Founded in 2015, Underscore.VC is a Boston-based venture capital firm focusing on seed to series A investments. It primarily invests in technology companies with an emphasis on sensor-related technologies, software for factories and home automation, healthcare infrastructure, data storage databases, and cloud-based marketing/commerce software.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

MassVentures is a venture capital firm based in Waltham, Massachusetts, established in 1978 as a quasi-public corporation by the Massachusetts Legislature. The firm focuses on providing seed and early-stage funding to high-growth startups, facilitating their transition from concept to commercialization. MassVentures invests primarily in sectors such as information technology, healthcare, cybersecurity, e-commerce, mobile, manufacturing, and robotics. With a governance structure that includes an independent Board of Directors and management by experienced venture capitalists, MassVentures leverages the state's entrepreneurial spirit and innovation centers to support the Massachusetts innovation economy. The firm also offers accelerator programs to further assist emerging companies in their growth journey.

WindSail Capital Group, LLC is a private equity and venture capital firm based in Boston, Massachusetts, established in 2013. The firm specializes in providing growth capital to companies focused on energy innovation and sustainability across various industries. WindSail offers a range of financing solutions, including senior secured loans, junior secured loans, stretch loans, and bridge loans, primarily targeting U.S.-based businesses. With an investment strategy that emphasizes flexible financing options, WindSail aims to support companies that are either revenue-generating or in the early stages of commercial development. The firm typically invests equity ranging from $2 million to $8 million and debt from $2 million to $10 million, ensuring its portfolio companies have the necessary resources to facilitate growth while minimizing equity dilution.

Avalon Ventures is a venture capital firm established in 1983 with operations in San Diego and Boston. The firm concentrates on seed and early-stage investments in technology and life sciences companies across the United States. It supports founders pursuing disruptive ideas in rapidly changing markets and seeks opportunities in information technology, software, telecommunications, and biopharma areas. Avalon often collaborates with other investors to expand opportunities and provides strategic guidance during the critical development phase of portfolio companies. The firm emphasizes a hands-on approach, leveraging its entrepreneurs-turned-investors background to help early ventures navigate product, market, and regulatory challenges.

Samsung Venture Investment Corporation is the corporate venture arm of Samsung Electronics, founded in 1999 and based in Seoul. It maintains a global presence with activity in innovation hubs such as the San Francisco Bay Area, Boston, London, Tel Aviv, Bangalore, Tokyo, and Beijing, and it backs emerging technology startups across Europe, Asia, and North America. The firm sources and invests in technology companies at multiple stages, from early-stage to pre-IPO, focusing on areas including semiconductors, materials, mobile services, internet, software, security, and enterprise solutions, as well as bioengineering and medical tech. Its investment approach targets companies developing AI, robotics, augmented and virtual reality, cybersecurity, 5G, next generation displays, battery technology, digital health, and insurtech, among others, to support shaping future technologies.

Omega Funds is a Boston-based venture capital and private equity firm founded in 2004 that concentrates on early-stage investments in healthcare and biotech across North America and Western Europe, backing companies in life sciences, digital health, immunology, rare diseases, precision medicine, oncology, cybersecurity, and software-as-a-service.

Founded in Toronto in 2007, Lumira Ventures is a venture capital firm focusing on investments in biotechnology, biopharmaceuticals, medical devices, digital health, and consumer health companies. With offices across North America, the firm invests primarily in Canada and the United States, typically allocating between USD 5 million to USD 15 million per investment. Lumira Ventures actively supports its portfolio companies by facilitating access to funding sources, partners, and market opportunities.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.

Boston Seed Capital is a seed- and early-stage venture capital firm based in Massachusetts, with offices in Boston and Wellesley Hills. Founded in 2010, it focuses on funding internet-enabled and technology-driven startups across the United States, including consumer products, B2B software as a service, cybersecurity, e-commerce, big data, artificial intelligence and machine learning, marketplaces, and related services. The firm backs early-stage companies, often in information technology and SaaS, providing capital and strategic support to help companies scale from initial traction to growth.

Matrix Partners is a venture capital firm founded in 1977 and based in San Francisco that backs early-stage and Series A technology companies across sectors such as artificial intelligence, B2B software, consumer technology, fintech, health tech, infrastructure, and semiconductors. The firm emphasizes practical, founder-centered collaboration, often supporting concepts from idea stage through Series A and taking board seats to help portfolio companies scale. It operates globally, including Matrix Partners China, which focuses on long-term relationships with entrepreneurs in China and has a track record of IPOs and strategic exits. The team combines former founders and experienced investors to bring local execution and global perspective. Notable investments span across the technology landscape, reflecting a history of involvement with companies like FedEx, Apple, Oculus, Canva, Zendesk, HubSpot, Postmates, Fivetran, Sila, and GOAT, illustrating the firm’s ability to support companies from early development to scale.

Romulus Capital, established in 2008, is a Boston-based venture capital firm that specializes in seed and early-stage investments, primarily in technology startups across the United States, with a focus on the East Coast, and select opportunities in London, Israel, and India. The firm invests in a broad range of sectors, including software, big data, healthcare IT, education, and energy technology, with a preference for B2B and B2B2C models. Romulus Capital typically invests between $100,000 and $1 million initially, with the ability to scale up to $5 million over time as companies grow. The firm is known for its company-building approach, partnering with brilliant, often first-time entrepreneurs frequently affiliated with top universities and incubators.

Founded in 2013, Bolt is a venture capital firm based in Boston, Massachusetts. It specializes in seed and early-stage investments in technology and data-driven sectors.

Accomplice is a Boston-based venture capital firm, with an additional office in San Francisco, specializing in seed and early-stage investments in technology startups. It primarily invests in companies focused on cybersecurity, eSports, data analytics, SMB class software, emerging hardware platforms, and marketplaces. Accomplice uniquely leverages community platforms like AngelList, Boston Syndicates, and Maiden Lane to empower and fund exceptional founders. With a majority of its investments in Boston and additional investments throughout the U.S., Canada, and the E.U., Accomplice is one of the most active early-stage firms in New England.

Boston-based venture capital firm founded in 2005 that focuses on early-stage and select growth investments in information technology and related services. The firm backs enterprise IT companies, emphasizing information security, cloud infrastructure, data analytics, and software-as-a-service models, as well as technology-enabled business services and digital health, and it also targets healthcare IT, fintech, mobile software, and next-generation software. It prefers open source and SaaS delivery. Typically investing initial rounds of 2 to 5 million and totaling 6 to 10 million per company, it seeks board representation and often serves as lead or first institutional investor, with minority to majority stakes ranging from 20 to 80 percent. The firm reserves capital for opportunistic investments in more mature companies where its team has prior experience and focuses on opportunities in the Northeast United States.

Founded in 1973, Abingworth is an international investment group dedicated to collaborating with life sciences entrepreneurs. With over $1 billion under management, it invests across all stages of development and sectors within the life sciences industry. The company supports its portfolio companies with a team of 27 based in London, Menlo Park, and Boston.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Morningside is a venture capital firm based in the greater Boston area, specializing in investments in companies that focus on innovative science and technology. Established in 1986 as a family office for the Chan family, Morningside emphasizes a long-term approach to company-building and maintains a strong commitment to ethical practices. The firm is staffed by a team of experienced investment professionals with expertise in various sectors, including life sciences, digital health, artificial intelligence, materials, and technology. In addition to its investment activities, Morningside is dedicated to philanthropic efforts, supporting education, research, and healthcare initiatives such as the Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Kodiak Venture Partners is a venture capital firm that specializes in seed and early-stage investments, primarily in emerging technology sectors. The firm focuses on communications and wireless, semiconductor and equipment, software and services, Internet and new media, and life technology companies. Kodiak Venture Partners is based in Boston, Massachusetts, and primarily invests in Eastern North America, with particular attention to Boston, New York, and Eastern Canada. The firm typically makes investments ranging from $100,000 to $3 million and emphasizes building strong relationships with entrepreneurs to help develop business strategies, management teams, and essential alliances. Founded in 1999, Kodiak Venture Partners has a reputation for fostering high-growth industry leaders through a hands-on investment approach.

Founded in 2010, BOLDstart Ventures is a venture capital firm based in Miami, Florida. It focuses on investing in early-stage technology companies, particularly those working on enterprise infrastructure and SaaS. The firm often partners with technical founders from the inception stage, providing lead investment and support to help them achieve product-market fit.

Established in 2011 and headquartered in Boston, Gutbrain Ventures is an independent venture capital firm specializing in investments within the enterprise software sector.

Founded in 2012, Fraser McCombs Capital is a venture capital firm headquartered in Boulder, Colorado. It specializes in early to mid-stage investments, focusing primarily on innovative automotive technology and niche mobile technologies within specific verticals.

Walnut Ventures is a venture capital firm headquartered in Boston, Massachusetts, that focuses on investing in seed and early-stage companies, primarily within the information technology sector. The firm is particularly interested in areas such as home entertainment software, data processing, online services, and internet marketing. It typically invests between $250,000 and $1 million in companies located in the New England region and aims to take an active role by seeking a board seat in its portfolio companies. Established in 1997, Walnut Ventures comprises a network of experienced entrepreneurs and investors who are dedicated to helping talented entrepreneurs build sustainable businesses in rapidly growing markets. The firm offers not only financial investment but also support in refining business plans, enhancing management teams, developing financing strategies, and facilitating strategic partnerships.

Headquartered in San Francisco with offices globally, Citi Ventures explores, incubates, and invests in innovative ideas across fintech, data analytics, commerce, security, marketing, property tech, distributed ledger technology, and digital assets. It collaborates with Citi colleagues, clients, and the broader innovation community to drive discovery of new value.

LaunchCapital, established in 2008, is a venture capital firm headquartered in New Haven, Connecticut, with additional offices in Boston, New York, and San Francisco. The company invests in early-stage startups, focusing on seed rounds with investments typically ranging from $50,000 to $150,000. LaunchCapital supports entrepreneurs across various sectors, including commerce, marketplace, consumer, media, entertainment, enterprise software, emerging tech, data, finance, healthcare, and medical technology. The firm employs two distinct investment strategies: LaunchCapital Ventures, which follows a traditional equity model for high-growth opportunities, and LaunchCapital Small Business, which offers a blend of equity and debt financing for businesses with linear growth expectations and local or regional reach.

IA Ventures, established in 2010, is a New York-based venture capital firm focusing on seed and early-stage investments. It specializes in financial services, fintech, fraud detection, healthcare, and data privacy sectors, with a particular interest in companies utilizing machine learning, predictive analytics, and data-driven technologies. The firm invests in the U.S. East Coast, Israel, and the United Kingdom, with transaction sizes ranging from $0.25 million to $0.75 million.

Founded in 1969, F-Prime Capital is a venture capital firm based in Cambridge, Massachusetts. It invests globally in technology and healthcare sectors, supporting entrepreneurs with its extensive domain expertise and relationships.

Tiger Global Management is a New York based investment firm that manages public and private market strategies to pursue technology-driven growth opportunities worldwide. Founded in 2001 by Charles (Chase) Coleman, the firm invests in leading global companies across various industries, with a particular emphasis on technology-enabled growth. In public markets it employs long/short and growth strategies, while in private markets it targets opportunities from early to late stage. The firm operates globally, including the United States, China, India, Latin America, and Eastern Europe, and works with portfolio companies across their lifecycle to drive long-term value.

Founded in 2023, Myriad Venture Partners is a venture capital firm based in Boston, Massachusetts. It invests in early-stage startups operating in the artificial intelligence and enterprise technology sectors.

Founded in 2020, Creacion Ventures is a venture capital firm based in Cambridge, Massachusetts. It focuses on investments within the healthcare industry, particularly the biopharma space.

BlueIO is a startup studio based in Boston, Massachusetts, founded in 2012 by Dave Furneaux. The company focuses on investing in various sectors, including healthcare, technology, cybersecurity, biotech, and consumer goods. Additionally, it emphasizes areas such as urban food access, community empowerment, and energy, aiming to foster innovation and growth within these industries.

Hongtai Capital Holdings, founded in 2014 and headquartered in Beijing, China, is a private equity and venture capital firm that specializes in direct investments and fund of funds strategies. The firm targets various sectors, including big data, artificial intelligence, financial technology, consumer upgrades, cultural entertainment, and advanced manufacturing. Additionally, Hongtai Capital focuses on healthcare-related investments, including biotechnology and health diagnostics, particularly in Shandong Province. The firm aims to invest in companies with the potential for initial public offerings and often seeks majority stakes through joint acquisitions. It prefers to exit investments by facilitating reorganizations or listings. Hongtai Capital's investment range typically spans from CNY 0.5 million to CNY 500 million per portfolio company, with a preference for firms valued at up to USD 100 million. The company actively seeks opportunities in both domestic and international markets, including Silicon Valley and Boston.

Angels with Attitude is an investment company established in 2000, based in Seattle, Washington. It operates as an angel group, utilizing a dedicated pool of capital referred to as an "active angel fund." The firm focuses on investing in regions where its members are located, primarily along the West Coast from Vancouver, British Columbia, to San Diego, and the East Coast from Boston to Washington, DC. Angels with Attitude targets sectors that promote sustainability, including clean and renewable energy, conservation, environmental technology, sustainable transportation, healthy organic foods, and education.

Established in 2021, Reflect Ventures is a Boston-based venture capital firm focusing on seed and early-stage investments. It identifies promising startups globally, with an emphasis on emerging markets, and supports them through strategic partnerships and expert networks.

Longwood Fund is a Boston-based venture capital firm that creates and invests in science-based companies developing novel solutions for important medical problems. The firm concentrates on healthcare and life sciences, including biotechnology, pharmaceuticals, oncology, and healthtech, supporting ventures from discovery through development with capital and strategic guidance. Established in 2010, Longwood seeks to translate laboratory advances into clinically meaningful products by backing companies built on strong scientific foundations and collaborations with leading research institutions. Through its investments, the firm aims to advance therapies and technologies that address unmet medical needs and improve patient outcomes.

Visible Hands, founded in 2020 and based in Boston, Massachusetts, operates as both a venture capital firm and an accelerator. The company is dedicated to supporting early-stage enterprises by offering substantial funding and resources. It targets a diverse range of sectors for investment, including medical devices, wearables, property technology, education technology, and software as a service (SaaS). Additionally, Visible Hands focuses on industries such as clean technology, artificial intelligence, health technology, and e-commerce, among others. By nurturing innovation across various fields, the firm aims to empower entrepreneurs and facilitate the growth of transformative startups.

Audeo Capital is a Boston-based venture capital firm founded in 2018 that invests in early-stage and growth technology companies, with a focus on software and technology services-enabled businesses. The firm emphasizes a collaborative, hands-on approach and partners with executive leadership to accelerate growth and deliver customer value.

Founded in 2007, Mass Medical Angels is a venture capital firm based in Brookline, Massachusetts. It specializes in seed and early-stage investments, focusing on life science and healthcare sectors including medical devices, therapeutics, diagnostics, health services, health information technologies, and relevant research-related tools.

Vinyl Capital is a venture capital firm established in 2021 and located in Boston, Massachusetts. The company focuses on investing in innovative businesses within the business-to-consumer (B2C) sector, as well as in media, advertising technology, gaming, technology, and telecommunications. Vinyl Capital aims to support the evolution of consumer purchasing experiences by backing companies that are poised to shape the future of these industries.

Curie.Bio is a Boston-based venture capital firm founded in 2022 that focuses on founder-led seed-stage investments in therapeutics companies.

TVM Capital is a private equity and venture capital firm established in 1983 and headquartered in Munich, with offices across Europe, the United States, the Middle East and Asia. It provides early-stage through growth investments in life sciences, including biopharma, diagnostics, medtech, digital health, and in information and communications technology spanning software, semiconductors, telecommunications and related services. The firm typically invests between modest seven figures and low tens of millions of euros, often taking majority stakes in portfolio companies and supporting growth to market readiness, licensing, or global expansion. Exits are pursued through initial public offerings or sales to strategic buyers. The firm favors investments in Western markets, with attention to cross-border licenses and international collaboration.

Founded in 2020, Epakon Capital is a Boston-based venture capital firm focusing on early-stage investments. They primarily invest across four sectors: B2B SaaS, Transportation/Logistics, Consumer, and Fintech.

Holtzbrinck Digital, established in 2010, is the corporate venture capital arm of Holtzbrinck Publishing Group, headquartered in Munich, Germany. The company specializes in investing in digital businesses across the fields of science, education, content, marketplaces, and e-learning. With offices in Munich, London, and Boston, Holtzbrinck Digital adopts a global approach to identify and support promising business models. The firm emphasizes collaboration with founders and management teams, providing strategic and operational guidance to foster growth and enhance economic value. Their investment strategy includes backing startups that have demonstrated proof-of-concept, offering growth capital to later-stage companies, and acquiring profitable businesses poised to become leaders in their respective markets. Holtzbrinck Digital maintains a rigorous focus on its investment areas while remaining flexible regarding transaction sizes and ownership stakes.

Joint Effects is a venture capital firm established in 2022 and headquartered in Boston, Massachusetts. The firm focuses on investing in innovative sectors, specifically fintech, deep tech, web3, and health technology. By targeting these dynamic industries, Joint Effects aims to support and foster the growth of emerging companies that are poised to transform their respective markets.

Founded in 2022, Perkins Cove Partners is a venture capital investment firm based in Boston, Massachusetts. The firm focuses on early-stage technology companies.

Founded in 2019, Nobska Point Capital is a venture capital firm based in Boston. It invests in early-stage startups across various sectors including fintech, corporate food catering, marketing intelligence, business analytics, farm tech, real estate finance, and consumer products.

DM Capital Ltd. is a venture capital and private equity firm based in Shenzhen, China, with additional offices in Beijing, Guangzhou, Wuhan, Zurich, Toronto, and Boston. Founded in 2001, the firm specializes in early-stage, growth, and PIPE investments, primarily focusing on the healthcare sector. Its investment areas include innovative medical technologies, artificial intelligence, big data, biomedicine, genetic technology, stem cell technology, and medical devices, among others. DM Capital also provides industrial investment and financial advisory services. In 2015, the firm spun off its private equity fund into an affiliated company, Pier99 Capital, which focuses on international mergers and acquisitions between China and Western markets, primarily in Europe.

Founded in 2015, Elephant Partners is a Boston-based private equity firm focusing on early-stage investment in enterprise software and consumer internet industries across the United States.

Victress Capital is a venture capital firm based in Boston, Massachusetts, established in 2016. The firm focuses on investing in technology-enabled consumer startups that are led by diverse leadership teams. By leveraging over 40 years of combined experience in consumer operations and investing, Victress Capital provides capital and resources to support the growth of visionary founding teams in the consumer sector. The firm employs a diversified investment strategy, aiming to foster innovation and drive success within its portfolio companies.

Hongtai Capital Holdings is a private equity and venture capital firm that specializes direct and fund of funds investments through Aplus Fund and Aplus Capital. For Aplus Fund, it specializes in direct investments covering angel and growth capital stage investments in big data, artificial intelligence, financial technology, consumer education, medical healthcare, cultural entertainment, internet of things, and intelligent manufacturing sectors. For Aplus Capital, it specializes in direct and fund of funds investments through mature stage investments, acquisitions, and industry consolidation in healthcare, new healthcare, health, medical treatment, biotechnology, healthcare education, next generation health diagnostics, alternative energy, advanced manufacturing in Shandong Province, China. For Aplus Capital, the firm prefers to invest in companies with IPO potential. For acquisitions, it typically makes joint acquisitions and acquire majority stakes in portfolio companies. For acquisition of majority stakes, the firm seeks to exit though selling or injecting into listed companies. For industry consolidation, it acquires minority stakes and prefers to exit through reorganization and listing. The firm also specializes in incubation, seed, start-up, early, middle, expansion, late stage, mergers and acquisitions investments. It typically invests in relaxation entertainment, media, culture, education, cultural sports, technology, information technology, mobile internet, network security, smart hardware, telecommunication, consumer, online consumer, food, beverage, leisure, environmental protection, pharmaceuticals, mobile agriculture, environment-friendly new materials, creativity, chain-style business, retail, and sensor technology, finance, internet finance, mobile internet products overturning industry models, new consumer, new technology, new finance, and new education sectors. The firm invests in non-listed companies and in companies listed in the new third board. It seeks to invest in Silicon Valley and Boston, U.S.A. The firm typically invests CNY 0.5 million (USD 74,903.00) to CNY 500 million (USD 81.61 million) per portfolio company. It prefers to invest in companies with a maximum valuation of USD 100 million. Hongtai Capital Holdings was founded on November 26, 2014 and is based in Beijing, China.