National Institute of Mental Health

Deliberate AI focuses on advancing mental health care through its development of multimodal artificial intelligence technologies. The company specializes in regulatory-grade measurement tools that enhance diagnostics and monitoring for behavioral and mental health applications. Their platform employs AI algorithms to deliver objective assessments and insights, supporting clinicians, physicians, and researchers in mental and neurological healthcare and clinical trials. By enabling precision therapy and integrating ambient clinical intelligence, Deliberate AI aims to improve the quality of care and outcomes for patients undergoing mental health treatment.

PsychoGenics is a research company offering preclinical testing and research services.

Rumi Scientific is a research-based company focused on developing medications and innovative treatments for genetic illnesses affecting the central nervous system, with a particular emphasis on Huntington's Disease. The company utilizes a proprietary human organoid platform that simulates human development in vitro, integrating genetic models created through gene editing with multi-cellular self-organization to generate defined diseased embryonic tissues. This platform facilitates drug discovery and high-throughput screening, allowing for the identification of effective treatments using advanced artificial intelligence techniques. By prioritizing synthetic human embryology in both normal and pathological contexts, Rumi Scientific aims to advance therapeutic options for numerous genetic disorders that currently lack viable cures, striving to enhance treatment success rates and improve patient outcomes.

Innerworld is a mental health community that operates within the metaverse, offering a virtual reality platform focused on cognitive-behavioral therapy. This innovative platform aims to provide a safe and supportive environment where individuals can build meaningful relationships while learning evidence-based techniques to address real-world mental health challenges. By facilitating the treatment and understanding of mental health disorders, Innerworld enables users to acquire essential skills for emotional regulation and overall well-being.

PsychoGenics is a research company offering preclinical testing and research services.

Arcade Therapeutics is focused on enhancing mental health through innovative mobile gaming solutions. Utilizing groundbreaking neuroscientific research, the company has developed a digital therapeutics platform that offers game-like cognitive training designed to modify attention patterns contributing to anxiety and stress. This platform employs an attention bias modification approach, helping users manage disruptive habits that sustain their mental health challenges. Additionally, Arcade Therapeutics incorporates artificial intelligence to gather data and provide risk stratification, allowing for a scientific approach to mental wellness. By making these therapeutic interventions accessible and engaging, the company aims to improve health outcomes for individuals dealing with behavioral and mental health issues.

Lyssn is a mental health care platform that utilizes artificial intelligence technology to enhance training and quality assurance for mental health professionals. The platform enables users to record and share psychotherapy conversations, transforming these recordings into data through comprehensive transcripts and metrics. This functionality provides valuable feedback to both trainees and experienced counselors, allowing them to assess the emotional states and behaviors of patients effectively. By analyzing health outcomes, Lyssn supports healthcare professionals in improving their practices and fostering better patient care.

Soterix Medical is a New York-based company that specializes in the development of medical devices and accessories focused on neuromodulation and brain stimulation technologies. Founded by Abhishek Datta, the company offers innovative products that include brain stimulation and transcranial electrical stimulation (tES), as well as high-definition transcranial electrical stimulation (HD-tES). Soterix Medical aims to provide safe, effective, and user-friendly neuromodulation solutions for clinicians and patients, enhancing therapeutic outcomes in various medical applications.

Meru Health, Inc. is a digital healthcare company that focuses on improving the lives of individuals dealing with mental health issues such as depression, anxiety, and stress. Founded in 2015 and based in San Mateo, California, with additional offices in Palo Alto and Helsinki, Meru Health develops a mobile application that connects users to licensed therapists through a structured 12-week program. This program combines continuous remote clinician support with at-home lessons, cognitive behavioral therapy, and coaching on sleep and nutrition. By offering clinically proven and cost-effective digital therapeutic solutions, Meru Health aims to empower patients and enhance the efficiency of mental health treatment.

Imaginostics specializes in developing advanced diagnostic tools aimed at enhancing precision medicine for clinicians and drug developers. Utilizing proprietary MRI physics-based technology, the company offers significantly improved vascular imaging and quantitative assessments of vascular structure, function, and leakage. This innovative approach not only produces images ten times better than traditional methods but is also compatible with existing MRI scanners and utilizes a safe iron supplement for contrast instead of toxic gadolinium. Imaginostics provides biomarker solutions through collaborations with contract research organizations and engages in pre-clinical and clinical research across various focus areas, working alongside leading researchers at prestigious institutions. The company's noninvasive imaging technology is designed to aid in the diagnosis of neurological disorders, facilitate safe vascular visualization for renal patients, and support acute diagnostics for conditions like traumatic brain injury or stroke, ultimately enabling hospitals to monitor disease progression and evaluate drug effects efficiently.

Mightier is a Boston-based gaming platform established in 2016 that focuses on helping children develop emotional regulation skills through bioresponsive video games. The company's innovative program, developed in collaboration with Boston Children's Hospital and Harvard Medical School, utilizes a heart rate monitor to create a unique gaming experience where the game's difficulty adjusts based on the player's emotional state. This approach allows children to visualize their emotions in real-time, enabling them to learn how to manage their feelings effectively. By engaging with these games, kids with behavioral and emotional challenges can discover their emotional strengths and improve their ability to cope with daily situations.

Camino Pharma is a San Diego-based startup company focused on discovering and developing first-in-class therapies for patients suffering from cancer and CNS disorders. They target signaling proteins based on emerging biological concepts and discover novel mechanisms for modulating these targets with small molecule drugs. Their leadership team has proven expertise in the relevant target biology, as well as extensive experience in drug discovery and development.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

FIRMM is a software-based biofeedback solution, called Framewise Integrated Real-Time MRI Monitoring (FIRMM), for acquiring better brain MR exams.

Cogito is a technology company that specializes in enhancing the emotional intelligence of phone professionals through advanced artificial intelligence and machine learning. By leveraging behavioral science, Cogito's software analyzes various behavioral signals during conversations, offering real-time coaching to agents. This system not only guides agents in their interactions but also provides a continuous assessment of customer experience for each call. Through its innovative approach, Cogito enables enterprises to foster stronger relationships with their customers, improve sales outcomes, and enhance the overall quality of service provided.

McLean Hospital was founded on Feb. 25, 1811, through a charter granted by the Massachusetts Legislature for the “Massachusetts General Hospital Corporation.” From its inception, the Corporation intended to treat both physical and mental illnesses, with a separate facility for each. Fundraising campaigns were held between 1812 and 1816, and a majority of the contributors earmarked their donations for the establishment of a facility to treat mental illnesses. McLean Hospital is dedicated to improving the lives of people and families affected by psychiatric illness. McLean Hospital is a comprehensive mental health care facility committed to providing a full range of high quality, cost effective, mental health services. At McLean Hospital, their staff, faculty, volunteers and supporters are dedicated to improving the lives of people and families affected by psychiatric illness. As the largest psychiatric affiliate of Harvard Medical School, McLean has been meeting the needs of individuals and families with psychiatric illness since their founding in 1811. McLean Hospital's staff of more than 1,900 caring and compassionate individuals are each dedicated to improving the lives of people living with mental illness and their families. McLean Hospital is an affiliate of Harvard Medical School and a member of Partners Healthcare. McLean Hospital is the largest psychiatric teaching facility of Harvard Medical School.

The Brown School offers excellence in social work, public health and social policy graduate education. The school's community of students and scholars dig in every day to work towards social, health, racial and economic equity so that all people can live and thrive. The future of social work and public health depends on leading evidence-based research; moving that research into practice; and preparing students to excel in their work. Brown School faculty excel in these pursuits, and the work they are doing is vital for creating change.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

DFusion is a science-based behavioral health research and development company that focuses on promoting behavior change for health, prevention, and adherence. Leveraging evidence-based models and learning theories, DFusion creates innovative applications of both modern and traditional technologies aimed at enhancing health outcomes. The company develops smartphone, tablet, and web applications that are informed by behavioral research, ensuring an optimal user experience. Additionally, DFusion offers consultation services and professional development opportunities within the health and education sectors. Their team, comprised of scientists and innovators, is dedicated to challenging existing paradigms and improving the health and well-being of individuals throughout their lifespans. DFusion operates from offices in Scotts Valley and Oakland, California.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

Omeros Corporation is a Seattle-based biopharmaceutical company that focuses on discovering, developing, and commercializing small-molecule and protein therapeutics targeting inflammation, complement-mediated diseases, and disorders of the central nervous system. The company offers OMIDRIA, a product used during cataract surgery in the United States. Omeros is advancing several clinical programs, including narsoplimab, which is in Phase III trials for conditions such as hematopoietic stem-cell transplant-associated thrombotic microangiopathy and immunoglobulin A nephropathy, as well as Phase II trials for lupus nephritis. Other key programs include OMS405, targeting opioid and nicotine addiction, and OMS527, aimed at treating addiction and movement disorders. The company's preclinical pipeline includes compounds addressing various conditions, such as paroxysmal nocturnal hemoglobinuria and other alternative pathway disorders. Founded in 1994, Omeros is dedicated to addressing both large-market and orphan indications through innovative therapeutic approaches.

Backyard Brains is a company that offers accessible neuroscience tools and experiment kits designed for individuals of all ages to engage in brain science exploration. By providing affordable, hands-on kits, the company empowers students and educators to conduct neurological experiments, allowing them to learn about electrophysiology in a practical manner. Their products enable users to record electrical activity from various biological systems, including motor units and the brain, facilitating a deeper understanding of how the brain communicates and functions. Through simple, guided experiments, Backyard Brains makes it possible for anyone, from schoolchildren to graduate students, to experience the wonders of neuroscience firsthand.

Acadia Pharmaceuticals Inc. is a biopharmaceutical company dedicated to developing and commercializing small molecule drugs for central nervous system disorders. Founded in 1993 and headquartered in San Diego, California, the company is best known for its product NUPLAZID (pimavanserin), which is approved for treating hallucinations and delusions associated with Parkinson’s disease psychosis. Acadia is actively advancing pimavanserin through Phase III clinical trials for dementia-related psychosis and as an adjunctive treatment for schizophrenia, as well as exploring its use for major depressive disorder. The company operates two subsidiaries in Sweden and Denmark and is committed to discovering novel treatments for conditions such as Alzheimer's and schizophrenia, while also seeking to in-license or acquire complementary products. Acadia holds several patent applications related to its proprietary technology, including innovative methods for drug discovery and development.