ARCH Venture Partners

Proniras Corp is an operator of a biomedical company intended to develop drugs. The company's biomedical service has already demonstrated preclinical efficacy in treating nerve agent-induced seizures, as well as in studies of rodents exposed to the chemical weapon soman, which is more toxic than sarin gas, enabling medical researchers to continue their research work and discover drugs. It was founded in 2016 and is headquartered in Seattle, Washington.

Rippl Care is a mental health company based in Seattle, Washington, dedicated to supporting seniors affected by dementia and other neurocognitive disorders. Founded in 2021, the company employs a value-based approach that emphasizes personalized care. Rippl Care utilizes innovative technology to deliver comprehensive support, allowing seniors to receive care through various channels, including phone, online, and in-person visits. By focusing on empowering clinicians and adopting a new care model, Rippl Care aims to enhance the quality of life for elderly individuals suffering from conditions such as Alzheimer's disease.

Sana Biotechnology is a biotechnology company based in Seattle, Washington, with additional offices in South San Francisco, California, and Cambridge, Massachusetts. Founded in 2018, the company specializes in developing engineered cells as medicines to treat a variety of diseases. Sana Biotechnology focuses on reprogramming cells in the body and replacing damaged cells and tissues, leveraging recent scientific advancements to create new therapeutic options. The company's research spans multiple therapeutic areas with significant unmet needs, including oncology, diabetes, B-cell-mediated autoimmune disorders, and central nervous system conditions. Its pipeline includes various product candidates aimed at addressing these challenges through innovative cell engineering programs.

Faraday Pharmaceuticals is an early-stage therapeutics company focused on developing novel therapies to treat ischemia-reperfusion injury. It has in-licensed proprietary liquid formulations of reduced nonmetal gaseous elements developed in the lab of Dr. Mark Roth at the Fred Hutchinson Cancer Center. The company was founded in 2014 and is located in Seattle, Washington.

Sana Biotechnology is a biotechnology company based in Seattle, Washington, with additional offices in South San Francisco, California, and Cambridge, Massachusetts. Founded in 2018, the company specializes in developing engineered cells as medicines to treat a variety of diseases. Sana Biotechnology focuses on reprogramming cells in the body and replacing damaged cells and tissues, leveraging recent scientific advancements to create new therapeutic options. The company's research spans multiple therapeutic areas with significant unmet needs, including oncology, diabetes, B-cell-mediated autoimmune disorders, and central nervous system conditions. Its pipeline includes various product candidates aimed at addressing these challenges through innovative cell engineering programs.

Nohla Therapeutics, Inc. is focused on developing and manufacturing ex vivo expanded universal donor cellular therapies aimed at treating cancer and other life-threatening illnesses. The company utilizes a unique umbilical cord blood expansion platform to create and expand key cancer-fighting cells, enabling treatment without the need for HLA matching. Nohla's primary offerings include a Natural Killer (NK) cell program and a hematopoietic stem cell (HSC) expansion platform, which supports the clinical development of its flagship product, Dilanubicel. This off-the-shelf, ex vivo expanded hematopoietic stem and progenitor cell product is designed for immediate use to aid in hematopoietic recovery and address chemotherapy-induced neutropenia, among other indications. Founded in 2015 and based in Seattle, Washington, Nohla Therapeutics aims to streamline treatment processes while reducing patient risk and costs compared to traditional cell therapies.

Nohla Therapeutics, Inc. is focused on developing and manufacturing ex vivo expanded universal donor cellular therapies aimed at treating cancer and other life-threatening illnesses. The company utilizes a unique umbilical cord blood expansion platform to create and expand key cancer-fighting cells, enabling treatment without the need for HLA matching. Nohla's primary offerings include a Natural Killer (NK) cell program and a hematopoietic stem cell (HSC) expansion platform, which supports the clinical development of its flagship product, Dilanubicel. This off-the-shelf, ex vivo expanded hematopoietic stem and progenitor cell product is designed for immediate use to aid in hematopoietic recovery and address chemotherapy-induced neutropenia, among other indications. Founded in 2015 and based in Seattle, Washington, Nohla Therapeutics aims to streamline treatment processes while reducing patient risk and costs compared to traditional cell therapies.

Arivale Inc. is a wellness service provider that focuses on helping individuals optimize their health and prevent disease through a scientific approach. Founded in 2014 and headquartered in Seattle, Washington, the company analyzes various aspects of individual health, including genetics, blood markers, the gut microbiome, and lifestyle factors. By integrating this data, Arivale delivers tailored recommendations and personalized coaching to empower individuals in making informed decisions about their wellness. This comprehensive approach not only aids members in understanding their unique health profiles but also contributes to a growing dataset that supports medical research aimed at enhancing health outcomes.

VentiRx Pharmaceuticals is a clinical stage biopharmaceutical company based in Seattle, Washington, focused on developing and commercializing immunotherapies targeting Toll-like Receptor 8 (TLR8) for the treatment of cancer, respiratory, and inflammatory diseases. Founded in 2006, the company’s lead investigational drug, Motolimod, works by mobilizing the patient's immune system to fight cancer through the activation of myeloid dendritic cells, monocytes, and natural killer cells. VentiRx's product pipeline includes VTX-2337, a TLR8 agonist aimed at enhancing immune responses against solid tumors and specific cancers such as ovarian and breast cancer, as well as VTX-1463, designed to address allergies. The company is also exploring TLR8 antagonists for autoimmune diseases and compounds intended as vaccine adjuvants. VentiRx Pharmaceuticals operates as a subsidiary of Celgene Corporation and has additional operations in San Diego.

Juno is a clinical-stage company that brings together three of the world’s leading cancer centers – Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and Seattle Children’s Research Institute – in unique partnership to advance a broad pipeline of breakthrough immunotherapies. With one of the largest ever Series A investments for a biotech startup, Juno will build on the foundation of novel immunotherapies to develop two distinct and complementary platforms – CARs and TCRs.

Faraday Pharmaceuticals is an early-stage therapeutics company focused on developing novel therapies to treat ischemia-reperfusion injury. It has in-licensed proprietary liquid formulations of reduced nonmetal gaseous elements developed in the lab of Dr. Mark Roth at the Fred Hutchinson Cancer Center. The company was founded in 2014 and is located in Seattle, Washington.

Juno is a clinical-stage company that brings together three of the world’s leading cancer centers – Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and Seattle Children’s Research Institute – in unique partnership to advance a broad pipeline of breakthrough immunotherapies. With one of the largest ever Series A investments for a biotech startup, Juno will build on the foundation of novel immunotherapies to develop two distinct and complementary platforms – CARs and TCRs.

Theraclone Sciences (formerly Spaltudaq) is a Seattle-based discovery-stage biotech focused on the development of novel therapeutic antibodies for the treatment of infectious disease and inflammation. The company's technology harnesses the power of the human immune system to identify naturally evolved monoclonal antibodies from the blood cells of immunologically relevant human subjects. Recombinant human monoclonal antibodies can be rapidly obtained using our discovery platform and scaled for large-scale industrial production. Such antibody drug candidates may be uniquely important in combating disease and may have potential as therapeutic products that can be administered to a broad patient population. Theraclone is a privately held company with venture investment from ARCH Venture Partners, Canaan Partners, Healthcare Ventures, Amgen Ventures, MPM Capital, and Alexandria Real Estate Investment.

Theraclone Sciences (formerly Spaltudaq) is a Seattle-based discovery-stage biotech focused on the development of novel therapeutic antibodies for the treatment of infectious disease and inflammation. The company's technology harnesses the power of the human immune system to identify naturally evolved monoclonal antibodies from the blood cells of immunologically relevant human subjects. Recombinant human monoclonal antibodies can be rapidly obtained using our discovery platform and scaled for large-scale industrial production. Such antibody drug candidates may be uniquely important in combating disease and may have potential as therapeutic products that can be administered to a broad patient population. Theraclone is a privately held company with venture investment from ARCH Venture Partners, Canaan Partners, Healthcare Ventures, Amgen Ventures, MPM Capital, and Alexandria Real Estate Investment.

Oncofactor is a Seattle, Washington-based developer of cancer therapeutics that disrupt signaling pathways between tumors and the immune system.

Theraclone Sciences (formerly Spaltudaq) is a Seattle-based discovery-stage biotech focused on the development of novel therapeutic antibodies for the treatment of infectious disease and inflammation. The company's technology harnesses the power of the human immune system to identify naturally evolved monoclonal antibodies from the blood cells of immunologically relevant human subjects. Recombinant human monoclonal antibodies can be rapidly obtained using our discovery platform and scaled for large-scale industrial production. Such antibody drug candidates may be uniquely important in combating disease and may have potential as therapeutic products that can be administered to a broad patient population. Theraclone is a privately held company with venture investment from ARCH Venture Partners, Canaan Partners, Healthcare Ventures, Amgen Ventures, MPM Capital, and Alexandria Real Estate Investment.

VentiRx Pharmaceuticals is a clinical stage biopharmaceutical company based in Seattle, Washington, focused on developing and commercializing immunotherapies targeting Toll-like Receptor 8 (TLR8) for the treatment of cancer, respiratory, and inflammatory diseases. Founded in 2006, the company’s lead investigational drug, Motolimod, works by mobilizing the patient's immune system to fight cancer through the activation of myeloid dendritic cells, monocytes, and natural killer cells. VentiRx's product pipeline includes VTX-2337, a TLR8 agonist aimed at enhancing immune responses against solid tumors and specific cancers such as ovarian and breast cancer, as well as VTX-1463, designed to address allergies. The company is also exploring TLR8 antagonists for autoimmune diseases and compounds intended as vaccine adjuvants. VentiRx Pharmaceuticals operates as a subsidiary of Celgene Corporation and has additional operations in San Diego.

Allozyne, Inc. is a biopharmaceutical company based in Seattle, Washington, focused on developing innovative protein therapeutic candidates for autoimmune and inflammatory diseases, as well as cancer. Its lead product candidate, AZ01, is currently in a Phase 1b clinical trial aimed at treating relapsing-remitting multiple sclerosis. The company is also advancing AZ17, a bispecific antibody designed for various autoimmune and inflammatory conditions, including Crohn's disease and multiple sclerosis, and AZ05, an antibody-drug conjugate targeting solid tumors. Founded in 2004, Allozyne is dedicated to enhancing the efficacy, safety, and dosing of protein-based therapeutics, including peptides and antibodies. It operates as a subsidiary of Poniard Pharmaceuticals, Inc.

Accelerator Corporation is a venture capital firm specializing in incubation, early stage, emerging growth and start-up investments. It does not participate in further rounds of financing. The firm prefers to invest in biotechnology companies. It seeks to invest up to $2 million in a company. The firm typically holds its investments for a period of 12 months to 24 months. Accelerator Corporation was founded in 2003 and is based in Seattle, Washington. Accelerator Corporation, founded in 2003, is a vehicle for disciplined and efficient investment in and management of emerging biotechnology opportunities. Located in Seattle, Washington, the company identifies, evaluates, finances, and manages ground breaking emerging life sciences opportunities. The company has established and built a largely proprietary array of sources of deal flow, as well as a key set of resources to bring to bear in the development of the best opportunities emerging from those sources. These key resources, provided by Accelerator and its Affiliates – Amgen Ventures, ARCH Venture Partners, OVP Venture Partners, WRF Capital, Alexandria Real Estate Equities, Inc., and the Institute for Systems Biology – include committed investment capital, state-of-the-art facilities, world-class scientific and technical expertise and support, and experienced start-up management. This panel of Accelerator participants will discuss the success of their business model and provide practical expertise for the next generation of biotech incubators. In the past five years, nine companies have been invested in through Accelerator. Three have emerged and raised follow on financings of more than $114 million. Four remain under management at Accelerator, having raised between them $11.3 million in initial Accelerator-based investments. In all, Accelerator companies have raised in excess of $143.5 million in initial and follow-on financings. Accelerator investors have committed an additional $22.5 million to enable Accelerator to continue to identify, capitalize, and develop the next-generation of exciting emerging biotechnologies. Accelerator Corporation relies upon a unique set of sources to fill a world-class pipeline of deal flow and has established and utilized a now proven array of resources to identify, evaluate, capitalize and manage emerging biotechnology companies. Accelerator provides this unprecedented collection of resources via a partnership between top-tiered investors, dedicated management, and a world-class research institute. These groups have come together because they recognize the potential of biotechnology both as an investment opportunity and as a critical component of the rapidly evolving future of medicine and healthcare. Moreover, these individuals and organizations have extensive experience in the difficult, complex and costly process of transforming an exciting laboratory discovery into a commercial product. By providing their expertise with companies in the Accelerator portfolio, these industry leaders provide critical knowledge and resources that can help to streamline the development and accelerate the commercialization of novel technologies. Accelerator, through the global activities of its affiliates, has access to exciting new technologies and commercial opportunities developed at leading research institutions, universities and biotechnology companies around the world. This enables Accelerator to select only the most compelling investments from a deep pool of promising opportunities.

Theraclone Sciences (formerly Spaltudaq) is a Seattle-based discovery-stage biotech focused on the development of novel therapeutic antibodies for the treatment of infectious disease and inflammation. The company's technology harnesses the power of the human immune system to identify naturally evolved monoclonal antibodies from the blood cells of immunologically relevant human subjects. Recombinant human monoclonal antibodies can be rapidly obtained using our discovery platform and scaled for large-scale industrial production. Such antibody drug candidates may be uniquely important in combating disease and may have potential as therapeutic products that can be administered to a broad patient population. Theraclone is a privately held company with venture investment from ARCH Venture Partners, Canaan Partners, Healthcare Ventures, Amgen Ventures, MPM Capital, and Alexandria Real Estate Investment.

VentiRx Pharmaceuticals is a clinical stage biopharmaceutical company based in Seattle, Washington, focused on developing and commercializing immunotherapies targeting Toll-like Receptor 8 (TLR8) for the treatment of cancer, respiratory, and inflammatory diseases. Founded in 2006, the company’s lead investigational drug, Motolimod, works by mobilizing the patient's immune system to fight cancer through the activation of myeloid dendritic cells, monocytes, and natural killer cells. VentiRx's product pipeline includes VTX-2337, a TLR8 agonist aimed at enhancing immune responses against solid tumors and specific cancers such as ovarian and breast cancer, as well as VTX-1463, designed to address allergies. The company is also exploring TLR8 antagonists for autoimmune diseases and compounds intended as vaccine adjuvants. VentiRx Pharmaceuticals operates as a subsidiary of Celgene Corporation and has additional operations in San Diego.

Omeros Corporation is a Seattle-based biopharmaceutical company that focuses on discovering, developing, and commercializing small-molecule and protein therapeutics for a range of indications, including inflammation, complement-mediated diseases, and central nervous system disorders. The company is known for its commercial product, OMIDRIA, which is used during cataract surgery in the United States. Omeros has several clinical programs, with its lead candidate, Narsoplimab, in Phase III trials for conditions such as thrombotic microangiopathy and immunoglobulin A nephropathy, as well as Phase II trials for lupus nephritis. Other clinical programs include OMS405 for opioid and nicotine addiction and OMS527 for addiction and compulsive disorders. The company also has a robust pipeline of preclinical programs targeting various disorders, including MASP-3 for paroxysmal nocturnal hemoglobinuria and a GPCR platform aimed at treating a broad range of diseases. Omeros was incorporated in 1994 and remains dedicated to addressing significant unmet medical needs.

Theraclone Sciences (formerly Spaltudaq) is a Seattle-based discovery-stage biotech focused on the development of novel therapeutic antibodies for the treatment of infectious disease and inflammation. The company's technology harnesses the power of the human immune system to identify naturally evolved monoclonal antibodies from the blood cells of immunologically relevant human subjects. Recombinant human monoclonal antibodies can be rapidly obtained using our discovery platform and scaled for large-scale industrial production. Such antibody drug candidates may be uniquely important in combating disease and may have potential as therapeutic products that can be administered to a broad patient population. Theraclone is a privately held company with venture investment from ARCH Venture Partners, Canaan Partners, Healthcare Ventures, Amgen Ventures, MPM Capital, and Alexandria Real Estate Investment.

Integrated Diagnostics Inc. specializes in the development of laboratory-based blood molecular diagnostic tools designed to assist physicians in the early detection of complex diseases through non-invasive blood tests. The company's flagship product, Xpresys Lung, provides objective information for assessing pulmonary nodules by monitoring multiple disease molecular markers simultaneously. Founded in 2005 and based in Seattle, Washington, Integrated Diagnostics aims to leverage emerging technologies to create a pipeline of innovative diagnostic products that facilitate the management of serious conditions such as cancer, diabetes, and Alzheimer's. The company operates under the principle that a systems view of disease, involving networks of proteins, genes, and other molecules, is essential for effective diagnosis and prognosis. Integrated Diagnostics is a subsidiary of Biodesix, Inc. and has established a strategic partnership with Agilent Technologies.

Accelerator Corporation is a venture capital firm specializing in incubation, early stage, emerging growth and start-up investments. It does not participate in further rounds of financing. The firm prefers to invest in biotechnology companies. It seeks to invest up to $2 million in a company. The firm typically holds its investments for a period of 12 months to 24 months. Accelerator Corporation was founded in 2003 and is based in Seattle, Washington. Accelerator Corporation, founded in 2003, is a vehicle for disciplined and efficient investment in and management of emerging biotechnology opportunities. Located in Seattle, Washington, the company identifies, evaluates, finances, and manages ground breaking emerging life sciences opportunities. The company has established and built a largely proprietary array of sources of deal flow, as well as a key set of resources to bring to bear in the development of the best opportunities emerging from those sources. These key resources, provided by Accelerator and its Affiliates – Amgen Ventures, ARCH Venture Partners, OVP Venture Partners, WRF Capital, Alexandria Real Estate Equities, Inc., and the Institute for Systems Biology – include committed investment capital, state-of-the-art facilities, world-class scientific and technical expertise and support, and experienced start-up management. This panel of Accelerator participants will discuss the success of their business model and provide practical expertise for the next generation of biotech incubators. In the past five years, nine companies have been invested in through Accelerator. Three have emerged and raised follow on financings of more than $114 million. Four remain under management at Accelerator, having raised between them $11.3 million in initial Accelerator-based investments. In all, Accelerator companies have raised in excess of $143.5 million in initial and follow-on financings. Accelerator investors have committed an additional $22.5 million to enable Accelerator to continue to identify, capitalize, and develop the next-generation of exciting emerging biotechnologies. Accelerator Corporation relies upon a unique set of sources to fill a world-class pipeline of deal flow and has established and utilized a now proven array of resources to identify, evaluate, capitalize and manage emerging biotechnology companies. Accelerator provides this unprecedented collection of resources via a partnership between top-tiered investors, dedicated management, and a world-class research institute. These groups have come together because they recognize the potential of biotechnology both as an investment opportunity and as a critical component of the rapidly evolving future of medicine and healthcare. Moreover, these individuals and organizations have extensive experience in the difficult, complex and costly process of transforming an exciting laboratory discovery into a commercial product. By providing their expertise with companies in the Accelerator portfolio, these industry leaders provide critical knowledge and resources that can help to streamline the development and accelerate the commercialization of novel technologies. Accelerator, through the global activities of its affiliates, has access to exciting new technologies and commercial opportunities developed at leading research institutions, universities and biotechnology companies around the world. This enables Accelerator to select only the most compelling investments from a deep pool of promising opportunities.

Accelerator Corporation is a venture capital firm specializing in incubation, early stage, emerging growth and start-up investments. It does not participate in further rounds of financing. The firm prefers to invest in biotechnology companies. It seeks to invest up to $2 million in a company. The firm typically holds its investments for a period of 12 months to 24 months. Accelerator Corporation was founded in 2003 and is based in Seattle, Washington. Accelerator Corporation, founded in 2003, is a vehicle for disciplined and efficient investment in and management of emerging biotechnology opportunities. Located in Seattle, Washington, the company identifies, evaluates, finances, and manages ground breaking emerging life sciences opportunities. The company has established and built a largely proprietary array of sources of deal flow, as well as a key set of resources to bring to bear in the development of the best opportunities emerging from those sources. These key resources, provided by Accelerator and its Affiliates – Amgen Ventures, ARCH Venture Partners, OVP Venture Partners, WRF Capital, Alexandria Real Estate Equities, Inc., and the Institute for Systems Biology – include committed investment capital, state-of-the-art facilities, world-class scientific and technical expertise and support, and experienced start-up management. This panel of Accelerator participants will discuss the success of their business model and provide practical expertise for the next generation of biotech incubators. In the past five years, nine companies have been invested in through Accelerator. Three have emerged and raised follow on financings of more than $114 million. Four remain under management at Accelerator, having raised between them $11.3 million in initial Accelerator-based investments. In all, Accelerator companies have raised in excess of $143.5 million in initial and follow-on financings. Accelerator investors have committed an additional $22.5 million to enable Accelerator to continue to identify, capitalize, and develop the next-generation of exciting emerging biotechnologies. Accelerator Corporation relies upon a unique set of sources to fill a world-class pipeline of deal flow and has established and utilized a now proven array of resources to identify, evaluate, capitalize and manage emerging biotechnology companies. Accelerator provides this unprecedented collection of resources via a partnership between top-tiered investors, dedicated management, and a world-class research institute. These groups have come together because they recognize the potential of biotechnology both as an investment opportunity and as a critical component of the rapidly evolving future of medicine and healthcare. Moreover, these individuals and organizations have extensive experience in the difficult, complex and costly process of transforming an exciting laboratory discovery into a commercial product. By providing their expertise with companies in the Accelerator portfolio, these industry leaders provide critical knowledge and resources that can help to streamline the development and accelerate the commercialization of novel technologies. Accelerator, through the global activities of its affiliates, has access to exciting new technologies and commercial opportunities developed at leading research institutions, universities and biotechnology companies around the world. This enables Accelerator to select only the most compelling investments from a deep pool of promising opportunities.

Appliant.com is the technology leader in monitoring Web infrastructure and application performance, availability and usage, with a focus on customer experience. Founded in 1997 in Seattle, Appliant.com helps e-businesses, enterprises and service providers maximize their return on investment in Web applications and infrastructure. Provided as an ASP solution, Appliant.com's Lateral Line Network monitors and reports Internet transactions through robust, unobtrusive monitors deployed across the Internet. Using real data from real users, the service provides a customer-centric view of a company's Web site performance, availability and usage. The company is privately held.

ProjectGuides.com is an online marketplace designed to connect buyers and sellers of professional services in the architectural, engineering, and environmental sectors. The platform utilizes advanced qualifications-based search technology to efficiently match these professionals with opportunities from both public and private buyers. By continuously scanning over 5,000 print and electronic sources, ProjectGuides.com provides its subscribers with a wealth of business leads, delivering approximately 3,000 leads each week and facilitating access to billions of dollars in business opportunities annually. Additionally, the platform offers industry news and online tools to support its users. Headquartered in Bellevue, Washington, ProjectGuides.com operates as a rapidly growing private company, committed to transforming how the professional service industry engages in business transactions.

Classmates, headquartered in Seattle, Washington, is a prominent online social networking service established in 1995, focused on reuniting high school alumni. With over 70 million members, the platform allows users to locate and reconnect with former classmates, facilitating communication and organization of activities. Classmates boasts the largest collection of digitized yearbooks on the Internet, featuring more than 300,000 yearbooks that enable users to reminisce and engage with their high school memories. This unique combination of features helps members strengthen connections and plan reunions with their peers.

ProjectGuides.com is an online marketplace designed to connect buyers and sellers of professional services in the architectural, engineering, and environmental sectors. The platform utilizes advanced qualifications-based search technology to efficiently match these professionals with opportunities from both public and private buyers. By continuously scanning over 5,000 print and electronic sources, ProjectGuides.com provides its subscribers with a wealth of business leads, delivering approximately 3,000 leads each week and facilitating access to billions of dollars in business opportunities annually. Additionally, the platform offers industry news and online tools to support its users. Headquartered in Bellevue, Washington, ProjectGuides.com operates as a rapidly growing private company, committed to transforming how the professional service industry engages in business transactions.