North Carolina Biotechnology Center

The North Carolina Biotechnology Center, established in 1981, is a private, non-profit organization based in Durham, North Carolina. It is funded by the North Carolina General Assembly with the mission of enhancing biotechnology research, business, and education across the state. Rather than serving as a laboratory for research, the Center focuses on fostering job creation and strengthening the biotechnology sector by providing support and resources to industry stakeholders. Through its initiatives, the Center aims to generate economic and societal benefits for the region, contributing to the advancement of biotechnology in North Carolina.

Drew Applefield Ph.D

Director, Business and Technology Development

Nancy Johnston

Executive Director, Piedmont Triad Office

Past deals in North Carolina

Atlantic Fish Company

Pre Seed Round in 2023
Atlantic Fish Company is focused on producing cultivated seafood through cellular agriculture, operating from its headquarters in Raleigh-Durham, North Carolina. The company aims to provide sustainable seafood options by cultivating fish in a controlled environment. This innovative approach allows Atlantic Fish Company to offer fresh fish meat that maintains the natural taste while minimizing the environmental impact associated with traditional fishing practices. By leveraging cellular agriculture, the company seeks to meet the growing demand for sustainable protein sources.

Duke University

Grant in 2023
Duke University is a private research university located in Durham, North Carolina. With approximately 15,000 students and a renowned faculty, Duke is dedicated to pushing the boundaries of knowledge and making a positive impact on society. The university's Office of News and Communications, along with Duke Web Services, played a key role in developing the university's web presence, collaborating with Viget Labs to create a cohesive design. Duke offers free tools to help members of the community align their websites with the university's branding, including messaging and style guidelines, color palettes, typefaces, web templates, and information on using the "Duke brand bar." For further details, individuals can refer to the online style guide or reach out to Duke Web Services for assistance.

Amalgent Therapeutics

Debt Financing in 2023
Founded in 2020, Amalgent Therapeutics is a biopharmaceutical company based in Chapel Hill, North Carolina. It specializes in developing combination drugs for pain management that significantly reduce required doses and minimize side effects.

North Carolina Central University

Grant in 2023
North Carolina Central University, founded in 1910 in Durham, North Carolina, is a historically black university that offers more than 100 undergraduate and graduate programs across nearly 30 academic departments. It is known for distinctive degrees such as a master’s in Jazz Studies and a bachelor’s in Apparel Design, as well as joint graduate programs that combine law, business, library science, and information science. The university provides a range of financial aid options, including need‑based government assistance and institutional scholarships, and encourages applications from students of all races and ethnicities. With a focus on academic excellence, research, and cultural awareness, the institution maintains a diverse student body and a commitment to inclusive education.

North Carolina State University

Grant in 2023
Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

UNC Kenan-Flagler Business School

Grant in 2023
The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

University of North Carolina at Greensboro

Grant in 2022
The University of North Carolina at Greensboro, also known as UNCG and UNC Greensboro, is a public coeducational and research university in Greensboro in North Carolina in the United States of America, and it is a constituent institution of the system of the University of North Carolina. However, the University of North Carolina at Greensboro is a stand-alone university and awards its own degrees like all members of the system of the University of North Carolina . The Southern Association of Colleges and Schools Commission on Colleges accredits the University of North Carolina at Greensboro to award baccalaureate, masters, specialist, and doctoral degrees.

North Carolina State University

Grant in 2022
Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

University of North Carolina at Charlotte

Grant in 2022
UNC Charlotte is North Carolina's urban research university. It leverages its location in the state's largest city to offer internationally competitive programs of research and creative activity, exemplary undergraduate, graduate and professional programs, and a focused set of community engagement initiatives. UNC Charlotte maintains a particular commitment to addressing the cultural, economic, educational, environmental, health, and social needs of the greater Charlotte region.

Oncotect

Debt Financing in 2022
Oncotect is a biotechnology company based in Raleigh, North Carolina. It specializes in pioneering early screening of cancer risks in dogs using their urine. The company's patent-pending in-vitro scientific test combines proprietary technology with the olfactory receptors of C. elegans to detect cancerous volatile metabolites.

University of North Carolina at Asheville

Grant in 2022
University of North Carolina at Asheville is a co-educational, four year, public liberal arts university.

University of North Carolina at Wilmington

Grant in 2022
The University of North Carolina Wilmington, the state's coastal university, is dedicated to the integration of teaching and mentoring with research and service. University of North Carolina Wilmington, commitment to student engagement, creative inquiry, critical thinking, thoughtful expression and responsible citizenship is expressed in our baccalaureate and master's programs, as well as doctoral programs in areas of expertise that serve state needs. Our culture reflects our values of diversity and globalization, ethics and integrity, and excellence and innovation.

UNC Kenan-Flagler Business School

Grant in 2022
The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

Enzerna

Debt Financing in 2022
Enzerna Biosciences is a biotechnology company based in Morrisville, North Carolina, specializing in gene therapy solutions. The company focuses on addressing nucleotide expansion disorders by utilizing Artificial Site-Specific RNA Endonucleases (ASREs). These engineered proteins are designed to target and eliminate toxic RNA molecules responsible for these disorders, offering a potential long-term curative approach. Enzerna's innovative RNA editing technology and related products aim to provide effective treatments for genetic diseases.

Plakous Therapeutics

Debt Financing in 2022
Plakous Therapeutics specializes in regenerative healing, developing bio-therapeutics from post-delivery human placentas. Its flagship product, Protego-PD, is an orally delivered acellular biotherapeutic containing cytokines and growth factors to promote healing. Founded in 2016, the company is headquartered in Winston-Salem, North Carolina.

Plakous Therapeutics

Grant in 2022
Plakous Therapeutics specializes in regenerative healing, developing bio-therapeutics from post-delivery human placentas. Its flagship product, Protego-PD, is an orally delivered acellular biotherapeutic containing cytokines and growth factors to promote healing. Founded in 2016, the company is headquartered in Winston-Salem, North Carolina.

Plakous Therapeutics

Grant in 2022
Plakous Therapeutics specializes in regenerative healing, developing bio-therapeutics from post-delivery human placentas. Its flagship product, Protego-PD, is an orally delivered acellular biotherapeutic containing cytokines and growth factors to promote healing. Founded in 2016, the company is headquartered in Winston-Salem, North Carolina.

University of North Carolina at Charlotte

Grant in 2021
UNC Charlotte is North Carolina's urban research university. It leverages its location in the state's largest city to offer internationally competitive programs of research and creative activity, exemplary undergraduate, graduate and professional programs, and a focused set of community engagement initiatives. UNC Charlotte maintains a particular commitment to addressing the cultural, economic, educational, environmental, health, and social needs of the greater Charlotte region.

East Carolina University

Grant in 2021
Founded in 1907, East Carolina University is a public doctoral/research university based in Greenville, North Carolina. It offers a wide range of undergraduate and graduate programs across various disciplines including business, fine arts, health sciences, nursing, and medicine.

NabGen

Debt Financing in 2021
NabGen, Inc. is a biotechnology company based in North Carolina, focused on developing an innovative antibody suppression platform designed to address a critical challenge in gene therapy. The company aims to mitigate the impact of patient-derived anti-drug antibodies, which can obstruct the effectiveness of adeno-associated virus (AAV)-based therapeutics. By employing a novel protein-based approach, NabGen’s technology functions as a universal antibody suppressant, effectively targeting and neutralizing various antibody types, including neutralizing antibodies, without compromising patients' immune systems. This capability not only facilitates the successful administration of gene therapies for patients with pre-existing vector immunity but also opens doors for re-dosing opportunities that are currently limited. Through its advancements, NabGen strives to enhance the accessibility and efficacy of cutting-edge genetic treatments for a wider range of patients.

North Carolina Agricultural and Technical State University

Grant in 2021
North Carolina A&T State University is so many things to so many people, both in our state and around the country. North Carolina A&T State University is an HBCU. We are a top-flight research university, the largest historically black university (HBCU) in the country, the #1 producer of degrees awarded to African Americans in North Carolina and nationally recognized or our excellence in science, technology, mathematics and engineering (STEM) education. We are a diverse community, bound by intense pride and tradition, with fiercely loyal alumni who hold positions of importance and influence in companies and government agencies across the state, the country and the world. We are achievers, driven by a curious, limitless, fearless spirit that fuels discovery and innovation, resulting in 41 patents issued based on our research, as well as numerous spin-off and start-up companies. We are inclusive and welcoming, with students from many backgrounds and cultures, every part of our state, our nation and countries around the globe. We are passionate, driven by a desire to do more, be more and make more of a difference. Since we opened our doors in 1892, we have focused on giving every student the hands-on opportunities, core knowledge and global perspective that will lead them to make real and lasting change in their lives and the lives of others. At N.C. A&T, we have so much to be proud of, and you can learn more about those "Points of Pride" here. You can also use the links below to learn more about what makes N.C. A&T unique, from our leadership and history to our many rankings and recognitions.

UNC Kenan-Flagler Business School

Grant in 2021
The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

North Carolina State University

Grant in 2021
Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

University of North Carolina at Wilmington

Grant in 2021
The University of North Carolina Wilmington, the state's coastal university, is dedicated to the integration of teaching and mentoring with research and service. University of North Carolina Wilmington, commitment to student engagement, creative inquiry, critical thinking, thoughtful expression and responsible citizenship is expressed in our baccalaureate and master's programs, as well as doctoral programs in areas of expertise that serve state needs. Our culture reflects our values of diversity and globalization, ethics and integrity, and excellence and innovation.

Appalachian State University

Grant in 2021
Appalachian State University, located in Boone, North Carolina, provides a comprehensive educational experience with over 170 undergraduate and graduate degree programs. The university offers diverse majors, including Actuarial Science, Archaeology, Nursing, and Theatre Arts, emphasizing both academic rigor and cultural enrichment. In addition to its academic offerings, Appalachian State hosts a variety of cultural activities such as concerts, literary readings, and theatre productions, along with events like a Summer Arts festival and a performing arts series. The university is selective in its admissions process, with a competitive average GPA of 3.94 and SAT score of 1141 among incoming students. Financial aid is available through institutional scholarships based on academic merit and extracurricular involvement, as well as federal aid options. The Appalachian State University Foundation, a non-profit organization, supports students through scholarships and academic program funding.

North Carolina State University

Grant in 2021
Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

BioAesthetics

Grant in 2020
BioAesthetics develops tissue-engineered nipple-areolar complex grafts to support breast reconstruction after mastectomy. The graft is designed as a scaffold for the patient's own cells to populate and regenerate the nipple and areola during reconstruction, aiming to improve cosmetic and reconstructive outcomes. The company originated as a Tulane University spin-out and was founded in 2015.

PRA Health Sciences

Grant in 2020
PRA Health Sciences, established in 1976 and headquartered in Raleigh, North Carolina, is a leading global contract research organization (CRO). It offers comprehensive outsourced clinical development and data solution services to the biotechnology and pharmaceutical industries worldwide. PRA's extensive services span clinical research, including product registration, early development, and strategic solutions, as well as data solutions such as market intelligence, consulting, and technology-enabled products. With over 17,000 employees across 90 offices in six continents, PRA has supported more than 3,800 clinical trials and contributed to the approval of over 85 products since 2000. The company is known for its commitment to excellence and high-quality global service.

Lindy Biosciences

Debt Financing in 2020
Founded in 2016, Lindy Biosciences specializes in developing protein-based therapeutic formulations using its proprietary Microglassification technology. This process converts proteins into stable, spherical microbeads, enabling high-concentration suspensions, encapsulation for controlled release, and dry powder pulmonary delivery.

East Carolina University

Grant in 2020
Founded in 1907, East Carolina University is a public doctoral/research university based in Greenville, North Carolina. It offers a wide range of undergraduate and graduate programs across various disciplines including business, fine arts, health sciences, nursing, and medicine.

North Carolina State University

Grant in 2020
Founded in 1887, North Carolina State University is a public research university offering over 300 degree programs across various disciplines at undergraduate and graduate levels. It is renowned for its engineering, agriculture, life sciences, textiles, design, natural resources, and management programs.

Tellus Therapeutics

Debt Financing in 2020
Tellus Therapeutics is a biopharmaceutical company based in Hillsborough, North Carolina, founded in 2018. The company focuses on developing innovative small molecules derived from human maternal breast milk to address unmet medical needs in newborns, specifically targeting perinatal brain injury. Its lead drug candidate promotes the regeneration of myelin-producing oligodendrocytes and aims to reverse white matter injury in premature infants. This therapeutic approach enables healthcare providers to offer treatment to all babies at risk of brain injury, ultimately striving to improve neurodevelopmental outcomes for affected children.

UNC Kenan-Flagler Business School

Grant in 2020
The University of North Carolina at Chapel Hill, established in 1789, is the first public university in the United States and operates as a non-profit educational institution. It is dedicated to teaching, research, and public service, serving a diverse community of undergraduate, graduate, and professional students. The university's mission is to foster scholarship and creativity while preparing future leaders to contribute positively to society. With a strong commitment to excellence, it leverages the expertise of its faculty and staff to enhance access to education and promote the success of its students. Additionally, the university manages an endowment fund that supports various initiatives, including scholarships, fellowships, professorships, and research across multiple disciplines. Through its outreach efforts, UNC Chapel Hill aims to improve the quality of life for the citizens of North Carolina and beyond.

Cereius

Debt Financing in 2020
Cereius, Inc. is a pre-clinical stage biotechnology company based in Durham, North Carolina, focused on developing innovative small-molecule therapies for brain metastasis, particularly in patients with HER2-positive breast cancer. Incorporated in 2017, the company specializes in novel radiolabeling chemistries that enhance the uptake and retention of radionuclides in targeted tumors while reducing the absorption in healthy tissues. This approach significantly improves both the therapeutic index and the diagnostic contrast of targeting agents, enabling medical practitioners to more effectively treat solid tumor brain metastasis and potentially improve patient survival rates.

University of North Carolina at Charlotte

Grant in 2020
UNC Charlotte is North Carolina's urban research university. It leverages its location in the state's largest city to offer internationally competitive programs of research and creative activity, exemplary undergraduate, graduate and professional programs, and a focused set of community engagement initiatives. UNC Charlotte maintains a particular commitment to addressing the cultural, economic, educational, environmental, health, and social needs of the greater Charlotte region.

University of North Carolina at Wilmington

Grant in 2020
The University of North Carolina Wilmington, the state's coastal university, is dedicated to the integration of teaching and mentoring with research and service. University of North Carolina Wilmington, commitment to student engagement, creative inquiry, critical thinking, thoughtful expression and responsible citizenship is expressed in our baccalaureate and master's programs, as well as doctoral programs in areas of expertise that serve state needs. Our culture reflects our values of diversity and globalization, ethics and integrity, and excellence and innovation.

Arrevus

Debt Financing in 2019
Arrevus, Inc. is a clinical-stage biotechnology company based in Raleigh, North Carolina, dedicated to developing innovative therapies for orphan diseases, with a particular emphasis on addressing antibiotic resistance. Founded in 2015, the company’s product pipeline includes several novel treatments: ARV-1801, an oral formulation of fusidic acid aimed at treating pulmonary exacerbations in cystic fibrosis; ARV-1907, an inhaled fusidic acid formulation targeting persistent staphylococcus aureus lung infections in cystic fibrosis patients; ARV-1502, an engineered inhibitor of bacterial DnaK for cancer treatment; and ARV-1802, a leptin receptor antagonist also for cancer treatment. Arrevus focuses on diseases where antibiotic resistance poses significant clinical challenges and is committed to developing Designer Proline-rich Antimicrobial Peptide Chaperone Protein Inhibitors to combat these issues, ultimately enhancing treatment options for serious, life-threatening conditions.

Aniluxx Biotechnology

Debt Financing in 2019
Aniluxx Biotechnology, Inc. is a biopharmaceutical company focused on developing innovative topical therapeutics for companion animals affected by skin diseases. Founded in 2019 and based in Chapel Hill, North Carolina, the company aims to enhance the health and well-being of pets by creating treatments for conditions such as atopic dermatitis and osteoarthritis. Aniluxx Biotechnology’s approach leverages a pipeline of topically formulated therapeutics based on compounds that have demonstrated safety and efficacy in humans. These therapeutics are designed to be easy to apply and virtually unnoticeable, minimizing the harsh side effects often associated with systemic medicines. Through its commitment to improving animal care, Aniluxx Biotechnology seeks to provide pet owners with effective solutions for managing their pets' health issues.

Emergo Therapeutics

Debt Financing in 2019
Founded in 2016, Emergo Therapeutics is a pharmaceutical company based in Durham, North Carolina. It specializes in developing drugs that modulate inflammatory cytokines to improve immune system functioning, with a focus on treating uncomplicated influenza and other infectious diseases.

Redbud Labs

Grant in 2019
Founded in 2010, Redbud Labs specializes in developing and manufacturing Micro-Electro-Mechanical Systems (MEMS) and microfluidics technologies for the life science industry. The company offers actuated surface-attached posts films for fluid manipulation and microfluidic technologies for biosensing, enabling small-volume sample collection, processing, and analysis.

TregTherapeutics

Grant in 2019
TregTherapeutics is a preclinical stage company based in North Carolina that focuses on developing treatments for multiple sclerosis. The company is dedicated to creating a tolerogenic vaccine aimed at inducing immune tolerance and potentially curing the disease. TregTherapeutics utilizes a proprietary technology platform, based on an exclusive license from East Carolina University, which harnesses the power of T-regulator cells (Tregs) to modulate immune responses. This innovative approach seeks to reverse the inflammatory attacks on demyelinating lesions in multiple sclerosis patients while promoting an anti-inflammatory response. The company's goal is to significantly improve patient outcomes in the management of autoimmune and neurodegenerative diseases.

Dualogics

Debt Financing in 2018
Dualogics is a biotechnology company based at the University of North Carolina at Chapel Hill, focused on the research and development of bispecific antibodies targeting oncology and autoimmune diseases. Utilizing a proprietary bispecific antibody technology, the company engineers new antibody therapeutics, diagnostics, and research tools that aim to offer enhanced properties compared to traditional methods. Dualogics collaborates with academic and industrial partners to develop and test a range of multifunctional therapies and reagents, striving to transform the treatment landscape for patients affected by autoimmune conditions and various types of cancers.

Cereius

Debt Financing in 2018
Cereius, Inc. is a pre-clinical stage biotechnology company based in Durham, North Carolina, focused on developing innovative small-molecule therapies for brain metastasis, particularly in patients with HER2-positive breast cancer. Incorporated in 2017, the company specializes in novel radiolabeling chemistries that enhance the uptake and retention of radionuclides in targeted tumors while reducing the absorption in healthy tissues. This approach significantly improves both the therapeutic index and the diagnostic contrast of targeting agents, enabling medical practitioners to more effectively treat solid tumor brain metastasis and potentially improve patient survival rates.

Baebies

Series B in 2017
Baebies develops and manufactures innovative screening equipment for newborn babies. Its flagship product, SEEKER, is an FDA-authorized laboratory solution that simultaneously performs multiple assays using a single dried blood spot specimen. FINDER, another key product, enables near-patient testing in pediatric care. Baebies serves hospitals and public health labs worldwide.

Baebies

Debt Financing in 2015
Baebies develops and manufactures innovative screening equipment for newborn babies. Its flagship product, SEEKER, is an FDA-authorized laboratory solution that simultaneously performs multiple assays using a single dried blood spot specimen. FINDER, another key product, enables near-patient testing in pediatric care. Baebies serves hospitals and public health labs worldwide.

Dignify Therapeutics

Grant in 2015
Dignify Therapeutics is a drug development company based in Raleigh, North Carolina. Founded in 2013, it focuses on restoring voluntary control of bladder and bowel functions for patients with spinal cord injury, spina bifida, multiple sclerosis, and other neurological conditions through novel pharmaceutical agents.
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