IndieBio, founded in 2014 and based in San Francisco, is the world’s first accelerator dedicated to startups that leverage biology to address significant global challenges. As part of SOSV, a global venture capital firm, IndieBio focuses on nurturing seed-stage and early-stage companies across various sectors, including healthcare, life sciences, biotechnology, and consumer products. The accelerator provides funding and support to innovative ventures aiming to create impactful solutions in areas such as pharmaceuticals, oncology, and advanced manufacturing. By fostering emerging technologies and biological applications, IndieBio plays a crucial role in advancing the next generation of startups that seek to make a positive difference in society.
AlkaLi Labs is a biotechnology research company based in San Francisco, California, established in 2023. The company focuses on developing biological solutions to harness domestic mineral resources. Currently operating in stealth mode, AlkaLi Labs aims to innovate in the field of biotechnology, leveraging biological processes to unlock valuable minerals.
Laguna Bio
Seed Round in 2024
Laguna Bio provides a drug discovery platform designed that activates and expands the innate immune system against cancer. It focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of a bispecific antibody drug. Laguna Biotherapeutics was founded in 2022 and is headquartered in Berkeley, California.
Sóliome
Seed Round in 2024
Sóliome is a Biotechnology company that develops protein-based sunscreens that are safe. The company was founded in 2021 and is based in San Francisco, California.
Finless Foods
Convertible Note in 2024
Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on growing marine-animal cells to create alternatives to traditional fish and seafood, including bluefin tuna. By offering a variety of responsibly produced food options, Finless Foods aims to cater to diverse tastes and dietary needs while promoting sustainability and better ocean health. The company's innovative approach provides consumers with healthy and accessible seafood alternatives, enabling them to maintain a balanced diet without compromising on flavor or variety.
California Cultured
Series A in 2024
California Cultured is a food company creating sustainable, lab-grown cocoa that is less bitter and requires less sugar to be tasty. It produces cocoa intended to provide cocoa that is less bitter and requires less sugar. The company's product entices cocoa cells to grow by stimulation by food ingredients that are found in any grocery store and produce cocoa cells that is good for human health, enabling customers to avail premium quality cocoa products. California Cultured was founded in 2020 and is headquartered in Davis, California.
Avisa Myko
Convertible Note in 2024
Avisa Myko Inc. is a biotechnology company based in San Francisco, California, specializing in the production of natural, water-soluble melanin. The company has developed a patented technology that allows for the large-scale and cost-effective manufacturing of melanin, which is used across various industries, including cosmetics, biomedicine, and environmental applications. Avisa Myko's melanin offers protection against ionizing radiation and is integrated into products such as latex, fabrics, laminated plastics, and glass. Additionally, the company is working on formulating a sunscreen that utilizes melanin as a natural ultraviolet blocker, eliminating the need for traditional chemical or mineral UV filters. By focusing on sustainable solutions, Avisa Myko aims to enhance human health and environmental safety through its innovative melanin products.
Zymochem
Series A in 2024
ZymoChem, Inc. is a biotechnology company based in Emeryville, California, founded in 2013. It specializes in the development of eco-friendly chemicals and bioprocesses using engineered microbes to convert renewable feedstocks, such as sugars, into industrial chemicals. The company’s bio-manufacturing platform aims to produce bio-based materials while minimizing carbon emissions during production, thereby supporting a carbon-efficient economy. By establishing cost-effective bioprocesses and novel biosynthetic pathways, ZymoChem enables clients to reduce production costs and enhance their competitiveness in the market. Through its innovative approach, the company contributes to sustainable manufacturing practices and the advancement of a real-zero economy.
Chronus Health
Convertible Note in 2024
Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.
Prellis Biologics
Series C in 2023
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
QuantumCyte
Series A in 2023
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
California Cultured
Convertible Note in 2023
California Cultured is a food company creating sustainable, lab-grown cocoa that is less bitter and requires less sugar to be tasty. It produces cocoa intended to provide cocoa that is less bitter and requires less sugar. The company's product entices cocoa cells to grow by stimulation by food ingredients that are found in any grocery store and produce cocoa cells that is good for human health, enabling customers to avail premium quality cocoa products. California Cultured was founded in 2020 and is headquartered in Davis, California.
AlkaLi Labs
Seed Round in 2023
AlkaLi Labs is a biotechnology research company based in San Francisco, California, established in 2023. The company focuses on developing biological solutions to harness domestic mineral resources. Currently operating in stealth mode, AlkaLi Labs aims to innovate in the field of biotechnology, leveraging biological processes to unlock valuable minerals.
Geltor
Convertible Note in 2023
Geltor, Inc. is a biodesign company based in San Leandro, California, that specializes in producing bioactive, animal-free collagens and proteins for various applications in beauty, nutrition, and wellness. Established in 2015, Geltor offers innovative products such as Collume, which promotes skincare cellular regeneration and dermal synthesis, and HumaColl21, which enhances skin health by boosting collagen and elastin levels. Additionally, the company provides vegan collagen peptides and other novel proteins designed for functional food and nutraceutical formulations. Geltor's products are sustainably cultivated and clinically validated, allowing businesses to create effective, plant-based solutions that contribute to a more sustainable future.
Stämm Biotech
Series B in 2023
Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.
DNALite Therapeutics
Convertible Note in 2023
DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, DNALite utilizes innovative oral lipid nanoparticle technology to deliver mRNA and pDNA directly to intestinal stem cells. This approach targets the underlying causes of diseases such as Familial Adenomatous Polyposis, a hereditary form of colorectal cancer that often necessitates invasive surgeries in adolescents. By enabling the intestinal tract to secrete therapeutic proteins into the bloodstream, DNALite aims to transform conventional protein biologics into oral medications, potentially improving patient outcomes and accessibility to treatment.
Michroma
Seed Round in 2023
Michroma Corporation is a biotechnology company that specializes in producing natural thermostable colorants derived from filamentous fungi through a fermentation process. Founded in 2019 and based in both San Francisco, California, and Rosario, Argentina, Michroma aims to replace synthetic pigments and those sourced from animals and plants with sustainable, naturally produced alternatives. The company harnesses synthetic biology to develop proprietary fungal strains that generate high-performance ingredients in bioreactors. Currently, Michroma is prototyping its innovative pH-stable and heat-stable food colorants in collaboration with leading food and beverage and cosmetic companies. Additionally, the company is exploring the production of mycoprotein and other ingredients, making strides in the sustainable ingredients market.
Prolific Machines
Convertible Note in 2022
Prolific Machines is a biotechnology company based in San Francisco, California, founded in 2020. It specializes in developing advanced cell technologies aimed at transforming the production of cells for sustainable applications, particularly in the cultivated meat industry. The company focuses on high-scale precision cell-differentiation techniques that enhance the efficiency, quality, reproducibility, and sustainability of cell production. Additionally, Prolific Machines is engaged in research and development efforts related to clean meat and cell therapies, utilizing innovative approaches to create better sustainable options. Through its work, the company aims to promote a healthier future for both humanity and the planet.
Aja Labs
Seed Round in 2022
Aja Labs is a biotechnology company founded in 2019 and based in San Francisco, California. The company specializes in producing biodegradable fiber designed to replace plastic-based fibers. By utilizing plant materials, Aja Labs creates fiber that mimics the appearance and texture of human hair, providing a sustainable alternative to chemical-laden synthetic fibers and human hair in the production of hair extensions. Aja Labs aims to offer innovative solutions that cater to diverse communities while promoting environmental sustainability.
OneSkin
Venture Round in 2022
OneSkin Inc. is a biotechnology company focused on developing innovative solutions to enhance skin health and combat aging. Founded by a team of PhDs and longevity scientists, the company has created a proprietary peptide, OS-01, which has been validated to reduce the biological age of skin by minimizing the accumulation of aged cells, enhancing cellular repair, and fortifying the epidermal barrier. OneSkin offers a flagship product, the OS-01 Topical Supplement, which is designed to be suitable for all skin types and is made from high-quality vegan ingredients. In addition to its product line, OneSkin specializes in creating advanced 3D human skin models for research and testing purposes, providing in vitro services to assess the efficacy and safety of cosmetic ingredients without the use of animals. Incorporated in 2016 and based in San Francisco, OneSkin is dedicated to advancing the understanding of skin biology and developing effective anti-aging solutions.
Michroma
Seed Round in 2022
Michroma Corporation is a biotechnology company that specializes in producing natural thermostable colorants derived from filamentous fungi through a fermentation process. Founded in 2019 and based in both San Francisco, California, and Rosario, Argentina, Michroma aims to replace synthetic pigments and those sourced from animals and plants with sustainable, naturally produced alternatives. The company harnesses synthetic biology to develop proprietary fungal strains that generate high-performance ingredients in bioreactors. Currently, Michroma is prototyping its innovative pH-stable and heat-stable food colorants in collaboration with leading food and beverage and cosmetic companies. Additionally, the company is exploring the production of mycoprotein and other ingredients, making strides in the sustainable ingredients market.
Laguna Bio
Seed Round in 2022
Laguna Bio provides a drug discovery platform designed that activates and expands the innate immune system against cancer. It focuses on providing a specific type of T cell for the immune system to fight solid tumors by increasing the response rate of a bispecific antibody drug. Laguna Biotherapeutics was founded in 2022 and is headquartered in Berkeley, California.
Melio
Seed Round in 2022
Melio is a healthcare company based in Santa Clara, California, specializing in blood testing technology aimed at detecting prevalent infections. The company has developed a comprehensive blood test platform that identifies common pathogens responsible for bloodstream infections. Utilizing a patented melting technique followed by detailed analysis, Melio's technology enables quick and accurate identification of blood-based pathogens. This innovation allows healthcare providers to deliver timely and targeted treatment, addressing the urgent need for effective therapies while also contributing to the fight against antibiotic resistance.
Prellis Biologics
Series C in 2022
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
SyntheX
Convertible Note in 2022
SyntheX, Inc. is a biotechnology company based in San Francisco, California, that specializes in drug discovery focused on therapeutic applications, particularly in oncology. Founded in 2016, SyntheX employs a proprietary screening platform that utilizes synthetic biology to expand the druggable proteome. This platform enables the identification of protein interaction modulators through empirical intracellular selection, allowing for the discovery of compounds that can disrupt specific protein-protein interactions or facilitate functional protein degradation. The company's development portfolio includes stabilized peptide therapeutics, such as STX101 and STX105, aimed at treating cancers that utilize homologous recombination for chemotherapy evasion. SyntheX's approach integrates advanced technologies and engineered circuits to create a robust internal pipeline targeting genetically validated therapeutic mechanisms, while also engaging in external discovery collaborations.
BioLumen
Convertible Note in 2022
BioLumen is a nutritional technology company that develops a patented dietary fiber technology platform that reduces the negative effect of a diet heavy in processed foods. BioLumen's technology is composed of insoluble dietary fiber matrix covered with a blend of food ingredients created from the latest drug delivery system research. The company's product, a nutraceutical, focuses on high risk individuals with prediabetes to help manage blood sugar levels, protect their liver from excess sugar and feed their gut microbiome, delivering health benefits. BioLumen was founded on 2018 and is headquartered in San Francisco, California.
UPSIDE Foods
Series C in 2022
UPSIDE Foods, founded in 2015 and based in Berkeley, California, specializes in the production of cultivated meat derived directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach allows the company to offer real meat, poultry, and seafood while significantly reducing the resource consumption typically associated with conventional meat production, including water, land, and energy. UPSIDE Foods focuses on creating products such as beef meatballs, chicken, and duck, all grown in controlled environments. The company's mission is to provide consumers with clean, humane, and sustainable food options, free from harmful chemicals.
DNALite Therapeutics
Venture Round in 2022
DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, DNALite utilizes innovative oral lipid nanoparticle technology to deliver mRNA and pDNA directly to intestinal stem cells. This approach targets the underlying causes of diseases such as Familial Adenomatous Polyposis, a hereditary form of colorectal cancer that often necessitates invasive surgeries in adolescents. By enabling the intestinal tract to secrete therapeutic proteins into the bloodstream, DNALite aims to transform conventional protein biologics into oral medications, potentially improving patient outcomes and accessibility to treatment.
Finless Foods
Series B in 2022
Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on growing marine-animal cells to create alternatives to traditional fish and seafood, including bluefin tuna. By offering a variety of responsibly produced food options, Finless Foods aims to cater to diverse tastes and dietary needs while promoting sustainability and better ocean health. The company's innovative approach provides consumers with healthy and accessible seafood alternatives, enabling them to maintain a balanced diet without compromising on flavor or variety.
QuantumCyte
Convertible Note in 2022
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
Avisa Myko
Convertible Note in 2022
Avisa Myko Inc. is a biotechnology company based in San Francisco, California, specializing in the production of natural, water-soluble melanin. The company has developed a patented technology that allows for the large-scale and cost-effective manufacturing of melanin, which is used across various industries, including cosmetics, biomedicine, and environmental applications. Avisa Myko's melanin offers protection against ionizing radiation and is integrated into products such as latex, fabrics, laminated plastics, and glass. Additionally, the company is working on formulating a sunscreen that utilizes melanin as a natural ultraviolet blocker, eliminating the need for traditional chemical or mineral UV filters. By focusing on sustainable solutions, Avisa Myko aims to enhance human health and environmental safety through its innovative melanin products.
Sóliome
Seed Round in 2022
Sóliome is a Biotechnology company that develops protein-based sunscreens that are safe. The company was founded in 2021 and is based in San Francisco, California.
Sóliome
Convertible Note in 2022
Sóliome is a Biotechnology company that develops protein-based sunscreens that are safe. The company was founded in 2021 and is based in San Francisco, California.
Zymochem
Seed Round in 2021
ZymoChem, Inc. is a biotechnology company based in Emeryville, California, founded in 2013. It specializes in the development of eco-friendly chemicals and bioprocesses using engineered microbes to convert renewable feedstocks, such as sugars, into industrial chemicals. The company’s bio-manufacturing platform aims to produce bio-based materials while minimizing carbon emissions during production, thereby supporting a carbon-efficient economy. By establishing cost-effective bioprocesses and novel biosynthetic pathways, ZymoChem enables clients to reduce production costs and enhance their competitiveness in the market. Through its innovative approach, the company contributes to sustainable manufacturing practices and the advancement of a real-zero economy.
Lingrove
Series A in 2021
Lingrove, LLC is a manufacturer of bio-composite materials based in San Francisco, California, founded in 2014. The company specializes in high-performance natural fiber composites made from plant-based materials, utilizing a proprietary process to create products that mimic the appearance and properties of wood. Its flagship product, Ekoa, combines flax linen fibers with resin derived from industrial waste, and is primarily used in the production of musical instruments, as well as in the furniture, transportation, and construction industries. Lingrove aims to address the challenges posed by diminishing wood supplies and seeks to reduce deforestation and the carbon footprint associated with the built environment by offering sustainable, carbon-negative alternatives.
New Culture
Series A in 2021
New Culture is a food and beverage company based in San Francisco, California, founded in 2018. The company specializes in producing animal-free cheese using innovative methods that involve microflora to create dairy proteins. By focusing on sustainable and ethical practices, New Culture aims to revolutionize the cheese-making process, offering a variety of delicious and healthy cheese alternatives. Their products are designed to reduce dependency on animal agriculture while providing consumers with access to nutritious dairy-like options.
Sundial Foods
Seed Round in 2021
Sundial Foods utilizes a macro and microstructural engineering approach to create plant-based meat alternatives for conscious consumers. The company is passionate about making the affordable, accessible, and nutritional value of plant-based meats, made from ingredients that customers know and created using simple processes. It is headquartered in Berkeley, California in 2019.
Prothegen
Convertible Note in 2021
Prothegen is a biotechnology company located in Palo Alto, California, focused on developing innovative medicines that precisely regulate cell death. The company has created a platform aimed at delivering therapies that can inhibit or promote ferroptosis, a form of regulated cell death. By targeting this process, Prothegen seeks to provide effective therapeutic options for patients, enhancing the treatment of conditions associated with uncontrolled cell death.
California Cultured
Seed Round in 2021
California Cultured is a food company creating sustainable, lab-grown cocoa that is less bitter and requires less sugar to be tasty. It produces cocoa intended to provide cocoa that is less bitter and requires less sugar. The company's product entices cocoa cells to grow by stimulation by food ingredients that are found in any grocery store and produce cocoa cells that is good for human health, enabling customers to avail premium quality cocoa products. California Cultured was founded in 2020 and is headquartered in Davis, California.
Indee Labs
Convertible Note in 2021
Indee Labs specializes in developing innovative hardware for gene delivery, focusing on a non-viral intracellular delivery system. This technology facilitates the efficient development and scalable manufacture of gene-modified cell therapies, including chimeric antigen receptor T cells. By employing microfluidic vortex shedding, the system enables the gentle delivery of constructs such as nucleic acids, proteins, and gene-editing complexes to a variety of cell types, ensuring maximum recovery of viable, modified cells with minimal disruption. Indee Labs collaborates with the Australian National Fabrication Facility and has established its presence with offices in Sydney and lab space at Bonneville Labs in Berkeley. The company is recognized for its contributions to the field, having affiliations with NSW Health, IndieBio, Y Combinator, and MBC Biolabs.
Khepra
Seed Round in 2021
Khepra is a company based in San Francisco, California, that focuses on transforming plastics and agricultural waste into renewable fuels using innovative technology. The company employs a proprietary process that combines ultrasonic technology, frictive heating, cavitation, and acoustic pressure to efficiently break down waste streams. This method utilizes excess renewable electricity generated from solar and wind sources, particularly during times of low energy generation or curtailment. By converting waste into drop-in fuels and renewable chemicals without extraction, Khepra aims to support industries in their transition towards cleaner energy solutions and promote sustainability.
Finless Foods
Convertible Note in 2021
Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on growing marine-animal cells to create alternatives to traditional fish and seafood, including bluefin tuna. By offering a variety of responsibly produced food options, Finless Foods aims to cater to diverse tastes and dietary needs while promoting sustainability and better ocean health. The company's innovative approach provides consumers with healthy and accessible seafood alternatives, enabling them to maintain a balanced diet without compromising on flavor or variety.
Filtricine
Seed Round in 2021
Filtricine, Inc. is a venture-backed, clinical stage biotech company based in Santa Clara, CA. We are developing a nutrient modulation platform which can identify metabolic vulnerabilities in cancers and exploit those vulnerabilities without the use of drugs.
QuantumCyte
Convertible Note in 2021
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
Stämm Biotech
Convertible Note in 2021
Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.
Sundial Foods
Convertible Note in 2021
Sundial Foods utilizes a macro and microstructural engineering approach to create plant-based meat alternatives for conscious consumers. The company is passionate about making the affordable, accessible, and nutritional value of plant-based meats, made from ingredients that customers know and created using simple processes. It is headquartered in Berkeley, California in 2019.
Sundial Foods
Seed Round in 2021
Sundial Foods utilizes a macro and microstructural engineering approach to create plant-based meat alternatives for conscious consumers. The company is passionate about making the affordable, accessible, and nutritional value of plant-based meats, made from ingredients that customers know and created using simple processes. It is headquartered in Berkeley, California in 2019.
DNALite Therapeutics
Convertible Note in 2021
DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, DNALite utilizes innovative oral lipid nanoparticle technology to deliver mRNA and pDNA directly to intestinal stem cells. This approach targets the underlying causes of diseases such as Familial Adenomatous Polyposis, a hereditary form of colorectal cancer that often necessitates invasive surgeries in adolescents. By enabling the intestinal tract to secrete therapeutic proteins into the bloodstream, DNALite aims to transform conventional protein biologics into oral medications, potentially improving patient outcomes and accessibility to treatment.
Prolific Machines
Seed Round in 2021
Prolific Machines is a biotechnology company based in San Francisco, California, founded in 2020. It specializes in developing advanced cell technologies aimed at transforming the production of cells for sustainable applications, particularly in the cultivated meat industry. The company focuses on high-scale precision cell-differentiation techniques that enhance the efficiency, quality, reproducibility, and sustainability of cell production. Additionally, Prolific Machines is engaged in research and development efforts related to clean meat and cell therapies, utilizing innovative approaches to create better sustainable options. Through its work, the company aims to promote a healthier future for both humanity and the planet.
Chronus Health
Convertible Note in 2021
Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.
Aja Labs
Seed Round in 2021
Aja Labs is a biotechnology company founded in 2019 and based in San Francisco, California. The company specializes in producing biodegradable fiber designed to replace plastic-based fibers. By utilizing plant materials, Aja Labs creates fiber that mimics the appearance and texture of human hair, providing a sustainable alternative to chemical-laden synthetic fibers and human hair in the production of hair extensions. Aja Labs aims to offer innovative solutions that cater to diverse communities while promoting environmental sustainability.
Dalton Bioanalytics
Convertible Note in 2021
Dalton Bioanalytics is a developer of analytical technology that unlocks access to the wealth of information available in the blood. It resolves the inefficiency and expense that plagues traditional laboratory testing by digitizing the biochemical composition of blood and translating that digital signature into a comprehensive array of actionable health insights. The analytical technology deciphers the biochemical signature of blood to build narratives about internal biology. Dalton was headquartered in Los Angeles, California in 2019.
Lingrove
Convertible Note in 2021
Lingrove, LLC is a manufacturer of bio-composite materials based in San Francisco, California, founded in 2014. The company specializes in high-performance natural fiber composites made from plant-based materials, utilizing a proprietary process to create products that mimic the appearance and properties of wood. Its flagship product, Ekoa, combines flax linen fibers with resin derived from industrial waste, and is primarily used in the production of musical instruments, as well as in the furniture, transportation, and construction industries. Lingrove aims to address the challenges posed by diminishing wood supplies and seeks to reduce deforestation and the carbon footprint associated with the built environment by offering sustainable, carbon-negative alternatives.
Microgenesis
Convertible Note in 2021
Microgenesis is a biotechnology company focused on improving fertility and pregnancy health through innovative diagnostic and treatment solutions. It offers a non-invasive fertility test that identifies subclinical inflammation affecting ovarian function and implantation, particularly beneficial for women who have experienced multiple IVF failures. The company's personalized nutritional supplementation aims to restore fertility potential in women, utilizing all-natural and drug-free methods. Operating out of a CLIA-certified lab in Oakland, Microgenesis is expanding its services to obstetricians and gynecologists, as well as direct-to-consumer markets. In addition to its fertility test, the company provides tools to analyze microbiota imbalances linked to infertility and immunological issues, thus addressing complex reproductive health cases comprehensively.
Synthetix
Convertible Note in 2020
Synthetix is a decentralized protocol based on the Ethereum blockchain that facilitates the issuance of synthetic assets for derivatives trading in decentralized finance (DeFi). Founded in 2017 by Kain Warwick in Sydney, Australia, Synthetix enables users to create and trade synthetic assets that provide exposure to various real-world assets, including currencies, commodities, stocks, and indices. The platform supports a range of financial products such as perpetual futures and options markets, allowing for peer-to-contract trading with infinite liquidity. Synthetix operates through a distributed collateral pool, ensuring users can access synthetic versions of both fiat and cryptocurrencies while maintaining an overview of the entire network.
Finless Foods
Series A in 2020
Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on growing marine-animal cells to create alternatives to traditional fish and seafood, including bluefin tuna. By offering a variety of responsibly produced food options, Finless Foods aims to cater to diverse tastes and dietary needs while promoting sustainability and better ocean health. The company's innovative approach provides consumers with healthy and accessible seafood alternatives, enabling them to maintain a balanced diet without compromising on flavor or variety.
OneSkin
Seed Round in 2020
OneSkin Inc. is a biotechnology company focused on developing innovative solutions to enhance skin health and combat aging. Founded by a team of PhDs and longevity scientists, the company has created a proprietary peptide, OS-01, which has been validated to reduce the biological age of skin by minimizing the accumulation of aged cells, enhancing cellular repair, and fortifying the epidermal barrier. OneSkin offers a flagship product, the OS-01 Topical Supplement, which is designed to be suitable for all skin types and is made from high-quality vegan ingredients. In addition to its product line, OneSkin specializes in creating advanced 3D human skin models for research and testing purposes, providing in vitro services to assess the efficacy and safety of cosmetic ingredients without the use of animals. Incorporated in 2016 and based in San Francisco, OneSkin is dedicated to advancing the understanding of skin biology and developing effective anti-aging solutions.
Advanced Microbubbles
Convertible Note in 2020
Advanced Microbubbles Inc specializes in developing microbubbles as ultrasound contrast agents for targeted drug delivery, particularly in overcoming significant biological barriers like the blood-brain barrier and tumor endothelium. Founded in 2020 and based in Newark, California, the company offers a range of products including size-isolated microbubbles, polydisperse microbubbles, and biotin- or streptavidin-tagged variants. These microbubbles are agitated with ultrasound at the tumor site, facilitating the local delivery of drugs by temporarily opening barriers that typically hinder treatment. By enabling more effective drug delivery, Advanced Microbubbles aims to reduce side effects and improve survival outcomes for patients with various neurological conditions and cancer.
Khepra
Convertible Note in 2020
Khepra is a company based in San Francisco, California, that focuses on transforming plastics and agricultural waste into renewable fuels using innovative technology. The company employs a proprietary process that combines ultrasonic technology, frictive heating, cavitation, and acoustic pressure to efficiently break down waste streams. This method utilizes excess renewable electricity generated from solar and wind sources, particularly during times of low energy generation or curtailment. By converting waste into drop-in fuels and renewable chemicals without extraction, Khepra aims to support industries in their transition towards cleaner energy solutions and promote sustainability.
Khepra
Seed Round in 2020
Khepra is a company based in San Francisco, California, that focuses on transforming plastics and agricultural waste into renewable fuels using innovative technology. The company employs a proprietary process that combines ultrasonic technology, frictive heating, cavitation, and acoustic pressure to efficiently break down waste streams. This method utilizes excess renewable electricity generated from solar and wind sources, particularly during times of low energy generation or curtailment. By converting waste into drop-in fuels and renewable chemicals without extraction, Khepra aims to support industries in their transition towards cleaner energy solutions and promote sustainability.
Dalton Bioanalytics
Convertible Note in 2020
Dalton Bioanalytics is a developer of analytical technology that unlocks access to the wealth of information available in the blood. It resolves the inefficiency and expense that plagues traditional laboratory testing by digitizing the biochemical composition of blood and translating that digital signature into a comprehensive array of actionable health insights. The analytical technology deciphers the biochemical signature of blood to build narratives about internal biology. Dalton was headquartered in Los Angeles, California in 2019.
Prellis Biologics
Convertible Note in 2020
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
Circularis Biotechnologies
Seed Round in 2020
Circularis Biotechnologies, Inc. is a biotechnology company focused on developing innovative methods to regulate gene expression, aiming to enhance the production yields of biotherapeutics. Founded in 2014 and based in Oakland, California, the company offers a range of products and services, including RACRE Variant Libraries, hCMV Variant Library, Protein expression with CMV promoters, and T7 Variant Library. Additionally, Circularis provides services such as RACRE Enhancement, RACRE Discovery, RACRE Technology Access Program, and Ribozyme Analysis of Cis-Regulatory Elements. Through its technology, Circularis Biotechnologies seeks to advance the capabilities of biotherapeutic production in the industry.
CASPR Biotech
Seed Round in 2020
CASPR Biotech, founded in 2018 and located in San Francisco, California, specializes in the development of a CRISPR-based platform for diagnosing antimicrobial resistances (AMR) and infectious diseases. The company creates portable diagnostic kits that enable the detection of specific DNA and RNA sequences, as well as signature amino acid sequences associated with infectious diseases and genetic mutations. These kits aim to provide healthcare professionals with a simple, rapid, and cost-effective solution for molecular detection, enhancing the accuracy and efficiency of clinical diagnostics.
CASPR Biotech
Convertible Note in 2020
CASPR Biotech, founded in 2018 and located in San Francisco, California, specializes in the development of a CRISPR-based platform for diagnosing antimicrobial resistances (AMR) and infectious diseases. The company creates portable diagnostic kits that enable the detection of specific DNA and RNA sequences, as well as signature amino acid sequences associated with infectious diseases and genetic mutations. These kits aim to provide healthcare professionals with a simple, rapid, and cost-effective solution for molecular detection, enhancing the accuracy and efficiency of clinical diagnostics.
UPSIDE Foods
Series B in 2020
UPSIDE Foods, founded in 2015 and based in Berkeley, California, specializes in the production of cultivated meat derived directly from animal cells, eliminating the need to raise and slaughter animals. This innovative approach allows the company to offer real meat, poultry, and seafood while significantly reducing the resource consumption typically associated with conventional meat production, including water, land, and energy. UPSIDE Foods focuses on creating products such as beef meatballs, chicken, and duck, all grown in controlled environments. The company's mission is to provide consumers with clean, humane, and sustainable food options, free from harmful chemicals.
Chronus Health
Seed Round in 2020
Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.
Primitives
Convertible Note in 2019
Primitives is a public benefit company based in San Francisco, California, specializing in the engineering of advanced biomaterials aimed at mitigating food waste and plastic pollution. The company focuses on manufacturing biodegradable plastics that are designed to help users reduce their environmental impact. Primitives develops environmentally sustainable materials that can be adapted for various applications, producing bioplastic products with innovative properties such as advanced sensing, display capabilities, and enhanced biodegradation. Through its efforts, Primitives seeks to provide effective solutions for businesses looking to address the challenges of plastic pollution.
Primitives
Seed Round in 2019
Primitives is a public benefit company based in San Francisco, California, specializing in the engineering of advanced biomaterials aimed at mitigating food waste and plastic pollution. The company focuses on manufacturing biodegradable plastics that are designed to help users reduce their environmental impact. Primitives develops environmentally sustainable materials that can be adapted for various applications, producing bioplastic products with innovative properties such as advanced sensing, display capabilities, and enhanced biodegradation. Through its efforts, Primitives seeks to provide effective solutions for businesses looking to address the challenges of plastic pollution.
BioLumen
Seed Round in 2019
BioLumen is a nutritional technology company that develops a patented dietary fiber technology platform that reduces the negative effect of a diet heavy in processed foods. BioLumen's technology is composed of insoluble dietary fiber matrix covered with a blend of food ingredients created from the latest drug delivery system research. The company's product, a nutraceutical, focuses on high risk individuals with prediabetes to help manage blood sugar levels, protect their liver from excess sugar and feed their gut microbiome, delivering health benefits. BioLumen was founded on 2018 and is headquartered in San Francisco, California.
Michroma
Seed Round in 2019
Michroma Corporation is a biotechnology company that specializes in producing natural thermostable colorants derived from filamentous fungi through a fermentation process. Founded in 2019 and based in both San Francisco, California, and Rosario, Argentina, Michroma aims to replace synthetic pigments and those sourced from animals and plants with sustainable, naturally produced alternatives. The company harnesses synthetic biology to develop proprietary fungal strains that generate high-performance ingredients in bioreactors. Currently, Michroma is prototyping its innovative pH-stable and heat-stable food colorants in collaboration with leading food and beverage and cosmetic companies. Additionally, the company is exploring the production of mycoprotein and other ingredients, making strides in the sustainable ingredients market.
Dalton Bioanalytics
Seed Round in 2019
Dalton Bioanalytics is a developer of analytical technology that unlocks access to the wealth of information available in the blood. It resolves the inefficiency and expense that plagues traditional laboratory testing by digitizing the biochemical composition of blood and translating that digital signature into a comprehensive array of actionable health insights. The analytical technology deciphers the biochemical signature of blood to build narratives about internal biology. Dalton was headquartered in Los Angeles, California in 2019.
Pando Nutrition
Seed Round in 2019
Pando Nutrition, Inc. is an animal microbiome company focused on developing innovative probiotics to support antibiotic-free livestock production. Based in San Francisco, California, and incorporated in 2017, the company aims to address the antibiotic resistance crisis by utilizing genetically engineered probiotics that enhance livestock health and performance without relying on medically significant drugs. Pando Nutrition offers Panbiotics, a platform designed to identify and control methane emissions, thereby improving feed efficiency and profitability in livestock. Additionally, the company is engaged in the development of solutions for poultry pathogens, such as Coccidiosis. By leveraging advanced biotechnology, Pando Nutrition creates yeast-based systems for animal feed that not only boost animal health and immunity but also enable the production of essential nutrients, contributing to a sustainable and efficient food supply chain.
Dahlia Biosciences
Convertible Note in 2019
Dahlia Biosciences is a biotechnology company based in California, founded in 2011. It focuses on DNA analysis and diagnostics, specializing in single-cell RNA analysis tools that are applicable for both research and diagnostic purposes. The company develops RNA detection tools utilizing CRISPR-Cas9 technology, which allows for the detection of multiple DNA and RNA biomarkers directly within cells and tissues. This innovative approach enables scientists to study and isolate cells with high precision and resolution, facilitating advancements in precision medicine research.
Stämm Biotech
Seed Round in 2019
Stämm Biotech is a San Francisco-based company specializing in advanced bioproduction systems designed to address the scaling challenges in the biotech industry. Founded in 2014, Stämm has developed an innovative biomanufacturing solution that integrates microfluidics, electroporation, and robotics, resulting in a compact, all-in-one Bioprocessor. This system has demonstrated productivity levels at least 70 times greater than traditional bioreactors, enabling clients to miniaturize bioreactors and optimize conditions more efficiently. Stämm's technology incorporates various sensors to monitor biological, physical, and chemical variations throughout the bioprocess, facilitating a streamlined approach to microbial growth and monoclonal cell line development. By transforming large-scale biotech operations into a more manageable micro-factory network, Stämm aims to unlock significant market potential in the coming years.
DNALite Therapeutics
Seed Round in 2019
DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, DNALite utilizes innovative oral lipid nanoparticle technology to deliver mRNA and pDNA directly to intestinal stem cells. This approach targets the underlying causes of diseases such as Familial Adenomatous Polyposis, a hereditary form of colorectal cancer that often necessitates invasive surgeries in adolescents. By enabling the intestinal tract to secrete therapeutic proteins into the bloodstream, DNALite aims to transform conventional protein biologics into oral medications, potentially improving patient outcomes and accessibility to treatment.
QuantumCyte
Convertible Note in 2019
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
Chronus Health
Seed Round in 2019
Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.
The EVERY Company
Series B in 2019
The EVERY Company is the market leader in engineering, manufacturing and formulating animal-free, animal proteins as ingredients for the global food and beverage industry. Leveraging advanced fermentation to produce functional and nutritional proteins from microorganisms, the Company is reimagining the factory farm model that underpins industrial animal agriculture with a more sustainable, kinder, and healthier alternative. Clara Foods is on a mission to decouple the world's most powerful proteins from the animals that make them.
New Culture
Pre Seed Round in 2019
New Culture is a food and beverage company based in San Francisco, California, founded in 2018. The company specializes in producing animal-free cheese using innovative methods that involve microflora to create dairy proteins. By focusing on sustainable and ethical practices, New Culture aims to revolutionize the cheese-making process, offering a variety of delicious and healthy cheese alternatives. Their products are designed to reduce dependency on animal agriculture while providing consumers with access to nutritious dairy-like options.
Prellis Biologics
Series A in 2019
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
CASPR Biotech
Pre Seed Round in 2019
CASPR Biotech, founded in 2018 and located in San Francisco, California, specializes in the development of a CRISPR-based platform for diagnosing antimicrobial resistances (AMR) and infectious diseases. The company creates portable diagnostic kits that enable the detection of specific DNA and RNA sequences, as well as signature amino acid sequences associated with infectious diseases and genetic mutations. These kits aim to provide healthcare professionals with a simple, rapid, and cost-effective solution for molecular detection, enhancing the accuracy and efficiency of clinical diagnostics.
Guided Clarity
Seed Round in 2019
Guided Clarity, Inc. is a biotechnology company based in San Francisco, California, established in 2018. The company specializes in the development and manufacturing of bioactive peptides aimed at promoting mitochondrial health, particularly for the aging population. Its product line includes medical foods that isolate specific bioactive proteins known for their potential to renew mitochondrial function. Guided Clarity is focused on addressing the health needs associated with aging through innovative nutritional solutions.
Filtricine
Seed Round in 2018
Filtricine, Inc. is a venture-backed, clinical stage biotech company based in Santa Clara, CA. We are developing a nutrient modulation platform which can identify metabolic vulnerabilities in cancers and exploit those vulnerabilities without the use of drugs.
Dahlia Biosciences
Convertible Note in 2018
Dahlia Biosciences is a biotechnology company based in California, founded in 2011. It focuses on DNA analysis and diagnostics, specializing in single-cell RNA analysis tools that are applicable for both research and diagnostic purposes. The company develops RNA detection tools utilizing CRISPR-Cas9 technology, which allows for the detection of multiple DNA and RNA biomarkers directly within cells and tissues. This innovative approach enables scientists to study and isolate cells with high precision and resolution, facilitating advancements in precision medicine research.
Convalesce
Seed Round in 2018
Convalesce Inc. is a therapeutic company based in San Francisco, California, focused on developing stem cell-based therapies for neurodegenerative conditions, particularly Parkinson's disease. Founded in 2018, Convalesce utilizes advanced biomaterials to enhance the efficacy of stem cell treatments. Their innovative implantable biomaterials aim to improve stem cell survival and facilitate the differentiation of these cells into neurons after implantation. By addressing critical challenges in stem cell therapy, Convalesce seeks to enable healthcare professionals to regenerate neuronal networks lost due to degeneration, ultimately offering new hope for patients suffering from debilitating neurological disorders.
Chronus Health
Seed Round in 2018
Chronus Health, Inc. is a company that specializes in developing a portable diagnostic platform aimed at delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and based in Mountain View, California, the company's innovative system utilizes microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time test results. This capability allows for immediate diagnosis at the point of care, enhancing the efficiency of treatment and significantly improving patient outcomes. By enabling doctors to obtain lab results in minutes, Chronus Health facilitates timely decision-making in clinical settings.
Filtricine
Pre Seed Round in 2018
Filtricine, Inc. is a venture-backed, clinical stage biotech company based in Santa Clara, CA. We are developing a nutrient modulation platform which can identify metabolic vulnerabilities in cancers and exploit those vulnerabilities without the use of drugs.
QuantumCyte
Convertible Note in 2018
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
Prellis Biologics
Convertible Note in 2018
Prellis Biologics, Inc. specializes in creating human tissues for drug development and the eventual production of human organs for transplantation. Founded in 2016 and based in San Francisco, California, the company employs advanced bioprinting technology to develop vascularized human tissues and organs, aiming to overcome the challenges associated with microvasculature. Its innovative products include TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X. Prellis Biologics also focuses on accurately replicating the human immune response through lymph node organoids, which can be utilized for various applications such as antibody discovery and immunogenicity assessment. By addressing critical issues in early-stage drug development and translational pharmacology, Prellis Biologics seeks to improve patient outcomes in healthcare.
Prime Roots
Pre Seed Round in 2017
Prime Roots is a San Francisco-based company founded in 2017 that specializes in plant-based food products, particularly meat and seafood alternatives. Utilizing koji mycelium, the company creates vegetarian offerings such as salmon burgers that replicate the taste, texture, and nutrition of traditional meat and seafood. By leveraging natural koji proteins, Prime Roots aims to reduce the reliance on carbon-intensive animal agriculture, providing both meat-eaters and vegans with protein-rich and sustainable food options. In addition to its product offerings, the company also organizes food events for its members.
Mezomax
Seed Round in 2017
MezoMax, Inc. is a biotechnology company based in San Francisco, California, founded in 2017. It specializes in developing oral therapies for nonhealing fractures and bone-related diseases, focusing on enhancing fracture healing and treating osteoporosis, particularly in elderly patients. The company’s innovative product features a novel calcium gluconate stereoisomer that regulates calcium and mineral metabolism, facilitating faster osteogenesis. By stimulating bone-forming cells, MezoMax's small molecule drug offers a safer and more effective approach to bone repair, enabling healthcare professionals to improve patient outcomes in the management of fractures and rare bone diseases.
Lingrove
Pre Seed Round in 2017
Lingrove, LLC is a manufacturer of bio-composite materials based in San Francisco, California, founded in 2014. The company specializes in high-performance natural fiber composites made from plant-based materials, utilizing a proprietary process to create products that mimic the appearance and properties of wood. Its flagship product, Ekoa, combines flax linen fibers with resin derived from industrial waste, and is primarily used in the production of musical instruments, as well as in the furniture, transportation, and construction industries. Lingrove aims to address the challenges posed by diminishing wood supplies and seeks to reduce deforestation and the carbon footprint associated with the built environment by offering sustainable, carbon-negative alternatives.
Dahlia Biosciences
Seed Round in 2017
Dahlia Biosciences is a biotechnology company based in California, founded in 2011. It focuses on DNA analysis and diagnostics, specializing in single-cell RNA analysis tools that are applicable for both research and diagnostic purposes. The company develops RNA detection tools utilizing CRISPR-Cas9 technology, which allows for the detection of multiple DNA and RNA biomarkers directly within cells and tissues. This innovative approach enables scientists to study and isolate cells with high precision and resolution, facilitating advancements in precision medicine research.
Scaled Biolabs
Seed Round in 2017
Scaled Biolabs Inc. is a biotechnology company founded in 2016 and based in San Francisco, California, specializing in research and development solutions for cell therapies. The company has developed a Cell Therapy Discovery Engine that leverages microfluidics, automation, and machine learning to enable biotech and pharmaceutical firms to explore numerous parameters across extensive experimental processes. This innovative platform allows for the simultaneous execution of multiple experiments in a miniaturized lab setting, leading to deeper biological insights and the identification of optimal conditions for cellular processes. Scaled Biolabs also engages in the internal development of cell therapy assets, including a program focused on induced pluripotent stem cell-derived dopaminergic neurons for treating Parkinson's disease. Through its technologies, Scaled Biolabs aims to streamline the manufacturing process of complex medicines, reduce time to market, and enhance clinical outcomes for patients.
Onconetics Pharmaceuticals
Seed Round in 2017
Onconetics Pharmaceuticals, Inc. is a biotechnology company based in Mill Valley, California, focused on developing personalized gene therapies for cancer and other genetic disorders. Established in 2016, the company employs a unique therapeutic platform that utilizes a genetic switch to activate an apoptotic inducer, selectively targeting and eliminating tumor cells while preserving healthy tissue. This innovative approach combines established gene therapy techniques with advanced research to create treatments that aim to improve patient outcomes by reducing the invasiveness and side effects associated with traditional therapies. Onconetics seeks to advance the field of personalized medicine by offering simpler, versatile therapies that prioritize patient safety and quality of life.
Indee Labs
Angel Round in 2017
Indee Labs specializes in developing innovative hardware for gene delivery, focusing on a non-viral intracellular delivery system. This technology facilitates the efficient development and scalable manufacture of gene-modified cell therapies, including chimeric antigen receptor T cells. By employing microfluidic vortex shedding, the system enables the gentle delivery of constructs such as nucleic acids, proteins, and gene-editing complexes to a variety of cell types, ensuring maximum recovery of viable, modified cells with minimal disruption. Indee Labs collaborates with the Australian National Fabrication Facility and has established its presence with offices in Sydney and lab space at Bonneville Labs in Berkeley. The company is recognized for its contributions to the field, having affiliations with NSW Health, IndieBio, Y Combinator, and MBC Biolabs.
Proteorex Therapeutics
Seed Round in 2017
Proteorex Therapeutics Inc. is a biotechnology company focused on developing novel therapeutics for diseases with significant unmet medical needs. Founded in 2014 and headquartered in Toronto, Canada, the company specializes in the creation of small molecule drugs targeting challenging and previously undruggable biological pathways. Utilizing a proprietary platform that integrates innovative synthesis design, computational modeling, and patient-derived cell-based screening, Proteorex aims to expedite the drug discovery process while reducing costs. The company's research primarily emphasizes oncology, leveraging protein-protein interactions to identify and develop new therapeutic candidates. Additionally, Proteorex operates an office in San Francisco, enhancing its reach and collaboration potential within the biotechnology landscape.
OneSkin
Seed Round in 2017
OneSkin Inc. is a biotechnology company focused on developing innovative solutions to enhance skin health and combat aging. Founded by a team of PhDs and longevity scientists, the company has created a proprietary peptide, OS-01, which has been validated to reduce the biological age of skin by minimizing the accumulation of aged cells, enhancing cellular repair, and fortifying the epidermal barrier. OneSkin offers a flagship product, the OS-01 Topical Supplement, which is designed to be suitable for all skin types and is made from high-quality vegan ingredients. In addition to its product line, OneSkin specializes in creating advanced 3D human skin models for research and testing purposes, providing in vitro services to assess the efficacy and safety of cosmetic ingredients without the use of animals. Incorporated in 2016 and based in San Francisco, OneSkin is dedicated to advancing the understanding of skin biology and developing effective anti-aging solutions.
Stelvio Therapeutics
Seed Round in 2017
Stelvio Therapeutics is a biopharmaceutical company focused on developing innovative treatments for incurable cancers and neurodegenerative diseases. Founded in 2017 and based in San Diego, California, the company utilizes a machine vision and learning platform to drive diseased stem cells toward non-diseased states. Its proprietary technology, known as microscopic imaging of epigenetic landscapes (MIEL), facilitates the discovery of small molecules that can induce epigenetic changes, allowing for the differentiation or reversal of cancerous cells into benign types, which holds potential for curative outcomes. Additionally, Stelvio is pursuing a personalized approach to glioblastoma treatment, leveraging its team's expertise in scientific innovation and clinical management to advance novel drug therapies and precision medicine diagnostics.
QuantumCyte
Seed Round in 2017
QuantumCyte, Inc. is a technology platform company based in Sunnyvale, California, that specializes in cell analysis systems aimed at predicting drug efficacy and improving cancer treatment outcomes. Founded in 2014, QuantumCyte develops automated microdissection solutions for molecular pathology, utilizing digital tissue maps to isolate regions of interest that contain important biomarkers. By harnessing artificial intelligence in digital pathology, the company enables healthcare providers to perform precise single-cell analysis, enhancing the understanding of immune system and cancer biology.
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