Morningside

Accro Bioscience is a biopharmaceutical company that specializes in the development of innovative small molecule drugs aimed at treating inflammatory and autoimmune diseases, as well as cancer. The company conducts research on the molecular mechanisms underlying regulated cell death processes, including necroptosis, pyroptosis, and ferroptosis. By understanding these mechanisms, Accro Bioscience aims to enhance current therapeutic approaches and address specific pathologies associated with various human diseases.

AdvanCell is a clinical-stage company developing novel radiopharmaceuticals for cancer treatment. It specializes in attaching alpha-emitting isotopes to molecules that deliver cytotoxic radiation directly to tumors, aiming to provide safe and effective therapies for multiple cancer types.

Geneoscopy develops non-invasive diagnostics using stool-derived eukaryotic RNA to prevent, detect, and guide treatment for gastrointestinal diseases. Its platform technology enables early-stage detection of colorectal cancer neoplasms and improves screening compliance.

Alentis Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapies for cancer and fibrotic diseases, including liver fibrosis, cirrhosis, and liver cancer. It pursues CLDN1-targeted approaches, developing anti-CLDN1 antibodies and antibody-drug conjugates to modify disease progression in CLDN1-positive cancers. Founded in 2019 and based in Basel, Switzerland, the company advances programs that aim to modulate the immune response and enhance anti-tumor activity while addressing liver-related conditions.

ENYO Pharma is a clinical-stage biopharmaceutical company headquartered in Lyon, France, with additional operations in Melbourne, Australia. Founded in 2014, it focuses on discovering and developing antiviral therapies by studying virus-host interactions within the human protein interaction network and leveraging its drug discovery platform to identify intracellular targets and molecules. The company's pipeline includes EYP001, a lead compound that modulates FXR, aiming to reduce the hepatitis B virus cccDNA reservoir and suppress viral transcription, and EYP002 for preclinical development. It also conducts toxicology testing for antiviral candidates against multiple viruses, including influenza, and pursues additional programs aimed at chronic hepatitis B and other infectious diseases. ENYO collaborates with researchers and institutions in Lyon, including Inserm and related biopole ecosystems, to advance its programs through early-stage clinical development and preclinical studies. The company aims to translate virus-host interaction biology into therapeutics for infectious diseases and related liver and metabolic conditions.

Cognito Therapeutics, established in 2016 and headquartered in Newton Centre, Massachusetts, with additional locations in San Francisco and Boston, is a clinical-stage neurotechnology company. It specializes in developing non-invasive, device-based therapies to treat neurodegenerative diseases, with a primary focus on Alzheimer's disease. The company's innovative approach involves using induced brain wave oscillations to reactivate the immune system in the brain, aiming to reduce typical disease hallmarks such as amyloid plaques and tau tangles. Co-founded by MIT professors Li-Huei Tsai and Ed Boyden, Cognito's lead therapy is currently in a pivotal study for Alzheimer's, and has been recognized as a Breakthrough Device by the FDA.

LumiraDx Ltd, incorporated in 2016 and based in London, United Kingdom, is a next-generation point-of-care diagnostics company. It specializes in manufacturing an innovative diagnostic platform that provides a wide range of tests with lab-comparable performance. LumiraDx aims to transform healthcare by offering solutions that facilitate integrated, patient-centered care, enhancing safety, efficiency, and health outcomes. The company's diagnostic system includes a portable instrument, low-cost test strips, and seamless digital connectivity, making diagnostic-led care simpler and more accessible. LumiraDx operates in multiple countries, including the United States, Italy, Germany, and Sweden, with a significant portion of its revenue generated from the U.S. market.

Founded in 2015, Evonetix develops innovative technology for parallel DNA synthesis on silicon arrays, facilitating synthetic biology research. Based in Little Chesterford, UK, the company combines scientific and engineering expertise to advance DNA synthesis capabilities.

Kezar Life Sciences, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, focused on the discovery and development of small molecule therapeutics aimed at addressing unmet medical needs in autoimmunity and cancer. The company's lead product candidate, KZR-616, is a selective immunoproteasome inhibitor currently undergoing Phase 2 clinical trials for five autoimmune conditions, including lupus nephritis and autoimmune hemolytic anemia, as well as Phase 1b/2 trials in systemic lupus erythematosus. In addition to KZR-616, Kezar is developing KZR-261, which targets oncology and autoimmune indications. Founded in 2015, the company leverages innovative research in protein homeostasis and has established a pipeline of potential therapies to advance treatment options for patients.

AdvanCell is a clinical-stage company developing novel radiopharmaceuticals for cancer treatment. It specializes in attaching alpha-emitting isotopes to molecules that deliver cytotoxic radiation directly to tumors, aiming to provide safe and effective therapies for multiple cancer types.

GreenLight Biosciences is a biotechnology company specializing in RNA-based solutions for agriculture and pharmaceutical applications. It develops mRNA vaccines, including COVID-19 candidates, and offers sustainable crop protection technologies using its proprietary cell-free production platform.

Adiso Therapeutics is a biotechnology company focused on developing therapies for inflammatory diseases. It is building a pipeline of small molecule drugs and single strain live biotherapeutic products with novel mechanisms of action to address disease progression and safety limitations of current treatments. The platform includes gut-restricted neutrophil modulators and inflammasome inhibitors, designed to provide improved efficacy with reduced systemic exposure. The research targets conditions such as ulcerative colitis, other inflammatory and neuroinflammatory diseases, and respiratory conditions, aiming to offer multi-modal treatment options. By combining different modalities within a single platform, Adiso seeks to deliver safer, more effective therapies for patients.

GreenLight Biosciences is a biotechnology company specializing in RNA-based solutions for agriculture and pharmaceutical applications. It develops mRNA vaccines, including COVID-19 candidates, and offers sustainable crop protection technologies using its proprietary cell-free production platform.

Virtue Diagnostics (Suzhou) Co., Ltd. is an in vitro diagnostic (IVD) company based in Suzhou, China, with a research and development office in Singapore. Founded in 2019, the company specializes in developing advanced diagnostic platforms for the detection of infectious diseases, cancer, and chronic diseases. Its technology offerings include clinical mass spectrometry, multiplex immunohistochemistry for pathology-based cancer detection, and a molecular and immunoassay platform. Virtue Diagnostics aims to enhance diagnostic capabilities and improve patient outcomes through its innovative solutions.

Generate Biomedicines, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapeutics through its pioneering platform in Generative Biology. Established in 2018, the company utilizes machine learning to analyze existing proteins, enabling it to understand the principles governing the relationship between genetic sequences and protein structure. This approach facilitates the invention of novel antibodies, peptides, enzymes, receptors, and other protein-based therapeutics optimized for specific biological functions. By harnessing its advanced technology, Generate Biomedicines aims to accelerate drug discovery by generating new biological molecules with significant therapeutic potential. Originally known as Generate Biologics, the company adopted its current name in March 2020 to reflect its expanded focus on biomedicine.

Geneoscopy develops non-invasive diagnostics using stool-derived eukaryotic RNA to prevent, detect, and guide treatment for gastrointestinal diseases. Its platform technology enables early-stage detection of colorectal cancer neoplasms and improves screening compliance.

Robigo is a biomanufacturing company focused on engineering microbes to develop sustainable crop protection solutions. The company creates precision microbial treatments aimed at enhancing plant health and recovering lost agricultural yields. By leveraging microbial engineering and data science, Robigo produces products that are designed to be more effective while ensuring safety for beneficial microbes, pollinators, humans, and the environment. This approach enables farmers to improve their financial performance while promoting sustainable agricultural practices.

Exo Therapeutics, Inc. is a drug discovery and development company focused on addressing challenging pharmaceutical targets. Founded in 2018 and based in Cambridge, Massachusetts, the company utilizes its proprietary ExoSight platform to create a pipeline of drug candidates that target exosites, which are unique and distal binding pockets on enzymes. This innovative approach aims to reprogram enzyme activity, leading to precise and effective therapeutic outcomes, particularly in oncology and inflammation, while also minimizing potential side effects for patients. Exo Therapeutics is committed to unlocking breakthrough therapeutics through its team of experienced researchers and a deep understanding of complex disease mechanisms.

Alamar Biosciences, founded in 2018 and headquartered in Fremont, California, specializes in developing advanced technologies for the early detection and treatment of cancer and other diseases. The company focuses on a precision proteomics platform that facilitates protein analysis and the creation of antibody technologies. This platform is designed to enhance the diagnosis of diseases, particularly cancer, while also supporting the discovery of new biomarkers. By enabling healthcare providers to detect diseases at an early stage, Alamar Biosciences aims to improve patient outcomes through timely interventions and potential cures.

Amylyx Pharmaceuticals, Inc. is a biotechnology company focused on developing innovative therapies for neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease, and Wolfram syndrome. Founded in 2013 and based in Cambridge, Massachusetts, the company is best known for its investigational therapy AMX0035, a fixed-dose co-formulation of sodium phenylbutyrate and Taurursodiol. This treatment aims to address the energy crisis within mitochondria and the accumulation of toxic, unfolded proteins in the endoplasmic reticulum, both of which contribute to the progression of neurodegenerative conditions. Through its research and development efforts, Amylyx seeks to provide effective solutions to mitigate the suffering caused by these debilitating diseases.

Founded in 2018, Fount Bio is a life science company based in Cambridge, Massachusetts. It specializes in developing biopolymer-based products to enhance tissue rejuvenation, utilizing proprietary bioorthogonal chemistry for targeted delivery of glycopolymers. This approach aims to improve product performance and patient outcomes in aesthetics and medical dermatology.

Alentis Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapies for cancer and fibrotic diseases, including liver fibrosis, cirrhosis, and liver cancer. It pursues CLDN1-targeted approaches, developing anti-CLDN1 antibodies and antibody-drug conjugates to modify disease progression in CLDN1-positive cancers. Founded in 2019 and based in Basel, Switzerland, the company advances programs that aim to modulate the immune response and enhance anti-tumor activity while addressing liver-related conditions.

Endolytix is a biotechnology company focused on developing innovative therapeutic solutions to combat antibiotic resistance, particularly in non-tuberculous mycobacterial (NTM) infections. The company's therapies are designed to effectively kill pathogenic bacteria, including those that are multidrug-resistant, thereby enabling healthcare providers to manage infections that are notoriously difficult to treat. Through its novel approaches, Endolytix aims to enhance the efficacy of treatments available for the most resistant antibiotic infections, addressing a critical need within the healthcare industry.

PhoreMost is a UK-based drug discovery company specializing in identifying new druggable targets for cancer and other diseases. Established in 2014, it develops Site-Seeker, a platform that systematically uncovers druggable sites in the human genome and links them to useful therapeutic functions in live cells.

30 Technology is a biopharmaceutical platform developer focused on improving the lives of patients facing serious and life-threatening medical conditions. The company specializes in harnessing the therapeutic potential of nitric oxide to create innovative treatments that enhance patient healing and bolster defense mechanisms. By facilitating the development of new models of care, 30 Technology aims to provide healthcare professionals with effective tools to address a range of critical medical issues, ultimately striving to advance patient outcomes and quality of life.

CellCentric Ltd. is a biotechnology company based in Cambridge, United Kingdom, focused on developing innovative cancer therapeutics. Established in 2003, the company specializes in small-molecule inhibitors targeting p300, CBP, and specific deubiquitinase enzymes, which play a crucial role in regulating gene expression in cancer cells. Its primary research program addresses prostate cancer, a significant cause of male mortality, by modulating the androgen receptor pathway and potentially overcoming resistance mechanisms found in existing treatments. Additionally, CellCentric's products have applications in treating other cancers, including non-small cell lung cancer, breast cancer, and colon cancer. The company's approach aims to provide targeted therapies for various malignancies, addressing unmet medical needs in the oncology field.

Founded in 2011, Revolo Biotherapeutics specializes in developing therapies for autoimmune and allergic diseases. Its innovative approach aims to achieve superior long-term remission with less frequent dosing, without suppressing the immune system.

F2G Ltd is a biotechnology company focused on developing innovative therapies for serious fungal infections. Founded in 1998 and based in Manchester, United Kingdom, F2G primarily works on its F3 series of anti-mold compounds, specifically targeting antifungal agents against Aspergillus and other filamentous molds. Utilizing proprietary genomics technology known as MycoBank, the company identifies essential gene targets in fungi, which informs its drug development process. F2G has diversified its approach to include chemistry-driven discovery, leveraging a strong development team to advance its patented compounds. The company's efforts aim to address difficult-to-treat fungal pathogens that pose significant mortality risks, particularly for immunocompromised patients, thereby enhancing treatment options in the pharmaceutical industry.

neoX Biotech is a Beijing-based biotechnology company founded in 2018 that specializes in the development of antigen-based cancer vaccines. By integrating artificial intelligence with biophysics, neoX Biotech focuses on the discovery and development of macromolecular and multispecific drugs, primarily in the field of immuno-oncology. The company has established a platform for early therapeutic discovery, which includes neoantigen prediction and T cell receptor screening, as well as the characterization of protein-protein interactions. This innovative approach aims to provide effective treatments for cancer patients by advancing drug research and development.

Amylyx Pharmaceuticals, Inc. is a biotechnology company focused on developing innovative therapies for neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease, and Wolfram syndrome. Founded in 2013 and based in Cambridge, Massachusetts, the company is best known for its investigational therapy AMX0035, a fixed-dose co-formulation of sodium phenylbutyrate and Taurursodiol. This treatment aims to address the energy crisis within mitochondria and the accumulation of toxic, unfolded proteins in the endoplasmic reticulum, both of which contribute to the progression of neurodegenerative conditions. Through its research and development efforts, Amylyx seeks to provide effective solutions to mitigate the suffering caused by these debilitating diseases.

Heyuan Biotechnology is a biotechnology company focusing on the field of gene therapy services. They offer gene therapy vectors, gene function research, drug targets, and efficacy for the basic research of gene therapy research, among other services.

Founded in 2015, Evonetix develops innovative technology for parallel DNA synthesis on silicon arrays, facilitating synthetic biology research. Based in Little Chesterford, UK, the company combines scientific and engineering expertise to advance DNA synthesis capabilities.

Adjuvance Technologies is a biopharmaceutical company focused on the design and manufacture of vaccine adjuvants. The company develops adjuvant molecules such as Saponex, a synthetic version of QS-21, and novel analogues including TQL1055 and TiterQuil, along with TriSST, a terpenoid saponin synthesis platform for creating new compositions of matter. Its platform centers on saponin-based adjuvants to enhance immune responses in vaccines across infectious disease, oncology, neurobiology, substance abuse, and allergy indications. Founded in 2009 and based in Lincoln, Nebraska, the company aims to improve vaccine efficacy through fundamental breakthroughs in adjuvant design and manufacturing.

Pinteon Therapeutics, Inc. is a biotechnology company founded in 2014 and based in Newton, Massachusetts. The company specializes in developing innovative therapeutics aimed at slowing down neurodegeneration and preserving brain function by interrupting the spread of toxic tau proteins. Pinteon focuses on the discovery and development of therapeutics that target the Pin1 protein, which plays a crucial role in regulating various disease processes, including those associated with cancer, central nervous system disorders, and autoimmune diseases. By inhibiting or activating Pin1, Pinteon Therapeutics aims to normalize these aberrant disease processes, ultimately improving patient outcomes in areas of significant unmet medical need.

IMTherapeutics is a biotechnology company focused on creating personalized immunotherapeutic drugs for autoimmune diseases, utilizing genetic insights linked to human leukocyte antigen (HLA) genes. Founded in 2015 and based in Aurora, Colorado, the company’s lead candidate is an oral medication designed to inhibit the autoimmune process in type 1 diabetes (T1D) by targeting specific immune cells. This approach aims to preserve the function of pancreatic beta cells and support normal insulin production in patients at risk or in the early stages of T1D. Additionally, IMTherapeutics is leveraging its HLA platform to expand its drug pipeline to include treatments for Celiac disease and potentially other autoimmune disorders. The company employs advanced screening techniques and rational drug design to develop targeted therapeutic candidates, enhancing early detection and management of autoimmune conditions.

ZielBio is an early-stage biotechnology company based in Charlottesville, Virginia. It identifies novel high-value disease targets and develops therapeutic interventions using its proprietary Zielfind platform, which combines functional high throughput screening with large content data analytics. ZielBio's lead compound, ZB131, is a humanized monoclonal antibody targeting cell surface plectin for cancer treatment.

Meissa Vaccines is a pharmaceutical company focused on developing vaccines against respiratory syncytial virus (RSV), rhinovirus, and human metapneumovirus. Incorporated in 2014, the company aims to reduce the burden of acute lower respiratory tract diseases, colds, and asthma exacerbations caused by these viruses.

Founded in 2009, MedAnnex is a UK-based biotechnology company dedicated to developing first-in-class antibody therapies for treating cancers and autoimmune diseases. Its lead product, annexuzlimab, targets annexin-A1 to inhibit cancer cell growth and autoimmune condition development.

Allysta Pharmaceuticals is a biopharmaceutical company focused on developing therapeutic peptides for ocular diseases and related fibrotic conditions. The company is advancing anti-inflammatory and anti-fibrotic peptide therapies aimed at inflammatory ocular surface disorders and dry eye disease, with potential applications to liver disease. Its pipeline includes ALY688 for inflammatory ocular surface conditions, and technologies such as an ophthalmic system that activates adiponectin signaling pathways, as well as a small-molecule multi-kinase inhibitor intended to treat glaucoma and ocular hypertension. Founded in 2013 and headquartered in Belmont, California, Allysta pursues medicines that address inflammation, fibrosis, and cellular regeneration in the eye and surrounding tissues, seeking to broaden treatment options for various ocular and fibrotic diseases.

Xgene Pharmaceutical Inc. is a pharmaceutical company founded in 2015 and based in the Cayman Islands. It focuses on developing small-molecule drugs aimed at treating chronic pain, infectious diseases, and tumors, with a particular emphasis on neurological disorders. As a late-clinical stage, venture-backed firm, Xgene utilizes proprietary linker technology to create novel, multimodal conjugated molecules. Its current programs are designed to enhance the efficacy and tolerability of pain medications, addressing unmet needs in the treatment of chronic pain and neurological conditions.

ENYO Pharma is a clinical-stage biopharmaceutical company headquartered in Lyon, France, with additional operations in Melbourne, Australia. Founded in 2014, it focuses on discovering and developing antiviral therapies by studying virus-host interactions within the human protein interaction network and leveraging its drug discovery platform to identify intracellular targets and molecules. The company's pipeline includes EYP001, a lead compound that modulates FXR, aiming to reduce the hepatitis B virus cccDNA reservoir and suppress viral transcription, and EYP002 for preclinical development. It also conducts toxicology testing for antiviral candidates against multiple viruses, including influenza, and pursues additional programs aimed at chronic hepatitis B and other infectious diseases. ENYO collaborates with researchers and institutions in Lyon, including Inserm and related biopole ecosystems, to advance its programs through early-stage clinical development and preclinical studies. The company aims to translate virus-host interaction biology into therapeutics for infectious diseases and related liver and metabolic conditions.

Apellis Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing therapeutic compounds through inhibiting the complement system for treating autoimmune and inflammatory diseases. Its lead product candidate, pegcetacoplan, is in Phase III trials for geographic atrophy in age-related macular degeneration and paroxysmal nocturnal hemoglobinuria, among other indications.

Kezar Life Sciences, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, focused on the discovery and development of small molecule therapeutics aimed at addressing unmet medical needs in autoimmunity and cancer. The company's lead product candidate, KZR-616, is a selective immunoproteasome inhibitor currently undergoing Phase 2 clinical trials for five autoimmune conditions, including lupus nephritis and autoimmune hemolytic anemia, as well as Phase 1b/2 trials in systemic lupus erythematosus. In addition to KZR-616, Kezar is developing KZR-261, which targets oncology and autoimmune indications. Founded in 2015, the company leverages innovative research in protein homeostasis and has established a pipeline of potential therapies to advance treatment options for patients.

Frequency Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to repairing or reversing damage caused by degenerative diseases through its innovative Progenitor Cell Activation approach. This method utilizes a combination of small molecules to activate progenitor cells in the body, which facilitates the creation of functional tissue without the complexities of genetic engineering. The company’s lead product candidate, FX-322, is currently undergoing phase 2a clinical trials aimed at treating the underlying causes of sensorineural hearing loss. In addition to FX-322, Frequency Therapeutics is exploring treatments for various degenerative conditions, including multiple sclerosis and diseases affecting muscle, the gastrointestinal tract, skin, and bone. Established in 2014 and based in Woburn, Massachusetts, Frequency Therapeutics has established a collaboration agreement with Astellas Pharma Inc. for the development and commercialization of FX-322.

Intima Biosciences is a New York City-based cell therapy company focused on developing innovative treatments for solid tumor cancers. The firm specializes in clinical-stage gene and cell therapies, particularly targeting genetically-engineered, neoantigen-specific tumor-infiltrating lymphocytes. Its proprietary technology aims to assess the safety and efficacy of these therapies, which are designed to inhibit the expansion of gastrointestinal cellular cells. Intima Biosciences operates a Molecular and Cell Therapy GMP production facility and is actively conducting clinical trials in collaboration with the University of Minnesota Masonic Cancer Center to advance its therapeutic offerings.

Amylyx Pharmaceuticals, Inc. is a biotechnology company focused on developing innovative therapies for neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease, and Wolfram syndrome. Founded in 2013 and based in Cambridge, Massachusetts, the company is best known for its investigational therapy AMX0035, a fixed-dose co-formulation of sodium phenylbutyrate and Taurursodiol. This treatment aims to address the energy crisis within mitochondria and the accumulation of toxic, unfolded proteins in the endoplasmic reticulum, both of which contribute to the progression of neurodegenerative conditions. Through its research and development efforts, Amylyx seeks to provide effective solutions to mitigate the suffering caused by these debilitating diseases.

Apellis Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing therapeutic compounds through inhibiting the complement system for treating autoimmune and inflammatory diseases. Its lead product candidate, pegcetacoplan, is in Phase III trials for geographic atrophy in age-related macular degeneration and paroxysmal nocturnal hemoglobinuria, among other indications.

ASLAN Pharmaceuticals, established in 2010 and based in Singapore, is a clinical-stage biopharmaceutical company focused on immunology and oncology. It develops innovative treatments, including a monoclonal therapy for atopic dermatitis and a small molecule inhibitor for cancer, aiming to transform patients' lives. The company collaborates with prominent pharmaceutical partners and operates as a subsidiary of ASLAN Pharmaceuticals Limited.

Advanced Cell Diagnostics, Inc. is a biotechnology company specializing in the development and commercialization of cell and tissue-based diagnostic tests for personalized medicine. Founded in 2007 and based in Hayward, California, the company utilizes its proprietary RNAscope technology, a multiplex fluorescent and chromogenic in situ hybridization platform, to detect and quantify RNA biomarkers at single molecule sensitivity. Its product offerings include RNAscope manual assays and reagent kits, automated tissue staining solutions, catalog probes, and software for quantitative analysis of RNA in situ hybridization samples. Advanced Cell Diagnostics also provides pharmaceutical assay services to aid in understanding disease mechanisms and support preclinical and clinical research, including companion diagnostic assay development. The company serves a global market through a network of distributors in various countries and has a direct online presence.

Kezar Life Sciences, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, focused on the discovery and development of small molecule therapeutics aimed at addressing unmet medical needs in autoimmunity and cancer. The company's lead product candidate, KZR-616, is a selective immunoproteasome inhibitor currently undergoing Phase 2 clinical trials for five autoimmune conditions, including lupus nephritis and autoimmune hemolytic anemia, as well as Phase 1b/2 trials in systemic lupus erythematosus. In addition to KZR-616, Kezar is developing KZR-261, which targets oncology and autoimmune indications. Founded in 2015, the company leverages innovative research in protein homeostasis and has established a pipeline of potential therapies to advance treatment options for patients.

Vigeo Therapeutics is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing innovative therapeutic agents for the treatment of advanced malignant tumors. Established in 2011, the company specializes in a first-in-class drug discovery pipeline that aims to reprogram the tumor immune microenvironment to enhance cancer treatment outcomes. One of its key products is a peptide fragment derived from the prosaposin protein, which inhibits metastasis and tumor growth by stimulating the production of an inhibitory molecule within the tumor microenvironment. Vigeo Therapeutics plans to initiate multiple combination studies to evaluate its lead candidate, VT1021, alongside chemotherapies and anti-PD-1 antibodies, with the goal of improving treatment options for various cancer types and enhancing patient quality of life.

Ark Biosciences Inc. is a biopharmaceutical company based in Shanghai, China, specializing in the discovery and development of therapeutics aimed at addressing unmet medical needs, particularly in the areas of respiratory viral infections and viral hepatitis. Founded in 2013, the company focuses on developing innovative treatments, including AK0701 for chronic obstructive pulmonary disease, AK0529 for respiratory syncytial virus, AK0612 for influenza, and AK0705 and AK0706 for hepatitis B. Ark Biosciences is committed to advancing antiviral drug research and development to serve both global and Chinese markets.

Aduro Biotech is a clinical-stage biopharmaceutical company focused on developing immunotherapies to harness the body's natural immune system for treating challenging diseases. Its pipeline includes ADU-S100, in Phase I/II trials for various solid tumors and head & neck cancer, and BION-1301, a monoclonal antibody in Phase I trial for IgA nephropathy.

Apellis Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing therapeutic compounds through inhibiting the complement system for treating autoimmune and inflammatory diseases. Its lead product candidate, pegcetacoplan, is in Phase III trials for geographic atrophy in age-related macular degeneration and paroxysmal nocturnal hemoglobinuria, among other indications.

InSilixa, Inc. is a biotechnology company based in Sunnyvale, California, specializing in the development of high-performance CMOS biochips for molecular diagnostics. Founded in 2011, the company aims to democratize access to diagnostic testing by offering low-cost, high-performance solutions for DNA and protein-based testing. InSilixa focuses on creating point-of-care and near-patient platforms that enhance the efficiency and accessibility of genomic testing, particularly for the diagnosis of infectious diseases. By leveraging its proprietary semiconductor technology, InSilixa seeks to provide mass-deployable diagnostic tools that improve healthcare outcomes. The team comprises industry veterans with diverse expertise in semiconductor technology, biotechnology, medicine, and informatics.

DNAtrix, Inc. is a clinical-stage biotechnology company based in Houston, Texas, with an additional office in San Diego, California. The company specializes in developing virus-driven immunotherapies for cancer treatment, focusing initially on glioblastoma, a highly aggressive and currently untreatable brain tumor. Its lead product, DNX-2401, is a modified oncolytic virus derived from a common cold virus, designed to selectively target and kill cancer cells. This innovative approach has shown promising results, with over 35 patients treated and positive early outcomes reported. In addition to DNX-2401, DNAtrix is advancing other candidates such as DNX-2440 and DNX-2450 for solid tumors, as well as MYX-135 for hematological malignancies. The company also has a strategic partnership with Valo Therapeutics, further enhancing its research and development capabilities in the field of cancer immunotherapy.

Aduro Biotech is a clinical-stage biopharmaceutical company focused on developing immunotherapies to harness the body's natural immune system for treating challenging diseases. Its pipeline includes ADU-S100, in Phase I/II trials for various solid tumors and head & neck cancer, and BION-1301, a monoclonal antibody in Phase I trial for IgA nephropathy.

Senhwa Biosciences, Inc. is a clinical-stage biopharmaceutical company based in New Taipei City, Taiwan, that focuses on identifying and developing innovative therapies for cancer treatment. Founded in 2012, the company is advancing several key drug candidates through clinical trials. These include CX-4945, which is being evaluated in combination with gemcitabine and cisplatin for cholangiocarcinoma, and CX-5461, which is undergoing phase I trials in patients with advanced hematologic malignancies and solid tumors, including breast cancer. Additionally, Senhwa is exploring CX-4945 in a pediatric brain tumor consortium for recurrent SHH medulloblastoma and basal cell carcinoma. The company aims to enhance treatment paradigms by leveraging validated therapeutic targets that have yet to be fully explored in clinical settings.

Argos Therapeutics is a biotechnology company specializing in developing immunotherapy treatments for cancer and infectious diseases. It focuses on personalized immunotherapies using its proprietary Arcelis technology platform, with product candidates including rocapuldencel-T for metastatic renal cell carcinoma and AGS-004 for HIV.

ASLAN Pharmaceuticals, established in 2010 and based in Singapore, is a clinical-stage biopharmaceutical company focused on immunology and oncology. It develops innovative treatments, including a monoclonal therapy for atopic dermatitis and a small molecule inhibitor for cancer, aiming to transform patients' lives. The company collaborates with prominent pharmaceutical partners and operates as a subsidiary of ASLAN Pharmaceuticals Limited.

Procarta Biosystems Ltd is a biotechnology company based in Norwich, United Kingdom, that specializes in the development of innovative DNA-based antibacterials. Founded in 2007 as a spin-out from the John Innes Centre, Procarta focuses on addressing the critical challenge of drug-resistant bacterial strains, commonly referred to as superbugs. The company has created a versatile platform for antibiotic development, which includes proprietary nanoparticles designed to deliver oligonucleotides directly into bacterial pathogens. Their product range features targeted therapies such as MRSA snare, a solution for both topical and intravenous use; Broad-spectrum Gram-negative therapy snare, aimed at treating hospital-acquired infections; and Cdiff snare, which helps prevent the recurrence of Clostridium difficile infections. With a commitment to combating the rising threat of antibiotic resistance, Procarta Biosystems is positioned to enhance therapeutic options in clinical settings.

Advanced Cell Diagnostics, Inc. is a biotechnology company specializing in the development and commercialization of cell and tissue-based diagnostic tests for personalized medicine. Founded in 2007 and based in Hayward, California, the company utilizes its proprietary RNAscope technology, a multiplex fluorescent and chromogenic in situ hybridization platform, to detect and quantify RNA biomarkers at single molecule sensitivity. Its product offerings include RNAscope manual assays and reagent kits, automated tissue staining solutions, catalog probes, and software for quantitative analysis of RNA in situ hybridization samples. Advanced Cell Diagnostics also provides pharmaceutical assay services to aid in understanding disease mechanisms and support preclinical and clinical research, including companion diagnostic assay development. The company serves a global market through a network of distributors in various countries and has a direct online presence.

Genocea Biosciences, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, focused on the discovery and development of innovative cancer immunotherapies and vaccines. Utilizing its proprietary ATLAS platform, the company profiles patient-specific CD4+ and CD8+ T cell immune responses to identify potential antigens in tumors. This technology enables Genocea to develop personalized immuno-oncology programs, including GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, as well as GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine program. Additionally, the company has pursued immunotherapies for other diseases, such as GEN-003, aimed at treating genital herpes, and it maintains a pre-clinical program focused on personalized cancer vaccines. Founded in 2006, Genocea is dedicated to addressing significant unmet medical needs through its advanced therapeutic approaches.

NuCana plc is a UK-based, clinical-stage biopharmaceutical company dedicated to developing innovative cancer treatments. It specializes in transforming widely-used chemotherapy agents into more effective and safer medicines using its proprietary ProTide technology. NuCana's pipeline includes Acelarin, in Phase III trials for biliary tract and metastatic pancreatic cancers, and NUC-3373 & NUC-7738, in Phase I trials for advanced solid tumors. The company collaborates with academic institutions for research and licensing agreements. NuCana was established in 1997 and is headquartered in Edinburgh, with a focus on the U.S. market.

Founded in 2006, Oxyrane UK Limited is a biopharmaceutical company based in Manchester, United Kingdom. It develops novel enzyme replacement therapies using its proprietary glycoengineering platform to treat lysosomal storage diseases.

Aduro Biotech is a clinical-stage biopharmaceutical company focused on developing immunotherapies to harness the body's natural immune system for treating challenging diseases. Its pipeline includes ADU-S100, in Phase I/II trials for various solid tumors and head & neck cancer, and BION-1301, a monoclonal antibody in Phase I trial for IgA nephropathy.

Genocea Biosciences, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, focused on the discovery and development of innovative cancer immunotherapies and vaccines. Utilizing its proprietary ATLAS platform, the company profiles patient-specific CD4+ and CD8+ T cell immune responses to identify potential antigens in tumors. This technology enables Genocea to develop personalized immuno-oncology programs, including GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, as well as GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine program. Additionally, the company has pursued immunotherapies for other diseases, such as GEN-003, aimed at treating genital herpes, and it maintains a pre-clinical program focused on personalized cancer vaccines. Founded in 2006, Genocea is dedicated to addressing significant unmet medical needs through its advanced therapeutic approaches.

Procarta Biosystems Ltd is a biotechnology company based in Norwich, United Kingdom, that specializes in the development of innovative DNA-based antibacterials. Founded in 2007 as a spin-out from the John Innes Centre, Procarta focuses on addressing the critical challenge of drug-resistant bacterial strains, commonly referred to as superbugs. The company has created a versatile platform for antibiotic development, which includes proprietary nanoparticles designed to deliver oligonucleotides directly into bacterial pathogens. Their product range features targeted therapies such as MRSA snare, a solution for both topical and intravenous use; Broad-spectrum Gram-negative therapy snare, aimed at treating hospital-acquired infections; and Cdiff snare, which helps prevent the recurrence of Clostridium difficile infections. With a commitment to combating the rising threat of antibiotic resistance, Procarta Biosystems is positioned to enhance therapeutic options in clinical settings.

Cylene Pharmaceuticals, Inc. is a biotech pharmaceutical company based in San Diego, California, focused on the discovery and development of small molecule drugs targeting cancer cells. The company specializes in nucleolus targeting agents, which are designed to provide targeted therapeutic solutions for carcinoid and neuroendocrine tumors as well as pediatric brain tumors. Additionally, Cylene develops serine/threonine protein kinase inhibitors and pre-clinical stage oral drug candidates. Established in 1997 as Cyternex, Inc., the company rebranded to Cylene Pharmaceuticals in October 2003. Its innovative approach aims to activate p53 through non-genotoxic pathways, offering improved treatment options for various cancer indications.

ProterixBio, Inc. is a biomedical company based in Billerica, Massachusetts, focused on developing disease management platforms for chronic respiratory diseases. The company specializes in proprietary blood-based biomarker tests aimed at transforming the management of conditions such as chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis. ProterixBio's ViBE platform, along with its Acoustic Membrane MicroParticle (AMMP) assays, facilitates the precise analysis of proteins in various sample types, delivering real-time biological assessments of a patient's disease state. This technological innovation enhances the sensitivity and specificity of traditional testing methods, allowing healthcare providers to make informed decisions that help reduce hospitalizations and improve patient outcomes, ultimately lowering healthcare costs. Founded in 2002, ProterixBio seeks to address the unmet needs in chronic care management through its advanced diagnostic capabilities.

OriGene Technologies, Inc. is a biotechnology company based in Rockville, Maryland, specializing in the development, manufacturing, and sale of genome-wide research and diagnostic products. Established in 1995, OriGene offers a comprehensive array of tools for academic, diagnostic, pharmaceutical, and biotech applications. Its product portfolio includes cDNA clones, shRNA and siRNA reagents, CRISPR/Cas9 genome editing tools, proteins, antibodies, and anatomic pathology products. Additionally, the company provides services such as gene synthesis, custom cloning, and assay development, supporting a variety of research areas including cancer biomarker research and stem cell research. OriGene's extensive resources aim to facilitate gene-based research, enabling researchers to validate antibodies and develop new drugs. The company's products are distributed globally through various channels, including online platforms.

Advanced Cell Diagnostics, Inc. is a biotechnology company specializing in the development and commercialization of cell and tissue-based diagnostic tests for personalized medicine. Founded in 2007 and based in Hayward, California, the company utilizes its proprietary RNAscope technology, a multiplex fluorescent and chromogenic in situ hybridization platform, to detect and quantify RNA biomarkers at single molecule sensitivity. Its product offerings include RNAscope manual assays and reagent kits, automated tissue staining solutions, catalog probes, and software for quantitative analysis of RNA in situ hybridization samples. Advanced Cell Diagnostics also provides pharmaceutical assay services to aid in understanding disease mechanisms and support preclinical and clinical research, including companion diagnostic assay development. The company serves a global market through a network of distributors in various countries and has a direct online presence.

BioVex Group is a biotechnology company specializing in the development and commercialization of biological treatments for cancer and infectious diseases. Its primary focus is OncoVEXGM-CSF, an oncolytic vaccine designed to target and destroy cancer cells while preserving surrounding healthy tissues. This innovative therapy utilizes a virus that replicates within solid tumors, leading to their destruction and stimulating a robust systemic immune response against the cancer. OncoVEXGM-CSF has undergone extensive clinical testing with over 110 patients across various solid tumors, including melanoma, head and neck cancer, breast cancer, and pancreatic cancer. The treatment has demonstrated significant efficacy, routinely eliminating tumors at the injection site and resulting in overall disease responses during Phase II trials. Additionally, BioVex is developing ImmunoVEXHSV2, a vaccine aimed at preventing genital herpes, further expanding its portfolio in biologic therapies.

Genocea Biosciences, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, focused on the discovery and development of innovative cancer immunotherapies and vaccines. Utilizing its proprietary ATLAS platform, the company profiles patient-specific CD4+ and CD8+ T cell immune responses to identify potential antigens in tumors. This technology enables Genocea to develop personalized immuno-oncology programs, including GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, as well as GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine program. Additionally, the company has pursued immunotherapies for other diseases, such as GEN-003, aimed at treating genital herpes, and it maintains a pre-clinical program focused on personalized cancer vaccines. Founded in 2006, Genocea is dedicated to addressing significant unmet medical needs through its advanced therapeutic approaches.

HD Biosciences Inc. is a biotechnology company based in Shanghai, specializing in contract research for drug discovery. As a subsidiary of WuXi PharmaTech, it offers a comprehensive suite of services including assay development, high-throughput drug screening, structure-activity relationship analysis, and hit-to-lead biology solutions. The company has developed advanced technology platforms for drug discovery and has established long-term research agreements with major pharmaceutical clients, including Pfizer and Organon. HD Biosciences is recognized as a leader in biology-based drug discovery services in China, providing a range of capabilities from hit identification to in vivo pharmacology, thereby supporting the development of innovative pharmaceutical and biotechnology solutions.