WRF Capital

Proniras Corporation is a preclinical-stage biotechnology company based in Seattle, Washington, focused on developing innovative small-molecule therapeutics for neurological disorders. The company is known for its parenteral medical countermeasure drug, tezampanel, which shows promise in treating seizures and brain injuries. Proniras has demonstrated preclinical efficacy in addressing nerve agent-induced seizures, particularly in studies involving rodents exposed to the highly toxic chemical weapon soman. Founded in 2016, the company aims to address significant unmet medical needs in the central nervous system by antagonizing glutamate signaling, thereby advancing medical research and drug discovery in this critical area.

AdaptX is a healthcare data analytics and AI company that specializes in enhancing clinical and workflow outcomes for hospitals and surgery centers. Founded in Seattle in 2016 as a spin-off from Seattle Children's Hospital, AdaptX provides a platform that enables medical leaders and clinicians to access and analyze clinical data effectively. The platform integrates algorithms with existing electronic data systems, allowing healthcare providers to monitor performance, compare treatment approaches, and define patient cohorts. Through automated analytics, AdaptX helps healthcare service providers improve the quality and safety of care while also reducing costs.

Somalytics specializes in the development of miniature sensors aimed at enhancing eye tracking, human-machine interfaces, wearables, and industrial safety applications. Founded in 2021 and based in Seattle, Washington, the company has introduced the world's first paper-composite capacitive sensor, which is characterized by its thin profile, low power consumption, and potential disposability. Utilizing innovative carbon nanotube technology, Somalytics' sensors offer improved sensitivity and aim to replace traditional cameras and sensors in various applications, ultimately enhancing the user experience through superior technology.

AdaptX is a healthcare data analytics and AI company that specializes in enhancing clinical and workflow outcomes for hospitals and surgery centers. Founded in Seattle in 2016 as a spin-off from Seattle Children's Hospital, AdaptX provides a platform that enables medical leaders and clinicians to access and analyze clinical data effectively. The platform integrates algorithms with existing electronic data systems, allowing healthcare providers to monitor performance, compare treatment approaches, and define patient cohorts. Through automated analytics, AdaptX helps healthcare service providers improve the quality and safety of care while also reducing costs.

2Morrow, Inc. is a digital health company based in Kirkland, Washington, that specializes in evidence-based behavioral change programs and applications. Founded in 2012, the company offers several products, including SmartQuit, a smoking cessation program utilizing acceptance commitment therapy; My Pocket Coach, a platform designed to help individuals set and achieve personal goals while forming or breaking habits; and Healthy Habits, which focuses on promoting positive behavior change. 2Morrow's programs are distributed through employers, states, wellness initiatives, and health plans, and they emphasize an evidence-based approach to health and wellness. With a commitment to addressing mental, emotional, and behavioral challenges, 2Morrow aims to support individuals in overcoming unhelpful thoughts and urges while pursuing their goals. The company also has ongoing developments in behavioral health and chronic condition management.

ThruWave specializes in millimeter wave imaging technology, catering to various commercial and industrial sectors such as robotics, construction, and quality control. Founded in 2017 and based in Seattle, Washington, the company offers low-cost sensors that leverage patent-pending radar signal processing and GPU-accelerated image reconstruction techniques. ThruWave's technology enhances operational efficiency by allowing construction professionals to visualize the internal structures of walls, ceilings, and floors, thereby reducing risks and expediting workflows. Additionally, its solutions support inventory verification, shipment confirmations, and detection of packaging issues, enabling clients to automate processes such as counting contents and identifying damaged or missing items.

Membrion, Inc., founded in 2016 and based in Seattle, Washington, specializes in the manufacturing and commercialization of advanced membranes that filter molecules, including ions, under a variety of conditions such as heat, acidity, and biological sensitivity. Originating as a spin-out from the University of Washington, Membrion has received funding from multiple organizations, including the National Science Foundation and private investors, which has facilitated the transition from research to commercial production. The company's innovative ion exchange membrane technology is designed for applications in flow batteries, water purification, fuel cells, and pharmaceuticals, offering clients membranes that feature a longer lifespan and reduced costs.

AnswerDash, Inc. is a Seattle-based company that offers a cloud-based Q&A platform designed to provide contextual answers to customers on websites, web applications, and mobile experiences. Founded in 2012 and originally known as Qazzow, Inc., the company allows businesses to integrate self-service features that enable customers to obtain answers through a point-and-click interface, facilitating easy access to information without cluttering web pages. By predicting user questions based on the content of the page, AnswerDash helps reduce support costs and enhances customer engagement. The platform can also integrate with live chat services to offer personalized assistance. As of June 2020, AnswerDash operates as a subsidiary of CloudEngage, Inc.

FlexMinder, Inc. is a Seattle-based company that develops enterprise software solutions aimed at private health exchanges, health carriers, and third-party administrators (TPAs). Founded in 2011, FlexMinder focuses on automating the healthcare reimbursement process, enhancing the management of medical spending for flexible spending accounts. The company aggregates healthcare information from various sources to streamline claims submission, significantly reducing manual processing time and costs for TPAs. By providing online tools for managing the reimbursement process, FlexMinder aims to improve the user experience for consumers utilizing their flexible spending arrangements. In 2013, the company secured $1.4 million in Series AA financing to support its growth initiatives and was selected for the TechStars incubator program. As of January 2017, FlexMinder operates as a subsidiary of Jelleyvision Lab Inc.

SNUPI Technologies, Inc. is a Seattle-based company specializing in sensor technology and services aimed at enhancing home safety, security, and loss prevention. Founded in 2012, the company developed a wireless sensing solution called WallyHome, which monitors critical environmental factors such as moisture, temperature, and humidity. This system is designed to detect water leaks and other hazards, alerting homeowners to potential issues before they escalate, including risks related to mold and humidity. SNUPI Technologies leverages existing electrical wiring in homes to create a comprehensive sensing platform, facilitating effective communication and notifications through its web service.

Mobisante, Inc., founded in 2009 and based in Redmond, Washington, develops cellphone-based diagnostic devices aimed at enhancing medical imaging for emergency physicians, surgeons, academic medical centers, and community clinics. The company specializes in smartphone and tablet-based ultrasound devices, as well as cloud-based image management services. Its innovative approach utilizes advanced mobile computing technology to provide affordable and accessible ultrasound solutions, thereby facilitating point-of-care imaging that can improve clinical outcomes and healthcare delivery efficiency. Additionally, Mobisante is expanding its offerings to veterinarians in the United States, delivering portable imaging solutions for companion animal diagnosis and treatment. By making ultrasound technology more accessible, Mobisante aims to transform traditional imaging practices in both human and veterinary medicine.

Modumetal, Inc. is a manufacturer and developer of nano laminated metals and materials, founded in 2006 and headquartered in Seattle, Washington, with an additional sales office in The Woodlands, Texas. The company specializes in producing industrial-scale nanolaminated alloys that are stronger and lighter than steel, as well as more corrosion-resistant and durable than traditional metals. By utilizing electricity instead of heat in their manufacturing process, Modumetal reduces environmental impact while delivering high-performance solutions. Their products, which include customized alloys, coatings, fasteners, pumps, valves, and production tubulars, cater to various industries, including energy, aerospace, automotive, defense, infrastructure, and construction. Modumetal's technology enables these sectors to enhance performance and achieve cost-effective alternatives to conventional materials.

Omeros Corporation is a Seattle-based biopharmaceutical company that focuses on discovering, developing, and commercializing small-molecule and protein therapeutics targeting inflammation, complement-mediated diseases, and disorders of the central nervous system. The company offers OMIDRIA, a product used during cataract surgery in the United States. Omeros is advancing several clinical programs, including narsoplimab, which is in Phase III trials for conditions such as hematopoietic stem-cell transplant-associated thrombotic microangiopathy and immunoglobulin A nephropathy, as well as Phase II trials for lupus nephritis. Other key programs include OMS405, targeting opioid and nicotine addiction, and OMS527, aimed at treating addiction and movement disorders. The company's preclinical pipeline includes compounds addressing various conditions, such as paroxysmal nocturnal hemoglobinuria and other alternative pathway disorders. Founded in 1994, Omeros is dedicated to addressing both large-market and orphan indications through innovative therapeutic approaches.

Alder BioPharmaceuticals is a clinical-stage biopharmaceutical company focused on discovering, developing, and commercializing therapeutic antibodies to improve treatment for migraine patients in the United States, Australia, and Ireland. The company's lead candidate, eptinezumab, is a monoclonal antibody targeting calcitonin gene-related peptide, currently in late-stage clinical development for migraine prevention. Alder is also developing ALD1910, a preclinical monoclonal antibody aimed at inhibiting pituitary adenylate cyclase-activating polypeptide-38 for similar purposes, and Clazakizumab, which targets the pro-inflammatory cytokine interleukin-6 and has completed two Phase 2b trials. In addition to its product development efforts, Alder engages in strategic collaborations, notably with CSL Limited for advancing clazakizumab as a treatment for solid organ transplant rejection. Incorporated in 2002 and headquartered in Bothell, Washington, Alder operates primarily in the United States, where it generates most of its revenue.