MassChallenge

Extracellular specializes in bioprocessing technologies designed to optimize cell-culture efficiency for a sustainable bio-economy. The company offers expertise in bioprocess development, scale-up, media development, and cell-line development, enabling clients in cultivated meat, plant-cell culture food, bio-cosmetics, and bio-supplements to create sustainable alternatives.

Fotortec is a biotechnology company focused on sustainable protein production. It uses fungal bioconversion to convert agricultural byproducts and vegetable waste into nutrient-rich biomass via mushroom cultivation and downstream refinement, creating plant-based ingredients aligned with a circular economy. These ingredients support flavor enhancement, protein enrichment, and natural food formulations across diverse product categories for food manufacturers.

ImpacFat is a food production company that develops fish meat alternatives through cell cultivation. It specializes in producing cultivated cell-based fish fat to enhance the flavor, texture, aroma, and nutrition of alternative protein products, enabling consumers to obtain healthy fats such as omega-3 fatty acids that support heart health.

Restoring crops' ability to defend against pests.

CNS Therapy is a spin-off from the University of North Carolina that develops mind-body therapy-based solutions and devices to alleviate chronic pain and related conditions. It combines operant behavioral therapy with a proprietary device called SET, Systolic Extinction Training, to enhance learning and reset the autonomic nervous system, with the aim of delivering long-lasting pain relief. The company tracks physiological parameters and uses the resulting data to optimize therapy, delivering an integrated program of psychological training and electrostimulation to help patients reduce or eliminate pain and return to daily activities.

Embryoxite is a biotechnology company specializing in non-invasive diagnostic services for pre-implantation embryos in human-assisted reproduction. It operates a platform that combines artificial intelligence, metabolomics, embryo imaging, and clinical data to enhance embryo selection accuracy and improve patient outcomes for fertility clinics and reproductive specialists.

Econutri produces sustainable proteins through innovative fermentation processes that utilize carbon dioxide and green hydrogen. Their eco-friendly proteins cater to diverse applications in food products and non-food industries, aiming to reduce environmental impact and meet growing protein demands.

Sonali Bioplastics solves the plastic pollution problem with plant based alternatives that reduces carbon emissions. Sonali Bioplastics takes a sustainable development approach toward solving plastic problems and promote eco-friendly farming. The company was founded in 2019 and is based in San Jose, California.

Organic Fields offers an innovative biological, certified organic fertilizing solution to commercial growers in the agricultural.

Founded in 2021, Sóliome is a biotechnology company based in San Francisco, California. It specializes in developing protein-based sunscreens that are safe and effective, using molecules naturally produced by the human body to protect against harmful UV rays.

Nature’s Principles is a Dutch biotechnology company that develops innovative fermentation technology. It uses mixed culture fermentation, inspired by principles of nature, to produce lactic acid and poly-lactic acid (bioplastic) from low-value waste streams like sugar beet pulp and molasses. This process enables clients to replace oil-based chemicals while improving sustainability metrics.

UpDairy is a food technology company specializing in the development of alternative dairy proteins. It employs precision fermentation using microorganisms to produce dairy proteins without relying on animals, thereby reducing greenhouse gas emissions and offering customers environmentally friendly alternatives.

SCALE develops sustainable bio-based materials that enhance performance while reducing costs and significantly lowering emissions. Its natural-fiber composites serve as eco-friendly alternatives to traditional materials in industries such as sporting goods, automotive, and aerospace.

Xibus Systems develops and markets innovative microbiological analytics tools. These tools test consumable solutions for pathogens, allergens, and spoilage organisms in the food and beverage industry. The company is headquartered in Somerville, Massachusetts.

SeaStock specializes in global marine science solutions, focusing on the production and extraction of substances from seaweed and algae. Its primary product is derived from Asparagopsis seaweed, used to create methane-reducing feed ingredients for sustainable options across agriculture, cosmetics, and pharmaceutical industries.

BioMixing is a biotechnology company dedicated to enhancing bio-fermentation processes. It specializes in developing innovative agitation systems for bioreactors, leveraging fluid dynamics principles to minimize cell damage and optimize mixing within the vessel. This enables other organizations to improve the efficiency of their fermenters and bioreactors, thereby addressing various biotechnological challenges.

LiveGrow Bio is a biotechnology company focused on microbial fermentation and formulation, specializing in the production of biopesticides and biostimulants. The company has developed a patented technology that significantly reduces production costs by up to 95% while enhancing product shelf life to over two years at room temperature. This innovation allows for the effective commercialization of biological products across various crop markets, not limited to high-value organic crops. LiveGrow Bio’s technology facilitates the modular and scalable production of microbes, enabling the manufacturing process to take place directly within retail packaging sold to farmers, thereby eliminating the need for traditional large-scale fermentation facilities and reducing downstream processing requirements. This unique approach positions LiveGrow Bio as a pivotal player in the biological products industry, providing accessible and cost-effective solutions for agricultural stakeholders.

YouthBio Therapeutics specializes in developing tissue-specific gene therapies based on partial cellular reprogramming, aiming to restore youthful gene expression in targeted cells. Its initial focus is on rejuvenating the brain to treat diseases like Alzheimer's by promoting cellular renewal in neurons and other brain cell types.

Arnav Biotech is a biotechnology company that operates as a Contract Development and Manufacturing Organization (CDMO), specializing in mRNA technology. It offers services for the design, development, and manufacturing of custom and cataloged mRNA products, supporting research, therapeutics, and vaccines. By providing these services, Arnav Biotech enables researchers to concentrate on their specific areas of interest, thereby democratizing access to mRNA-based life sciences.

Intek Scientific develops multiplexed immunofluorescence imaging technology.This will empower clinicians and researchers to gain a deeper understanding of cancer and provide effective and customized therapeutic strategies to tackle even the most challenging cancers.

Speratum is a biopharmaceutical company focused on microRNA-directed oncology therapies. The Company was founded in 2014 by Christian Marín-Müller, Ph.D. and is dedicated to the development of a patented treatment for pancreatic cancer based on the combination of tumor suppressive microRNA molecules and nanoparticle-based drug delivery technologies. The Company is currently entering the final stage of preclinical trials for the pancreatic cancer therapy, while simultaneously expanding the patent’s coverage to incorporate other types of cancer and non-cancer indications and illnesses and expanding its intellectual property (IP) portfolio with complementary technologies in the fields of nanotechnology, medical devices and veterinary medicine.

PlusVitech specializes in developing safe and effective therapeutic treatments for cancer patients. Its innovative approach focuses on non-invasive genetic cancer detection using small molecule and monoclonal antibody therapies, aiming to enable early diagnosis and treatment.

Azul Bio specializes in marine ecosystem preservation and enhancement, focusing on coral reef restoration. They employ advanced biological analysis services to monitor and maintain aquatic environments, offering DNA-based biodiversity assessments, species genotyping, microbiome profiling, and disease detection. This data empowers marine researchers and industries to improve aquaculture practices and safeguard ocean ecosystems against climate change.

Women aged 20-45 cannot get screened for breast cancer because existing solutions are unreliable. However, 81% want to. At The Blue Box, we have built a pain-free, low-cost, sensitive, radiation-free device to detect breast cancer in urine with a sensitivity of 83%. In 2024, we’ll launch into the market, bringing The Blue Box to private gynecology clinics with a Diagnostics-as-a-Service subscription model, and a pay-per-test revenue stream that we’ll share with doctors.

Hydrobee develops innovative clean energy technology to address global challenges. Their flagship product, Firebee™, converts heat from stoves into USB charging power for devices like phones and LED lights. By improving combustion efficiency and reducing smoke, Hydrobee aims to alleviate indoor air pollution and energy poverty among the billions who rely on biomass stoves daily.

Astron Medtech specializes in developing disposable, minimally invasive surgical devices for tendon repair. Their innovative solutions aim to reduce recovery time by half, from six months to four.

Drizzle Health develops affordable, high-performance diagnostics for tuberculosis and other bacterial infections. Their innovative tools enable real-time detection of bacteria in various environments, improving testing accuracy, reducing healthcare costs, and ensuring food and water safety.

Cellorama multipurpose devices, reagents, and processes are patent-pending and protect cell structure and integrity during many procedures. User-friendly and cost-effective devices are designed to minimize stressful stages in the laboratory while saving time and vital resources.

Earnest Agriculture collaborates with farmers to transform agricultural waste into innovative biofertilizers that enhance crop yields. By converting waste products such as manure and vegetable remnants, the company provides an eco-friendly solution that not only helps farmers manage their waste but also offers them a potential source of additional income. Utilizing a combination of composting, vermicomposting, and advanced microbial technologies, Earnest Agriculture develops proprietary fertilizers designed to improve soil quality, promote drought resistance, and suppress pathogens. This approach not only reduces the environmental impact of farming but also allows farmers to lower their input costs while increasing their productivity.

electronRx specializes in digital medicine solutions for chronic disease management. They develop personalized healthcare platforms that monitor cardiovascular health remotely, enabling patients to self-manage their conditions with clinical oversight.

Form Biologics is a new platform technology for the injectable formulation of biologic medicines in order to make treatments more patient-friendly and efficacious.

Azooka Labs specializes in the production of proprietary fluorophores for biotechnology applications. Their products include fluorescent dyes and tags for DNA, RNA, chromosomes, live cells, and molecular-grade sample collection mediums. The company aims to provide affordable and sustainable biotech consumables globally.

Skygenic is an innovative infrastructure and data analysis platform that accelerates biological research by lowering barriers for scientists. Developed in collaboration with Harvard Medical School and Boston Children's Hospital, Skygenic enables non-programming scientists to perform their own data analysis, offloading workload from bioinformaticians, allowing more research at lower cost and faster pace.

ZiO Health is a biotechnology company that develops pocket-sized devices featuring proprietary biosensor technology and machine learning algorithms. These devices enable real-time laboratory testing at the point-of-care, enhancing patient care by combining immediate results with individual patient profiles.

Trove Health is a company that offers a clinical trial recruitment platform designed to facilitate access to patient data for patients, healthcare providers, and life sciences organizations. The platform creates a diverse and consented database of prospective trial participants, enabling researchers to efficiently identify and recruit patients who meet specific enrollment criteria across various geographies and therapeutic areas. By doing so, Trove Health supports the advancement of medical research while empowering patients to manage their own health data, including the potential to monetize it and receive personalized treatment options.

Anviron is a biotechnology company that develops small-molecule inhibitor therapies for aggressive and late-stage cancers. The company focuses on scientific research to halt or shrink tumor growth in cancers such as pancreatic, breast, gastric, and cervical cancers, aiming to provide healthcare professionals with potential new treatment options. It employs a team of scientists, doctors, and clinicians dedicated to advancing cancer therapies.

Stellate Therapeutics is a global biotechnology company specializing in the development of small molecules derived from human gut bacteria into personalized therapies for neurological diseases. The company's platform has generated a portfolio of new drug candidates, with capabilities spanning discovery, screening, production, and diagnostic development.

Dart Biosciences works in the healthcare industry. It creates tailored gene therapies for a variety of uncommon and prevalent disorders.

Developer of cancer drugs designed to help treat solid tumors. The company focuses on treating cancer diseases using biomaterials, enabling healthcare professionals to improve survival rates, reduce adverse effects, and offer new hope to patients.

Narval is a biotechnology company specializing in the development of synthetic antibody mimetic proteins (AMPs). These AMPs are significantly smaller than conventional antibodies, yet retain their biological functionality. They offer several advantages, including the ability to penetrate tissue barriers, generate limited immune reactions, target small and hard-to-reach antigens, and withstand heat. This technology enables Narval to create novel first-in-class immunotherapeutics for diseases previously challenging to treat using monoclonal antibodies. Their focus includes respiratory, eye, and autoimmune diseases, with delivery methods such as inhaled antibodies, eye drops, and transdermal patches. Narval leverages machine learning and artificial intelligence to optimize its drug development capabilities.

Lura Health develops a non-invasive continuous health monitoring platform that uses saliva as a diagnostic fluid. The company integrates micro-sensors into orthodontic devices such as retainers, aligners, and brackets to continuously measure saliva analytes and securely transmit data to a smartphone app, enabling users to monitor oral health metrics and potentially support broader chronic disease management. Target markets include heart disease, chronic kidney disease, diabetes, and tooth decay. Founded in 2017, the company is based in Cambridge, Massachusetts.

Cultimate Foods is a cellular agriculture company focused on cultivated fat for hybrid alternative-meat products. It develops cell-cultured fat that mimics the structure of animal fat tissue, using a three-dimensional cultivation approach to create structured fat ingredients and lower production costs. The company also pursues cell-engineered adipose tissue to enable meat alternatives that combine cultivated fat biomass with other ingredients, delivering the flavor and texture of meat while supporting sustainability.

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

myBiometry is developing a platform to monitor/manage patients with chronic disease using biomarker data from proprietary sensors and ML to identify patients at risk of treatment failure. Our initial focus is asthma where treatment failure occurs over 46% of the time (11.5M US patients, $80 billion). We are developing a single use, disposable sensor and device to track a biomarker of inflammation in breath. The data determines changes in adherence, treatment response, and risk of attack.

Ostiio develops an innovative bone distraction system designed to correct skeletal deformities and deficiencies. Its fully implantable device is buried under the patient's skin, eliminating the need for external components, and features a programmable driver that enables remote monitoring and control by prescribing surgeons.

miniMarrow presents a new disruptive therapeutic approach for the in-situ production of blood components in leukemic patients to replace weekly and burdensome transfusions markedly increasing patient quality-of-life. miniMarrow is operating in stealth mode. miniMarrow was established in Renens, Vaud

Oculogenex is a biopharmaceutical company founded in 2020 and based in La Habra, California. It specializes in the development of gene therapies aimed at treating retinal disorders. The company’s innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced cell death, a condition linked to macular degeneration. By focusing on these therapies, Oculogenex seeks to enable researchers to enhance the detection and treatment of retinal-related disorders, contributing significantly to advancements in this critical area of medical research.

Algdeha is a biotechnology company focused on providing sustainable solutions for industries reliant on fish-based products. The company specializes in developing innovative production methods for algae, enabling its cultivation on an industrial scale at reduced costs. By harnessing renewable resources such as wave energy, sunlight, and ambient heat, Algdeha aims to create an efficient alternative to animal-based feeds. This approach not only addresses the growing demand for sustainable animal feed but also seeks to alleviate the pressure on fish populations, promoting ecological balance within the industry.

MyoGene Bio is a biotechnology company focused on developing innovative therapies for muscle diseases, with an initial emphasis on gene-editing treatments for Duchenne muscular dystrophy. The company employs advanced technologies to address the underlying causes of this condition, aiming to significantly improve disease progression and outcomes for patients. By targeting the root of the disorder, MyoGene Bio seeks to provide clinicians and patients with effective solutions that have a meaningful impact on the management of devastating muscle disorders.

Selmod, based in Basel's life science hub, develops innovative antibiotics targeting multi-drug resistant infections. Its first-in-class drug candidates focus on high-revenue hospital patients where first-line treatments have failed due to resistance. With a disruptive approach featuring new dual modes of action, all candidates have shown success in animal infection studies. The company aims to capture a significant share of the estimated $9 billion total available market for its three lead assets.

Condor empowers pharmaceutical and biotechnology companies to optimize financial resources during clinical development. Its software combines real-time data with automation and industry expertise to streamline workflows, enhance decision-making, and accelerate innovation.

Opsin Biotherapeutics specializes in the development of gene therapies based on opsins, a class of light-sensitive proteins. The company's primary focus is to create a pipeline of treatments for pain management, aiming to provide effective alternatives to opioids.

Galileo Innovations develops human performance-optimizing biotech gear and equipment for athletes, first responders, military members, and labor industry workers. Its proposed technology, KordoFan, augments users with actionable insights concerning environmental and biometric hazards in real-time to target heat injuries; through an array of biomimicry cooling designs, the device aids in speed, agility, mental clarity, muscle recovery, strength, and stamina during training/shifts.

Ronawk is a biotechnology company specializing in the development of T-Block technology that produces patient-specific biologics for the treatment of various diseases, including cancer, organ injuries, and burns. The company's proprietary method allows for the growth of primary stem cells in a three-dimensional environment, preserving the essential characteristics of these cells outside the human body. This innovative approach enables the rapid expansion of stem cells, facilitating their use in early-stage diagnostics and the repair of damaged tissues. Ronawk's technology not only enhances the efficiency of growing human cells but also supports tissue generation and disease modeling, making significant contributions to the fields of regenerative medicine and reconstructive surgery.

BioBQ cultivates meat directly from animal cells, specializing in slaughter-free beef brisket and other BBQ meats. Its proprietary technology produces these products in weeks, reducing environmental impacts compared to conventional cattle farming.

Netnoids Rx Laboratories operates a cancer contract research organization that uses patient-derived organoid model systems to help find a cure for rare cancers.

INIA Biosciences is a developer of innovative medical devices that leverage sound wave technology to create non-invasive, home-administered systems for managing chronic inflammatory diseases. The company focuses on a closed-loop monitoring system designed to treat and prevent organ failure by integrating biomarker monitoring with an ultrasound stimulator. This approach aims to reduce inflammation linked to transplant rejection rates and minimize reliance on immunosuppressant drugs. By providing novel diagnostic sensing capabilities, INIA Biosciences enables physicians to better manage chronic diseases and improve patient outcomes.

GreenBTS develops high-technology and sustainable products and solutions to make farming more efficient, environmentally friendly, and smart. It manufactures organic biofertilizers and biopesticides to enhance urban farming, plant care, and food production, protecting crops from pests and diseases. Its formulations provide nutritious ingredients tailored to different crops, improving growth and quality and helping farmers preserve crops until harvest.

Labinnova detects Breast Cancer in a Breath Sample with 98% sensibility. providing Qualitative results.

LIALT Laboratorio de Investigación Alternativa develops toxicological evaluations without the use of animals. LIALT replaces the use of animals through the use of three-dimensional tissues in conjunction with internationally recognized protocols that provide more specific information on the mechanisms of toxic action than that obtained in animals, offering a solution to the problem previously exposed.

We create healthy and sustainable solutions for the world based on insects. A very nutritive and eco friendly food source. Currently we are using about 50% of the habitable land for agriculture and the livestock industry is the major contributor to CO2 emisions, but In just 30 years the amount of food available will not be enough for the world`s population. By making healthy, and tasty products from insect powder such as flour for bread, cake mix, and even protein shakes, we are able to reduce the amount of livestock usage and also provide a sustainable and scalable solution. Our business model is based on 3 keypoints: >Mass and Standarized Production which is possible using our insect incubator (which is patent pending) >Sustainable and efficient Production since Costa Rica has the perfect weather conditions, >And our Partner Program to provide jobs and income to the poorest sectors of Costa Rican society. Our partner program is supported by BID Lab and Fundecooperación who are helping us deliver the program on a national scale. Costa Rica Insect Company and we Save the World Eating Bugs!

NurLabs develops label-free and reagent-free diagnostics to detect cancer early when it is most treatable.

Lepidext is a company based in Lexington, Kentucky, founded in 2015 by Angelika Fath-Goodin and Bruce Webb. It specializes in pest control technology aimed at managing Lepidoptera populations, particularly targeting pests like the corn earworm. The company develops bio-pesticides that are species-specific, safe, and effective, providing an alternative to genetically modified plants and chemical pesticides. By leveraging a deep understanding of insect biology and collaborating closely with farmers, Lepidext seeks to enhance crop security and promote agricultural prosperity. Its innovative approach allows for improved pest management strategies, benefiting farmers and contributing to sustainable agricultural practices.

Uniphage is a biotechnology company specializing in the development of safer and more efficient alternatives to traditional pesticides in plant agriculture. It leverages artificial intelligence and bacteriophages (viruses that infect bacteria) to predict and combat specific bacterial infections. The company's primary focus is on citrus greening, a devastating disease costing the U.S. over $2 billion annually. By employing AI algorithms, Uniphage accelerates the discovery of effective and safe bacterial viruses, aiming to reduce the use of harmful fungicides, bactericides, and antibiotics, thereby minimizing risks to human health and the environment.

Therapeutic Vision focuses on the development of pharmaceuticals primarily for the companion animal market and eventually their owners.

Akttyva Therapeutics develops targeted therapeutics to address cell barrier dysfunction across multiple indications.

BioSens8 is a developer of advanced biosensors designed to facilitate holistic health monitoring and prevent chronic diseases. The company's innovative platform offers novel quantitative and real-time biosensors that cater to various sectors. For individuals, the technology assists women in assessing their fertility health, thereby supporting family planning. In agriculture, BioSens8 provides tools for farmers to manage herd reproduction and monitor animal health. Additionally, the biosensors evaluate environmental health, contributing to the revitalization of fragile ecosystems. By serving the healthcare, agriculture, military, and biomanufacturing sectors, BioSens8 aims to enhance overall health and operational efficiency across diverse applications.

Glamorous AI develops an artificial intelligence driven drug discovery platform that accelerates pharmaceutical research by leveraging prior experimental results to identify and optimize chemical scaffolds, predict activities, and screen ultra-large chemical libraries. The platform addresses low-data, sparse, and noisy datasets, enabling the discovery of novel compounds and potential therapeutics.

AcousticaBio develops technologies to reformulate intravenous biologics for subcutaneous delivery. Its advanced fluid processing platform and proprietary microgel formulation enable ultra-concentrated, small-volume subcutaneous injections of typically IV therapies, empowering patients to self-administer life-saving biologics outside hospital settings. By converting IV medicines into subcutaneous formats, the company aims to reduce pain and discomfort, minimize hospital visits, and improve convenience and access to treatment.

Organic Robotics Corporation, founded in 2018 and based in Rochester, New York, specializes in the design and development of advanced sensors for real-time touch measurement. The company's flagship product, Light Lace, utilizes fiber-optic technology to create a flexible sensor capable of bending and twisting to conform to the human body. This innovative sensor not only captures motion but also measures pressure, offering unique advantages in sensibility, elasticity, and washability at a competitive cost. Organic Robotics focuses on enhancing performance monitoring, particularly for professional athletes, by providing real-time feedback on motion, muscle fatigue, and vital signs. Their technology is designed for comfort and minimizes distraction, enabling accurate analysis of chest movement to deliver actionable insights that help optimize athletic performance.

Transcera is a biotechnology company that develops a lipid-based drug delivery system. This platform enables precise targeting of therapeutic molecules, allowing large molecules to cross cellular barriers for improved treatment of chronic diseases.

Gensor develops a virus testing platform based on the gene field-effect transistor technology.

Stemloop is a biosensor company dedicated to harnessing biological technology to meet global challenges in chemical sensing and detection. The company focuses on developing innovative, cell-free biosensing products that simplify and enhance the testing process for chemical and molecular analysis. By utilizing genetically encoded sensing mechanisms, Stemloop aims to provide accurate and scalable solutions that are both cost-effective and accessible. This approach allows medical professionals to obtain faster and more reliable test results, ultimately improving healthcare outcomes while addressing unmet needs in laboratory testing. Through its novel technology, Stemloop seeks to revolutionize the landscape of biosensing and contribute meaningfully to various sectors.

Diamante is a company based in Verona, Italy, that specializes in the development and manufacturing of diagnostic devices for autoimmune diseases, utilizing innovative nanomaterials. Founded in 2016, the company leverages plants as bioreactors to produce nanoparticles derived from modified plant viruses. This approach allows Diamante to create advanced tools for diagnosing and potentially treating autoimmune conditions, focusing on sustainable and efficient production methods. Through its research and development efforts, Diamante aims to contribute significantly to the field of autoimmune disease therapy.

Biotic Circular Technologies specializes in the development and manufacturing of fully bio-based, biodegradable polymers, offering a sustainable alternative to fossil-fuel plastics. The company's end-to-end manufacturing process is designed to eliminate the need for recycling, thus promoting a zero-waste and circular economy. By providing a scalable and environmentally friendly solution, Biotic Circular Technologies aims to address the growing demand for sustainable materials across various applications, including packaging, disposables, and single-use products. Their innovative approach contributes to the reduction of greenhouse gas emissions, aligning with global efforts to transition towards more sustainable practices.

Michroma is a biotech company that develops natural, thermostable colorants for fungus-based food and cosmetics by leveraging fermentation of filamentous fungi and synthetic biology. It aims to replace synthetic pigments with natural pigments produced through biotechnological fermentation, delivering pH- and heat-stable colorants at scale for food and cosmetic applications. The company operates in multiple locations, including San Francisco, United States, and Rosario, Argentina, and pursues scalable production in bioreactors using proprietary fungal strains.

Sophie's Bionutrients is a company focused on creating sustainable plant-based proteins derived from microalgae through advanced fermentation technologies. By employing strain optimization, precision fermentation, and protein extraction methods, the company develops high-purity protein powders with various functionalities. These innovative products cater to the food industry, particularly in the production of imitation seafood, offering an alternative that aligns with growing demands for sustainable and environmentally friendly food sources.

BestHealth4U specializes in developing advanced adhesive technologies for medical applications. Their innovative solutions aim to prevent skin injuries, enhance healing, and improve overall patient health by transforming how bandages, dressings, and medical devices adhere to the skin.

Frankles is a climate tech startup developing NoDex, a platform for designing molecular extraction processes from plant raw materials and agro-industrial waste. This enables the production of high-value sustainable ingredients such as flavorings, functional compounds, antioxidants, and biocompounds, aiming to replace petroleum-based extraction methods.

Organifarms specializes in developing robotic solutions tailored for greenhouses and vertical farms. Their primary product is harvesting robots designed to automate the harvest, quality control, and monitoring processes of fruit and vegetable crops. This automation addresses the challenges posed by labor shortages and rising labor costs within indoor farming environments, while also enabling cultivation methods free from pesticides.

ClearLeaf is a company specializing in the development of non-toxic agricultural solutions, utilizing patent-pending technology that is organic certified in the EU and Japan. The firm offers a range of environmentally friendly fungicides and bactericides designed for various crops, including coffee, bananas, pineapples, and several vegetables. ClearLeaf's flagship product, GotaBlanca®, is currently sold in Costa Rica, with plans for expansion into Central America. The company has secured an exclusive commercial agreement with Colono Agropecuario, the largest agrochemical distributor in the region, enabling it to significantly increase sales since entering the market. ClearLeaf's mission is to provide sustainable alternatives to conventional agrochemicals, promoting environmental health and worker safety on farms while supporting farmers in achieving greater efficiency and productivity.

FermBiotics is a microbiome company focused on improving gut health through natural, fermented seaweed and plant ingredients for food, dietary supplements, and medical foods for humans and animals. It develops sustainable fermented inputs that combine prebiotics, probiotics, and bioactives to support gut barrier function by stabilizing microflora, reducing inflammation, and strengthening the intestinal lining. The company's products are designed as ingredients for food, dietary supplements, and medical nutrition, enabling clients to incorporate gut-friendly components across various applications.

BrightCure Ltd., established in 2019 and based in London, United Kingdom, specializes in developing probiotic-based therapies aimed at treating urinary tract infections (UTIs). The company focuses on addressing recurrent and difficult-to-treat bacterial infections, a significant health issue affecting 50% of women and 12% of men globally. BrightCure's approach involves utilizing the natural microbiome to reduce harmful bacteria and replenish beneficial bacteria in the vaginal flora, thereby boosting the immune system to promote urinary tract health. The company has garnered recognition through various competitions and accelerators, including selection for Indiebio, the world's largest biotech accelerator.

Ittinsect is the biotech startup that developed the sustainable alternative to aquaculture feed. Ittinsect produces high performance feeds through the microbiological treatment of novel raw ingredients including insects, microalgae and agricultural by-products, in line with the circular economy principles. With Ittinsect, there is no longer need to catch fish from the marine environment as nutrition for farmed fish. The company’s mission is making aquaculture ocean-impact neutral.

FairFlavor develops nutritious vegan alternative dairy food made of a super nut from Indonesia using a patented fermentation technology

Vectech develops AI-powered diagnostic systems for medical entomology, currently used in seven countries. Its IDX system enables non-specialists to identify mosquito species and characteristics, aiding global public health efforts against diseases like malaria and dengue.

B’ZEOS specializes in developing seaweed-based packaging solutions, offering industries a sustainable alternative to combat single-use plastics and reduce their carbon footprint.

Oxyle specializes in wastewater treatment, focusing on the removal of hazardous micropollutants such as pesticides, chemicals, pharmaceuticals, and endocrine disruptors. Serving industries like pharmaceuticals, biotech, chemicals, food & beverage, electronics, hospitals, and wastewater plants, Oxyle's innovative technology helps reduce toxic pollutants and carbon emissions while providing regulatory relief to clients.

Digi.Bio develops software and automation platforms for the healthcare and life sciences sector. The company creates digital microfluidics and electrowetting-based automation software to streamline multistep liquid handling in laboratories, replacing traditional pipetting robots. It operates a lab-on-a-chip and computational platform that analyzes cell therapies, evaluating performance and outcomes at the single-cell level to deliver high-content results quickly with minimal material waste. The company uses artificial intelligence to rapidly and precisely manipulate droplets on a microscale, enabling automated workflows for medical and pharmaceutical applications and the scaling of bioengineering processes. It is based in Amsterdam, Netherlands.

Fybraworks Foods, Inc. is a biotechnology company based in Minnetonka, Minnesota, focused on developing alternative meat substitutes through innovative fermentation techniques. Founded in 2020, the company specializes in creating animal-free meat structural proteins and synthetic meat, aiming to replicate the taste and texture of traditional meat products. By leveraging its advanced technological solutions, Fybraworks Foods enables both industry leaders and individual consumers to access sustainable meat alternatives, thus promoting humane practices and reducing environmental impact associated with animal agriculture.

Microbe Plus develops innovative microbiological bio-products that combine biological products and molecular biology. Their bioproducts are multi-strain probiotics designed to protect plants from a wide spectrum of pathogens, promoting plant growth and reducing reliance on synthetic pesticides.

Criam is a Portuguese biotechnology company based in Braga that develops portable diagnostic technology for blood typing and infectious disease detection. Its stand-alone platform does not require electricity or laboratory infrastructure, enabling rapid testing at the point of care. A single reader can perform multiple tests using cartridges and computer vision algorithms to detect a broad range of diseases, including HIV, with real-time data to support clinical decisions. The system leverages lab-on-a-chip concepts and biomarker detection algorithms to deliver fast, user-friendly, and cost-effective diagnostics in diverse settings, including remote environments and emergency care.

Umami Bioworks is a company focused on the discovery and development of a scalable platform for producing cultivated seafood, aiming to protect endangered marine species while providing consumers with sustainable seafood options. The company utilizes systems engineering to enhance the discovery and industrialization processes, facilitating local production that is both price competitive and environmentally responsible. Its innovative approach involves creating cell-based food products derived from fish cells and tissue, which are designed to be free from harmful substances such as mercury, antibiotics, microplastics, and ocean pollutants. By offering affordable, cell-cultured seafood and meat alternatives, Umami Bioworks addresses the growing demand for healthy and sustainable food choices.

TissueLabs is the platform for creating organs and tissues in the lab. We offer biomaterials, equipment, and services to support tissue engineering and regenerative medicine. Our products are created to allow performing state-of-the-art research, from drug discovery to organ fabrication. Currently, we are focused on attending the academic life sciences market. In the future, our mission is to fabricate lab-grown tissues and organs, for both research and therapeutic applications.

Founded in Italy in 2016 by Silvia Scaglione and Maurizio Aiello, React4life is a biotech company dedicated to advancing biomedical research. The company specializes in the development of MIVO®, an innovative organ-on-a-chip technology that enhances the reliability and predictability of various applications such as pharmaceutical drug testing, personalized medicine, immuno-oncology therapies, cosmetics, dermatology, and nutraceuticals.

Babylat develops a compact, automated medical device designed for protein enrichment of human milk. This tabletop device enables on-site concentration of the protein fraction in hospitals, ensuring newborn babies receive sufficient protein.

Epios personalized and precision management of brain disorders using daily life monitoring and therapeutics. The Epios system comprises a series of thin leads incorporating sensing electrodes and a miniature implant, inserted beneath the skin. The neural signals are wirelessly transmitted to an external receiver held in place on the skin directly over the implant with a magnet, and from there are conveyed to a wearable data processor and are finally securely stored in the Epios Cloud.

Paragit Solutions specializes in developing innovative systems for remote patient monitoring and data-driven clinical management of movement disorders, particularly Parkinson's disease. Central to their offerings is the Paragit Sleeve, which employs a patented sEMG (electromyography) technology to gather precise data on muscle activation, movement, and grip force during patients' daily activities. Paragit provides two main software suites for data interpretation: the PD Monitor, tailored for caregivers, which visualizes key motor symptoms like rigidity and tremors to enhance treatment optimization and facilitate telemedicine; and the MD Lab, designed for decentralized clinical trials across various movement disorders. MD Lab enables researchers to analyze over 20 metrics related to disease severity, track trends, and compare groups consistently, with a robust API that supports extensive data access for further analysis. Through these technologies, Paragit aims to improve the management and understanding of movement disorders, enhancing patient care and clinical research.

Leucine Rich Bio is India's pioneering genomics-based company focused on microbiome analysis. It aims to bridge uncertainties in precision medicine by studying the 'second genome', offering personalized nutritional recommendations based on intestinal microflora, with applications across various health fields.

Gelatex is a materials technology company based in Estonia, founded in 2016 and incorporated in the UK in 2019. The company specializes in producing bio-based nanofibers using a patented technology that allows for large-scale production at significantly lower costs. Gelatex's nanofibers are derived from gelatin sourced from low-value waste in the meat and leather industries, ensuring that its products are environmentally friendly and made from natural, non-toxic substances. Initially focused on developing eco-friendly leather-like textiles, the company recognized the broader applications of its technology during the COVID-19 pandemic, leading to a strategic pivot. Gelatex's innovative solutions have potential applications in various fields, including tissue engineering, cultured meat production, bio-based filtration, energy storage, and wound care.