aMoon Fund is a venture capital firm based in Ra'anana, Israel, focused on the healthtech and life sciences sectors. Founded in 2017 by Marius Nacht and Dr. Yair Schindel, the firm specializes in providing growth capital to early, mid, and late-stage companies. aMoon targets investments in pre-IPO and public companies that are innovating in areas such as digital health, medical technologies, and biopharmaceuticals, particularly those integrating advanced technologies like AI and big data into their solutions. The firm is dedicated to supporting companies that offer life-saving innovations or significantly reduce costs in global healthcare systems. With a preference for investments ranging from $5 million to $50 million, aMoon seeks opportunities primarily in Israel and other health-tech hubs worldwide, partnering with management teams committed to accelerating cures for serious medical conditions.
Character Therapeutics is a patient-driven therapeutics company that uses genomics, longitudinal clinical and imaging data, machine learning, and novel experimental approaches to identify the molecular drivers of disease progression and develop innovative targeted medicines. Its dedication to patients is reflected in the high standards set to ensure privacy, data security, ethics, scientific rigor, and a meaningful impact on patient health. To enable clinical genomic research, the company collaborates with patients, providers, payers, and scientists to create deeply phenotyped patient cohorts.
MetaSight Diagnostics
Series A in 2024
MetaSight Diagnostics, a health technology company, is on a mission to develop affordable and precise liquid biopsy diagnostics for the early detection of a wide range of chronic and acute diseases by leveraging proprietary mass spectrometry technologies (metabolomics, lipidomics, and proteomics).
Hopscotch Primary Care
Series C in 2024
Operator of a data-driven healthcare startup intended to transform healthcare in rural communities through exceptional care, bringing better access and quality service to its patients. The company delivers tailored quality care through a team-based model, with resources and support for patients, inside and outside clinics, thereby enabling healthcare professionals to provide the support and care that patients need.
AltruBio
Series B in 2024
AltruBio is a biopharmaceutical company focused on developing targeted antibody therapeutics for cancer and immune-related inflammatory diseases. Established in Delaware with its principal office in the San Francisco Bay Area, AltruBio integrates global resources to advance its research and development initiatives. The company has its roots in Taipei, Taiwan, where it has been working since June 2000 on discovering and developing novel therapeutics to address unmet medical needs. AltruBio employs a sophisticated discovery platform to identify and validate new antibody therapeutics. Currently, the company is developing several potential therapeutic antibodies that target a range of conditions, including autoimmune diseases and various types of cancer, such as pancreatic, stomach, colorectal, ovarian, and lung cancers, at different stages of development.
Eleos Health
Series B in 2023
Eleos Health develops innovative health technology solutions aimed at enhancing decision-making for clinicians in the behavioral health sector. The company's AI-powered Speech-to-Insights system operates during mental health sessions to analyze voice data in real time. By gathering insights on patients through this voice technology, Eleos Health enables clinicians to deliver personalized, efficient, and cost-effective care. The automated nature of the system helps streamline the clinical process, ultimately supporting mental health professionals in providing the necessary care and support for their patients.
Ibex Medical Analytics
Series C in 2023
Ibex Medical Analytics Ltd, based in Tel Aviv, Israel, specializes in developing AI-based diagnostic systems for cancer pathology. The company's flagship product, the Ibex Second Read system, works alongside human pathologists to analyze cases, identifying discrepancies in diagnoses. This innovative technology harnesses artificial intelligence, data science, and machine learning to analyze digitized glass slides and electronic medical records, revealing critical patterns that enhance clinical decision-making. By streamlining pathology workflows, Ibex aims to provide rapid, objective, and accurate diagnoses, ultimately improving patient outcomes and quality of life. The company comprises a multidisciplinary team of entrepreneurs, data scientists, software engineers, and medical experts dedicated to advancing cancer care through AI applications in diagnostics.
Better Life Partners
Series B in 2023
Better Life Partners Inc. is a healthcare provider based in Hanover, New Hampshire, focused on supporting individuals struggling with opioid use disorder in the United States. Established in 2018, the company offers a range of services including medication-assisted treatment, counseling, peer coaching, and group sessions. Better Life Partners utilizes technology to create personalized care plans that adapt to clients' needs, ensuring effective healthcare delivery through telehealth and community-based solutions. By integrating medical and behavioral healthcare, the company aims to address the complex needs of patients, providing comprehensive support to help them recover from addiction. Better Life Partners has additional offices across various locations in New Hampshire, reflecting its commitment to serving vulnerable populations.
Nectin Therapeutics
Series A in 2022
Nectin Therapeutics Ltd., founded in 2017 and based in Jerusalem, Israel, specializes in the development of monoclonal antibodies targeting members of the Nectin family of receptors and ligands. These antibodies are designed to address immune checkpoint mechanisms that play a crucial role in cancer immunotherapy. By focusing on both solid and hematological malignancies, Nectin Therapeutics aims to create therapies that can overcome the inhibitory pathways utilized by tumors, thereby enhancing the ability of immune cells to eradicate cancer cells. The company's innovative approach seeks to improve patient outcomes in cancer treatment.
Ibex Medical Analytics
Debt Financing in 2022
Ibex Medical Analytics Ltd, based in Tel Aviv, Israel, specializes in developing AI-based diagnostic systems for cancer pathology. The company's flagship product, the Ibex Second Read system, works alongside human pathologists to analyze cases, identifying discrepancies in diagnoses. This innovative technology harnesses artificial intelligence, data science, and machine learning to analyze digitized glass slides and electronic medical records, revealing critical patterns that enhance clinical decision-making. By streamlining pathology workflows, Ibex aims to provide rapid, objective, and accurate diagnoses, ultimately improving patient outcomes and quality of life. The company comprises a multidisciplinary team of entrepreneurs, data scientists, software engineers, and medical experts dedicated to advancing cancer care through AI applications in diagnostics.
Lyfegen
Series A in 2022
Lyfegen is an independent provider of drug access, pricing, and rebate management solutions, with operations in Basel, Switzerland, and Boston, USA. The company specializes in helping healthcare payers and pharmaceutical companies establish appropriate pricing agreements for medications while efficiently managing drug rebates. Its platform is designed for the healthcare industry, assisting health insurance providers, pharmaceutical companies, MedTech firms, and hospitals worldwide in collecting, analyzing, and reconciling diverse healthcare data. This technology facilitates the automation of value-based healthcare contracting, ultimately aiming to enhance access to treatments, improve patient health outcomes, and increase affordability.
Theranica
Series C in 2022
Theranica is a medical device company that has combined neuromodulation therapy with modern wireless technology to develop proprietary wearable solutions that address various medical conditions and disease states. The noninvasive and therapeutic 'smart' patches are controlled by a smartphone app to allow for personalized, portable, and affordable care. The patch consists of a proprietary 'smart' chip that delivers electrical pulses to neuro-modulate the sensory nerves under the skin. The first application of the technology is for treatment of migraine headaches.
Ultima Genomics
Venture Round in 2022
Ultima Genomics is unleashing the power of genomics at scale. Ultima Genomics drives the scale of genomic information to enable unprecedented advances in biology and improvements in human health. The company was founded in 2016 and is based in Newark, California.
Eleos Health
Series A in 2022
Eleos Health develops innovative health technology solutions aimed at enhancing decision-making for clinicians in the behavioral health sector. The company's AI-powered Speech-to-Insights system operates during mental health sessions to analyze voice data in real time. By gathering insights on patients through this voice technology, Eleos Health enables clinicians to deliver personalized, efficient, and cost-effective care. The automated nature of the system helps streamline the clinical process, ultimately supporting mental health professionals in providing the necessary care and support for their patients.
PrognomiQ
Venture Round in 2022
PrognomiQ is a technology company dedicated to advancing early disease detection and treatment, particularly for cancer and other complex diseases. By harnessing multi-omics data, including proteomic, genomic, and metabolomic information, the company aims to enhance understanding and management of health conditions. PrognomiQ's innovative approach allows for the development of advanced medical test products that improve diagnostic capabilities and recurrence monitoring, ultimately seeking to enhance patient outcomes. Through its focus on integrating diverse health data, PrognomiQ is committed to transforming how medical practitioners approach disease detection and treatment.
Satellite Bio
Series A in 2022
Satellite Bio is a company that specializes in cell therapy, regenerative medicine, synthetic biology, cell biology, and tissue engineering. It is dedicated to developing a therapeutic platform aimed at creating innovative cell therapies to address complex diseases. The company’s primary focus is on the design and implementation of proprietary, off-the-shelf, implantable satellite organs, which serve as living therapeutic solutions. These satellite organs are intended to improve the lives of millions of patients suffering from serious health conditions.
MDClone
Series C in 2022
MDClone Ltd. is a company that specializes in developing software for analyzing medical records while ensuring the privacy of patient data. Founded in 2016 and based in Beersheba, Israel, MDClone's platform generates synthetic medical records for fictitious patients, which allows researchers to study disease behavior, healthcare practices, and treatment outcomes without exposing actual patient information. The MDClone ADAMS Platform provides a self-service data analytics environment that facilitates exploration, discovery, and collaboration across healthcare systems, both nationally and internationally. This innovative approach addresses common barriers in healthcare by enabling users to organize and access data efficiently, thereby improving operations and enhancing patient outcomes. MDClone serves various clients in the healthcare sector, including major health systems, payers, and life sciences organizations in the United States, Canada, and Israel.
Scipher Medicine
Series D in 2022
Scipher Medicine is a biotechnology company that has developed a precision medicine platform aimed at improving drug therapy outcomes for patients with cardiovascular and autoimmune diseases. The company's flagship products, including PrismDx, PrismRA, and PrismUC, utilize molecular testing to predict patient responses to specific drug therapies, enabling healthcare providers to prescribe more effective treatments tailored to individual patient needs. For example, PrismRA identifies rheumatoid arthritis patients who are unlikely to respond to certain anti-TNF therapies, allowing for timely alternative treatments. By leveraging a simple blood sample to analyze RNA and generate genomic signatures, Scipher Medicine helps healthcare professionals select the most suitable therapies based on the underlying biology of diseases rather than relying on traditional classifications or symptomatic assessments. This innovative approach not only enhances patient care but also addresses significant inefficiencies in the healthcare system, reducing costs associated with ineffective treatments. Scipher Medicine, incorporated in 2013 and based in Waltham, Massachusetts, aims to transform drug prescribing and development through its advanced molecular technology.
Omada
Series E in 2022
Omada Health, Inc. is a digital healthcare company that creates and implements online programs aimed at managing chronic conditions. Founded in 2011 and headquartered in San Francisco, with an additional office in Atlanta, Omada Health focuses on helping employers and health plans identify individuals at risk for preventable chronic diseases such as prediabetes, diabetes, hypertension, and heart disease. The company offers personalized programs that adapt to the unique needs of participants, incorporating professional health coaching, connected health devices, and real-time data to foster sustainable lifestyle changes. Omada Health is recognized as the largest provider of the National Diabetes Prevention Program, delivering clinically effective solutions that empower individuals to take charge of their health and achieve their wellness goals.
Eleos Health
Seed Round in 2021
Eleos Health develops innovative health technology solutions aimed at enhancing decision-making for clinicians in the behavioral health sector. The company's AI-powered Speech-to-Insights system operates during mental health sessions to analyze voice data in real time. By gathering insights on patients through this voice technology, Eleos Health enables clinicians to deliver personalized, efficient, and cost-effective care. The automated nature of the system helps streamline the clinical process, ultimately supporting mental health professionals in providing the necessary care and support for their patients.
Sentient Med
Pre Seed Round in 2021
We're a digital healthcare company on a mission to enhance patients outcome by helping doctors and companies make better decisions through the generation of reliable synthetic data and by developing decision support systems
DayTwo
Series B in 2021
DayTwo Ltd. is a precision nutrition company headquartered in Tel Aviv-Yafo, Israel, that focuses on leveraging gut microbiome insights to improve health outcomes and prevent diseases such as diabetes, prediabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Founded in 2015, DayTwo employs microbiome sequencing to create personalized dietary recommendations, known as Food Prescriptions™, tailored to individual responses to food. This approach helps manage blood sugar levels, enhance energy, control hunger, and promote weight loss. DayTwo delivers its services through a digital platform and mobile application, enabling users to track their progress and communicate with certified diabetes care specialists and registered dietitians. By emphasizing personalized nutrition based on scientific research, DayTwo aims to empower patients to lead healthier lives through informed dietary choices.
Sera Prognostics
Series E in 2021
Sera Prognostics, Inc. is a biotechnology company based in Salt Lake City, Utah, focused on developing diagnostic tests that assess a woman's individual risk of premature birth, preeclampsia, gestational diabetes, stillbirth, and other pregnancy-related complications. Founded in 2008, Sera aims to improve maternal and neonatal health while addressing the significant economic and healthcare burdens associated with premature birth. The company's proprietary proteomics and bioinformatics platform underpins its pipeline of innovative diagnostic tests, including the PreTRM® Test, which provides physicians with critical information to identify women at higher risk for spontaneous premature delivery. By enabling earlier proactive interventions, Sera seeks to enhance pregnancy care and reduce healthcare delivery costs.
Biosplice Therapeutics
Venture Round in 2021
Biosplice Therapeutics is engaged in the research and development of therapeutic drugs aimed at tissue-level regeneration, with a focus on osteoarthritis and oncology. The company utilizes a platform that originated from small molecule-based modulation of the Wnt pathway, enabling the discovery of new biological targets and processes. This innovative approach allows Biosplice to develop therapeutics that address a variety of degenerative diseases, aiming to create effective treatments for conditions that currently lack adequate options. By concentrating on regenerative medicine, the company aspires to improve patient health through the advancement of new curative therapies.
Scipher Medicine
Series C in 2021
Scipher Medicine is a biotechnology company that has developed a precision medicine platform aimed at improving drug therapy outcomes for patients with cardiovascular and autoimmune diseases. The company's flagship products, including PrismDx, PrismRA, and PrismUC, utilize molecular testing to predict patient responses to specific drug therapies, enabling healthcare providers to prescribe more effective treatments tailored to individual patient needs. For example, PrismRA identifies rheumatoid arthritis patients who are unlikely to respond to certain anti-TNF therapies, allowing for timely alternative treatments. By leveraging a simple blood sample to analyze RNA and generate genomic signatures, Scipher Medicine helps healthcare professionals select the most suitable therapies based on the underlying biology of diseases rather than relying on traditional classifications or symptomatic assessments. This innovative approach not only enhances patient care but also addresses significant inefficiencies in the healthcare system, reducing costs associated with ineffective treatments. Scipher Medicine, incorporated in 2013 and based in Waltham, Massachusetts, aims to transform drug prescribing and development through its advanced molecular technology.
Absci
Venture Round in 2021
Absci is a drug and target discovery company that utilizes deep learning AI and synthetic biology to enhance the therapeutic potential of proteins. By employing its Integrated Drug Creation Platform, Absci identifies novel drug targets and discovers optimal biotherapeutic candidates while simultaneously generating the necessary cell lines for manufacturing. This innovative approach allows biotech and pharmaceutical partners to develop next-generation protein-based drugs, including Bionic Proteins that incorporate nonstandard amino acids and other unique drug designs that may be unattainable through traditional methods. Absci's mission focuses on advancing the development of improved medicines by effectively translating innovative ideas into viable drugs.
Ibex Medical Analytics
Series B in 2021
Ibex Medical Analytics Ltd, based in Tel Aviv, Israel, specializes in developing AI-based diagnostic systems for cancer pathology. The company's flagship product, the Ibex Second Read system, works alongside human pathologists to analyze cases, identifying discrepancies in diagnoses. This innovative technology harnesses artificial intelligence, data science, and machine learning to analyze digitized glass slides and electronic medical records, revealing critical patterns that enhance clinical decision-making. By streamlining pathology workflows, Ibex aims to provide rapid, objective, and accurate diagnoses, ultimately improving patient outcomes and quality of life. The company comprises a multidisciplinary team of entrepreneurs, data scientists, software engineers, and medical experts dedicated to advancing cancer care through AI applications in diagnostics.
Viracta Therapeutics
Post in 2021
Viracta Therapeutics, Inc. is a clinical-stage drug development company based in Cardiff, California, focused on precision oncology for virus-associated malignancies. The company specializes in a viral activation therapy platform aimed at treating cancers linked to the Epstein-Barr Virus (EBV) and other virus-associated diseases. Its lead investigational drug, nanatinostat, is being evaluated in combination with the antiviral valganciclovir in Phase 2 clinical trials for EBV-positive lymphoma, including conditions such as post-transplant lymphoproliferative disorder and plasmablastic lymphoma. Viracta is also exploring the application of this therapeutic approach in treating other EBV-related malignancies, such as nasopharyngeal carcinoma and gastric carcinoma. Founded in 2007 and previously known as HemaQuest Pharmaceuticals, Viracta Therapeutics continues to advance its mission to develop innovative treatments for serious viral-associated cancers.
Viracta Therapeutics
Series E in 2020
Viracta Therapeutics, Inc. is a clinical-stage drug development company based in Cardiff, California, focused on precision oncology for virus-associated malignancies. The company specializes in a viral activation therapy platform aimed at treating cancers linked to the Epstein-Barr Virus (EBV) and other virus-associated diseases. Its lead investigational drug, nanatinostat, is being evaluated in combination with the antiviral valganciclovir in Phase 2 clinical trials for EBV-positive lymphoma, including conditions such as post-transplant lymphoproliferative disorder and plasmablastic lymphoma. Viracta is also exploring the application of this therapeutic approach in treating other EBV-related malignancies, such as nasopharyngeal carcinoma and gastric carcinoma. Founded in 2007 and previously known as HemaQuest Pharmaceuticals, Viracta Therapeutics continues to advance its mission to develop innovative treatments for serious viral-associated cancers.
SOPHiA GENETICS
Series F in 2020
SOPHiA GENETICS is a healthcare technology company focused on advancing data-driven medicine and enhancing life sciences research. The company has developed the SOPHiA DDM™ Platform, a cloud-based software-as-a-service solution that analyzes complex multimodal data sets and various diagnostic modalities. This platform is utilized by over 780 hospitals, laboratories, and biopharma institutions worldwide. Headquartered in Switzerland, SOPHiA GENETICS also maintains a presence in France, the United States, and Brazil, underscoring its commitment to improving healthcare outcomes through innovative technology.
PrognomiQ
Venture Round in 2020
PrognomiQ is a technology company dedicated to advancing early disease detection and treatment, particularly for cancer and other complex diseases. By harnessing multi-omics data, including proteomic, genomic, and metabolomic information, the company aims to enhance understanding and management of health conditions. PrognomiQ's innovative approach allows for the development of advanced medical test products that improve diagnostic capabilities and recurrence monitoring, ultimately seeking to enhance patient outcomes. Through its focus on integrating diverse health data, PrognomiQ is committed to transforming how medical practitioners approach disease detection and treatment.
MiNA Therapeutics
Series A in 2020
MiNA Therapeutics is a clinical-stage biotechnology company based in London, United Kingdom, focused on developing small activating RNA medicines aimed at restoring normal cell function in patients. Established in 2008, the company is advancing its pipeline with products such as MTL-CEBPA combined with Sorafenib for hepatocellular carcinoma and MTL-CEBPA in conjunction with Pembrolizumab for advanced solid tumors. MiNA's innovative approach leverages gene activation mechanisms to transform the treatment landscape for cancer and other serious diseases, enabling healthcare professionals to better address these conditions.
MOBILion Systems
Series B in 2020
MOBILion Systems is a biotechnology company that specializes in identifying and analyzing the most challenging molecules that other instruments fail to detect. Its technology focuses on biologic therapeutics, discovering biomarkers, and improving the accuracy of diagnostic tests.MOBILion’s technology makes it easy to separate, identify, and analyze the most challenging molecules that other instruments fail to detect. The company's analytical instruments provide unprecedented sensitivity, resolution, and throughput that will fuel the development of better therapeutics, the ability to detect disease earlier, and the power to attack diseases at their roots instead of their symptoms.
Seer
Series D in 2020
Seer is a developer of a life sciences and health data platform intended to facilitate early, pre-symptomatic detection of chronic life-threatening diseases. The company's platform captures and translates molecular insights from the proteome with improved accuracy and speed, enabling healthcare professionals to detect cancer and neurological diseases, drive earlier treatment and improve patient outcomes.
Nectin Therapeutics
Venture Round in 2020
Nectin Therapeutics Ltd., founded in 2017 and based in Jerusalem, Israel, specializes in the development of monoclonal antibodies targeting members of the Nectin family of receptors and ligands. These antibodies are designed to address immune checkpoint mechanisms that play a crucial role in cancer immunotherapy. By focusing on both solid and hematological malignancies, Nectin Therapeutics aims to create therapies that can overcome the inhibitory pathways utilized by tumors, thereby enhancing the ability of immune cells to eradicate cancer cells. The company's innovative approach seeks to improve patient outcomes in cancer treatment.
Curesponse
Series A in 2020
Curesponse is a diagnostics company based in Tel Aviv-Yafo, Israel, founded in 2017. It specializes in developing a three-dimensional tissue culture system that models cancer growth and drug response. The company's innovative platform allows patients and clinicians to send tumor samples for testing, preserving the cancer tissue's architecture, including its vasculature and immune system. This accurate reflection of cancer growth enables healthcare providers to make more informed decisions about drug therapies tailored to individual patients. By moving beyond traditional genomic predictions to functional responses in living patient cells, Curesponse aims to enhance personalized cancer medicine, improve survival rates, and reduce unnecessary medical interventions.
AtaCor Medical
Series B in 2020
AtaCor Medical Inc., is a San Clemente-based medical device maker. It designs innovative solutions to deliver temporary, interim, and permanent cardiac pacing when, and where it matters most.
Mammoth Biosciences
Series B in 2020
Mammoth Biosciences, Inc. is a biotechnology company based in South San Francisco, California, that focuses on developing innovative CRISPR solutions for a variety of applications. The company offers DETECTR™, a diagnostic platform that identifies specific nucleic acids in samples, aiding in the detection of diseases such as bacterial infections, cancer, and viral infections. Additionally, Mammoth Biosciences provides CRISPR-Cas systems for genome editing, targeting therapeutic areas including immuno-oncology, autoimmune diseases, and liver diseases. By harnessing proprietary ultracompact proteins and leveraging advanced research and development, Mammoth aims to create affordable point-of-care tests and enhance diagnostics across healthcare, agriculture, and environmental monitoring. Co-founded by CRISPR pioneer Jennifer Doudna, the company has attracted significant investment from institutional and individual backers.
NanoGhost
Venture Round in 2019
NanoGhost is a company focused on developing innovative drug-delivery technology aimed at treating the most aggressive forms of cancer. Founded on research from the Technion, which has been patented in the U.S. and Europe, the company's approach utilizes adult stem cells to transport medication directly to tumor sites. This targeted delivery system is designed to shrink tumors associated with small lung carcinoma, prostate cancer, and pancreatic cancer, thereby alleviating the pain and discomfort often experienced during radiation treatments. Through its advanced technology, NanoGhost seeks to improve the quality of life for cancer patients by enhancing the efficacy of treatment while minimizing side effects.
Seer
Series D in 2019
Seer is a developer of a life sciences and health data platform intended to facilitate early, pre-symptomatic detection of chronic life-threatening diseases. The company's platform captures and translates molecular insights from the proteome with improved accuracy and speed, enabling healthcare professionals to detect cancer and neurological diseases, drive earlier treatment and improve patient outcomes.
Vocalis Health
Venture Round in 2019
Vocalis Health will develop an artificial intelligence (AI)-based platform that analyses voice to assess the health status of a person.The technology facilitates healthcare providers to remotely interact with patients for screening and monitoring patients with a variety of voice-affecting diseases,including chronic respiratory or cardiac conditions or depression.Beyond Verbal Communication and Healthymize merged and formed Vocalis Health.
Igentify
Venture Round in 2019
Igentify Ltd is a company focused on preventive healthcare through genomic products and services, with a particular emphasis on the Jewish and Israeli population. Founded in 2016 and headquartered in Haifa, Israel, Igentify developed FamilyFirst, an expanded carrier screening tool designed to identify genetic conditions. The company operates an end-to-end digital genetic platform that enhances the accessibility and usability of genomic information for clinicians, laboratories, and patients. By streamlining processes such as education on genetic testing, consent collection, and data analysis, Igentify aims to facilitate a more efficient and comprehensive approach to genomic medicine.
MDClone
Series B in 2019
MDClone Ltd. is a company that specializes in developing software for analyzing medical records while ensuring the privacy of patient data. Founded in 2016 and based in Beersheba, Israel, MDClone's platform generates synthetic medical records for fictitious patients, which allows researchers to study disease behavior, healthcare practices, and treatment outcomes without exposing actual patient information. The MDClone ADAMS Platform provides a self-service data analytics environment that facilitates exploration, discovery, and collaboration across healthcare systems, both nationally and internationally. This innovative approach addresses common barriers in healthcare by enabling users to organize and access data efficiently, thereby improving operations and enhancing patient outcomes. MDClone serves various clients in the healthcare sector, including major health systems, payers, and life sciences organizations in the United States, Canada, and Israel.
DayTwo
Series B in 2019
DayTwo Ltd. is a precision nutrition company headquartered in Tel Aviv-Yafo, Israel, that focuses on leveraging gut microbiome insights to improve health outcomes and prevent diseases such as diabetes, prediabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Founded in 2015, DayTwo employs microbiome sequencing to create personalized dietary recommendations, known as Food Prescriptions™, tailored to individual responses to food. This approach helps manage blood sugar levels, enhance energy, control hunger, and promote weight loss. DayTwo delivers its services through a digital platform and mobile application, enabling users to track their progress and communicate with certified diabetes care specialists and registered dietitians. By emphasizing personalized nutrition based on scientific research, DayTwo aims to empower patients to lead healthier lives through informed dietary choices.
Ayala Pharmaceuticals
Series B in 2019
Ayala Pharmaceuticals is a clinical-stage biopharmaceutical company dedicated to developing and commercializing small molecule therapeutics for patients with rare and aggressive cancers. Founded in 2017 and based in Rehovot, Israel, the company aims to address genetically defined patient populations by targeting the tumorigenic drivers of cancer. Its lead product candidate, AL101, is an intravenous gamma secretase inhibitor currently undergoing Phase II clinical trials for the treatment of recurrent and metastatic adenoid cystic carcinoma in patients with Notch-activating mutations. Additionally, Ayala is developing AL102, an oral gamma secretase inhibitor, which is in Phase I clinical trials for desmoid tumors and has a collaboration with Novartis to further develop this compound for multiple myeloma. The company's innovative approach combines bioinformatics and next-generation sequencing to deliver targeted therapies to underserved patient populations.
Theranica
Series B in 2019
Theranica is a medical device company that has combined neuromodulation therapy with modern wireless technology to develop proprietary wearable solutions that address various medical conditions and disease states. The noninvasive and therapeutic 'smart' patches are controlled by a smartphone app to allow for personalized, portable, and affordable care. The patch consists of a proprietary 'smart' chip that delivers electrical pulses to neuro-modulate the sensory nerves under the skin. The first application of the technology is for treatment of migraine headaches.
AtaCor Medical
Series A in 2018
AtaCor Medical Inc., is a San Clemente-based medical device maker. It designs innovative solutions to deliver temporary, interim, and permanent cardiac pacing when, and where it matters most.
Nobio
Venture Round in 2018
NobioTM developed game-changing technology with the goal to prevent medical device contamination indefinitely, as the first and only fully-integrated anti-biofilm solution. The technology core consists of extremely potent particles which are covered with a high concentration of highly-active anti-microbial structures that kill bacteria upon contact. The NobioTM particles can be permanently embedded in many products and materials to inhibit formation of biofilm, indefinitely.
Zebra Medical Vision
Series C in 2018
Zebra Medical Vision Ltd. is a company that develops an imaging analytics platform aimed at enhancing patient care in healthcare institutions. Founded in 2014 and based in Shefayim, Israel, the platform utilizes advanced learning and computer vision algorithms to assist clinicians in identifying patients at risk of various diseases. This technology supports healthcare providers in implementing effective risk management and preventative care strategies. Zebra Medical Vision also supplies tools and datasets for machine-learning researchers, facilitating the rapid development of decision support tools and diagnostic solutions. The company has established strategic partnerships with organizations such as USARAD Holdings and TELUS Ventures, and has secured a total of $52 million in funding from notable investors, including Khosla Ventures and Nvidia. Its AI-driven products are FDA cleared and are utilized in hospitals across multiple regions, including the U.S., Europe, Australia, India, and Latin America, positioning Zebra Medical Vision as a leader in the field of medical imaging and analytics.
Medial EarlySign
Series B in 2018
Medial EarlySign develops an AI algorithmic platform for the discovery of clinical insights that indicate the likelihood of disease from basic medical information, such as blood test results, and other EMR data. Called AlgoMarkers, its predictive engines are built in collaboration with healthcare organizations, through the combination of 10s of millions of patient years-worth of data, clinical rigor and some of the most brilliant algorithmic minds. The company develops clinical decision support and population health solutions that can assist in the early prediction of clinical outcomes related to cancers, metabolic, immune and infectious diseases. These tools are designed to place at the fingertips of healthcare organizations only those insights that could prove critical in disease management and prevention empowering them with proactive, predictive and personalized care management capabilities
Karius
Series A in 2017
Karius, Inc. is a life sciences company based in Redwood City, California, specializing in genomic insights for infectious diseases. The company offers a non-invasive blood test known as the Karius Test, which utilizes sequencing of microbial cell-free DNA to identify and quantify various pathogens, including bacteria, DNA viruses, fungi, and parasites. This test is particularly useful for diagnosing complicated pneumonia, infections in immunocompromised patients, and endocarditis. By mapping the microbial landscape of each patient from a single blood draw, Karius aims to assist clinicians in making rapid and informed treatment decisions. The company's laboratory is CLIA-certified and CAP-accredited, ensuring high standards in clinical laboratory testing. Additionally, Karius provides laboratory services for pathogen biomarker detection tailored to biopharmaceutical companies.
CartiHeal
Series C in 2011
CartiHeal is a medical device company based in Kfar Sava, Israel, specializing in cartilage and bone regeneration. Founded in 2009, the company has developed the Agili-C implant, a cell-free and off-the-shelf solution designed to address focal articular cartilage and osteochondral defects. This innovative implant promotes the regeneration of hyaline cartilage and the underlying subchondral bone without the need for cells or growth factors, making it a significant advancement in the treatment of cartilage injuries. Given the limited natural healing capacity of hyaline cartilage, CartiHeal's technology offers a promising option for patients suffering from cartilage damage, which can lead to severe pain and disability if untreated. The Agili-C implant can be inserted using arthroscopic or minimally invasive techniques, facilitating faster rehabilitation and enhanced recovery outcomes for patients.
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