MassChallenge

Extracellular specializes in accelerating biotechnology advancements by applying its expertise in extracellular channels biology, digitalization, and biomanufacturing. The company leverages its deep insights into cellular behavior and scale-up experience to efficiently produce biomass for cultivated meat companies. It achieves this by digitalizing process development, enabling data-driven decision-making at scale. Additionally, Extracellular offers an R&D platform and biomanufacturing solutions tailored for sustainable biotech sectors such as cultivated meat, plant cell culture, bio-cosmetics, supplements, and materials. Its focus is on reducing R&D costs and timeframes to facilitate the swift market entry of sustainable biotech companies.

Fotortec is a biotechnology company focused on sustainable protein production through innovative technology. It specializes in creating mushroom-based ingredients that are derived from vegetable waste, effectively transforming what would otherwise be discarded into valuable, fully traceable plant-based products. This process not only contributes to waste reduction but also ensures that consumers have access to nutritious food options. Fotortec's commitment to sustainability and nutrition positions it as a leader in the development of environmentally friendly food solutions.

Producer of food products intended to provide fish meat alternatives through cell cultivation. The company specializes in producing cultivated cell-based fish fat to greatly enhance the flavor, texture aroma and nutrition of alternative protein products, enabling consumers to get healthy fats such as omega-3 that protect from heart diseases.

Restoring crops' ability to defend against pests.

CNS Therapy, they contribute to human well-being through mind-body therapy and the research, design, education, and sale of devices that alleviate chronic disease, restore health, and extend useful life. They are a spin off from the University of North Carolina (UNC). Their base technology is a patent pending approach to chronic pain which combines operant behavioral therapy with a proprietary device which enhances learning and resets the autonomic nervous system - called SET - Systolic Extinction Training. They are dedicated to providing long lasting pain relief to patients. Their unique combination of psychological training and electrostimulation helps chronic pain patients to starkly reduce or even eliminate their pain and allow them to return to their daily lives.

Embryoxite is a biotechnology company specializing in non-invasive diagnostic services for pre-implantation embryos in human-assisted reproduction. It operates a platform that combines artificial intelligence, metabolomics, embryo imaging, and clinical data to enhance embryo selection accuracy and improve patient outcomes for fertility clinics and reproductive specialists.

Econutri is a producer of sustainable protein solutions aimed at addressing environmental challenges and meeting diverse market needs. The company has developed a high-tech bio-process that recycles carbon dioxide into high-quality proteins. This innovative approach provides eco-friendly and nutritious protein alternatives for various applications, including livestock feed, pet food, non-food products, and human food options. By focusing on sustainability, Econutri aims to reduce the global carbon footprint while contributing to the growing demand for sustainable food sources.

Sonali Bioplastics solves the plastic pollution problem with plant based alternatives that reduces carbon emissions. Sonali Bioplastics takes a sustainable development approach toward solving plastic problems and promote eco-friendly farming. The company was founded in 2019 and is based in San Jose, California.

Organic Fields offers an innovative biological, certified organic fertilizing solution to commercial growers in the agricultural.

Sóliome is a biotechnology company based in San Francisco, California, founded in 2021. The company specializes in the development of protein-based sunscreens designed to be safe for both human use and the environment. Sóliome's innovative products aim to reduce the absorption of harmful chemicals found in traditional sunscreens, which can contribute to skin inflammation and ecological damage. By focusing on skin protection from harmful rays while minimizing environmental impact, Sóliome addresses growing concerns about both personal health and sustainability in skincare.

Nature's Principles is a pioneering company that originated from a Ph.D. project at the Delft University of Technology in the Netherlands. The company has developed a patented mixed culture fermentation technology that aims to revolutionize traditional agro-chemical production methods. This innovative process utilizes principles derived from nature to cultivate microorganisms, enhancing their productivity without the need for genetic engineering. By transforming low-value waste streams such as sugar beet, pulp, and molasses into valuable products like lactic acid and poly-lactic acid for bioplastics, Nature's Principles enables clients to reduce reliance on oil-based chemicals. The technology not only improves efficiency but also demonstrates significant advantages in terms of water usage, carbon dioxide emissions, and land utilization compared to conventional alternatives.

Updairy is a company that produces food ingredients, specifically animal-free dairy proteins. It uses microorganisms to create these proteins, replicating the taste and nutritional value of traditional dairy products while significantly reducing greenhouse gas emissions. This allows customers to develop new dairy products with a lower environmental impact than traditional dairy farming.

SCALE Advanced Biocomposites specializes in the development and manufacturing of bio-based materials, focusing on natural-fiber composites. The company aims to enhance performance while reducing costs and greenhouse gas emissions, contributing to the decarbonization of various industries, including sporting goods, automotive, wind power, and aerospace. SCALE's innovative materials and technologies are designed to fully or partially replace carbon fiber, making them a sustainable alternative that meets the demands of high-performance applications. By accelerating the adoption of bio-based materials, SCALE plays a crucial role in transforming the built environment towards lower emissions and greater sustainability.

Xibus Systems, Inc. is a company based in Somerville, Massachusetts, that specializes in developing and marketing advanced microbiological analytics and testing tools. These tools are designed to test consumable solutions for pathogens, allergens, and spoilage organisms. The company's innovative platform combines materials science, biotechnology, and optical technology to facilitate quantitative and array-based testing. This approach allows for high throughput and cost-effective solutions with rapid results, making it particularly beneficial for food safety and quality assurance. Xibus Systems aims to create a range of products, including low-cost hardware and consumables, that cater to the growing demand for effective microbiological testing in various industries.

SeaStock is a global marine research company focused on developing solutions for the production and extraction of compounds derived from seaweed and algae. The company specializes in the processing of asparagopsis seaweed, which is utilized in creating methane-reducing feed ingredients among various other applications. By offering a range of products, SeaStock enables clients to select specific solutions tailored to their needs, contributing to advancements in marine science and sustainability.

BioMixing is a biotechnology company dedicated to enhancing bio-fermentation processes. It specializes in developing innovative agitation systems for bioreactors, leveraging fluid dynamics principles to minimize cell damage and optimize mixing within the vessel. This enables other organizations to improve the efficiency of their fermenters and bioreactors, thereby addressing various biotechnological challenges.

LiveGrow Bio is a biotechnology company focused on microbial fermentation and formulation, specializing in the production of biopesticides and biostimulants. The company has developed a patented technology that significantly reduces production costs by up to 95% while enhancing product shelf life to over two years at room temperature. This innovation allows for the effective commercialization of biological products across various crop markets, not limited to high-value organic crops. LiveGrow Bio’s technology facilitates the modular and scalable production of microbes, enabling the manufacturing process to take place directly within retail packaging sold to farmers, thereby eliminating the need for traditional large-scale fermentation facilities and reducing downstream processing requirements. This unique approach positions LiveGrow Bio as a pivotal player in the biological products industry, providing accessible and cost-effective solutions for agricultural stakeholders.

YouthBio Therapeutics Inc. is a biotechnology company specializing in the development of rejuvenation gene therapies through partial reprogramming techniques inspired by Yamanaka factors. The company aims to harness cellular reprogramming to restore youthful gene expression profiles in targeted cells, which can lead to beneficial therapeutic effects in corresponding organs. By focusing on these innovative approaches, YouthBio Therapeutics seeks to empower patients to prevent age-related diseases and potentially delay or reverse the aging process.

Arnav Biotech is a biotechnology company that operates as a Contract Development and Manufacturing Organization (CDMO), specializing in mRNA technology. It offers services for the design, development, and manufacturing of custom and cataloged mRNA products, supporting research, therapeutics, and vaccines. By providing these services, Arnav Biotech enables researchers to concentrate on their specific areas of interest, thereby democratizing access to mRNA-based life sciences.

Intek Scientific develops multiplexed immunofluorescence imaging technology.This will empower clinicians and researchers to gain a deeper understanding of cancer and provide effective and customized therapeutic strategies to tackle even the most challenging cancers.

Speratum is a biopharmaceutical company focused on microRNA-directed oncology therapies. The Company was founded in 2014 by Christian Marín-Müller, Ph.D. and is dedicated to the development of a patented treatment for pancreatic cancer based on the combination of tumor suppressive microRNA molecules and nanoparticle-based drug delivery technologies. The Company is currently entering the final stage of preclinical trials for the pancreatic cancer therapy, while simultaneously expanding the patent’s coverage to incorporate other types of cancer and non-cancer indications and illnesses and expanding its intellectual property (IP) portfolio with complementary technologies in the fields of nanotechnology, medical devices and veterinary medicine.

PlusVitech is a biotechnology company that specializes in developing effective and safe therapeutic treatments and complementary diagnostic tests for cancer patients. The company focuses on non-invasive genetic cancer detection through innovative therapies that utilize small molecules and monoclonal antibodies. By offering alternatives to traditional tissue biopsies, PlusVitech enables healthcare professionals to detect and treat cancers at an early stage, thereby improving patient outcomes and enhancing the overall management of cancer care.

Azul Bio specializes in marine ecosystem preservation and enhancement, focusing on coral reef restoration. They employ advanced biological analysis services to monitor and maintain aquatic environments, offering DNA-based biodiversity assessments, species genotyping, microbiome profiling, and disease detection. This data empowers marine researchers and industries to improve aquaculture practices and safeguard ocean ecosystems against climate change.

Women aged 20-45 cannot get screened for breast cancer because existing solutions are unreliable. However, 81% want to. At The Blue Box, we have built a pain-free, low-cost, sensitive, radiation-free device to detect breast cancer in urine with a sensitivity of 83%. In 2024, we’ll launch into the market, bringing The Blue Box to private gynecology clinics with a Diagnostics-as-a-Service subscription model, and a pay-per-test revenue stream that we’ll share with doctors.

Hydrobee, based in Seattle, develops innovative clean energy solutions. Their flagship product, Firebee™, converts heat from biomass stoves into USB charging power for devices like phones and LED lights. This thermoelectric generator also improves stove combustion efficiency via a Jet-Flame blower, reducing smoke and indoor air pollution. Hydrobee's technology enables mobile network financing for cleaner, more efficient stoves, benefiting over three billion people who currently rely on biomass cooking methods. As a Social Purpose Corporation, Hydrobee aims to alleviate energy poverty and indoor air pollution globally.

Astron Medtech is a medical technology company focused on enhancing patient outcomes through innovative surgical solutions. The company specializes in developing disposable, minimally invasive devices specifically designed for tendon repair, significantly reducing recovery time from six months to four months. By utilizing less invasive and more sustainable surgical techniques, Astron Medtech aims to streamline surgical services and improve the overall patient experience.

Drizzle Health develops low-cost, high-performance tuberculosis and other bacterial disease diagnostics.

Cellorama multipurpose devices, reagents, and processes are patent-pending and protect cell structure and integrity during many procedures. User-friendly and cost-effective devices are designed to minimize stressful stages in the laboratory while saving time and vital resources.

Earnest Agriculture collaborates with farmers to transform agricultural waste into innovative biofertilizers that enhance crop yields. By converting waste products such as manure and vegetable remnants, the company provides an eco-friendly solution that not only helps farmers manage their waste but also offers them a potential source of additional income. Utilizing a combination of composting, vermicomposting, and advanced microbial technologies, Earnest Agriculture develops proprietary fertilizers designed to improve soil quality, promote drought resistance, and suppress pathogens. This approach not only reduces the environmental impact of farming but also allows farmers to lower their input costs while increasing their productivity.

Electronrx specializes in personalized digital medicine, focusing on the development of innovative solutions for chronic disease management and hospital patient care. The company leverages a multidisciplinary team, comprising experts in biomedical engineering, data science, machine learning, computer engineering, mathematics, physics, neuroscience, and drug discovery. Electronrx's predictive healthcare and diagnostics platform is designed to monitor physiological conditions and facilitate personalized therapeutic interventions. Its products enable remote monitoring of cardiovascular health by clinical professionals, delivering short waveforms of current and voltage to provide relief. This technology empowers patients to self-monitor their health and effectively manage conditions such as period pain during treatment.

Form Biologics is a new platform technology for the injectable formulation of biologic medicines in order to make treatments more patient-friendly and efficacious.

Azooka is a biotechnology company specializing in the production of proprietary fluorophores, which are used as molecular biology tools in life science research and diagnostic applications. Their product portfolio includes fluorescent dyes for DNA, RNA, chromosomes, live cells, and molecular-grade sample collection mediums. Azooka's mission is to provide secure, sustainable, and affordable biotech consumables globally, with a focus on accessibility for all nations. Notably, the company has been recognized as the "Best Women-Led Enterprise."

Skygenic is an innovative infrastructure and data analysis platform designed to facilitate the research process for scientists working with biological data. Developed in collaboration with physician scientists from Harvard Medical School and Boston Children's Hospital, the platform addresses challenges faced in early-stage and translational research by enabling non-programming scientists to conduct their own data analyses. By streamlining the storage, transfer, and interpretation of genomic data, Skygenic reduces the reliance on bioinformaticians, thereby accelerating discovery within academic institutions, hospitals, biotechnology, and pharmaceutical organizations. This approach allows for more efficient research efforts at a lower cost and in a shorter timeframe.

ZiO Health is a biotechnology company focused on enhancing patient outcomes through its innovative pocket-sized laboratory testing technology. The company has developed proprietary biosensor devices that utilize machine learning algorithms to provide real-time results tailored to individual patient profiles. These multi-functional electronic devices are designed for measuring, testing, and detecting the molecular composition of various chemical and biological substances, enabling users to assess the presence, absence, or quantity of specific target molecules. By delivering quality home diagnostics and personalized testing solutions, ZiO Health aims to empower individuals to optimize their health and prevent illness.

Trove Health is a company that offers a clinical trial recruitment platform designed to facilitate access to patient data for patients, healthcare providers, and life sciences organizations. The platform creates a diverse and consented database of prospective trial participants, enabling researchers to efficiently identify and recruit patients who meet specific enrollment criteria across various geographies and therapeutic areas. By doing so, Trove Health supports the advancement of medical research while empowering patients to manage their own health data, including the potential to monetize it and receive personalized treatment options.

Anviron is an advanced therapeutic company focused on developing innovative treatments for late-stage cancers. The organization is committed to addressing unmet medical needs in oncology through its platform, which is grounded in cutting-edge scientific research. Anviron's team comprises scientists, doctors, and clinicians who collaborate to create therapies aimed at improving patient outcomes and transforming cancer care. By leveraging their collective expertise, the company seeks to make significant advancements in the fight against difficult-to-treat cancers.

Stellate Therapeutics is a private biotechnology company that specializes in the development of small molecules derived from human gut bacteria, aimed at creating personalized therapies for neurological diseases. The company focuses on researching the gut-brain axis and its implications for age-related neurological conditions. Stellate has established a robust portfolio of drug candidates, including AMA-101, which is positioned as a potential first-in-class therapy for Parkinson's disease. Through its innovative microbiome-derived medicine platform, Stellate Therapeutics engages in various stages of drug development, including discovery, screening, production, and diagnostic development, with the goal of providing effective treatments for patients suffering from neurological disorders.

Dart Biosciences works in the healthcare industry. It creates tailored gene therapies for a variety of uncommon and prevalent disorders.

Symphony Biosciences is a biotechnology company dedicated to developing innovative cancer treatments that target solid tumors, with a primary focus on triple-negative breast cancer. Recognizing the limitations of existing therapies, which often involve toxic chemotherapies with poor survival rates, Symphony Biosciences aims to orchestrate the immune response to improve outcomes for patients. The company's research emphasizes the use of biomaterials to enhance cancer treatment options, providing healthcare professionals with effective tools to combat challenging cancer types. Through its focused efforts, Symphony Biosciences strives to advance the field of oncology and improve the quality of care for patients facing solid tumors.

Narval is a biotechnology company specializing in the development of synthetic antibody mimetic proteins (AMPs). These AMPs are significantly smaller than conventional antibodies, yet retain their biological functionality. They offer several advantages, including the ability to penetrate tissue barriers, generate limited immune reactions, target small and hard-to-reach antigens, and withstand heat. This technology enables Narval to create novel first-in-class immunotherapeutics for diseases previously challenging to treat using monoclonal antibodies. Their focus includes respiratory, eye, and autoimmune diseases, with delivery methods such as inhaled antibodies, eye drops, and transdermal patches. Narval leverages machine learning and artificial intelligence to optimize its drug development capabilities.

Lura Health is a pioneering company that has developed a non-invasive continuous health monitoring platform utilizing saliva as a diagnostic fluid. Founded in 2017 and headquartered in Cambridge, Massachusetts, the company focuses on chronic disease management, targeting conditions such as heart disease, chronic kidney disease, diabetes, and tooth decay. Lura Health's innovative sensors are designed to be integrated into patient-friendly orthodontic devices, including removable retainers and fixed brackets. These sensors continuously monitor oral acidity and other analytes in saliva, automatically transmitting valuable health data to a mobile application. This approach empowers users to track key diagnostic metrics within their oral environment, facilitating improved personal health management and potentially enhancing clinical outcomes.

Cultimate Foods is a pioneering cellular agriculture company specializing in the development of cultivated fat for hybrid alt-meat products. The company's unique technological approach involves 3D cultivation, replicating the structure of animal fat tissue and reducing production costs. Cultimate Foods aims to provide consumers with a more efficient, sustainable, and ethical way to enjoy meat-like experiences while minimizing environmental impact.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

myBiometry is developing a platform to monitor/manage patients with chronic disease using biomarker data from proprietary sensors and ML to identify patients at risk of treatment failure. Our initial focus is asthma where treatment failure occurs over 46% of the time (11.5M US patients, $80 billion). We are developing a single use, disposable sensor and device to track a biomarker of inflammation in breath. The data determines changes in adherence, treatment response, and risk of attack.

Ostiio is a medical device company focused on innovating solutions for skeletal deformities and deficiencies. The company is developing a fully implantable bone distraction system that remains entirely buried beneath the patient's skin, eliminating the need for external components. This advanced system features a magnetically driven device that allows for wireless and precise adjustments. The implant's programmable nature enables physicians to remotely monitor and manage the distraction process, providing greater transparency and control for surgeons. Ostiio is associated with the Penn Center for Innovation, highlighting its commitment to advancing healthcare technologies.

miniMarrow presents a new disruptive therapeutic approach for the in-situ production of blood components in leukemic patients to replace weekly and burdensome transfusions markedly increasing patient quality-of-life. miniMarrow is operating in stealth mode. miniMarrow was established in Renens, Vaud

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

Algdeha is a biotechnology company focused on providing sustainable solutions for industries reliant on fish-based products. The company specializes in developing innovative production methods for algae, enabling its cultivation on an industrial scale at reduced costs. By harnessing renewable resources such as wave energy, sunlight, and ambient heat, Algdeha aims to create an efficient alternative to animal-based feeds. This approach not only addresses the growing demand for sustainable animal feed but also seeks to alleviate the pressure on fish populations, promoting ecological balance within the industry.

MyoGene Bio is a biotechnology company focused on developing innovative therapies for muscle diseases, with an initial emphasis on gene-editing treatments for Duchenne muscular dystrophy. The company employs advanced technologies to address the underlying causes of this condition, aiming to significantly improve disease progression and outcomes for patients. By targeting the root of the disorder, MyoGene Bio seeks to provide clinicians and patients with effective solutions that have a meaningful impact on the management of devastating muscle disorders.

Selmod, located in Basel, Switzerland, specializes in the development of innovative small molecule therapies aimed at treating life-threatening, multi-drug resistant infections. The company is committed to discovering and advancing first-in-class drug candidates that provide second-line and last-resort treatment options for patients in hospital settings, particularly where conventional therapies have failed due to resistance. Selmod's approach includes the development of antibiotics with dual modes of action to effectively counteract existing resistance mechanisms. Its leading candidates, SLM500, SLM100, and SLM300, have demonstrated success in preclinical animal studies and are positioned within a promising market projected to exceed $9 billion. The company aims to capture a substantial market share shortly after entry, supported by a leadership team with extensive experience in clinical development for major pharmaceutical firms. Funding will be utilized to advance SLM500 through IND-enabling studies and to optimize additional lead candidates for further development.

Condor Software is a provider of clinical finance software that enhances financial decision-making in the clinical development sector. The company specializes in integrating real-time clinical trial data with third-party vendor collaboration, facilitating more accurate accounting processes. By leveraging financial intelligence and automation alongside deep industry expertise, Condor Software enables pharmaceutical and biotech companies to optimize their financial resources and streamline complex workflows. Its software allows for efficient management of clinical accruals, forecasts, and financial plans, which helps organizations reduce time spent on cash flow management. Ultimately, Condor Software aims to accelerate the development of life-changing medical breakthroughs by empowering companies to make informed business decisions that drive innovation and impact.

Opsin Biotherapeutics specializes in the development of gene therapies based on opsins, a class of light-sensitive proteins. The company's primary focus is to create a pipeline of treatments for pain management, aiming to provide effective alternatives to opioids.

Galileo Innovations develops human performance-optimizing biotech gear and equipment for athletes, first responders, military members, and labor industry workers. Its proposed technology, KordoFan, augments users with actionable insights concerning environmental and biometric hazards in real-time to target heat injuries; through an array of biomimicry cooling designs, the device aids in speed, agility, mental clarity, muscle recovery, strength, and stamina during training/shifts.

Ronawk is a biotechnology company specializing in the development of T-Block technology that produces patient-specific biologics for the treatment of various diseases, including cancer, organ injuries, and burns. The company's proprietary method allows for the growth of primary stem cells in a three-dimensional environment, preserving the essential characteristics of these cells outside the human body. This innovative approach enables the rapid expansion of stem cells, facilitating their use in early-stage diagnostics and the repair of damaged tissues. Ronawk's technology not only enhances the efficiency of growing human cells but also supports tissue generation and disease modeling, making significant contributions to the fields of regenerative medicine and reconstructive surgery.

BioBQ is a cultivated meat company focused on producing slaughter-free beef brisket and other barbecue meats from cultured animal cells. Utilizing proprietary technologies, BioBQ can efficiently create whole cuts of meat in a matter of weeks, significantly reducing the time required compared to traditional cattle farming. This innovative process not only allows for precise control over meat content and flavor but also minimizes the environmental impact typically associated with conventional meat production. By offering a sustainable alternative, BioBQ aims to meet consumer demand for tasty and ethically produced barbecue options, ensuring that meat can be enjoyed without adverse effects on the climate, environment, or animal welfare.

Netnoids Rx Laboratories operates a cancer contract research organization that uses patient-derived organoid model systems to help find a cure for rare cancers.

INIA Biosciences is a developer of innovative medical devices that leverage sound wave technology to create non-invasive, home-administered systems for managing chronic inflammatory diseases. The company focuses on a closed-loop monitoring system designed to treat and prevent organ failure by integrating biomarker monitoring with an ultrasound stimulator. This approach aims to reduce inflammation linked to transplant rejection rates and minimize reliance on immunosuppressant drugs. By providing novel diagnostic sensing capabilities, INIA Biosciences enables physicians to better manage chronic diseases and improve patient outcomes.

GreenBTS is a company focused on developing innovative and sustainable products aimed at enhancing farming efficiency and environmental friendliness. It specializes in the manufacturing of organic biofertilizers and biopesticide products designed to improve urban farming, plant care, and overall food production. The company's offerings protect crops from pests and diseases, while its unique formulations provide essential nutrients tailored to various crop types, thereby promoting better growth and quality. GreenBTS aims to support farmers in maintaining their crops through to the harvest, contributing to a more sustainable agricultural landscape.

Labinnova detects Breast Cancer in a Breath Sample with 98% sensibility. providing Qualitative results.

LIALT Laboratorio de Investigación Alternativa develops toxicological evaluations without the use of animals. LIALT replaces the use of animals through the use of three-dimensional tissues in conjunction with internationally recognized protocols that provide more specific information on the mechanisms of toxic action than that obtained in animals, offering a solution to the problem previously exposed.

We create healthy and sustainable solutions for the world based on insects. A very nutritive and eco friendly food source. Currently we are using about 50% of the habitable land for agriculture and the livestock industry is the major contributor to CO2 emisions, but In just 30 years the amount of food available will not be enough for the world`s population. By making healthy, and tasty products from insect powder such as flour for bread, cake mix, and even protein shakes, we are able to reduce the amount of livestock usage and also provide a sustainable and scalable solution. Our business model is based on 3 keypoints: >Mass and Standarized Production which is possible using our insect incubator (which is patent pending) >Sustainable and efficient Production since Costa Rica has the perfect weather conditions, >And our Partner Program to provide jobs and income to the poorest sectors of Costa Rican society. Our partner program is supported by BID Lab and Fundecooperación who are helping us deliver the program on a national scale. Costa Rica Insect Company and we Save the World Eating Bugs!

NurLabs develops label-free and reagent-free diagnostics to detect cancer early when it is most treatable.

Lepidext is a company based in Lexington, Kentucky, founded in 2015 by Angelika Fath-Goodin and Bruce Webb. It specializes in pest control technology aimed at managing Lepidoptera populations, particularly targeting pests like the corn earworm. The company develops bio-pesticides that are species-specific, safe, and effective, providing an alternative to genetically modified plants and chemical pesticides. By leveraging a deep understanding of insect biology and collaborating closely with farmers, Lepidext seeks to enhance crop security and promote agricultural prosperity. Its innovative approach allows for improved pest management strategies, benefiting farmers and contributing to sustainable agricultural practices.

Uniphage is a biotechnology company specializing in the development of safer and more efficient alternatives to traditional pesticides in plant agriculture. It leverages artificial intelligence and bacteriophages (viruses that infect bacteria) to predict and combat specific bacterial infections. The company's primary focus is on citrus greening, a devastating disease costing the U.S. over $2 billion annually. By employing AI algorithms, Uniphage accelerates the discovery of effective and safe bacterial viruses, aiming to reduce the use of harmful fungicides, bactericides, and antibiotics, thereby minimizing risks to human health and the environment.

Therapeutic Vision focuses on the development of pharmaceuticals primarily for the companion animal market and eventually their owners.

Akttyva Therapeutics is a biopharmaceutical company focused on developing targeted therapeutics for vascular barrier disorders. The company utilizes insights from biological pathways, along with artificial intelligence and machine learning, to understand and address cell barrier dysfunction. By leveraging advanced technologies, Akttyva aims to create innovative treatments that can effectively target multiple medical indications related to cell barrier impairments, enhancing the ability of healthcare providers to manage these complex conditions.

BioSens8 is a developer of advanced biosensors designed to facilitate holistic health monitoring and prevent chronic diseases. The company's innovative platform offers novel quantitative and real-time biosensors that cater to various sectors. For individuals, the technology assists women in assessing their fertility health, thereby supporting family planning. In agriculture, BioSens8 provides tools for farmers to manage herd reproduction and monitor animal health. Additionally, the biosensors evaluate environmental health, contributing to the revitalization of fragile ecosystems. By serving the healthcare, agriculture, military, and biomanufacturing sectors, BioSens8 aims to enhance overall health and operational efficiency across diverse applications.

Glamorous AI is a developer of an advanced artificial intelligence-based drug discovery platform that focuses on low-data drug discovery. The platform utilizes AI to identify and optimize novel chemical scaffolds and screen extensive chemical libraries. By leveraging a large repository of pre-trained and customizable AI models, Glamorous AI addresses the challenges posed by sparse, noisy, and limited data. This innovative approach enables researchers to explore complex compounds and facilitates the discovery of first-in-class therapeutics, ultimately aiming to drive advancements in medicine and contribute to curing diseases.

AcousticaBio is a biotechnology company focused on reformulating intravenous medications for subcutaneous administration. It has developed a fluid processing technology that enables the creation of complex microparticles necessary for effective subcutaneous formulations. By converting intravenously delivered biologic products into highly concentrated, small-volume injections, AcousticaBio aims to enhance patient experiences by allowing for self-administration of life-saving medications. This innovation significantly reduces the pain and discomfort associated with traditional delivery methods and minimizes the need for lengthy hospital visits, improving accessibility and convenience for patients.

Organic Robotics Corporation, founded in 2018 and based in Rochester, New York, specializes in the design and development of advanced sensors for real-time touch measurement. The company's flagship product, Light Lace, utilizes fiber-optic technology to create a flexible sensor capable of bending and twisting to conform to the human body. This innovative sensor not only captures motion but also measures pressure, offering unique advantages in sensibility, elasticity, and washability at a competitive cost. Organic Robotics focuses on enhancing performance monitoring, particularly for professional athletes, by providing real-time feedback on motion, muscle fatigue, and vital signs. Their technology is designed for comfort and minimizes distraction, enabling accurate analysis of chest movement to deliver actionable insights that help optimize athletic performance.

Transcera is a biotechnology company focused on innovating biological drug delivery systems to enhance the treatment of chronic diseases. The company has developed a novel lipid-based delivery platform that aims to improve the targeting and efficacy of therapeutic molecules. This technology enables large therapeutic molecules to effectively cross cellular barriers, facilitating better absorption and pharmacokinetics. Through its advancements in drug delivery, Transcera seeks to transform how chronic diseases are treated, providing healthcare professionals with tools to optimize therapeutic outcomes for patients.

Gensor develops a virus testing platform based on the gene field-effect transistor technology.

Stemloop is a biosensor company dedicated to harnessing biological technology to meet global challenges in chemical sensing and detection. The company focuses on developing innovative, cell-free biosensing products that simplify and enhance the testing process for chemical and molecular analysis. By utilizing genetically encoded sensing mechanisms, Stemloop aims to provide accurate and scalable solutions that are both cost-effective and accessible. This approach allows medical professionals to obtain faster and more reliable test results, ultimately improving healthcare outcomes while addressing unmet needs in laboratory testing. Through its novel technology, Stemloop seeks to revolutionize the landscape of biosensing and contribute meaningfully to various sectors.

Diamante is a company based in Verona, Italy, that specializes in the development and manufacturing of diagnostic devices for autoimmune diseases, utilizing innovative nanomaterials. Founded in 2016, the company leverages plants as bioreactors to produce nanoparticles derived from modified plant viruses. This approach allows Diamante to create advanced tools for diagnosing and potentially treating autoimmune conditions, focusing on sustainable and efficient production methods. Through its research and development efforts, Diamante aims to contribute significantly to the field of autoimmune disease therapy.

Biotic Circular Technologies specializes in the development and manufacturing of fully bio-based, biodegradable polymers, offering a sustainable alternative to fossil-fuel plastics. The company's end-to-end manufacturing process is designed to eliminate the need for recycling, thus promoting a zero-waste and circular economy. By providing a scalable and environmentally friendly solution, Biotic Circular Technologies aims to address the growing demand for sustainable materials across various applications, including packaging, disposables, and single-use products. Their innovative approach contributes to the reduction of greenhouse gas emissions, aligning with global efforts to transition towards more sustainable practices.

Michroma Corporation is a biotechnology company that specializes in producing natural thermostable colorants derived from filamentous fungi for the food and cosmetics industries. Founded in 2019, the company operates from locations in San Francisco, California, and Rosario, Argentina. By leveraging synthetic biology, Michroma develops proprietary fungal strains that can be cultivated in bioreactors, allowing for the sustainable and cost-effective production of high-performance ingredients. Its initial offerings focus on pH-stable and heat-stable colorants, which are designed to replace synthetic pigments and those sourced from animals and plants. In addition to colorants, Michroma is also engaged in the production of mycoprotein and other innovative ingredients, collaborating with leading companies in the food and beverage and cosmetic sectors.

Sophie's Bionutrients is a company focused on creating sustainable plant-based proteins derived from microalgae through advanced fermentation technologies. By employing strain optimization, precision fermentation, and protein extraction methods, the company develops high-purity protein powders with various functionalities. These innovative products cater to the food industry, particularly in the production of imitation seafood, offering an alternative that aligns with growing demands for sustainable and environmentally friendly food sources.

BestHealth4U is a company focused on researching and developing advanced medical adhesive technologies aimed at enhancing patient health and safety. The company offers innovative, eco-friendly adhesive solutions that prevent skin injuries, accelerate healing, and improve overall patient well-being. By transforming the attachment methods of bandages, dressings, and medical devices, BestHealth4U addresses common issues such as skin damage, pain, irritation, and infection caused by traditional medical adhesives. Its commitment to creating safe and effective products positions the company as a leader in the medical device industry, particularly in the realm of class 1 medical devices.

Frankles is a Climate Tech startup dedicated to revolutionizing the ingredient industry by eliminating petroleum extraction methods. The company has developed NoDex, an innovative technological platform that designs molecular extraction processes from plant raw materials and agro-industrial waste. This platform enables the creation of high-value, sustainable ingredients, including flavorings, functional compounds, antioxidants, and biocompounds. By leveraging machine learning and molecular data, Frankles aims to facilitate a decentralized and petroleum-free production model that can scale effectively. The company's vision addresses the urgent need for a transition to green ingredients, contributing to the goal of achieving net-zero emissions by 2050.

Organifarms specializes in developing robotic solutions tailored for greenhouses and vertical farms. Their primary product is harvesting robots designed to automate the harvest, quality control, and monitoring processes of fruit and vegetable crops. This automation addresses the challenges posed by labor shortages and rising labor costs within indoor farming environments, while also enabling cultivation methods free from pesticides.

ClearLeaf is a company specializing in the development of non-toxic agricultural solutions, utilizing patent-pending technology that is organic certified in the EU and Japan. The firm offers a range of environmentally friendly fungicides and bactericides designed for various crops, including coffee, bananas, pineapples, and several vegetables. ClearLeaf's flagship product, GotaBlanca®, is currently sold in Costa Rica, with plans for expansion into Central America. The company has secured an exclusive commercial agreement with Colono Agropecuario, the largest agrochemical distributor in the region, enabling it to significantly increase sales since entering the market. ClearLeaf's mission is to provide sustainable alternatives to conventional agrochemicals, promoting environmental health and worker safety on farms while supporting farmers in achieving greater efficiency and productivity.

FermBiotics is a microbiome company focused on enhancing gut health globally through the production of sustainable, fermented plant ingredients. The firm develops a range of plant and seaweed-based products designed to support gut health, including food ingredients, dietary supplements, and medical foods. By combining prebiotics, probiotics, and bioactive compounds, FermBiotics has created a novel category of fermented products that promote a positive gut microbiome. These innovations are aimed at benefiting both humans and animals, allowing families and pet owners to support the gut health of the elderly and their animals effectively.

BrightCure Ltd., established in 2019 and based in London, United Kingdom, specializes in developing probiotic-based therapies aimed at treating urinary tract infections (UTIs). The company focuses on addressing recurrent and difficult-to-treat bacterial infections, a significant health issue affecting 50% of women and 12% of men globally. BrightCure's approach involves utilizing the natural microbiome to reduce harmful bacteria and replenish beneficial bacteria in the vaginal flora, thereby boosting the immune system to promote urinary tract health. The company has garnered recognition through various competitions and accelerators, including selection for Indiebio, the world's largest biotech accelerator.

Ittinsect is the biotech startup that developed the sustainable alternative to aquaculture feed. Ittinsect produces high performance feeds through the microbiological treatment of novel raw ingredients including insects, microalgae and agricultural by-products, in line with the circular economy principles. With Ittinsect, there is no longer need to catch fish from the marine environment as nutrition for farmed fish. The company’s mission is making aquaculture ocean-impact neutral.

FairFlavor develops nutritious vegan alternative dairy food made of a super nut from Indonesia using a patented fermentation technology

Vectech is a public benefit corporation based in Baltimore, MD, specializing in an AI-based diagnostic medical entomology system. Its flagship product, IDX, is designed to identify species, sex, and other critical characteristics of mosquito and tick populations. Deployed in seven countries, IDX serves municipal and national public health programs, NGOs, malaria control initiatives, and researchers. By equipping non-experts with the capabilities of professional entomologists, the system significantly reduces the labor costs associated with mosquito surveillance. This technology enables public health organizations and scientists to detect threats from mosquito-borne diseases, such as dengue and malaria, at an early stage, allowing for customized interventions to prevent outbreaks. Vectech is committed to expanding access to its innovative solutions in areas most affected by these health challenges.

B'ZEOS is a technology-based start-up that specializes in the development of seaweed-based packaging solutions aimed at providing sustainable alternatives to single-use plastics. The company focuses on creating novel bio-based packaging materials that are designed to combat environmental issues associated with conventional plastic use. Utilizing advanced green processing technology, B'ZEOS manufactures its products without toxic chemicals, ensuring that their offerings are both environmentally friendly and compostable. By tailoring its material formulations, B'ZEOS effectively addresses the needs of industries seeking to decarbonize and adopt more sustainable packaging practices.

Oxyle AG, established in 2020 and headquartered in Zurich, Switzerland, specializes in wastewater treatment solutions. The company offers services to diverse industries including pharmaceuticals, chemicals, food & beverage, research labs, electronics, hospitals, and wastewater plants. Oxyle's proprietary technology eliminates persistent micropollutants such as pharmaceuticals, pesticides, endocrine disruptors, color pigments, and industrial chemicals from wastewater. This helps clients comply with regulations, reduce CO2 emissions by avoiding wastewater incineration, and protect water bodies from toxic pollutants.

Digi.Bio is a Netherlands-based company specializing in software development for the healthcare sector, focusing on automating liquid handling processes through advanced microfluidic technology. The company offers a lab-on-a-chip and computational platform designed to enhance the efficiency and accuracy of cell therapy development, allowing for rapid analysis of therapeutic outcomes at the single-cell level. By employing artificial intelligence and electrowetting techniques, Digi.Bio's platform enables medical and pharmaceutical laboratories to automate repetitive workflows, significantly reducing material waste and accelerating the bioengineering process. The innovative solutions provided by Digi.Bio aim to streamline multistep liquid handling applications, replacing traditional pipetting methods and facilitating the advancement of life-saving cell therapies.

Fybraworks Foods, Inc. is a biotechnology company based in Minnetonka, Minnesota, focused on developing alternative meat substitutes through innovative fermentation techniques. Founded in 2020, the company specializes in creating animal-free meat structural proteins and synthetic meat, aiming to replicate the taste and texture of traditional meat products. By leveraging its advanced technological solutions, Fybraworks Foods enables both industry leaders and individual consumers to access sustainable meat alternatives, thus promoting humane practices and reducing environmental impact associated with animal agriculture.

Microbe Plus specializes in the development of innovative microbiological bio-products aimed at enhancing agricultural productivity. The company offers multi-strain probiotics for plants, which serve to protect crops against a broad range of pathogens while promoting growth. Its products are formulated with carefully selected beneficial bacteria, designed to increase crop yields and defend against diseases and pests. By providing efficient and cost-effective solutions, Microbe Plus supports farmers in improving crop health and reducing dependence on synthetic pesticides, ultimately contributing to sustainable agricultural practices.

Criam is a biotechnology company based in Braga, Portugal, founded in 2015. It specializes in the research and development of a medical device that facilitates blood type analysis and the detection of various infectious diseases, including HIV, Brucella, tick fever, syphilis, mononucleosis, and meningitis. The company's portable platform operates independently of electricity and does not require additional laboratory infrastructure, making it accessible for use in diverse settings. Criam's device allows for rapid and accurate blood testing, which enhances clinical decision-making by providing timely health information. The technology is designed to be scalable, with one reader capable of performing multiple tests using specialized cartridges and computer vision algorithms. This innovation aims to improve the efficiency and reliability of blood testing services, ultimately enhancing patient care.

Umami Bioworks is a company focused on the discovery and development of a scalable platform for producing cultivated seafood, aiming to protect endangered marine species while providing consumers with sustainable seafood options. The company utilizes systems engineering to enhance the discovery and industrialization processes, facilitating local production that is both price competitive and environmentally responsible. Its innovative approach involves creating cell-based food products derived from fish cells and tissue, which are designed to be free from harmful substances such as mercury, antibiotics, microplastics, and ocean pollutants. By offering affordable, cell-cultured seafood and meat alternatives, Umami Bioworks addresses the growing demand for healthy and sustainable food choices.

TissueLabs is the platform for creating organs and tissues in the lab. We offer biomaterials, equipment, and services to support tissue engineering and regenerative medicine. Our products are created to allow performing state-of-the-art research, from drug discovery to organ fabrication. Currently, we are focused on attending the academic life sciences market. In the future, our mission is to fabricate lab-grown tissues and organs, for both research and therapeutic applications.

React4life is an Italian biotech company established in 2016 by Silvia Scaglione and Maurizio Aiello, following over 15 years of research and development. The company focuses on advancing biomedical research through its innovative MIVO® (Multi In Vitro Organ) technology, which represents the next generation of organ-on-a-chip systems. This microphysiological platform allows scientists to replicate human biology in the laboratory more accurately, addressing the limitations of traditional in vitro assays and animal models. React4life's technology enhances the reliability and predictivity of various applications, including pharmaceutical drug testing, personalized medicine, immuno-oncology therapies, cosmetics, dermatology, and nutraceuticals. The company aims to improve laboratory testing effectiveness while reducing reliance on animal testing, facilitating the cultivation of three-dimensional tissues that closely resemble human tissues for more clinically relevant in vitro experiments.

Babylat is a company that has developed an automated medical device designed to extract proteins from human milk without the need for expensive laboratory equipment. Their tabletop device, intended for small-scale use, concentrates the protein fraction from human milk on-site in hospitals. This technology allows for efficient and rapid protein extraction, ensuring that newborn babies receive an adequate protein supply.

Epios personalized and precision management of brain disorders using daily life monitoring and therapeutics. The Epios system comprises a series of thin leads incorporating sensing electrodes and a miniature implant, inserted beneath the skin. The neural signals are wirelessly transmitted to an external receiver held in place on the skin directly over the implant with a magnet, and from there are conveyed to a wearable data processor and are finally securely stored in the Epios Cloud.

Paragit Solutions specializes in developing innovative systems for remote patient monitoring and data-driven clinical management of movement disorders, particularly Parkinson's disease. Central to their offerings is the Paragit Sleeve, which employs a patented sEMG (electromyography) technology to gather precise data on muscle activation, movement, and grip force during patients' daily activities. Paragit provides two main software suites for data interpretation: the PD Monitor, tailored for caregivers, which visualizes key motor symptoms like rigidity and tremors to enhance treatment optimization and facilitate telemedicine; and the MD Lab, designed for decentralized clinical trials across various movement disorders. MD Lab enables researchers to analyze over 20 metrics related to disease severity, track trends, and compare groups consistently, with a robust API that supports extensive data access for further analysis. Through these technologies, Paragit aims to improve the management and understanding of movement disorders, enhancing patient care and clinical research.

Leucine Rich Bio is a pioneering genomics-based company in India, focused exclusively on the human microbiome, often referred to as the "Second Genome." By leveraging advanced genomic techniques, the company aims to address crucial uncertainties in precision medicine related to the microbiome's impact on health and wellness. Leucine Rich Bio offers a unique platform that provides customized nutritional recommendations and personalized supplements tailored to an individual's intestinal microflora. Its applications span various medical fields, including gastroenterology, endocrinology, oncology, mental health, and reproductive health, enabling clients to achieve clinical resolutions and improve overall well-being. The company is dedicated to advancing understanding and utilization of microbiome research for better health outcomes.

Gelatex is a materials technology company based in Estonia, founded in 2016 and incorporated in the UK in 2019. The company specializes in producing bio-based nanofibers using a patented technology that allows for large-scale production at significantly lower costs. Gelatex's nanofibers are derived from gelatin sourced from low-value waste in the meat and leather industries, ensuring that its products are environmentally friendly and made from natural, non-toxic substances. Initially focused on developing eco-friendly leather-like textiles, the company recognized the broader applications of its technology during the COVID-19 pandemic, leading to a strategic pivot. Gelatex's innovative solutions have potential applications in various fields, including tissue engineering, cultured meat production, bio-based filtration, energy storage, and wound care.