Trendlines

ViAqua Therapeutics Ltd is an Israeli company founded in 2014 that specializes in developing innovative drugs and therapeutics for the aquaculture industry. The company focuses on creating the first orally administered treatment designed to combat viral diseases affecting aquatic species, particularly shrimp. ViAqua's proprietary platform employs a unique RNAi nanoparticle formulation that triggers a cellular response to disable viral infections. This technology enables the delivery of coated nanoparticles through feed or immersion techniques, enhancing the resistance of aquaculture species against viral epidemics. With a management team experienced in business development and industrial biotechnology, ViAqua aims to improve the health and sustainability of aquaculture practices.

Phytolon Ltd, founded in 2000 and based in Misgav, Israel, specializes in the development of natural food colorants. The company has established a novel and sustainable technology that utilizes fermentation processes with baker’s yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach provides a healthy alternative to synthetic food dyes, offering food manufacturers safe, cost-effective, and stable all-natural colors. Phytolon is dedicated to promoting human health and environmental sustainability through scientific advancement in the food color industry.

FruitSpec Ltd. specializes in designing and manufacturing hyperspectral sensor systems for fruit yield estimation, catering to farmers, distributors, and insurance companies. Founded in 2016 and based in Tel Aviv, Israel, the company offers FruitSpec sensor pods that scan orchards to analyze fruit trees. This technology employs hyperspectral imaging and deep learning algorithms to differentiate between leaves and fruits, generating valuable insights for agribusinesses. FruitSpec provides a comprehensive yield estimation service, which includes scanning the orchard and delivering detailed reports. These reports feature the number of fruits and their size distribution, as well as heat maps indicating fruit quantity distribution within the orchard. By facilitating data collection and yield prediction, FruitSpec enables stakeholders in the fruit value chain to optimize their demand-to-supply processes and make informed business decisions.

Fidmi Medical is an Israeli start-up established in 2014, focused on creating innovative feeding devices aimed at improving nutrition delivery and enhancing the quality of life for patients who cannot consume food orally. The company’s devices are designed to eliminate the drawbacks of existing feeding solutions, providing a secure, reliable, and discreet method for delivering food, liquids, and medications directly into the stomach. With a focus on user-friendly design, Fidmi Medical ensures that its devices allow for easy insertion, replacement, and removal, thereby facilitating better access and management for patients and caregivers alike.

AgroScout Ltd. is an Israeli company founded in 2017 that specializes in developing an artificial intelligence-based agricultural intelligence platform. This platform aids farmers by identifying and monitoring crop diseases, ultimately enhancing crop yields and promoting sustainable farming practices. AgroScout's solutions leverage advanced analytics and high-resolution aerial imagery to provide detailed insights into crop health, which helps food production companies optimize their operations for greater profitability. The platform tracks various growth parameters, including plant stand counts and biomass, throughout the growing season. Additionally, it continuously monitors for pests and diseases, facilitating early detection and reducing pesticide use by predicting regional outbreaks. By offering actionable insights into crop management, AgroScout enables farmers to make informed decisions and improve their strategic planning.

ViAqua Therapeutics Ltd is an Israeli company founded in 2014 that specializes in developing innovative drugs and therapeutics for the aquaculture industry. The company focuses on creating the first orally administered treatment designed to combat viral diseases affecting aquatic species, particularly shrimp. ViAqua's proprietary platform employs a unique RNAi nanoparticle formulation that triggers a cellular response to disable viral infections. This technology enables the delivery of coated nanoparticles through feed or immersion techniques, enhancing the resistance of aquaculture species against viral epidemics. With a management team experienced in business development and industrial biotechnology, ViAqua aims to improve the health and sustainability of aquaculture practices.

Phytolon Ltd, founded in 2000 and based in Misgav, Israel, specializes in the development of natural food colorants. The company has established a novel and sustainable technology that utilizes fermentation processes with baker’s yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach provides a healthy alternative to synthetic food dyes, offering food manufacturers safe, cost-effective, and stable all-natural colors. Phytolon is dedicated to promoting human health and environmental sustainability through scientific advancement in the food color industry.

Vessi Medical is an Israeli medical device startup focused on innovating treatment for Non-Muscle-Invasive Bladder Cancer (NMIBC) through a novel surface cryotherapy approach. This method employs extreme cold to freeze and eliminate abnormal tissue, addressing the limitations of traditional first-line therapies like TransUrethral Resection of Bladder Tumor (TURBT), which can be invasive, costly, and often result in cancer recurrence. Vessi's technology offers a minimally invasive, office-based therapy that reduces the need for hospital stays and repeat surgeries, which are common in conventional treatments. The system comprises a standalone console and a disposable catheter that allows for targeted cell destruction while safeguarding healthy bladder tissue. Vessi Medical, supported by the Trendlines Group and led by experienced professionals in the medical device and cryotherapy fields, has already shown promising results in animal studies. The company's initial focus is on the $1.2 billion NMIBC market, with plans to expand into treatment options for overactive bladder and urinary tract infections in the future.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

AgroScout Ltd. is an Israeli company founded in 2017 that specializes in developing an artificial intelligence-based agricultural intelligence platform. This platform aids farmers by identifying and monitoring crop diseases, ultimately enhancing crop yields and promoting sustainable farming practices. AgroScout's solutions leverage advanced analytics and high-resolution aerial imagery to provide detailed insights into crop health, which helps food production companies optimize their operations for greater profitability. The platform tracks various growth parameters, including plant stand counts and biomass, throughout the growing season. Additionally, it continuously monitors for pests and diseases, facilitating early detection and reducing pesticide use by predicting regional outbreaks. By offering actionable insights into crop management, AgroScout enables farmers to make informed decisions and improve their strategic planning.

BioFishency Ltd. is an Israeli company that specializes in providing a plug-and-play water treatment system for land-based aquaculture. Founded in 2013 and based in Misgav, the company has developed a cost-effective, all-in-one solution that operates with various aquaculture methods, including extensive, intensive, and recirculated systems. BioFishency's technology addresses key challenges in aquaculture, such as limited water availability and the buildup of toxic ammonia, which can hinder fish growth and survival. By enhancing water conditions, the system allows fish farms to significantly increase production—potentially doubling or tripling yields—while utilizing existing infrastructure. This innovative approach not only boosts profitability for fish farmers but also promotes sustainability by minimizing ecological impact and reducing resource expenditures.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

ElastiMed Ltd. specializes in the development of innovative medical devices focused on compression therapy, specifically for treating Chronic Venous Insufficiency and preventing Deep Venous Thrombosis. Founded in 2015 and headquartered in Misgav, Israel, the company has created a wearable active compression device that employs advanced smart materials. This device, often referred to as a smart sock, uses electric pulses to compress and massage the legs, enhancing circulation and offering a comfortable and effective treatment solution. It aims to provide an affordable option for patients, particularly the elderly, to alleviate symptoms such as swelling, blood clots, leg ulcers, and sports injuries, thereby improving their overall quality of life.

FruitSpec Ltd. specializes in designing and manufacturing hyperspectral sensor systems for fruit yield estimation, catering to farmers, distributors, and insurance companies. Founded in 2016 and based in Tel Aviv, Israel, the company offers FruitSpec sensor pods that scan orchards to analyze fruit trees. This technology employs hyperspectral imaging and deep learning algorithms to differentiate between leaves and fruits, generating valuable insights for agribusinesses. FruitSpec provides a comprehensive yield estimation service, which includes scanning the orchard and delivering detailed reports. These reports feature the number of fruits and their size distribution, as well as heat maps indicating fruit quantity distribution within the orchard. By facilitating data collection and yield prediction, FruitSpec enables stakeholders in the fruit value chain to optimize their demand-to-supply processes and make informed business decisions.

Gordian Surgical Ltd. is a company based in Misgav, Israel, founded in 2012, that specializes in the development of laparoscopic surgical equipment. The company's flagship product, TroClose 1200, is an integrated port closure solution designed to facilitate the opening and suturing of the abdominal wall during laparoscopic procedures. Gordian Surgical holds three U.S. patents related to laparoscopic trocar, fascial closure systems, and suture anchor deployment methods. These innovations aim to provide surgeons with a simple, secure, and effective means of closing internal tissue layers, enhancing the safety and efficiency of laparoscopic surgeries. The company has developed an initial prototype and has plans to initiate preclinical trials to further test its technology.

EdenShield is an Israel-based AgTech company, established in 2012. Their unique, proprietary, proven plant protection products are helping growers increase and improve their yield of cannabis, vegetable, and flower crops. These organic, safe, chemical free products leverage the naturally protective characteristics found in extracts from native Israeli semi-desert plants. The success of their products lies in their proprietary aromatic ingredients that mask plant odor and lower insect attraction thus eliminating pest born viruses. Additionally, EdenShield products contain important botanical extracts and nutrients, vital for plant health and development.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

EdenShield is an Israel-based AgTech company, established in 2012. Their unique, proprietary, proven plant protection products are helping growers increase and improve their yield of cannabis, vegetable, and flower crops. These organic, safe, chemical free products leverage the naturally protective characteristics found in extracts from native Israeli semi-desert plants. The success of their products lies in their proprietary aromatic ingredients that mask plant odor and lower insect attraction thus eliminating pest born viruses. Additionally, EdenShield products contain important botanical extracts and nutrients, vital for plant health and development.

Catalyst AgTech is an Israeli company developing a breakthrough technology which minimizes the environmental impact of agrochemical products, a major issue in modern agrotechnology. Catalyst AgTech's technology solves the conflict between the growing demand for more essential pesticides and the need to prevent any negative impact on the environment. Their solution leads to billions of dollars more business while alleviating environmental contamination. The company is led by an experienced management team and has the scientific backing of the Weizmann Institute of Science. Trendlines Agtech – Mofet is a partner and shareholder of Catalyst AgTech, and Trendlines AgTech is its investor.

Valentis was founded in 2013 and operates within the framework of Trendlines Agtech, part of The Trendlines Group. Valentis has a patent (national phase), covering the use of cellulose nanocrystals (CNC) with a combination of nanoparticles for use in a wide range of applications. In lab tests and limited trials, the Valentis films showed added strength, greater spectral control, improved oxygen barrier and other functionalities. Since July 2014, Valentis has collaborated on new product development with one of Israel’s leading agricultural thermoplastics applications companies.

LapSpace Medical Ltd. is a company based in Misgav, Israel, that specializes in developing devices for laparoscopic surgery. Founded in 2011, it operates under the Misgav Venture Accelerator as part of The Trendines Group. The company has created an inflatable balloon retractor designed to enhance laparoscopic procedures by providing effective and gentle retraction of abdominal organs, such as the intestines. This innovative device minimizes the risk of complications, shortens operating times, eliminates the need for additional assistance, and reduces overall surgical expenses. Consequently, LapSpace Medical's technology enables patients to recover more quickly with minimal incisions.

ApiFix Ltd. develops a minimally invasive system for correcting scoliosis deformities, specifically targeting adolescents with Adolescent Idiopathic Scoliosis (AIS). Founded in 2011 and based in Misgav, Israel, the company focuses on patients classified as Lenke Type 1 or Type 5, who present with a Cobb angle between 35 and 55 degrees. The ApiFix system incorporates a miniature ratchet mechanism that allows for incremental corrections as the patient bends in the desired direction. This approach contrasts with traditional scoliosis surgeries, which typically involve a single, aggressive operation. Instead, ApiFix promotes a gradual correction process that extends over several months, supported by specialized physical therapy. As of April 2020, ApiFix operates as a subsidiary of OrthoPediatrics Corp.

Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy drug products that utilize living immune cells to treat cancer and infectious diseases. The company's product portfolio includes AlloStim, an infusion of activated T-Stim cells; CryoVax, an in-situ therapeutic cancer vaccine for patients with metastatic tumors; CRCL, which provides patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine aimed at educating the immune system during cancer remission to prevent recurrence. Immunovative Therapies is engaged in creating treatment protocols for various types of cancer, including hematological malignancies, prostate and breast cancers, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has been supported by the Israel Office of the Chief Scientist and has participated in the Misgav Venture Accelerator program.

InnoLap Surgical develops a device for scarless laparoscopic procedures. The device comprises a handle, thin 3 mm needle, and 5-10 mm detachable and replaceable operating heads. The company was founded in 2012 and is based in Misgav, Israel. As of September 30, 2013, InnoLap Surgical Ltd. operates as a subsidiary of Teleflex Incorporated.

Nephera Ltd. is a development-stage medical device company based in Misgav, Israel, founded in 2008. The company specializes in an implantable pulse generator that protects and enhances kidney function in patients suffering from congestive heart failure (CHF) and acute heart failure. Nephera's innovative technology leverages electrical stimulation of the urinary tract to modulate sympathetic nerve activity, which helps maintain renal function and improve the effectiveness of diuretic therapy. This treatment addresses a critical need in managing kidney dysfunction during the frequent hospitalizations of CHF patients, ultimately aiming to preserve kidney health and improve patient outcomes.

BioSight is a biopharmaceutical company focused on developing innovative cancer-targeted chemotherapy pro-drugs. Founded in 2000 and based in Lod, Israel, BioSight has developed a technology known as S2DOT, which allows for the targeted delivery of chemotherapy drugs directly into cancer cells. This approach significantly reduces the systemic toxicity often associated with traditional chemotherapy treatments. The company’s lead product is a non-toxic conjugate of cytarabine and asparagine, designed specifically for the treatment of acute myeloid leukemia. Through its research and development efforts, BioSight aims to provide safe and effective therapeutic options for patients suffering from hematological malignancies and disorders.

Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy drug products that utilize living immune cells to treat cancer and infectious diseases. The company's product portfolio includes AlloStim, an infusion of activated T-Stim cells; CryoVax, an in-situ therapeutic cancer vaccine for patients with metastatic tumors; CRCL, which provides patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine aimed at educating the immune system during cancer remission to prevent recurrence. Immunovative Therapies is engaged in creating treatment protocols for various types of cancer, including hematological malignancies, prostate and breast cancers, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has been supported by the Israel Office of the Chief Scientist and has participated in the Misgav Venture Accelerator program.