Instalimb
Series B in 2025
Instalimb, Inc. is a pioneering company based in Tokyo, Japan, specializing in the development of low-cost 3D printed prosthetics and orthotics. Leveraging advanced 3D-CAD, 3D printing, and machine learning technologies, Instalimb aims to revolutionize the prosthetics industry by significantly reducing production costs and delivery times. The company utilizes an innovative algorithm that enhances design efficiency, allowing for the creation of customized prosthetic devices tailored to individual needs. This cutting-edge approach not only makes prosthetics more accessible to amputees but also represents a significant advancement in the field of assistive technology. As the world's first business dedicated to 3D printed prostheses, Instalimb is committed to improving the quality of life for individuals requiring these essential devices.
Ubitus
Venture Round in 2025
Founded in 2013, Ubitus specializes in deploying cloud-enabled rich media services. It offers a leading cloud gaming solution for major game companies and telecom service providers worldwide. Additionally, it streams metaverse content across multiple devices for platform operators and digital content developers.
Leading Mark
Venture Round in 2025
Leading Mark Inc. is an employment agency based in Tokyo, Japan, specializing in human resources services. The company is focused on streamlining the recruitment process through its online platform, which aggregates job listings tailored to users' interests. This approach aims to enhance the job-seeking experience by prioritizing the needs of applicants, in contrast to larger, traditional agencies that may focus more on the hiring companies. Additionally, Leading Mark is expanding its operations to include mid-career and international hiring, with a dedicated team in China working to connect top Japanese-speaking Chinese students with domestic employers. By emphasizing a user-centric model, Leading Mark seeks to alleviate the frustrations often faced by job seekers, ensuring they receive the information and opportunities they need to advance their careers.
Libero Thera
Venture Round in 2024
LiberoThera provides drug discovery research and development services. It focuses on making drugs with GPCRs for membrane proteins. LiberoThera was founded in 2018 and is located in Tokyo.
Girasol Energy
Series B in 2024
Founded in Tokyo, Japan in 2017, Girasol Energy develops an IoT platform for photovoltaic plants. It installs sensor networks, collects data at the panel level via its cloud engine, and uses AI to automatically detect anomalies. The company's exclusive technology leverages satellite-based solar radiation statistics, enabling it to offer services at a significantly lower price compared to competitors.
HarvestX is a technology company that focuses on developing robotic solutions for the agricultural sector, specifically targeting the challenges of indoor vertical farming. Originating from a project at the University of Tokyo, the company aims to enhance fruit production through automation. HarvestX specializes in creating automated pollination robots, addressing a significant challenge in fruit cultivation. Its technology utilizes a depth camera and advanced image processing algorithms to identify flowers and fruits, facilitating effective pollination and harvesting. By implementing these innovations, HarvestX seeks to alleviate the labor shortages in agriculture and ensure a consistent and stable food supply.
Heartseed
Series D in 2023
Heartseed Inc. is a Tokyo-based biotechnology company founded in 2015, focused on developing myocardial regeneration medicine utilizing induced pluripotent stem (iPS) cells. The company's mission is to advance treatments for heart disease through regenerative medicine, specifically targeting advanced heart failure with iPS cell-derived cardiomyocyte replacement therapy. Heartseed aims to enable the clinical application of its innovative therapies to improve outcomes for patients suffering from heart conditions.
BionicM is a Tokyo‑based company that develops robotic prostheses for lower‑limb amputees. Its products include powered knee joints and ankle‑foot devices that mimic natural muscle function, allowing users to stand, walk, and climb stairs with reduced effort. The company’s technology was first researched in 2015 at the University of Tokyo’s Information Systems Engineering Laboratory and received support from the Japan Science and Technology Agency in 2016. BionicM was formally established in 2018 and continues to advance high‑performance prosthetic solutions that enhance mobility for people with disabilities.
Alivexis is a private preclinical stage drug discovery company based in Tokyo, specializing in the rapid design and generation of small molecule clinical candidates targeting high-value disease conditions. The company leverages advanced computational drug discovery techniques and unique biological insights to expedite the development of new medicines. Its international team comprises experts in drug design and disease biology, drawing on extensive research and development experience from global pharmaceutical, biotechnology, and technology firms. By focusing on innovative approaches, Alivexis aims to enhance biotechnological research and improve the efficiency of delivering essential medicines to patients with unmet medical needs.
Heartseed
Series C in 2021
Heartseed Inc. is a Tokyo-based biotechnology company founded in 2015, focused on developing myocardial regeneration medicine utilizing induced pluripotent stem (iPS) cells. The company's mission is to advance treatments for heart disease through regenerative medicine, specifically targeting advanced heart failure with iPS cell-derived cardiomyocyte replacement therapy. Heartseed aims to enable the clinical application of its innovative therapies to improve outcomes for patients suffering from heart conditions.
Libero Thera
Venture Round in 2021
LiberoThera provides drug discovery research and development services. It focuses on making drugs with GPCRs for membrane proteins. LiberoThera was founded in 2018 and is located in Tokyo.
Sonas
Venture Round in 2021
Sonas Inc. is a Tokyo-based company specializing in the planning, design, manufacturing, and sale of innovative hardware and software solutions for sensing and measurement. The company is developing its UNISONet technology, which aims to enhance the Internet of Things (IoT) by providing high-quality wireless sensing capabilities. This technology addresses traditional challenges in IoT communications by utilizing advanced features such as power-saving mechanisms, high-speed data acquisition, low-latency bidirectional communication, and robust retransmission controls to prevent data loss. Sonas's solutions enable the sensing of various parameters, from small-scale measurements like temperature and humidity to larger-scale data such as acceleration and images, thereby positioning the company as a key player in the evolving IoT landscape.
RIN Institute
Venture Round in 2021
Founded in 2016, RIN Institute is a Japanese biotechnology company dedicated to the research and development of antibody-based medicines and external diagnostic drugs. Its primary focus is on developing monoclonal antibodies for cancer diagnostics and therapeutics.
HarvestX
Venture Round in 2021
HarvestX is a technology company that focuses on developing robotic solutions for the agricultural sector, specifically targeting the challenges of indoor vertical farming. Originating from a project at the University of Tokyo, the company aims to enhance fruit production through automation. HarvestX specializes in creating automated pollination robots, addressing a significant challenge in fruit cultivation. Its technology utilizes a depth camera and advanced image processing algorithms to identify flowers and fruits, facilitating effective pollination and harvesting. By implementing these innovations, HarvestX seeks to alleviate the labor shortages in agriculture and ensure a consistent and stable food supply.
BionicM is a Tokyo‑based company that develops robotic prostheses for lower‑limb amputees. Its products include powered knee joints and ankle‑foot devices that mimic natural muscle function, allowing users to stand, walk, and climb stairs with reduced effort. The company’s technology was first researched in 2015 at the University of Tokyo’s Information Systems Engineering Laboratory and received support from the Japan Science and Technology Agency in 2016. BionicM was formally established in 2018 and continues to advance high‑performance prosthetic solutions that enhance mobility for people with disabilities.
Adriakaim
Series B in 2020
Adriakaim Inc. is a Tokyo-based company established in 2018 that specializes in the research, design, development, manufacture, and sale of medical and health-related equipment. In addition to its core product offerings, Adriakaim provides consulting services focused on management and technology strategy, specifically within the medical device sector. The company also supports research and development processes, contributing to advancements in healthcare technology.
Alivexis is a private preclinical stage drug discovery company based in Tokyo, specializing in the rapid design and generation of small molecule clinical candidates targeting high-value disease conditions. The company leverages advanced computational drug discovery techniques and unique biological insights to expedite the development of new medicines. Its international team comprises experts in drug design and disease biology, drawing on extensive research and development experience from global pharmaceutical, biotechnology, and technology firms. By focusing on innovative approaches, Alivexis aims to enhance biotechnological research and improve the efficiency of delivering essential medicines to patients with unmet medical needs.
Founded in 2014, Aidemy offers an online platform for individuals to learn artificial intelligence programming and for businesses to leverage AI technology using their own data. Its services include practical blockchain applications, supporting DX human resource development, problem selection, proof-of-concept development, and operation.
WealthNavi
Series D in 2019
WealthNavi Inc., established in 2015 and based in Tokyo, Japan, specializes in developing and delivering a cloud-based online platform for asset management and risk management. This platform offers robo-advisory services, enabling users to discover diversified investment opportunities globally. The company's core offering is a risk management algorithm-driven platform designed to assist asset managers in their decision-making processes.
Synspective
Series A in 2019
Synspective specializes in developing and operating small synthetic aperture radar (SAR) satellites, providing SAR data and remote monitoring services. It caters to urban design, infrastructure, energy, insurance, finance sectors, and government agencies.
EdiGENE Japan
Series B in 2019
EdiGENE Japan, now known as Modalis Therapeutics Corporation, is an emerging biotechnology company based in Tokyo, Japan. Founded in 2016, it specializes in the research and development of innovative therapeutics aimed at addressing serious genetic disorders. The company utilizes its proprietary CRISPR-GNDM technology, which allows for locus-specific modulation of gene expression and histone modification without the necessity for double-stranded DNA cleavage or traditional gene editing techniques. Modalis Therapeutics has established a solid intellectual property foundation, including licenses from the University of Tokyo, to support its focus on developing treatments for orphan genetic diseases and other unmet medical needs.
Crewt Medical Systems
Series D in 2018
Crewt Medical Systems, established in Tokyo, Japan in 2013, specializes in manufacturing innovative medical devices. The company's flagship product is the world's first head-mounted perimeter, designed to meet clinical needs and compatible with standard automated perimeters. Crewt's mission is to create new value in healthcare by integrating advanced technologies, focusing on human-centric solutions that enhance visual quality.
Synspective
Venture Round in 2018
Synspective specializes in developing and operating small synthetic aperture radar (SAR) satellites, providing SAR data and remote monitoring services. It caters to urban design, infrastructure, energy, insurance, finance sectors, and government agencies.
Braizon Therapeutics
Series B in 2018
Braizon Therapeutics, Inc. is a biopharmaceutical company based in Tokyo, Japan, founded in 2015. It focuses on the research and development of innovative drug delivery technologies specifically aimed at treating central nervous system disorders. The company was established through collaborative research efforts led by prominent academics from the University of Tokyo and Tokyo Medical and Dental University. Braizon’s primary objective is to create effective methods for delivering therapeutic drugs across the blood-brain barrier, thereby addressing the challenges associated with treating incurable neuronal diseases. Through its advanced platform, Braizon Therapeutics seeks to enhance the efficacy of treatments for patients suffering from various central nervous system conditions.
Alivas
Venture Round in 2017
Alivas is a medical device company based in Tokyo, Japan, that develops a therapeutic device to treat refractory constipation. Founded in 2017, the company aims to provide a treatment option for patients with intractable chronic constipation. It is described as a joint venture between Stanford University and the University of Tokyo, in collaboration with the Japan Biodesign program for innovative medical device creation.
Xenoma, Inc. is a Tokyo-based company specializing in the development of e-skin technology, which integrates wearable electronics into apparel. As a spin-off from the University of Tokyo's Someya Group Organic Transistor Lab, Xenoma leverages advancements in organic electronics to create ultrathin and flexible devices that can seamlessly interface with the human body. The company's innovative clothing line incorporates highly sensitive motion sensors capable of monitoring movement, posture, breathing, and body temperature, while also being durable and machine washable. By collecting accurate data from these sensors, Xenoma aims to enhance healthcare through the integration of big data and IoT solutions, ultimately providing users with comfortable and functional wearable technology.
Crewt Medical Systems
Series D in 2017
Crewt Medical Systems, established in Tokyo, Japan in 2013, specializes in manufacturing innovative medical devices. The company's flagship product is the world's first head-mounted perimeter, designed to meet clinical needs and compatible with standard automated perimeters. Crewt's mission is to create new value in healthcare by integrating advanced technologies, focusing on human-centric solutions that enhance visual quality.