is a healthcare platform focused on enhancing access to clinical trials for oncology patients. It features an intuitive and intelligent search interface that caters to both healthcare professionals and patients. The platform allows users to efficiently locate relevant clinical trials for specific conditions such as breast, skin, and lymphoma cancers, facilitating contact with trial centers and improving the overall trial search experience. By connecting patients and doctors with appropriate clinical research opportunities, Klineo aims to streamline the process of finding critical treatment options in the oncology field.

ABIONYX Pharma SA is a French biopharmaceutical company established in 2005, currently based in Labege. It specializes in the discovery and development of therapies targeting high-density lipoprotein (HDL) for treating cardiovascular and metabolic diseases. The company's primary focus is on developing HDL mimetics to rapidly regress atherosclerotic plaque in high-risk patients. Its lead product candidate, CER-001, is a Phase II clinical trial asset designed to mimic the properties of pre-beta HDL for treating post-acute coronary syndrome patients and familial primary hypoalphalipoproteinemia patients. Additionally, ABIONYX Pharma has another drug candidate, CER-209, in Phase I trials for metabolic diseases and liver-related conditions such as atherosclerosis and non-alcoholic steato-hepatitis.

Okomera is a biotech start-up focused on enhancing access to more effective, precision-based cancer therapies. The company has pioneered the automation and miniaturization of individualized tumor biopsy research, developing advanced medical technologies that leverage microfluidic 3D cellular assays. These innovative technologies enable the prediction of patient-specific responses to cancer treatments by automating relevant biopsy testing. In this process, tumor cells are cultivated within thousands of microfluidic droplets and exposed to numerous conditions simultaneously. This approach allows healthcare providers to expedite the development and delivery of modern cancer therapies, ultimately improving treatment outcomes for patients.

Eligo Bioscience S.A.S is a biotechnology company founded in 2014 and based in Paris, France, specializing in the development of Eligobiotics, a novel class of antimicrobials. These therapeutics are designed to target specific bacteria based on their genomic information, utilizing a combination of CRISPR/Cas technology and engineered phage capsids. This advanced approach allows Eligo to create precision antibiotics aimed at eradicating resistant pathogens and virulent bacteria within the human microbiome. The applications of Eligobiotics extend beyond pharmaceuticals; they also encompass areas such as cosmetics and biodefense, addressing a variety of bacteria-associated diseases and offering next-generation solutions to combat superbugs.

GenSight Biologics S.A. is a clinical-stage biotechnology company based in Paris, France, focused on the discovery and development of gene therapies for retinal degenerative diseases and neurodegenerative disorders of the central nervous system. Founded in 2012, the company utilizes innovative technologies, including mitochondrial targeting sequences and optogenetics, to develop treatments that aim to preserve or restore vision in patients with severe vision impairments. Its lead product candidates include GS010, an AAV2-based gene therapy that is currently undergoing Phase III clinical trials for Leber hereditary optic neuropathy caused by mutations in the ND4 gene, and GS030, which is in Phase I/II trials for retinitis pigmentosa and geographic atrophy associated with dry age-related macular degeneration. GenSight Biologics is also advancing other product candidates in preclinical development targeting various ophthalmic and neurodegenerative conditions.

Diamidex SAS, established in 2014 and based in Marseille, France, specializes in the development and production of rapid detection tests for legionella, a type of bacteria that can cause severe lung infections. The company offers turnkey test solutions, designed for both laboratory and field use, which provide semi-quantitative counts of microorganisms in water samples and industrial goods. Diamidex's products aim to enhance the accuracy and speed of microbial contamination detection, facilitating more efficient screening and data collection in research and testing environments.

EverImmune is a biotechnology company dedicated to developing innovative treatments in the field of microbiome oncology to support cancer patients. The company specializes in creating live biotherapeutic products that serve as oral adjuvants to enhance anticancer immunotherapies. By focusing on technologies that safely boost the immune system, EverImmune aims to restore sensitivity to immunotherapies, particularly in patients experiencing primary resistance. The company is committed to conducting well-designed clinical trials to evaluate the efficacy of its flagship product, Oncobax, in improving treatment outcomes for cancer patients.

Resolve Stroke, headquartered in Paris, is a HealthTech company dedicated to revolutionizing medical imaging. It specializes in enhancing ultrasound technology to extract more detailed information, enabling advanced diagnostics, particularly in neurology. The company's innovative software engines improve ultrasound contrast, resolution, and penetration depth, allowing for the visualization of micro-vessels through the human skull in 3D. With a global focus, Resolve Stroke aims to accelerate treatments for over 1 billion people affected by brain diseases. To date, it has secured €3 million in pre-seed funding to pioneer software-based ultrasound innovation.

BioMAdvanced Diagnostics is a company focused on developing molecular diagnostic and biomarker tests that enhance patient care through individualized treatment strategies. Their innovative tests are designed to integrate seamlessly into existing diagnostic and treatment protocols, ensuring ease of use for healthcare personnel. By providing predictive scores and identifying biomarkers, BioMAdvanced Diagnostics enables clinicians to assess the immune response of patients and evaluate the risk of transplant rejection. This capability allows for improved anticipation and adaptation of treatment plans, ultimately aiming to enhance patient outcomes significantly.

Alentis Therapeutics AG is a clinical-stage biopharmaceutical company based in Basel, Switzerland, specializing in the development of innovative therapies for advanced liver diseases and cancers associated with Claudin-1 (CLDN1) expression. Founded in 2019, Alentis focuses on addressing conditions such as liver fibrosis, cirrhosis, and liver cancer through the use of anti-CLDN1 antibody-drug conjugates and other targeted treatments. The company's unique approach combines clinically relevant read-outs with advanced techniques like single-cell RNA sequencing of patient liver tissues, aiming to reverse disease progression and improve patient outcomes. Alentis Therapeutics is recognized for its pioneering role in exploring anti-CLDN1 therapeutics, contributing to advancements in the treatment of fibrotic diseases and CLDN1-positive tumors.

Kayentis is a global leader in electronic clinical outcome assessment (eCOA) and Decentralized Clinical Trial solutions, focused on enhancing the efficiency and quality of data collection in clinical trials for the pharmaceutical, biotech, and contract research organization sectors. Founded in 2005, the company has specialized in eCOA solutions across various phases of clinical development, addressing over 200 indications in more than 20 therapeutic areas. Kayentis has adapted to the evolving clinical research landscape by offering a comprehensive suite of services aimed at supporting science-driven and patient-centric approaches. With operational capabilities spanning the USA, Europe, and Asia, Kayentis provides a range of adaptable tools to streamline electronic data capture, simplifying the clinical trial process for both patients and research sites.

AlgoTherapeutix is a biotechnology company focused on developing innovative topical treatments for patients suffering from difficult-to-treat conditions, particularly complex pain syndromes. The company targets damaged nerve fibers in the skin to provide localized pain relief while minimizing the systemic side effects often associated with oral medications. AlgoTherapeutix is actively advancing its lead product, ATX01, which has received FDA approval to enter Phase 2 clinical trials for chemotherapy-induced peripheral neuropathy, a painful condition that lacks proven therapeutic options. Additionally, the company is exploring the potential of its treatments for erythromelalgia, a rare and debilitating disorder characterized by severe pain and inflammation. By tailoring therapies to the specific needs of patients, AlgoTherapeutix aims to improve treatment outcomes for individuals facing these challenging health issues.

NFL Biosciences is a biotechnology company focused on developing solutions for tobacco addiction. The company specializes in research and development of medicines that utilize both botanical and pharmaceutical agents to aid individuals attempting to quit smoking. Its primary product, NFL-101, is a clinically developed botanical drug designed specifically to target smoking addiction. This innovative treatment contains minimal amounts of nicotine and is formulated from well-characterized natural tobacco leaf proteins, offering a unique approach to support smokers in overcoming their addiction.

BiPER Therapeutics is a biotechnology company focused on developing and commercializing innovative therapeutic solutions. The company specializes in creating drugs that target critical proteins involved in the metabolism of cancer cells, aiming to overcome treatment resistance and enhance cancer cell survival. Their primary focus is on providing effective treatments for gastrointestinal cancers.

NFL Biosciences is a biotechnology company focused on developing solutions for tobacco addiction. The company specializes in research and development of medicines that utilize both botanical and pharmaceutical agents to aid individuals attempting to quit smoking. Its primary product, NFL-101, is a clinically developed botanical drug designed specifically to target smoking addiction. This innovative treatment contains minimal amounts of nicotine and is formulated from well-characterized natural tobacco leaf proteins, offering a unique approach to support smokers in overcoming their addiction.

ErVaccine Technologies creates immunotherapies that integrate T-cell treatments with cancer vaccinations to meet a medical need for cold tumors. They are committed to identifying tumor epitopes that are physician. They come from endogenous retroviruses and are novel cancer epitopes. They use a bioinformatics-based strategy to find possible epitopes, which are then verified by proteomics and immunological testing.

Clarity is a clinical-stage company pioneering a new category of non-pharmacological treatments for neurodegenerative diseases. We develop a neuromodulation device combining immersive technology, AI and biosensors to deliver gamma sensory stimulation. Gamma waves’ sensory stimulation has been shown to significantly slow down Alzheimer's progression, reducing neurodegeneration and cognitive decline. Clarity takes a platform approach by enabling the customization of sensory stimulation protocols based on patient data, improving experience, efficacy and scalability across a wide range of indications. The company was founded by neuroscientists from UC Berkeley, and Oxford along with execs from OURA and Philips, and is supported by leading institutions such as UCSF's Neuroscape.

Jalon Therapeutics is a biotechnology company focused on developing innovative therapies that inhibit critical yet untargeted tumor signaling pathways. By exploring non-oncogene addiction, the company aims to identify new therapeutic targets and create effective anticancer treatment strategies. Through its research and development efforts, Jalon Therapeutics is dedicated to transforming the lives of cancer patients by providing novel medications that address unmet medical needs in oncology.

Lys Therapeutics is a biotechnology company focused on developing therapies for patients with neurovascular and neurodegenerative disorders. The company is notable for its lead drug, Glunozumab, a monoclonal antibody that employs a novel mechanism of action. This drug hyperactivates both vascular and neuronal NMDA receptors, leading to off-target toxicity that can disrupt the blood-brain and blood-spinal cord barriers, resulting in neuronal excitotoxicity associated with conditions such as stroke and multiple sclerosis. Lys Therapeutics aims to address neuroinflammation and its effects on neurodegeneration through innovative biotherapies.

Valneva is a biopharmaceutical company specializing in the development, manufacturing, and distribution of prophylactic vaccines for infectious diseases. Its portfolio comprises two commercially available vaccines (IXIARO/JESPECT for Japanese encephalitis and DUKORAL for traveler's diarrhea), along with vaccine candidates targeting Lyme disease, chikungunya virus, and COVID-19. Valneva operates through segments including Commercialized Vaccines, Covid-19 Vaccine, Vaccine Candidates, and Technologies & Services. The company aims to address significant unmet medical needs in infectious diseases by leveraging its expertise and capabilities to advance vaccine candidates through clinical trials and ultimately commercialize them.

BioMAdvanced Diagnostics is a company focused on developing molecular diagnostic and biomarker tests that enhance patient care through individualized treatment strategies. Their innovative tests are designed to integrate seamlessly into existing diagnostic and treatment protocols, ensuring ease of use for healthcare personnel. By providing predictive scores and identifying biomarkers, BioMAdvanced Diagnostics enables clinicians to assess the immune response of patients and evaluate the risk of transplant rejection. This capability allows for improved anticipation and adaptation of treatment plans, ultimately aiming to enhance patient outcomes significantly.

Tridek-One is a biotechnology company focused on developing immunomodulatory products aimed at addressing auto-immune and inflammatory disorders. The company's primary product is a peptide designed to maintain a cluster of truncated CD31 molecules at the membrane, which helps moderate overactive immune responses without complete blockade. By facilitating improved treatment options for medical companies, Tridek-One seeks to enhance the quality of life for patients suffering from these conditions.

Apmonia Therapeutics is a biotechnology company focused on developing next-generation peptide-based therapies aimed at targeting the tumor microenvironment to enhance cancer treatment. The company is dedicated to creating innovative drugs for various types of cancer, including glioblastoma, ovarian, colorectal, and pancreatic cancers. By offering new therapeutic perspectives, Apmonia aims to improve the lives of cancer patients and support researchers in developing personalized immunotherapy approaches. Their proprietary therapeutic peptides are designed to provide effective strategies for treating solid tumors, thereby contributing to advanced cancer care.

Carroucell is a supplier of microcarriers specifically designed for cell culture in bioreactors. The company has developed a unique platform featuring flat-shaped microcarriers made from a glass xenofree composition. This innovative design aims to enhance the efficiency of biomanufacturing by addressing common challenges associated with cell culture performance. Through its specialized products, Carroucell supports advancements in the field of cell culture, contributing to the overall improvement of biotechnological processes.

DeepLife is a biotech company founded in 2019 and based in Paris, France. The company specializes in developing digital twins of cells to enhance drug discovery processes. By utilizing deep learning techniques on multi-omics data, DeepLife models cellular behavior and simulates responses to various genetic screenings, such as siRNA and CRISPR-Cas9. This innovative approach aims to identify new targets, biomarkers, and potential drug candidates, while also addressing drug resistance and sensitivity. DeepLife operates in a collaborative manner, working alongside academic institutions to ensure a smooth transition from laboratory discoveries to patient applications. The company focuses on leveraging state-of-the-art technologies in systems biology and machine learning to identify molecular triggers that restore cells to their healthy states, thereby accelerating the target identification processes for biotech and pharmaceutical firms.

Thabor Therapeutics is a biotechnology company focused on developing innovative treatments for mucosal inflammatory diseases. The company targets a new class of proteins involved in inflammation resolution, aiming to inhibit specific processes in the early stages of inflammation and the recruitment of innate immune cells. By leveraging monoclonal antibodies, Thabor Therapeutics seeks to provide effective solutions for healthcare providers to treat patients suffering from these conditions.

DBV Technologies S.A. is a clinical-stage biopharmaceutical company headquartered in Montrouge, France, focused on developing innovative treatments for food allergies through epicutaneous immunotherapy. The company's lead candidate, Viaskin Peanut, has completed Phase III clinical trials for the treatment of peanut allergies in children, adolescents, and adults. Additionally, DBV Technologies is advancing Viaskin Milk, which is in Phase I/II trials for cow’s milk protein allergy and related conditions, and Viaskin Egg, currently in pre-clinical development for hen’s egg allergy. The company is also exploring a booster vaccine for Bordetella pertussis and has ongoing research programs targeting respiratory syncytial virus, Crohn’s disease, celiac disease, and type I diabetes. Notably, DBV Technologies collaborates with Nestlé Health Science to develop MAG1C, an atopy patch test aimed at diagnosing non-IgE mediated cow’s milk protein allergy in infants and toddlers. Founded by pediatricians and entrepreneurs in 2002, DBV Technologies aims to revolutionize the field of immunotherapy by safely activating the immune system through its proprietary Viaskin technology.

Ribonexus is a biotechnology company dedicated to developing innovative therapies aimed at treating cancer. The firm focuses on creating a pipeline of small molecules that specifically target the eukaryotic translation initiation factor-4A to address resistance in patients who have become unresponsive to existing targeted therapies. With a primary emphasis on melanoma, Ribonexus aims to enhance the effectiveness of current treatments by restoring sensitivity to them in patients whose cancers have developed resistance. Through its research and development efforts, Ribonexus seeks to contribute meaningful advancements in oncology and improve treatment outcomes for patients facing challenging cancer types.

Ribonexus is a biotechnology company dedicated to developing innovative therapies aimed at treating cancer. The firm focuses on creating a pipeline of small molecules that specifically target the eukaryotic translation initiation factor-4A to address resistance in patients who have become unresponsive to existing targeted therapies. With a primary emphasis on melanoma, Ribonexus aims to enhance the effectiveness of current treatments by restoring sensitivity to them in patients whose cancers have developed resistance. Through its research and development efforts, Ribonexus seeks to contribute meaningful advancements in oncology and improve treatment outcomes for patients facing challenging cancer types.

LimFlow is a medical technology company focused on developing innovative solutions for treating end-stage chronic limb ischemia (CLI) patients. Its flagship product, the LimFlow System, utilizes a novel percutaneous procedure to restore blood flow to the ischemic foot by diverting blood around diseased arteries into the tibial vein. This approach is designed to provide an elevated flow of oxygenated blood, thereby alleviating ischemic pain, promoting wound healing, reducing the risk of amputations, and enhancing patient mobility. Currently approved for sale in CE-mark regulated markets, the LimFlow System is also undergoing investigational use in the United States, where it offers new hope to patients who have exhausted other revascularization options. LimFlow emphasizes a multi-disciplinary team approach to maximize the benefits of its technology.

Priothera Ltd is a clinical-stage biotechnology company based in Dublin, Ireland, with an additional location in Saint Louis, France. Founded in 2020, Priothera specializes in the development of orally administered sphingosine 1 phosphate (S1P) receptor modulators aimed at treating haematological malignancies. The company's leading candidate, mocravimod, is designed to reduce the egress of T cell subsets from lymphatic tissue, thereby enhancing the curative potential of allogeneic hematopoietic stem cell transplantation. By providing dual inhibition of graft versus host disease while promoting graft versus leukemia effects, Priothera aims to significantly improve outcomes for patients undergoing such transplants.

Brenus Pharma is a biotechnology company focused on developing innovative allogeneic cell-based immunotherapies aimed at treating solid tumors. The company specializes in creating anti-cancer cell vaccines that leverage the patient’s immune system to prevent cancer resistance during treatment. With a strong emphasis on derisking strategies, Brenus Pharma generates multiple candidates efficiently, allowing for cost-effective scaling and a strategic entry into the market alongside established standards of care. The company boasts a robust intellectual property portfolio and a highly skilled team, including renowned oncologists, who work to educate the immune system to recognize tumor-associated and tumor-specific antigens. This approach enhances the potential for effective responses in cancer treatment.

Cell-Easy SAS is a contract development and manufacturing organization (CDMO) based in Toulouse, France, specializing in stem cell services. Established in 2017, the company focuses on providing ready-to-inject adipose-derived allogeneic stem cells for preclinical and clinical development projects. By utilizing biological material from healthy donors, Cell-Easy aims to offer a scalable solution that can potentially benefit thousands of patients. The company's innovative production process helps reduce manufacturing costs associated with stem cell therapies, addressing the affordability challenges faced by the healthcare industry in advancing cell therapies.

Cureety is a telemedicine startup focused on enhancing the follow-up and care of cancer patients through its innovative healthcare telemonitoring platform. The company provides tools that assist healthcare professionals in adjusting treatments for cancer patients while also gathering real-world data. This approach not only improves patient management but also supports researchers and industry stakeholders in advancing research initiatives. By transforming the care pathway for cancer patients, Cureety aims to facilitate better health outcomes and foster ongoing improvements in cancer treatment methodologies.

StarkAge Therapeutics is a discovery-stage biotechnology company focused on improving the quality of life for patients through innovative treatments. The company specializes in developing a platform that utilizes immunotherapy combined with cancer therapy to target and deplete senescent cells associated with age-related diseases. Its research and development efforts are aimed at addressing conditions such as idiopathic pulmonary fibrosis, neurodegenerative diseases, and metabolic dysfunctions, including hepatic fibroses. By leveraging its unique approach, StarkAge Therapeutics seeks to provide effective therapeutic options for managing these challenging health issues.

AlgoTherapeutix is a biotechnology company focused on developing innovative topical treatments for patients suffering from difficult-to-treat conditions, particularly complex pain syndromes. The company targets damaged nerve fibers in the skin to provide localized pain relief while minimizing the systemic side effects often associated with oral medications. AlgoTherapeutix is actively advancing its lead product, ATX01, which has received FDA approval to enter Phase 2 clinical trials for chemotherapy-induced peripheral neuropathy, a painful condition that lacks proven therapeutic options. Additionally, the company is exploring the potential of its treatments for erythromelalgia, a rare and debilitating disorder characterized by severe pain and inflammation. By tailoring therapies to the specific needs of patients, AlgoTherapeutix aims to improve treatment outcomes for individuals facing these challenging health issues.

Pherecydes Pharma SA is a biotechnology company based in Romainville, France, that specializes in the research and development of lytic bacteriophages for therapeutic and diagnostic purposes, particularly in the context of antibiotic resistance. Established in 2006, the company is dedicated to creating personalized phage therapies aimed at treating bacterial infections. It has developed several banks of bacteriophages, including those targeting Escherichia coli, and has initiated multicenter clinical trials across Europe to assess the efficacy of phage therapy in treating infected burn wounds. By harnessing the natural ability of bacteriophages to infect and eliminate bacteria without affecting human cells, Pherecydes Pharma aims to provide innovative solutions for combating a wide range of bacterial threats, including multi-resistant and emergent strains.

MedinCell S.A. is a pharmaceutical company focused on developing innovative therapeutic solutions through its proprietary BEPO technology, which facilitates long-acting injectable products utilizing biodegradable polymers and a biocompatible solvent. Based in Jacou, France, the company is engaged in ongoing research and development to optimize the efficiency and accessibility of medical treatments across various therapeutic areas. MedinCell's product pipeline includes several candidates, such as mdc-IRM, a subcutaneous injection for schizophrenia currently in Phase III trials, and mdc-CWM, an intra-articular injection aimed at treating pain and inflammation. Additionally, the company is exploring formulations like mdc-WWM for contraception and mdc-ANG for central nervous system disorders, alongside other candidates targeting pain management and organ transplant applications. Through its advancements in controlled, long-acting injectables, MedinCell aims to enhance treatment outcomes for patients.

Lysogene S.A. is a biotechnology company based in Neuilly-sur-Seine, France, focused on the research and clinical development of gene therapy for neurodegenerative disorders. Founded in 2009, the company is advancing several clinical programs, including LYS-SAF302, currently in Phase II/III trials for the treatment of mucopolysaccharidosis type IIIA, and LYS-GM101, which is in Phase I/II trials for GM1 gangliosidosis. Lysogene is also engaged in a collaborative research effort with the Weizmann Institute of Science to develop a novel AAV gene therapy approach targeting neuronopathic Gaucher disease, Parkinson's disease, and other conditions. The company aims to enhance the health outcomes of patients suffering from life-threatening, incurable disorders by utilizing AAV vectors that effectively deliver genetic material to the central nervous system.

TreeFrog Therapeutics is a stem cell company based in Pessac, France, founded in 2018. The company specializes in scalable stem cell cultivation using bioreactors for cGMP cell therapy manufacturing. Its proprietary technology platform, known as C-Stem, offers an end-to-end 3D scalable solution aimed at enhancing cell production and quality. By addressing critical manufacturing challenges, TreeFrog Therapeutics seeks to accelerate clinical development and improve market access for cell therapies, ultimately reducing treatment costs and expanding patient access to innovative medical solutions.

PEP-Therapy is a biotechnology company specializing in the development of innovative peptide-based therapies aimed at treating severe diseases, with a primary emphasis on cancer. The company focuses on creating Cell Penetrating and Interfering Peptides, which are designed for intracellular delivery of targeted treatments. These peptides effectively penetrate cell membranes to block crucial intracellular protein-protein interactions, thereby inhibiting important pathogenic mechanisms associated with various diseases. By harnessing the potential of these active compounds, PEP-Therapy aims to advance therapeutic options in oncology and beyond.

Inotrem S.A. is a biotechnology company focused on developing innovative immunotherapies for acute and chronic inflammatory conditions. The company specializes in targeting the TREM-1 pathway to modulate unbalanced inflammatory responses. Inotrem's proprietary technology platform has led to the creation of nangibotide (LR12), a first-in-class TREM-1 inhibitor with potential applications in critical medical situations such as septic shock and myocardial infarction. Additionally, Inotrem is advancing research on new therapeutic modalities aimed at addressing chronic inflammatory diseases. By leveraging its expertise in immunomodulation, Inotrem aims to provide effective treatments for patients suffering from various inflammatory syndromes, enhancing critical care solutions in healthcare.

Alentis Therapeutics AG is a clinical-stage biopharmaceutical company based in Basel, Switzerland, specializing in the development of innovative therapies for advanced liver diseases and cancers associated with Claudin-1 (CLDN1) expression. Founded in 2019, Alentis focuses on addressing conditions such as liver fibrosis, cirrhosis, and liver cancer through the use of anti-CLDN1 antibody-drug conjugates and other targeted treatments. The company's unique approach combines clinically relevant read-outs with advanced techniques like single-cell RNA sequencing of patient liver tissues, aiming to reverse disease progression and improve patient outcomes. Alentis Therapeutics is recognized for its pioneering role in exploring anti-CLDN1 therapeutics, contributing to advancements in the treatment of fibrotic diseases and CLDN1-positive tumors.

Biophytis SA is a clinical-stage biotechnology company headquartered in Paris, France, dedicated to developing therapeutics aimed at slowing the degenerative processes associated with aging and enhancing functional outcomes for patients with age-related diseases. The company is focused on activating key biological resilience pathways that may protect against the effects of various biological and environmental stresses linked to these diseases. Biophytis's lead drug candidate, Sarconeos (BIO101), is an orally administered small molecule designed for treating neuromuscular conditions such as sarcopenia and Duchenne muscular dystrophy. Additionally, its second candidate, Macuneos (BIO201), targets retinal diseases, including age-related macular degeneration and Stargardt disease. The company has established a collaboration agreement with AFM-Telethon to further the development of Sarconeos. Since its founding in 2006, Biophytis has aimed to position itself as a leader in the emerging field of aging science by providing innovative therapies for patients with limited treatment options.

Biophytis SA is a clinical-stage biotechnology company headquartered in Paris, France, dedicated to developing therapeutics aimed at slowing the degenerative processes associated with aging and enhancing functional outcomes for patients with age-related diseases. The company is focused on activating key biological resilience pathways that may protect against the effects of various biological and environmental stresses linked to these diseases. Biophytis's lead drug candidate, Sarconeos (BIO101), is an orally administered small molecule designed for treating neuromuscular conditions such as sarcopenia and Duchenne muscular dystrophy. Additionally, its second candidate, Macuneos (BIO201), targets retinal diseases, including age-related macular degeneration and Stargardt disease. The company has established a collaboration agreement with AFM-Telethon to further the development of Sarconeos. Since its founding in 2006, Biophytis has aimed to position itself as a leader in the emerging field of aging science by providing innovative therapies for patients with limited treatment options.

UroMems is a medical device company dedicated to addressing specific clinical needs related to urinary conditions that significantly impact patients' quality of life. The company specializes in the design, development, and commercialization of active implantable medical devices. Its innovative approach aims to enhance existing surgical treatments by minimizing associated side effects and ensuring that patients receive appropriate care promptly. Through its commitment to improving treatment options, UroMems seeks to benefit a wide range of patients facing urinary health challenges.

OncoDiag is a biotechnology company based in Normandy, France, specializing in the development of non-invasive diagnostic tests aimed at the early detection of cancers. Its flagship product, Urotest, is a urine test designed for the diagnosis and monitoring of bladder cancer. Additionally, the company is advancing its pipeline with Colodiag, which focuses on the early detection of colorectal cancer. OncoDiag's portfolio also includes a tissue-based test for predicting non-evolutive localized prostate cancer. By offering these innovative diagnostic solutions, OncoDiag aims to enhance the capabilities of healthcare professionals in cancer diagnosis and management.

Argobio Studio is a start-up studio dedicated to developing innovative therapeutic solutions and launching biotech firms. The studio sources advanced early-stage projects from top European academic research institutions, focusing on areas such as rare diseases, neurological disorders, oncology, and immunology. Argobio aims to cultivate these projects to create promising platform technologies for therapeutic products. By providing financial support and operational expertise, the studio facilitates the growth of early-stage biotechnology initiatives, enabling startups to enhance their medicinal and drug research processes.

NovAliX is a research organization specializing in drug discovery and pharmaceutical development. It provides a range of integrated services designed to address the outsourcing needs of the pharmaceutical industry, from initial discovery through to manufacturing. Utilizing proprietary technologies such as surface plasmon resonance (SPR), X-ray protein crystallography, and advanced NMR techniques, NovAliX offers comprehensive support for small molecule drug discovery and biologics characterization. The company's collaborative approach enables clients to access a unique combination of screening, medicinal chemistry, and structural biology, facilitating the development of effective drugs. Additionally, NovAliX conducts thorough analyses of active pharmaceutical ingredients (APIs) and polymorphism studies, supporting pharmaceutical development and manufacturing teams in their efforts to bring new therapies to market.

Kayentis is a global leader in electronic clinical outcome assessment (eCOA) and Decentralized Clinical Trial solutions, focused on enhancing the efficiency and quality of data collection in clinical trials for the pharmaceutical, biotech, and contract research organization sectors. Founded in 2005, the company has specialized in eCOA solutions across various phases of clinical development, addressing over 200 indications in more than 20 therapeutic areas. Kayentis has adapted to the evolving clinical research landscape by offering a comprehensive suite of services aimed at supporting science-driven and patient-centric approaches. With operational capabilities spanning the USA, Europe, and Asia, Kayentis provides a range of adaptable tools to streamline electronic data capture, simplifying the clinical trial process for both patients and research sites.

OSE Immunotherapeutics SA is a clinical-stage biotechnology company based in Nantes, France, specializing in the development of innovative immunotherapies aimed at immune activation and regulation, particularly in the areas of immuno-oncology and autoimmune diseases. The company's product portfolio includes Tedopi, which is in Phase III clinical trials for lung cancer and Phase II for pancreatic cancer; BI 765063, currently in Phase I trials for solid tumors; and OSE-703, a humanized monoclonal antibody in preclinical development for various cancers. Additionally, OSE Immunotherapeutics is advancing FR104, which is in Phase I trials for rheumatoid arthritis, and OSE-127, a humanized monoclonal antibody in Phase I trials for inflammatory autoimmune diseases. The company collaborates with notable partners such as GERCOR, Memorial Sloan Kettering Cancer Center, Boehringer Ingelheim, Servier, and HalioDx. OSE Immunotherapeutics was previously known as OSE Pharma SA before its name change in May 2016.

AlgoTherapeutix is a biotechnology company focused on developing innovative topical treatments for patients suffering from difficult-to-treat conditions, particularly complex pain syndromes. The company targets damaged nerve fibers in the skin to provide localized pain relief while minimizing the systemic side effects often associated with oral medications. AlgoTherapeutix is actively advancing its lead product, ATX01, which has received FDA approval to enter Phase 2 clinical trials for chemotherapy-induced peripheral neuropathy, a painful condition that lacks proven therapeutic options. Additionally, the company is exploring the potential of its treatments for erythromelalgia, a rare and debilitating disorder characterized by severe pain and inflammation. By tailoring therapies to the specific needs of patients, AlgoTherapeutix aims to improve treatment outcomes for individuals facing these challenging health issues.

Advicenne is a late-stage biopharmaceutical company established in 2007 and headquartered in Nîmes, France. It focuses on developing and commercializing innovative treatments for unmet medical needs in nephrology, particularly for orphan renal diseases and niche neurology indications. The company's lead drug candidate, ADV7103, is currently undergoing late-stage clinical trials for two specific conditions: distal renal tubular acidosis (dRTA) and cystinuria. Advicenne aims to create pediatric-friendly therapeutics that enhance the quality of life for patients from early childhood through adulthood.

VectivBio AG is a clinical-stage biotechnology company based in Basel, Switzerland, founded in 2019 as a spinout from Therachon. The company specializes in the discovery, development, and commercialization of innovative treatments for severe rare diseases, particularly those with significant unmet medical needs. Its lead product candidate, Apraglutide, is a synthetic GLP-2 analog designed to enhance the intestine’s ability to absorb fluids and nutrients, thereby reducing the reliance on parenteral support in patients with short bowel syndrome. VectivBio is dedicated to developing best-in-disease therapies that aim to meaningfully improve the lives of patients and their families, providing more than just incremental advancements over existing standard-of-care options.

Pixium Vision SA is a bioelectronics company based in Paris, France, focused on developing innovative implantable medical devices aimed at restoring vision for individuals blinded by the degeneration of photoreceptor cells in the retina. The company’s flagship product, the PRIMA System, is a bionic vision system designed to improve visual acuity and enhance the independence of patients. Pixium Vision also works on the Intelligent Retinal Implantable System (IRIS1), which is currently undergoing clinical trials, and is developing two subsequent generations, IRIS2 and IRIS3, each designed to provide improved visual capabilities through advanced technologies. Founded in 2011 as a spin-out from the Vision Institute and Université Pierre et Marie Curie, Pixium collaborates with prestigious institutions such as Stanford University and Moorfields Eye Hospital to further its research and development efforts in retinal implant systems.

Synapse Medicine is a company based in Bordeaux, France, that specializes in developing an online medical intelligence platform aimed at improving drug prescription management for healthcare professionals. Founded in 2017, the company has created a comprehensive knowledge base that utilizes algorithms to deliver reliable and up-to-date information about medications. This platform allows doctors and pharmacists to analyze treatment options in real time, ensuring the safety and efficacy of drug therapies. By working with leading hospitals and digital health companies across the United States, Europe, and Japan, Synapse Medicine is committed to transforming medication management and enhancing patient care through innovative technology solutions.

ABC Transfer is a biopharmaceutical company specializing in the development of Rapid Transfer Systems (RTS) solutions. It manufactures secure transfer systems specifically designed for sterile drug manufacturing and bioprocessing. The company's innovative systems utilize patented components such as alpha doors, beta containers, and single-use bags. These systems enhance sterility assurance, promote operator safety, and improve overall efficiency in pharmaceutical manufacturing processes.

Ona Therapeutics, S.L. is a biotechnology company founded in 2019 and based in Barcelona, Spain. It specializes in the discovery and development of therapeutic biologics that specifically target tumor metastatic-initiating cells and lipid metabolism. As a spin-off from ICREA and the IRB Institute for Research in Biomedicine, the company focuses on blocking the pathways involved in fat metabolism in animal models of cancer. Its innovative therapies aim to inhibit the cells responsible for metastasis, thereby preventing the development of malignant tumors and potentially eradicating existing ones. Ona Therapeutics is positioned to offer treatment solutions for various metastatic cancers, including those affecting the oral cavity, breast, ovaries, stomach, bladder, prostate, and melanoma.

UroMems is a medical device company dedicated to addressing specific clinical needs related to urinary conditions that significantly impact patients' quality of life. The company specializes in the design, development, and commercialization of active implantable medical devices. Its innovative approach aims to enhance existing surgical treatments by minimizing associated side effects and ensuring that patients receive appropriate care promptly. Through its commitment to improving treatment options, UroMems seeks to benefit a wide range of patients facing urinary health challenges.

UroMems is a medical device company dedicated to addressing specific clinical needs related to urinary conditions that significantly impact patients' quality of life. The company specializes in the design, development, and commercialization of active implantable medical devices. Its innovative approach aims to enhance existing surgical treatments by minimizing associated side effects and ensuring that patients receive appropriate care promptly. Through its commitment to improving treatment options, UroMems seeks to benefit a wide range of patients facing urinary health challenges.

Dynacure is a clinical-stage drug development company dedicated to enhancing the lives of patients with rare and orphan diseases. The company focuses on creating innovative therapeutics, notably developing DYN101, an investigational antisense medicine aimed at modulating the expression of dynamin 2 for the treatment of Centronuclear Myopathies, in collaboration with Ionis Pharmaceuticals. In addition to DYN101, Dynacure is expanding its research portfolio to address other orphan disorders, including a program targeting hereditary spastic paraplegias caused by specific genetic mutations. Through its commitment to rare disease drug development, Dynacure seeks to provide effective treatment options for patients with limited therapeutic alternatives.

Cureety is a telemedicine startup focused on enhancing the follow-up and care of cancer patients through its innovative healthcare telemonitoring platform. The company provides tools that assist healthcare professionals in adjusting treatments for cancer patients while also gathering real-world data. This approach not only improves patient management but also supports researchers and industry stakeholders in advancing research initiatives. By transforming the care pathway for cancer patients, Cureety aims to facilitate better health outcomes and foster ongoing improvements in cancer treatment methodologies.

Deinove SA is a biotechnology company based in Grabels, France, focused on discovering, developing, and producing microbial-derived compounds for the health, nutrition, and cosmetics sectors. The company is advancing its portfolio of antibiotic candidates, including DNV3837, which is currently undergoing Phase II clinical trials for treating Clostridioides difficile infections. In the cosmetics arena, Deinove offers various bioactive ingredients such as PHYT-N-Resist, Luminity, HEBELYS, and BIOME Oléoactif, which serve functions ranging from anti-aging to balancing skin microbiota. Additionally, Deinove is exploring processes for producing natural ingredients for animal feed. The company has established partnerships with several organizations, including bioMérieux and the Institut Pasteur, to enhance its research and development initiatives. Founded in 2006, Deinove is committed to leveraging its bacterial biodiversity to create sustainable solutions across multiple industries.

Inotrem S.A. is a biotechnology company focused on developing innovative immunotherapies for acute and chronic inflammatory conditions. The company specializes in targeting the TREM-1 pathway to modulate unbalanced inflammatory responses. Inotrem's proprietary technology platform has led to the creation of nangibotide (LR12), a first-in-class TREM-1 inhibitor with potential applications in critical medical situations such as septic shock and myocardial infarction. Additionally, Inotrem is advancing research on new therapeutic modalities aimed at addressing chronic inflammatory diseases. By leveraging its expertise in immunomodulation, Inotrem aims to provide effective treatments for patients suffering from various inflammatory syndromes, enhancing critical care solutions in healthcare.

Urania Therapeutics is a biopharmaceutical company focused on the identification and development of readthrough compounds aimed at treating genetic diseases and certain cancers. The company utilizes a proprietary structure-based drug design platform to create novel therapeutic treatments that address conditions caused by mutations, specifically those involving premature stop codons during protein synthesis. By enabling the production of full-length, functional proteins, Urania Therapeutics targets a range of monogenic disorders, including Duchenne muscular dystrophy and cystic fibrosis, as well as cancers linked to nonsense mutations. Through its innovative approach, the company seeks to restore normal protein production, offering potential new solutions for patients with these challenging genetic conditions.

Eyevensys S.A.S. is a Paris-based company that specializes in non-viral gene therapy for ophthalmology. Founded in 2008, it focuses on developing innovative solutions to improve drug delivery methods for ocular diseases. The company utilizes its proprietary Electro-Transfection (ET) technology to administer plasmids to the ciliary muscle, allowing for the sustained release of therapeutic proteins directly into the vitreous, addressing conditions such as uveitis, age-related macular degeneration, and various retinopathies, including central retinal vein occlusion and diabetic retinopathy. Eyevensys aims to overcome the limitations of current treatment options, which often involve invasive procedures like intravitreal injections and surgeries. By enhancing compliance, ocular bioavailability, and tolerability, Eyevensys seeks to create a robust product pipeline that delivers improved clinical outcomes while minimizing the need for frequent and invasive interventions.

VectivBio AG is a clinical-stage biotechnology company based in Basel, Switzerland, founded in 2019 as a spinout from Therachon. The company specializes in the discovery, development, and commercialization of innovative treatments for severe rare diseases, particularly those with significant unmet medical needs. Its lead product candidate, Apraglutide, is a synthetic GLP-2 analog designed to enhance the intestine’s ability to absorb fluids and nutrients, thereby reducing the reliance on parenteral support in patients with short bowel syndrome. VectivBio is dedicated to developing best-in-disease therapies that aim to meaningfully improve the lives of patients and their families, providing more than just incremental advancements over existing standard-of-care options.

ImCheck Therapeutics is a biopharmaceutical company based in Marseille, France, that specializes in developing immunotherapeutics aimed at addressing severe unmet medical needs, particularly in the field of immuno-oncology. Founded in 2015, the company focuses on designing and developing immuno-modulatory antibodies that target members of the butyrophilin super-family of checkpoint molecules. These innovative therapies engage γ9δ2 T cells, a specific type of immune cell, to effectively treat various cancers, including breast, gastric, and ovarian cancers, as well as other solid tumors. Through its advanced research and development efforts, ImCheck Therapeutics seeks to provide next-generation immunotherapeutics for patients suffering from immune-related diseases.

AlgoTherapeutix is a biotechnology company focused on developing innovative topical treatments for patients suffering from difficult-to-treat conditions, particularly complex pain syndromes. The company targets damaged nerve fibers in the skin to provide localized pain relief while minimizing the systemic side effects often associated with oral medications. AlgoTherapeutix is actively advancing its lead product, ATX01, which has received FDA approval to enter Phase 2 clinical trials for chemotherapy-induced peripheral neuropathy, a painful condition that lacks proven therapeutic options. Additionally, the company is exploring the potential of its treatments for erythromelalgia, a rare and debilitating disorder characterized by severe pain and inflammation. By tailoring therapies to the specific needs of patients, AlgoTherapeutix aims to improve treatment outcomes for individuals facing these challenging health issues.

TreeFrog Therapeutics is a stem cell company based in Pessac, France, founded in 2018. The company specializes in scalable stem cell cultivation using bioreactors for cGMP cell therapy manufacturing. Its proprietary technology platform, known as C-Stem, offers an end-to-end 3D scalable solution aimed at enhancing cell production and quality. By addressing critical manufacturing challenges, TreeFrog Therapeutics seeks to accelerate clinical development and improve market access for cell therapies, ultimately reducing treatment costs and expanding patient access to innovative medical solutions.

Exeliom is a clinical-stage biopharmaceutical company based in Dijon, France, focused on developing innovative microbial therapies that utilize commensal bacteria as therapeutic agents. Founded in 2016, Exeliom aims to unlock the therapeutic potential of gut microbiota to enhance health and longevity. The company specializes in creating a new class of medicines known as Live Biotherapeutics, which are designed to deliver microbiome-based immunotherapy for conditions such as inflammatory bowel diseases and cancer, with an initial focus on Crohn's Disease. By harnessing the role of microbiota in the immune system, Exeliom strives to provide patients with advanced treatments that improve their quality of life.

ImCheck Therapeutics is a biopharmaceutical company based in Marseille, France, that specializes in developing immunotherapeutics aimed at addressing severe unmet medical needs, particularly in the field of immuno-oncology. Founded in 2015, the company focuses on designing and developing immuno-modulatory antibodies that target members of the butyrophilin super-family of checkpoint molecules. These innovative therapies engage γ9δ2 T cells, a specific type of immune cell, to effectively treat various cancers, including breast, gastric, and ovarian cancers, as well as other solid tumors. Through its advanced research and development efforts, ImCheck Therapeutics seeks to provide next-generation immunotherapeutics for patients suffering from immune-related diseases.

Amolyt Pharma is a clinical-stage biotechnology company focused on developing peptide-based therapies for rare endocrine and metabolic disorders. The company is advancing several programs, including AZP-3601, a parathyroid hormone analog aimed at treating hypoparathyroidism by maintaining stable calcium levels in the blood. Additionally, Amolyt Pharma is developing AZP-3404, a peptide with a novel mechanism of action designed to restore fat and glucose metabolism. Through its innovative approaches, the company aims to provide effective solutions for patients suffering from critical and rare metabolic conditions.

Alentis Therapeutics AG is a clinical-stage biopharmaceutical company based in Basel, Switzerland, specializing in the development of innovative therapies for advanced liver diseases and cancers associated with Claudin-1 (CLDN1) expression. Founded in 2019, Alentis focuses on addressing conditions such as liver fibrosis, cirrhosis, and liver cancer through the use of anti-CLDN1 antibody-drug conjugates and other targeted treatments. The company's unique approach combines clinically relevant read-outs with advanced techniques like single-cell RNA sequencing of patient liver tissues, aiming to reverse disease progression and improve patient outcomes. Alentis Therapeutics is recognized for its pioneering role in exploring anti-CLDN1 therapeutics, contributing to advancements in the treatment of fibrotic diseases and CLDN1-positive tumors.

NH TherAguix SAS is a clinical-stage pharmaceutical company based in Villeurbanne, France, focused on the development of nanomedicines for cancer treatment. The company specializes in creating innovative therapeutics that enhance radiotherapy for solid tumors. Its lead product, AGuIX, is a theranostic nanoparticle designed to improve the localization of tumors and optimize radiation therapy outcomes. By facilitating intravenous administration, AGuIX enables healthcare professionals to determine the best timing for irradiation, targets tumor tissues more effectively, and minimizes adverse effects on healthy tissues by reducing radiation doses. Founded in 2015, NH TherAguix is dedicated to advancing cancer treatment through its pioneering approach to combining imaging and radiotherapy.

Deinove SA is a biotechnology company based in Grabels, France, focused on discovering, developing, and producing microbial-derived compounds for the health, nutrition, and cosmetics sectors. The company is advancing its portfolio of antibiotic candidates, including DNV3837, which is currently undergoing Phase II clinical trials for treating Clostridioides difficile infections. In the cosmetics arena, Deinove offers various bioactive ingredients such as PHYT-N-Resist, Luminity, HEBELYS, and BIOME Oléoactif, which serve functions ranging from anti-aging to balancing skin microbiota. Additionally, Deinove is exploring processes for producing natural ingredients for animal feed. The company has established partnerships with several organizations, including bioMérieux and the Institut Pasteur, to enhance its research and development initiatives. Founded in 2006, Deinove is committed to leveraging its bacterial biodiversity to create sustainable solutions across multiple industries.

TreeFrog Therapeutics is a stem cell company based in Pessac, France, founded in 2018. The company specializes in scalable stem cell cultivation using bioreactors for cGMP cell therapy manufacturing. Its proprietary technology platform, known as C-Stem, offers an end-to-end 3D scalable solution aimed at enhancing cell production and quality. By addressing critical manufacturing challenges, TreeFrog Therapeutics seeks to accelerate clinical development and improve market access for cell therapies, ultimately reducing treatment costs and expanding patient access to innovative medical solutions.

C4Diagnostics is a developer of in vitro diagnostic (IVD) kits that leverages proprietary technology to enhance the speed and sensitivity of diagnostic testing. The company focuses on creating medical devices and equipment that streamline the screening process for urinary tract infections, allowing for the reliable detection, counting, and concentration of relevant microorganisms in clinical microbiology. By enabling hospitals and laboratories to conduct culture-based IVD tests and specific fluorescence assessments, C4Diagnostics contributes to more efficient and effective diagnostic practices in healthcare settings.

Dynacure is a clinical-stage drug development company dedicated to enhancing the lives of patients with rare and orphan diseases. The company focuses on creating innovative therapeutics, notably developing DYN101, an investigational antisense medicine aimed at modulating the expression of dynamin 2 for the treatment of Centronuclear Myopathies, in collaboration with Ionis Pharmaceuticals. In addition to DYN101, Dynacure is expanding its research portfolio to address other orphan disorders, including a program targeting hereditary spastic paraplegias caused by specific genetic mutations. Through its commitment to rare disease drug development, Dynacure seeks to provide effective treatment options for patients with limited therapeutic alternatives.

ENYO Pharma SA is a clinical-stage biopharmaceutical company based in Lyon, France, founded in 2014 by scientists from the Infectiology Research Center. The company focuses on drug discovery and development for the treatment of acute and chronic viral infections, utilizing a unique platform to identify intracellular therapeutic targets and molecules. ENYO Pharma is developing a pipeline of drug candidates addressing various indications, including hepatitis B virus, nonalcoholic steatohepatitis, and oncology. Its lead compound, EYP001, is designed to modulate specific nuclear receptors, aiming to reduce viral reservoirs and inhibit harmful viral protein expression. The company is also advancing EYP002 through preclinical studies. ENYO Pharma collaborates closely with established research institutions and aims to conduct its molecules into Phase II clinical trials, striving to become a global leader in antiviral therapeutics.

LimFlow is a medical technology company focused on developing innovative solutions for treating end-stage chronic limb ischemia (CLI) patients. Its flagship product, the LimFlow System, utilizes a novel percutaneous procedure to restore blood flow to the ischemic foot by diverting blood around diseased arteries into the tibial vein. This approach is designed to provide an elevated flow of oxygenated blood, thereby alleviating ischemic pain, promoting wound healing, reducing the risk of amputations, and enhancing patient mobility. Currently approved for sale in CE-mark regulated markets, the LimFlow System is also undergoing investigational use in the United States, where it offers new hope to patients who have exhausted other revascularization options. LimFlow emphasizes a multi-disciplinary team approach to maximize the benefits of its technology.

Nosopharm SAS is a biotechnology company focused on the research and development of innovative antibacterial molecules to combat the growing threat of multidrug-resistant infections, particularly in hospital settings. Established in 2009 and headquartered in Nimes, France, Nosopharm specializes in Odilorhabdins, a novel class of antibiotics designed to target resistant gram-negative pathogens such as Escherichia coli and Pseudomonas aeruginosa. The company's lead product, NOSO-95179, is a first-generation Odilorhabdin aimed at treating Carbapenem-resistant Enterobacteriaceae infections, while NOSO-95400 represents a second-generation option for addressing a broader range of multidrug-resistant bacteria. Nosopharm employs an innovative drug discovery platform that leverages the medicinal properties of microbial biodiversity, particularly focusing on metabolites from the bacterial genera Xenorhabdus and Photorhabdus. Through its dedicated efforts, Nosopharm seeks to address the critical medical need for effective treatments against hospital-acquired infections.

TxCell S.A. is a biotechnology company based in Valbonne, France, specializing in the development of cellular immunotherapies utilizing regulatory T cells (Tregs) to address severe chronic inflammatory diseases and autoimmune disorders. The company’s innovative approach includes the creation of Treg-based therapies with chimeric antigen receptors (CAR), targeting conditions such as graft rejection in solid organ transplantation, bullous pemphigoid, multiple sclerosis, and refractory Crohn's disease. TxCell has completed a Phase I/II study for its therapy in Crohn's disease and plans to advance further studies, including a Phase IIb trial in the same patient population and additional trials for rheumatoid arthritis. The company collaborates with various research institutions, enhancing its development capabilities. As of October 2018, TxCell operates as a subsidiary of Sangamo Therapeutics, Inc.

ImCheck Therapeutics is a biopharmaceutical company based in Marseille, France, that specializes in developing immunotherapeutics aimed at addressing severe unmet medical needs, particularly in the field of immuno-oncology. Founded in 2015, the company focuses on designing and developing immuno-modulatory antibodies that target members of the butyrophilin super-family of checkpoint molecules. These innovative therapies engage γ9δ2 T cells, a specific type of immune cell, to effectively treat various cancers, including breast, gastric, and ovarian cancers, as well as other solid tumors. Through its advanced research and development efforts, ImCheck Therapeutics seeks to provide next-generation immunotherapeutics for patients suffering from immune-related diseases.

OSE Immunotherapeutics SA is a clinical-stage biotechnology company based in Nantes, France, specializing in the development of innovative immunotherapies aimed at immune activation and regulation, particularly in the areas of immuno-oncology and autoimmune diseases. The company's product portfolio includes Tedopi, which is in Phase III clinical trials for lung cancer and Phase II for pancreatic cancer; BI 765063, currently in Phase I trials for solid tumors; and OSE-703, a humanized monoclonal antibody in preclinical development for various cancers. Additionally, OSE Immunotherapeutics is advancing FR104, which is in Phase I trials for rheumatoid arthritis, and OSE-127, a humanized monoclonal antibody in Phase I trials for inflammatory autoimmune diseases. The company collaborates with notable partners such as GERCOR, Memorial Sloan Kettering Cancer Center, Boehringer Ingelheim, Servier, and HalioDx. OSE Immunotherapeutics was previously known as OSE Pharma SA before its name change in May 2016.

Advicenne is a late-stage biopharmaceutical company established in 2007 and headquartered in Nîmes, France. It focuses on developing and commercializing innovative treatments for unmet medical needs in nephrology, particularly for orphan renal diseases and niche neurology indications. The company's lead drug candidate, ADV7103, is currently undergoing late-stage clinical trials for two specific conditions: distal renal tubular acidosis (dRTA) and cystinuria. Advicenne aims to create pediatric-friendly therapeutics that enhance the quality of life for patients from early childhood through adulthood.