MassChallenge

CNS Therapy, they contribute to human well-being through mind-body therapy and the research, design, education, and sale of devices that alleviate chronic disease, restore health, and extend useful life. They are a spin off from the University of North Carolina (UNC). Their base technology is a patent pending approach to chronic pain which combines operant behavioral therapy with a proprietary device which enhances learning and resets the autonomic nervous system - called SET - Systolic Extinction Training. They are dedicated to providing long lasting pain relief to patients. Their unique combination of psychological training and electrostimulation helps chronic pain patients to starkly reduce or even eliminate their pain and allow them to return to their daily lives.

Via a combination of materials, biotechnology and optics IP, we are developing a microbiological testing solution applicable to pathogens, allergens and spoilage organisms. The core technology enables quantitative and array-based tests for high throughput, low component and overall solution cost, best in class time-to-result, and a hardware design road-map including small footprint and handheld form factors. The combination of consumables incorporating our proprietary materials and biological agents, low-cost hardware and analytics we're developing is uniquely positioned to serve the market.

HeroSupport is a medical device manufacturing company that transforms imaging and/or treatment tables into personalized solutions. The company was founded in 2019 and is headquartered in Veyrier, Geneva.

Elythea is an ML/DL-driven platform that obstetricians in any setting use to predict risk for complications of pregnancy (postpartum hemorrhage, c-section, eclampsia) before they ever happen. We use information that is available at the point of care, so we can make the prediction as early as the 1st trimester, allowing doctors months to prepare in advance! We use clinical history/demographic information that is available at the point-of-care, so we can make the prediction as early as the 1st trimester, in developed or developing countries, allowing doctors months to prepare in advance! Knowing high-risk earlier allows for blood/medicine/tailored clinical guidance to be prepared, reducing mortality/costs >90%. Our models use proprietary models to surpass gold standard risk assessments in the current clinical space. Our preliminary clinical trials have demonstrated 3x greater sensitivity for high risk classification of hemorrhage when comapred to the current widely used hemorrhage assessment score.

SafeGuard Surgical provides much-needed products that will ensure safer surgery for better patient outcomes while lowering costs, preventing additional surgical interventions, and reducing patient length of stay, but most importantly, preventing mortality and morbidity, which is an all-too-common risk of surgery.

AI startup that provides treatment personalization using patients' tumor samples

Cellorama multipurpose devices, reagents, and processes are patent-pending and protect cell structure and integrity during many procedures. User-friendly and cost-effective devices are designed to minimize stressful stages in the laboratory while saving time and vital resources.

Form Biologics is a new platform technology for the injectable formulation of biologic medicines in order to make treatments more patient-friendly and efficacious.

KardioStatus specializes in transforming biometric data into actionable therapeutics. The KardioStatus platform has a wide range of features created by premiere physicians and engineers to develop a patient's unique biometric profile and provide personalized clinical therapeutics.

Astron Medtech is a medical technology company focused on improving patient outcomes in tendon repair. The company develops disposable minimally invasive surgical devices that significantly reduce recovery time from six months to four months. By utilizing less invasive and sustainable surgical techniques, Astron Medtech aims to enhance the efficiency of surgical services while providing better options for patients undergoing tendon repair procedures.

Oatmeal Health is a pioneering virtual cancer clinic that focuses on delivering high-quality, patient-centered care through the integration of AI technology. The organization supports patients in Community Health Centers, Health Systems, and Imaging Centers by utilizing nurse practitioners and AI agents. Its services encompass a wide range of offerings, including lung cancer screenings, risk assessments, diagnosis, care navigation, and educational resources aimed at saving lives. By developing a multispecialty primary care and radiology platform, Oatmeal Health aims to enhance cancer screening and care for underserved populations, providing innovative virtual and on-site services. These services include AI-driven patient identification and matching, as well as AI-nodule risk assessments, ultimately empowering medical professionals to deliver preventative, image-based cancer screening at scale.

Dream Team Baby is a premiere infant and toddler sleep consulting business. One of the original sleep consultancies and backed by an esteemed board of medical advisers, we have been helping families and children with sleep for more than a decade. At Dream Team Baby, our holistic and proven sleep philosophy is that children never age out of a chance to learn to love sleep. Every child is a great sleeper, waiting to enjoy a good night’s rest. We work with families across the country and our sleep advice is regularly featured on national media outlets, including the Today Show. Included in each sleep consultation are parent support, lactation/feeding evaluation, child behavior advice, nap support, and more.

Aevice Health specializes in non-invasive wearable technology aimed at monitoring respiratory health in real-time. The company develops devices specifically for asthmatic patients, which track and record vital historical data related to respiratory symptoms and medication usage. This technology facilitates the early detection of cardiopulmonary issues, enabling clinicians to monitor patient responses to treatment effectively. By providing critical health insights from the comfort of home, Aevice Health enhances patient care and allows for quicker, more targeted medical interventions.

Eztia specializes in the manufacturing of cold therapy wearables designed to provide effective and environmentally safe cooling solutions for users. Their products are portable and easy to apply directly to the skin, eliminating the need for refrigeration or batteries. These wearables safely reduce body temperature for extended periods without the risk of freezer burn associated with traditional ice packs. By contouring to the skin, Eztia's products offer a comfortable and practical option for individuals seeking relief from heat or discomfort, all at an affordable price.

Lura Health has developed a groundbreaking non-invasive health monitoring platform that utilizes saliva as a diagnostic fluid, aiming to enhance clinical outcomes in chronic disease management. Founded in 2017 and based in Cambridge, Massachusetts, the company targets various chronic disease markets, including heart disease, chronic kidney disease, diabetes, and tooth decay. Its innovative sensors are integrated into patient-friendly orthodontic devices such as removable retainers and fixed braces. These sensors continuously measure analytes in saliva and automatically transmit data to a smartphone application, allowing users to track key diagnostic metrics related to their oral health. By enabling individuals to monitor their health in real-time, Lura Health seeks to improve personal health management and empower users to take charge of their well-being.

Narval develops synthetic antibody mimetic proteins (AMP) to replace conventional antibodies on novel first-in-class immunotherapeutics, making them as affordable, flexible and easy to use as small molecule drugs. AMPs are 40 times smaller than a monoclonal antibody but with the same biological function. Our AMP can penetrate tissue barriers, generate limited immune reactions, can target very small and hard-to-reach antigens, and are heat resistant. These advantages gives our AMP technology the ability to develop immunotherapeutic drugs for disease applications that have been previously impossible to develop because of monoclonal antibody limitations. Our AMPs can be used to generate novel first-in-class antibody drugs to treat, for example, respiratory diseases with inhaled antibodies, eye diseases with non-invasive antibodies on eye drops or autoimmune and skin diseases with antibodies in transdermal controlled release patches.

Taurus Vascular is a medical device company dedicated to enhancing long-term outcomes for patients with aortic aneurysms. The company is focused on developing innovative technology aimed at transforming the standard of care for these patients. Its novel medical device is designed to eliminate the adverse effects of endoleaks and promote accelerated shrinkage of aneurysm sacs following endovascular aortic aneurysm repair (EVAR). By addressing these critical issues, Taurus Vascular aims to improve patient outcomes within the healthcare industry.

Lighthanded Enterprises specializes in the development of innovative medical technology aimed at diagnosing middle ear effusions, particularly otitis media with effusion (OME), which is common in children. The company has created a laser otoscope that enhances diagnostic accuracy by providing an additional illumination source. This technology enables healthcare professionals to achieve up to ninety percent accuracy in identifying OME during examinations. By improving the detection of chronic middle ear effusions, Lighthanded Enterprises empowers doctors to make more informed decisions regarding patient care and treatment referrals, ultimately addressing a significant issue that can impair children's hearing for prolonged periods.

DocNexus is transforming the healthcare landscape by leveraging AI-powered knowledge graphs to enhance access to critical information. The company's platform provides a comprehensive database for key opinion leader (KOL) searches, advanced publication searches, and news aggregation, allowing medical affairs organizations to efficiently find evidence and stay updated on KOLs' digital presence. By delivering insights from millions of scientific publications, clinical trials, and news articles in seconds, DocNexus streamlines the process of connecting healthcare professionals across the ecosystem. This innovative approach enables clients to strengthen their medical affairs strategies and improve scientific exchange.

Stellate Therapeutics is a private biotechnology company specializing in the development of small molecules derived from human gut bacteria to create personalized therapies for neurological diseases. The company focuses on addressing age-related neurological conditions, particularly through its research on the gut-brain axis. Stellate has developed a portfolio of drug candidates, including AMA-101, which aims to be a first-in-class therapy for Parkinson's disease. Through its microbiome-derived medicine platform, Stellate Therapeutics is engaged in comprehensive research and has established capabilities in discovery, screening, production, and diagnostic development, striving to provide effective treatments for neurological disorders.

True Concepts Medical Technologies is a medical company that focuses on reducing financial waste in the healthcare system while improving patient outcomes. It delivers innovative and manufacturable solutions based on clinical experience. The company's flagship series of novel, cost-effective, technologies developed with the potential to save billions of dollars annually. True Concepts Medical Technologies' innovative devices deliver safe and effective solutions that reduce errors, provide consistent clinical delivery, and reduce costs. The company is creating these devices with the product development horsepower of Pixel and Timber a product design and development team that has developed dozens of innovative medical devices for clinician-inventors, startups, and manufacturers alike. True Concepts Medical Technologies was founded in 2017 and is headquartered in Centerville, Ohio, USA.

SensArs is a medical equipment manufacturing company specializing in neuromodulation technology aimed at treating diabetic neuropathy. The company has developed an innovative implantable neurostimulator electrode designed to restore sensory feedback by delivering precise electrical impulses to the nerve fibers that transmit pain signals. This technology not only assists healthcare providers in enhancing patient functionality but also offers a long-term solution for pain management. SensArs' flagship system, SENSY, is particularly beneficial for patients with amputations or nerve damage, as it helps to restore natural sensations in their feet.

Wisedocs provides a machine-learning software platform designed for insurance, legal, and independent medical evaluation firms to streamline the review of medical records. The platform addresses the challenges associated with unstructured medical data, catering to industries such as auto, liability, disability, workers' compensation, and tort law. By automating tasks like indexing and duplication detection, Wisedocs enhances the efficiency of document processing workflows, leading to improved accuracy and faster outcomes for clients. Its solution is designed for easy integration, allowing firms to simplify their back-office operations and reduce error rates in managing medical records.

Card Medic is an app that improves communication between healthcare staff and patients across any barrier, including foreign language; visual, hearing, or cognitive impairment; illiteracy; or PPE. It hosts an A-Z library of digital flashcards replicating clinical conversations around common healthcare topics; multilingual, sign language, easy read, and read-aloud. Improves quality of care, and reduces health inequalities.

Oculogenex is a biopharmaceutical company that specializes in gene therapy for the treatment of retinal disorders. The company was founded in 2020 and is headquartered in La Habra, California.

SOAP Health is a healthcare technology company based in Boca Raton, Florida, founded in 2019. It develops an artificial intelligence-powered platform designed to enhance physician productivity and improve patient outcomes. The platform captures and analyzes detailed patient data before medical visits and integrates with electronic health records to streamline clinical practice. By utilizing a conversational interface, it simplifies patient-reported data collection and risk assessment, producing nearly complete SOAP notes to assist physicians in clinical decision-making. This approach not only helps identify at-risk patients and facilitates early disease detection but also aims to increase patient engagement and satisfaction while reducing errors and liability exposure for healthcare providers.

Carium is a developer of an individualized healthcare platform that enhances the management of health and wellness journeys for users. The platform aims to deliver a personalized, actionable, and efficient care experience for both healthcare providers and their clients. By integrating augmented data from daily life, Carium equips care teams with the insights necessary to make informed clinical decisions. This approach not only fosters improved health outcomes but also helps reduce costs for healthcare providers and payers. As a result, Carium's platform contributes to better overall satisfaction for both care teams and the individuals they support.

Together by Renee is a free app that uses generative AI to streamline and automate health tasks like ordering refills, booking appointments and completing forms in an easy user experience perfect for the 123 million aging Americans managing diabetes, obesity, hypertension, and more. Together measures vital signs like blood pressure via smartphone camera - with no devices or wearables required. Together requires no data entry, typing or integration to legacy systems, using just AI to automate patient-centric care coordination. 67% of Together’s first 15,000 users are over 55 years of age and Together enjoys NetPromoter score of +85.

Ferrum Health, Inc. is a health technology company based in Santa Clara, California, that develops an artificial intelligence platform aimed at preventing medical errors and improving patient outcomes. The platform analyzes patient data across health systems to identify gaps in care and deploys multiple computer vision algorithms to evaluate radiologic images for commonly overlooked pathologies, such as lung nodules and fractures. Additionally, a proprietary natural language processing algorithm correlates these findings with physician notes, enabling hospital quality officers to address potentially missed diagnoses. Founded in 2017, Ferrum Health focuses on ensuring quality assurance in critical healthcare decisions, thereby enhancing the overall patient care experience through the integration of AI-driven tools.

Delfina is a company that specializes in developing a personalized prenatal care system aimed at ensuring the safety of mothers and infants during pregnancy. By leveraging data and machine learning, Delfina's platform creates individualized pregnancy care plans that assess patient risk through various metrics. This approach not only enhances interventional workflows but also improves provider efficiency, facilitating early intervention in prenatal care. Delfina's commitment to data-driven insights is paving the way for clinical innovation, ultimately striving to deliver equitable and cost-effective healthcare solutions for expectant families.

Eupnoos is a health-tech company specializing in digital healthcare solutions for lung health and disease detection. The company has developed a smartphone-based application that utilizes the device's microphone and camera to perform clinical-grade lung function tests and symptom-guided assessments. This platform enables users to screen, measure, and track the progression of lung health issues. By providing device-agnostic, API-accessible automated testing and data interpretation, Eupnoos supports both clinical and consumer-grade respiratory monitoring devices. The company's services facilitate telehealth and remote patient monitoring, empowering individuals to gain insights into their lung health and access professional healthcare guidance.

Patientory, Inc. is a healthcare technology company based in Atlanta, Georgia, established in 2015. It offers a health data management platform that enables individuals to securely store, manage, and share their health information. The platform empowers patients to take control of their medical records and chronic illness management while facilitating better communication and support between healthcare providers and patients. By integrating a blockchain-enabled network, Patientory streamlines access to health data, enhances care coordination, and provides insights into health outcomes. This approach aims to democratize health data ownership, reduce healthcare costs, and improve overall patient engagement and health management.

Card Medic is an app that improves communication between healthcare staff and patients across any barrier, including foreign language; visual, hearing, or cognitive impairment; illiteracy; or PPE. It hosts an A-Z library of digital flashcards replicating clinical conversations around common healthcare topics; multilingual, sign language, easy read, and read-aloud. Improves quality of care, and reduces health inequalities.

Oculogenex is a biopharmaceutical company that specializes in gene therapy for the treatment of retinal disorders. The company was founded in 2020 and is headquartered in La Habra, California.

miniMarrow presents a new disruptive therapeutic approach for the in-situ production of blood components in leukemic patients to replace weekly and burdensome transfusions markedly increasing patient quality-of-life. miniMarrow is operating in stealth mode. miniMarrow was established in Renens, Vaud

Ostiio is focused on developing an innovative bone distraction system aimed at correcting skeletal deformities and deficiencies. The company has created a fully implantable device that is buried beneath the patient's skin, eliminating the need for external components. This advanced system features a magnetically driven distraction mechanism that can be expanded with precision and monitored remotely by physicians. This programmability provides surgeons with enhanced transparency and control during the treatment process, addressing a longstanding challenge in skeletal correction. Ostiio operates as a company under the Penn Center for Innovation, emphasizing its commitment to advancing medical technology in orthopedics.

Netnoids Rx Laboratories operates a cancer contract research organization that uses patient-derived organoid model systems to help find a cure for rare cancers.

Selmod, based in Basel, Switzerland, specializes in developing innovative therapies aimed at treating life-threatening, multi-drug resistant infections. The company focuses on discovering and advancing small molecules and peptides that target new mechanisms of action, addressing the urgent need for effective treatments in hospital settings where first-line therapies have failed. Selmod aims to provide second-line and last-resort options through a disruptive approach that incorporates dual modes of action to overcome resistance mechanisms. The company's lead candidates, SLM500, SLM100, and SLM300, have shown promise in preclinical studies, with market projections indicating a total available market exceeding $9 billion. With an experienced leadership team skilled in advancing clinical candidates for major pharmaceutical companies, Selmod plans to utilize funding to advance three IND-enabling candidates and six lead-optimized candidates into proof-of-concept stages.

Davenport SAF-T Systems focuses on medical care, rehab, and loss of independence. It helps in preventing injuries or death in seniors.

Galileo Innovations develops human performance-optimizing biotech gear and equipment for athletes, first responders, military members, and labor industry workers. Its proposed technology, KordoFan, augments users with actionable insights concerning environmental and biometric hazards in real-time to target heat injuries; through an array of biomimicry cooling designs, the device aids in speed, agility, mental clarity, muscle recovery, strength, and stamina during training/shifts.

Ronawk is a biotechnology company that specializes in the development of T-Block technology, which produces patient-specific biologics for the treatment of diseases, including cancer, organ injuries, and burns. The company has created a proprietary method for growing primary stem cells in a three-dimensional environment, allowing these cells to retain their essential characteristics outside the body. This innovative approach enables the rapid expansion of stem cells, making them suitable for early-stage diagnostics and the repair of injured tissues. Additionally, Ronawk focuses on preserving primary cells from patients for future use in reconstructive surgeries, thereby enhancing the efficiency and density of human cell growth for tissue generation and disease modeling.

Newton Tech offers Mobi, a syytem that helps heal stroke patients with individualized insights and real-time fall detection and prevention.

WestFace Medical is a medical device company focused on enhancing vascular access procedures through innovative imaging technology. Their flagship product, SingleStick™, features a patented imaging adapter that employs optical coherence tomography (OCT) to provide real-time visualization of needle trajectories during vascular access. The system consists of a disposable handheld imaging adapter that attaches to any hollow bore needle and an OCT image processor, which displays the captured images. This technology allows clinicians to visualize anatomical markers in real-time, thereby improving clinical outcomes and patient satisfaction while potentially reducing costs associated with vascular access procedures. By offering a solution that facilitates traditional techniques with advanced imaging capabilities, WestFace Medical aims to redefine the standard of care in this critical area of healthcare.

Labinnova detects Breast Cancer in a Breath Sample with 98% sensibility. providing Qualitative results.

MoviWear is a technology company that specializes in medical AI and remote monitoring solutions, primarily through its platform MoviWearMED. This platform is designed to monitor patients' vital signs in real-time, whether they are at home, in retirement facilities, or on the go. By utilizing proprietary 5G IoT NurtureWatch wearables, MoviWear can detect critical changes in health indicators such as heart rate, temperature, blood pressure, and oxygen levels, as well as alerting caregivers in case of falls. The company addresses the increasing demand for continuous health monitoring outside of traditional hospital settings, particularly for seniors. Founded in 2017, MoviWear aims to enhance patient safety and prevent health emergencies, drawing inspiration from a personal family experience. Its clientele includes health and telecommunications companies across North America, Europe, and Israel.

LIALT Laboratorio de Investigación Alternativa develops toxicological evaluations without the use of animals. LIALT replaces the use of animals through the use of three-dimensional tissues in conjunction with internationally recognized protocols that provide more specific information on the mechanisms of toxic action than that obtained in animals, offering a solution to the problem previously exposed.

Mutuus is a pioneering digital healthcare membership service in Mexico, providing a comprehensive range of healthcare solutions through an intuitive platform. The service emphasizes prevention, care, and the restoration of health while also safeguarding the assets of its members. Key features of the platform include the ability to book home appointments, track physical activity, receive healthy meal suggestions, and request ambulance services. Additionally, it offers continuous medicinal, nutritional, and emotional support, allowing users to complete their treatments at hospitals without incurring extra costs. By combining these various services, Mutuus aims to enhance the overall health and well-being of its members while ensuring affordability and accessibility.

ModoScript develops a B2B hardware SaaS solution focused on remote treatment monitoring and big data analytics to enhance medication and treatment protocol efficiency. The company specializes in high-cost specialty pharmaceuticals, particularly Oral Oncolytics, and aims to leverage treatment progress data to create more personalized and safer therapies. By targeting pharmaceutical companies, health insurance providers, and medical practices, ModoScript facilitates the delivery of remote treatment care for patients with cancer and other chronic conditions. Their customizable data analytics model allows for real-time assessment of treatment effectiveness while ensuring that patients can access the service at no cost. Distribution partners include mail-order specialty pharmacies and in-office integrated pharmacies. ModoScript is committed to improving patient outcomes and ensuring equitable access to high-quality care, regardless of patients' backgrounds or socioeconomic status.

Uniphage is a biotech company that eliminates bacterial infections by combining the power of bacteriophages with artificial intelligence. Their first target disease is citrus greening, an incurable and debilitating disease that costs the United States more than $2 billion each year. Uniphage created the first commercially effective models for computationally predicting safe bacterial viruses against target bacterial infections, as well as discovered a variety of targets. This enables them to deliver new antimicrobial, safe, and precise products to market much more quickly.

Therapeutic Vision focuses on the development of pharmaceuticals primarily for the companion animal market and eventually their owners.

AcousticaBio is focused on transforming intravenous medications into formulations suitable for subcutaneous injection. The company has developed a fluid processing technology that creates complex microparticles necessary for these subcutaneous formulations. This innovative approach allows for the conversion of intravenously delivered biologic products into highly concentrated, small-volume injections. By enabling patients to self-administer life-saving drugs with reduced pain and discomfort, AcousticaBio aims to streamline treatment processes, minimizing the need for lengthy hospital visits and enhancing patient convenience.

Free Dynamics develops innovative electronic temperature sensors that operate without external batteries, leveraging quantum dynamics for enhanced performance. These miniature and cost-effective sensors are designed to be integrated into essential drug vials, ensuring compliance with stringent storage conditions. By providing reliable sensing, recording, and authentication capabilities, Free Dynamics' technology helps the pharmaceutical industry protect against tampering and counterfeiting, thereby facilitating the safe distribution of temperature-sensitive products, including pharmaceuticals and food.

Akttyva Therapeutics specializes in the development of targeted therapeutics aimed at addressing cell barrier dysfunction associated with various vascular disorders. The company leverages a deep understanding of biological pathways, along with advanced artificial intelligence and machine learning techniques, to design solutions that enhance the treatment of these conditions. Through its innovative approach, Akttyva Therapeutics seeks to provide healthcare professionals with effective tools to manage and treat disorders related to cell barriers.

Kinder is a full-service digital pediatric clinic that combines digital health with concierge care, bringing the pediatrician back to the family's living room.

Histofi is a digital health platform focused on enhancing cancer care through the use of artificial intelligence in diagnostic and treatment processes. The company offers a software-as-a-service (SaaS) platform that integrates advanced technologies with accessible services, particularly tailored for healthcare providers in various regions, including developing countries. Histofi's platform delivers cost-effective and high-quality diagnostic data, which aids physicians in generating interpretable disease scores. This functionality is designed to improve patient outcomes and quality of life, supporting users in achieving their wellness goals. By combining innovative technology with a user-friendly approach, Histofi aims to scale its solutions efficiently to contribute to better cancer care globally.

Stemloop is a biotechnology company focused on developing innovative cell-free biosensing products that enhance chemical and molecular testing processes. By utilizing genetically encoded sensing and response mechanisms, Stemloop creates accessible and actionable biosensors that are faster, cheaper, and easier to use than traditional laboratory tests. The company's mission is to address unmet needs in chemical sensing and detection, enabling medical professionals to deliver accurate and timely test results at reduced costs. Through its novel technology, Stemloop aims to unlock the potential of biology to respond effectively to various global challenges.

US Sleep Apnea aims to combat the increasing Sleep Apnea pandemic by enlisting the help of dentists. Sleep apnea is a developing problem that will kill 48 million individuals prematurely. Dentists are perfectly positioned to solve this need; but, because this is the only medical service a dentist can provide, operational inefficiencies and expensive start-up costs have kept the majority of dentists from delivering care. The US Sleep Apnea platform provides dentists with a digital solution that automates every touchpoint in the patient experience and dramatically saves front office expenditures.

BioEclosion seeks to enhance user-friendly quantitative diagnostics to new molecular biomarkers for fast identification of emerging diseases that affect global health. The company started its activity with several patents, the most important being Celifast: a non-invasive approach for the detection of celiac disease. Addressing point of care attention of patients, the core technology has been successfully validated and the team is currently working on further development for commercialization.

Kobara Medical is focused on addressing the heart failure market, specifically targeting Heart Failure with Preserved Ejection Fraction (HFpEF), a condition impacting over three million individuals and on the rise. The company has developed a minimally invasive therapeutic device that utilizes neuromodulation therapies to improve cardiac function without the need for invasive procedures. By employing the heart's transverse pericardial sinus, the device allows for multi-chamber pacing and combines multiple leads into a single, elegant solution, thus avoiding the complications associated with penetrating blood vessels. Kobara Medical aims to enhance treatment options for patients suffering from heart failure and cardiac arrhythmias by leveraging innovative approaches to heart anatomy.

React4life is an Italian biotech company established in 2016 by Silvia Scaglione and Maurizio Aiello, following over 15 years of research and development. The company focuses on advancing biomedical research through its innovative technology, MIVO® (Multi In Vitro Organ), which represents a next-generation organ-on-a-chip system. This microphysiological platform allows researchers to simulate human biology more accurately in laboratory settings, addressing the limitations of traditional in vitro assays and animal testing. React4life's technology enhances the reliability and predictivity of various applications, including pharmaceutical drug testing, personalized medicine, immuno-oncology therapies, cosmetics, dermatology, and nutraceuticals. By enabling the cultivation of three-dimensional human-like tissues for in vitro testing, React4life aims to improve the effectiveness of laboratory experiments and promote ethical research practices.

Vectech is a public benefit corporation based in Baltimore, MD, specializing in an AI-based diagnostic system for medical entomology. The company has developed an identification system that accurately determines species, sex, and other essential characteristics of mosquito and tick populations. This technology is currently deployed in seven countries and serves various clients, including municipal and national public health programs, NGOs, and malaria control initiatives. By providing tools that reduce labor costs associated with mosquito surveillance, Vectech empowers researchers and public health organizations to detect threats from mosquito-borne diseases like dengue and malaria, facilitating early intervention and customized responses to potential outbreaks.

TissueLabs is the platform for creating organs and tissues in the lab. We offer biomaterials, equipment, and services to support tissue engineering and regenerative medicine. Our products are created to allow performing state-of-the-art research, from drug discovery to organ fabrication. Currently, we are focused on attending the academic life sciences market. In the future, our mission is to fabricate lab-grown tissues and organs, for both research and therapeutic applications.

Brightcure is solving the lack of treatment options available for patients suffering from recurrent urinary tract infections (UTIs). UTIs are one of world’s most common infections, affecting 50% of women and 12% of men worldwide. Current UTI treatments are not effective, can cause serious side effects, and often accelerate antibiotic-resistant infections. Total UTI costs currently amount over $ 8.6B per year. With UTI bacteria becoming increasingly difficult to treat, the size of the UTI market is expected to reach $ 12.41B by 2025. Brightcure utilizes the natural microbiome to reduce harmful bacteria and replenish the good bacteria in the vaginal flora. Brightcure’s bioactive intimate cream boosts the natural immune system to promote a healthy urinary tract. BrightCure was founded in 2019 and is headquartered in London, England. In 2020, BrightCure got a seed investment from SOSV and was selected as 1 out of 9 companies to be part of the world's largest biotech accelerator, Indiebio, to develop its first product. BrightCure has been selected as one of the Top 7 companies of the McKinsey Venture Challenge, Top 5 of the Mayor of London Competition, has won Imperial College's White City Innovation Program, and has taken part in the finals of ‘The Pitch’ London Competition being selected among 850 other applications.

Digi.Bio is a Netherlands-based company that specializes in developing software solutions for the healthcare industry, particularly in the field of cell therapies. It offers a microfluidic platform that automates repetitive and manual laboratory workflows, utilizing artificial intelligence and electrowetting technology to manipulate droplets at a microscale. This innovative approach aims to streamline multistep liquid handling applications, replacing traditional pipetting methods. Digi.Bio's platform delivers comprehensive analysis of cell therapies, evaluating their performance and outcomes at the single-cell level within 24 hours, while minimizing material waste. By enhancing automation in medical and pharmaceutical settings, Digi.Bio supports the advancement of bioengineering processes.

BestHealth4U focuses on the research and development of advanced solutions for manufacturers of class 1 medical devices. The company specializes in medical adhesive technologies that aim to prevent skin injuries, accelerate healing, and enhance overall patient health. Its innovative and environmentally friendly adhesive products are designed to safeguard patients from skin damage, discomfort, irritation, and infections by improving the attachment of bandages, dressings, and medical devices to the skin. By providing effective solutions, BestHealth4U assists healthcare providers in reducing medical adhesive-related skin injuries and promoting the well-being of patients.

Matricelf is a biotechnology company focused on the development of advanced tissue and organ engineering solutions. Established in 2019 by Professor Tal Dvir from Tel Aviv University, the company utilizes a proprietary decellularization process to extract stromal cells and extracellular matrix (ECM) from small omental biopsy samples. This process produces a thermo-responsive hydrogel that incorporates reprogrammed induced pluripotent stem cells (iPSCs), which are differentiated into functional tissues using a patent-pending methodology. Matricelf's innovative approach aims to reduce the risk of implant rejection and includes the production of spinal cord implants designed for patients with traumatic spinal cord injuries. These implants help restore neuronal activity and motor functions, enabling patients to reintegrate into their communities and improve their daily lives. The company is committed to advancing medical treatments through its platform for autologous matrix and cell implants, addressing a wide range of medical conditions.

Semantic Health is a Toronto-based healthcare technology company that utilizes proprietary artificial intelligence to enhance medical coding, auditing, and clinical documentation improvement processes for hospitals. The company's online medical data platform automates the extraction of medical codes and insights from patient charts, creating a real-time, actionable data layer. This disruptive data engine enables hospitals to analyze medical data more effectively, ultimately improving patient care, operational efficiencies, and the delivery of value-based care.

Augment Therapy, Inc. is a Cleveland-based company that develops an interactive augmented reality software solution aimed at enhancing pediatric physical therapy. Established in 2017, its platform facilitates remote monitoring and real-time sessions for patients, allowing therapists to automate data collection during therapy. Designed by a pediatric physical therapist, the software engages and motivates children in their rehabilitative exercises through gamified technology. It utilizes depth-sensing camera technology and features a library of evidence-based exercises and interactive games, enabling therapists to collect and analyze objective patient data while making therapeutic activities more enjoyable for young users.

Kinto.Care is a provider of an online platform to improve communication. The company's platform features user-generated content and digital tools to improve care team collaboration, medication management, and check-in data tracking, enabling the family members of a patient to coordinate care and manage medicines through a single platform.

Mosaic health data provides medical records of complete data of a patient's health across the continuum of care

See Yourself Health specializes in chronic care management by leveraging immersive technology, data science, and social learning to enhance health and wellness. The company offers a platform focused on diabetes treatment within a virtual environment, utilizing a peer network and a constructivist curriculum to foster engagement. By emphasizing peer support, online learning, and measurement-based care coaching, See Yourself Health aims to improve outcomes for individuals managing chronic diseases. Their approach is designed to help both healthcare professionals and patients navigate high-intensity, high-stress situations, thereby accelerating behavior change and optimizing health results.

Sympti is an AI discovery platform designed to enhance healthcare services by helping consumers locate nearby care centers and hospitals. Founded in 2015 by Raghu Dhulipala and Alex Guastella and headquartered in Orlando, Florida, the platform improves patient experiences by providing quick access to medical services, including emergency rooms, urgent care facilities, and telehealth providers. Users can register on the platform to benefit from features such as online check-ins, which streamline the process of receiving care. Additionally, healthcare providers gain access to a wider patient base, facilitating more efficient service delivery.

Qumata specializes in life and health insurance underwriting by utilizing digital data to assess the risk of over 800 medical conditions. The company's innovative approach streamlines the application process, reducing the need for lengthy questionnaires and medical visits, thereby saving applicants significant time. Qumata aims to enhance the underwriting experience for insurers while maintaining accuracy, ultimately enabling them to discover new revenue opportunities. Through its platform, Qumata is setting a new standard in the insurance industry by improving efficiency and customer satisfaction in the underwriting process.

Soshe Inc. is a Boston-based company that specializes in a mobile application designed to support women's health during pregnancy, childbirth, and the postpartum period. The app facilitates birth preparation and planning, enabling women to articulate their preferences for labor and delivery. It also serves as a valuable resource for doulas, midwives, and childbirth educators, allowing them to assist their clients in navigating their birth choices. Additionally, the application features an online community where users can engage with instructors to ask questions and seek guidance throughout their pregnancy journey. By providing real-time labor support, Soshe aims to enhance childbirth satisfaction and reduce the likelihood of unplanned cesarean sections. Soshe Inc. was established in 2018 and was previously known as STRAMA INC.

Path Ex, Inc. is a Nashville-based company established in 2017 that specializes in the development of extracorporeal blood-cleansing equipment aimed at treating sepsis, a severe and often fatal condition linked to blood-borne infections. The company has created a proprietary technology that selectively separates and captures bacteria and toxins from human blood, offering a novel approach to treatment. Unlike traditional methods that rely on broad-spectrum antibiotics to kill infections, Path Ex's device effectively removes intact bacteria from the bloodstream, regardless of the bacteria type or antibiotic resistance. This innovative technology has the potential to improve patient outcomes by reducing diagnostic times, treatment costs, readmission rates, and fatalities associated with sepsis.

TalkON is a technological SaaS platform focused on enhancing speech therapy outcomes through innovative solutions. It offers a practice management platform that simplifies administrative tasks and delivers therapy sessions effectively. The platform enables users to input and manage patient information, including demographics, contact details, and treatment history. It also allows for the electronic distribution of assessment forms to parents, appointment scheduling, and progress tracking. By facilitating communication between doctors and parents, TalkON aims to improve outcomes for children with speech and communication disorders.

O2 RegenTech is focused on developing innovative wound care solutions that are both cost-effective and user-friendly. Utilizing proprietary biopolymer technology, the company's flagship product, OXAID™, serves as an oxygenating, moist, and antimicrobial dressing designed to enhance and accelerate the healing of chronic wounds. By addressing the need for effective wound management, O2 RegenTech aims to provide accessible options for individuals suffering from chronic conditions, ultimately improving patient outcomes and quality of life.

Medflyt is a digital health platform that connects the healthcare industry with caregivers, streamlining the staffing process for home care agencies. The platform facilitates the assignment of staff to patients and offers caregivers real-time job alerts, enhancing their income opportunities. In addition to staffing solutions, Medflyt provides a range of services including online training, remote onboarding, clinical documentation, and compliance passport solutions. Customer inquiries can be managed through various channels such as phone, email, and online applications, ensuring comprehensive support for users.

Thinks Works is an early-stage biomedical company developing ideas and products that help to solve problems that humans are dealing with. It is the concept of founder Ryan C. Murdock, MD. Through his interactions with his patients dealing with the condition of scoliosis, he saw a need for improvement in the treatment of scoliosis. He set this as a goal and now has begun to build an incredible team to bring his vision to reality so that we may dramatically improve the lives of these patients. Its device is for the non-operative treatment of adolescent scoliosis, a severe curvature of the spine in kids. Approximately 10,000 US kids per year require brace treatment. The current treatment is a custom-made hard plastic brace. It keeps the spine immobile by compressing the ribs. It has poor patient compliance and outcomes at a high patient cost. Its novel device will improve patient comfort, compliance, and outcomes at a lower total patient cost.

Lainomedical is engaged in the development of respiratory devices, focusing on innovative solutions for the administration of medication through inhalation. The company specializes in designing and manufacturing nebulizers used to treat conditions such as asthma and cystic fibrosis. Their products are engineered to minimize medication errors and eliminate the need for cleaning or disinfection, thereby enhancing treatment outcomes for patients and improving their overall quality of life. Additionally, Lainomedical offers an OTC solution portfolio that incorporates a patented delivery technology aimed at the nose and throat area, further expanding their range of pharmaceutical offerings.

Pegwin is a healthcare software company that focuses on improving patient safety through its platform, KBCore. This system employs predictive technology to enhance communication among doctors, nurses, and staff while also reducing costs. Pegwin's enterprise data management platform provides real-time clinical tools that facilitate hospital rounds and offer meaningful insights for quality improvement. Additionally, it captures data to streamline risk management functions, helping healthcare organizations analyze patient safety information. By identifying active threats, Pegwin's solutions aim to predict and prevent potential harm, ultimately enabling better and safer patient care processes.

Vyasa Analytics is a company that specializes in providing an AI-powered platform tailored for life sciences and healthcare organizations. Its flagship product, Vyasa Layar, facilitates the integration and analysis of diverse data across various environments, including both cloud and on-premise sources. The platform offers a unified data landscape that allows users to explore their data through a suite of low-code, deep learning applications. Vyasa's technology incorporates scalable deep learning software that is capable of performing dark data analytics, neural concept recognition, and collaborative analytics, empowering organizations to extract insights from their enterprise data effectively and securely.

Microbial Pulse Diagnostics is developing and deploying an innovative NIST technology for the rapid measurement of antimicrobial susceptibility. This technology “takes the pulse” of bacterial cells, sensing changes in their metabolism, motility, and growth after exposure to an effective antibiotic.

Soma Devices offers a Train-of-Four (TOF) quantitative device that measures the level of neuromuscular blockade in patients during surgery. A novel approach to measure TOF requires the capture of limited movement of the thumb when the hands are strapped in suboptimal locations. The device includes a full glove, versatile to accommodate many hand sizes, and is easy to put on. Our vision is that anesthesiologists will be using the TOF device as part of routine checking to avoid postoperative issues.

MIBIOMICS mission is to develop innovative, safe, and effective microbiome-based solutions to treat currently incurable skin diseases.

UniExo is high tech startup company, that create modular exoskeletons under control machine learning algorithms and doctor online-surveillance. Our devices combines medical science, experience of doctors, modern robotics and advanced programming, that give for us a leader position of innovation in exoskeleton industry.

Karuna strives to help every patient access a guide in the healthcare system. Its integrated solution leverages infrastructure, workflow, and automation tools to form a single platform that copilots every interaction between patients, family members or other support, and the care team. The company was founded bin 2018 and is headquartered in San Francisco, California.

NUBIX stores and remotely interprets specialty studies connecting specialist with clinics, hospitals, laboratories and public and private cabinets, insurers and patients. We support the diagnosis by managing, storing and interpreting studies of specialty in 3 simple steps: storage of studies, access to studies from anywhere and interpretation of the study at any time. We improve the communication systems available between clinics and hospitals with medical specialists. Our focus is on 3 areas: insurers that seek to reduce their costs based on the reduction of mounted claims, clinics and public and private hospitals that do not have a radiologist or other specialist in their staff, to the public health sector as a third party authorized for distance interpretation and patients who are seeking a second medical opinion about their medical procedures. During its first year of operations (2018) NUBIX serves more than 39,000 patients including more than 35,000 patients for the early detection of breast cancer. Times of up to 25 hours for patient care are achieved through NUBIX compared to other options that take more than a month to perform the interpretation, this is very important since with most types of cancer Breast division takes one to two months, that is, the lesion doubles in size from a treatable finding to a high-risk one.

Onexio Biosystems is a research and development company. They offer HTS screens that typically utilize a single reporter cell type that lacks important confounding biology, including drug metabolism and paracrine and endocrine cell interactions. Their microDUO supports co-culture and multi-culture to improve human relevance in drug discovery and chemical screening.

Adiposs SA is a clinical-stage life science company focused on developing innovative medical imaging products aimed at the early detection of cachexia, a serious condition characterized by severe body wasting. The company has created a first-in-class CT contrast product that allows for the detection of body wasting prior to noticeable weight loss, potentially up to a year earlier. This advancement enables healthcare providers to identify cancer at an earlier stage, ultimately improving patient outcomes and enhancing their quality of life. By facilitating timely intervention, Adiposs aims to provide patients with a better chance of survival against cancer and other chronic illnesses.

Sano Chemicals is an early-stage biotechnology company focused on developing innovative anti-infectives for both clinical and agricultural applications. The company aims to enhance health and promote a sustainable environment through its unique products. Sano Chemicals specializes in antifungal treatments, particularly targeting fungal infections in humans as well as bio-control methods for crops. One of their key compounds, occidiofungin, is a novel antifungal discovered by researchers at Mississippi State University and Texas A&M University. The company is working on various applications of occidiofungin to address fungal infections affecting nails, skin, and systemic health, while also developing solutions to combat fungal diseases in plants. Through these efforts, Sano Chemicals seeks to revolutionize the antifungal industry and improve quality of life for patients and sustainable agricultural practices.

UDoTest is a Boston-based B2B disease testing platform established in 2017 by Allison Martin. The company specializes in self-sampling screening test kits designed for early detection of various diseases, including colon cancer, HPV, and STDs. By offering convenient at-home testing solutions, UDoTest aims to improve the wellness experience and enhance the quality of disease screening. Its human-centered platform facilitates accurate pathology tests, allowing patients to access personalized services that simplify the screening process.

Articulate Labs, Inc. is a medical device company based in Austin, Texas, that specializes in developing wearable technology for the treatment of knee osteoarthritis. Founded in 2009, the company produces KneeStim, a device that employs neuromuscular electrical stimulation (NMES) to enhance muscle function and support rehabilitation during everyday activities. By integrating motion-tracking hardware and clinician input, the device tailors stimulation patterns to align with the user's natural movement, effectively combating muscle atrophy and inhibition associated with chronic conditions or recovery from surgery. Articulate Labs aims to make physical rehabilitation more accessible and effective, allowing patients to engage in their daily routines while receiving therapeutic benefits.

mk2 Biotechnologies uses a synthesis process to design, synthesize, and research peptides and proteins. Their process allows the scalable and production of purity peptides and proteins for a range of applications.

Simply Speak is a digital health company founded in 2019 and based in New York, New York. It specializes in developing an artificial intelligence platform that assists physicians in documenting telehealth encounters with patients. By leveraging conversational AI, Simply Speak's platform extracts meaningful medical data from interactions and automatically integrates this information into electronic medical records. This functionality not only streamlines the documentation process but also enhances the physician-patient relationship and boosts overall productivity within medical practices.

Knot is a modern case log that helps doctors and patients.

KriyaBio specializes in developing innovative drug delivery solutions centered on its proprietary permeation enhancer, KB01. This advanced technology functions as a tight junction modulator, significantly improving the absorption of co-administered therapies. KriyaBio aims to replace traditional intravitreal injections of biologics with eye drops, promoting greater patient safety and compliance while reducing overall healthcare costs. Through its novel approach, the company addresses key challenges in drug delivery, enhancing the efficacy and convenience of therapeutic treatments.

Syntr Health Technologies, founded in 2019 by Ahmed Zobi, Hugo Salas, and Justin Stovner, is a start-up based in Irvine, California. The company specializes in the development and testing of the SyntrFuge™, a medical device designed for the micro fragmentation of adipose tissue. This device allows healthcare providers to process autologous adipose tissue harvested through existing liposuction systems directly at the point of care. The SyntrFuge™ aims to address various age-related medical conditions, including reducing diabetic amputations, treating diabetic foot ulcers, combating facial fat loss, and alleviating knee osteoarthritis.

Computational Life Inc. is a software development company based in Wilmington, Delaware, that creates innovative solutions for the healthcare sector. Founded in 2018, the company specializes in a Digital Avatar Platform (DAP) that simulates human and animal physiological systems using advanced mathematical models. This technology allows for detailed simulations of various bodily systems, including arterial and venous dynamics, heart function, microcirculation, and cerebrospinal fluid movement. By leveraging validated physical laws, Computational Life's platform aids healthcare professionals in predicting personalized patient outcomes and managing complex medical conditions. The software's ability to model the effects of medical treatments enhances decision-making in clinical settings, particularly for multisystemic diseases.

Moving Analytics is a telehealth service provider that specializes in cardiovascular prevention programs. Its first product Movn is an end-to-end, integrated program to deliver remote and virtual cardiac rehab. The platform reduces readmissions and empowers the effective and efficient delivery of quality care to patients based on 30+ years of research in remote disease management from Stanford University.