MassVentures

Bloomer Tech is a company that designs and manufactures bras embedded with advanced fabric engineering technology to monitor women's cardiovascular health. Founded in 2015 and based in Cambridge, Massachusetts, the company utilizes everyday fabrics and machine learning to collect critical health metrics, including electrocardiograms, pulse rates, respiratory rates, and heart rhythms. By integrating biometric sensors into its products, Bloomer Tech aims to create a reliable data set that enhances understanding of women's heart health and supports personalized healthcare solutions. The company's innovative approach enables real-time access to meaningful health data for users and healthcare professionals, facilitating improved monitoring and treatment of chronic diseases. The founders of Bloomer Tech, Aceil Halaby, Alicia Chong Rodriguez, and Monica Abarca, are committed to addressing global cardiovascular health challenges through their technology.

Ortholevo develops joint injectable therapies that helps to cure tight, restrained joints.

BioSens8 is a developer of advanced biosensors designed to facilitate holistic health monitoring and prevent chronic diseases. The company's innovative platform offers novel quantitative and real-time biosensors that cater to various sectors. For individuals, the technology assists women in assessing their fertility health, thereby supporting family planning. In agriculture, BioSens8 provides tools for farmers to manage herd reproduction and monitor animal health. Additionally, the biosensors evaluate environmental health, contributing to the revitalization of fragile ecosystems. By serving the healthcare, agriculture, military, and biomanufacturing sectors, BioSens8 aims to enhance overall health and operational efficiency across diverse applications.

Osmoses specializes in decarbonizing gas separations using innovative membrane technology. Its solution efficiently purifies gas molecules, reducing energy consumption and capital requirements while integrating seamlessly into existing industrial processes. This enables energy producers to achieve cleaner and more sustainable operations.

PhagePro is an early-stage biotechnology company developing bacteriophage-based products to combat global health disparities and antibiotic resistance. Its lead program focuses on treating cholera, with a commitment to affordable and locally adaptable healthcare solutions through collaboration with stakeholders.

Theromics Inc., founded in 2016, develops innovative cell therapies. It specializes in HeatSYNC Gel, a biopolymer thermal accelerant that enhances microwave and radiofrequency energy absorption during soft tissue ablation procedures. This gel amplifies heat movement, optimizes ablation zone shape, increases treatment area, and protects critical tissues.

Notch Inc., located in Cambridge, Massachusetts, specializes in developing advanced metamaterial solutions that enhance antenna technology. The company's innovations enable electronically controlled beamforming, which improves communication ranges and performance. Additionally, Notch Inc. incorporates features that bolster cybersecurity, ensuring that their solutions not only optimize connectivity but also protect against potential threats. Through its cutting-edge technology, Notch Inc. aims to address the evolving needs of modern communication systems.

Advanced Silicon Group is a nanotechnology company founded in 2015, focused on commercializing innovative silicon nanotechnology developed by its employees. The company specializes in measuring host cell proteins in biomanufacturing, utilizing its advanced technology to enhance various applications, including photovoltaics, lithium-ion batteries, microfluidics, and micro-electromechanical systems (MEMS). Advanced Silicon Group is also engaged in the development of next-generation biosensors, leveraging silicon to enable multiplexed measurements that allow for the simultaneous detection of multiple protein concentrations. This capability aids clients in improving performance and reducing costs by integrating silicon nanowire arrays into their products.

Versatope Therapeutics is a preclinical-stage biotechnology company that specializes in immuno-therapeutics aimed at enhancing vaccine potency and therapeutic delivery. The company has developed a proprietary bacterial factory nanoparticle technology that allows for the display of multiple epitopes. This innovative approach is designed to address challenges associated with strain-specific immunity, enabling the creation of a single vaccine capable of providing protection against multiple strains of influenza. By focusing on these advancements, Versatope aims to support biotechnology companies in their efforts to develop more effective vaccines.

Emvolon is a technology company focused on creating a platform for distributed chemical production that utilizes wasted resources. The company's innovative approach involves converting wasted natural gas from flare sites into usable chemicals, which can serve a variety of industrial applications or be transformed into carbon-negative fuels. Emvolon reimagines traditional diesel engines as miniature chemical reactors, allowing for efficient and effective production without the need for large refineries or chemical plants. This process facilitates the establishment of economically viable small-scale production facilities by leveraging the advantages of mass production alongside economies of scale, ultimately providing communities with the essential raw materials they require.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

Electrified Thermal Solutions, founded in 2021 and based in Medford, Massachusetts, develops innovative energy storage technology. The company converts intermittent renewable electricity into constant heat using low-cost conductive ceramic blocks, enabling industrial sectors to replace fossil fuels with zero-carbon heat.

Gel4Med LLC is a Boston-based medical technology company founded in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix that addresses the challenge of antibiotic-resistant bacteria while facilitating tissue regeneration. Utilizing bioinspired and engineering approaches, Gel4Med's technology aims to improve patient outcomes in various therapeutic areas, particularly in wound care and tissue regeneration. Their leading asset features a self-assembling peptide technology that acts as both an antibacterial barrier and a promoter of tissue regeneration, enabling patients to prevent infections during surgical procedures.

Guardion is a technology company specializing in advanced sensor technology, particularly in the development of radiation detectors that utilize the quantum properties of nanomaterials. This innovative approach allows Guardion to create low-cost, highly sensitive, and energy-efficient detectors suitable for large-scale deployment, especially in urban environments. The company focuses on applications that demand high sensitivity and miniaturization, providing analytical instruments and chemical detectors that serve various industries, including aerospace, healthcare, and national security. Guardion has received recognition for its contributions to the field, winning multiple awards such as the MassChallenge Gold Prize and the Technology in Space Prize from CASIS and Boeing. Additionally, the company participated in the inaugural cohort of the Techstars Autonomous Tech Accelerator, which is sponsored by the Air Force.

Transcend Air develops and designs aircraft for private air travel and regional mobility, focusing on high-speed tiltwing VTOL platforms intended to transform VIP transport, defense, and city-to-city travel. The company’s patented aircraft platform leverages proven aerospace technologies, including a certified engine and whole-aircraft parachute, to offer faster, safer operations at lower operating costs compared with conventional options.

Eyebot develops innovative eye examination technology designed to eliminate barriers and enhance accessibility to vision care. Their flagship product is a freestanding, self-serve vision testing terminal that provides accurate eye prescriptions directly at the point of sale, enabling ophthalmologists to proactively improve eye care quality and reduce costs.

Active Surfaces, a Massachusetts-based company, specializes in commercializing ultra-thin-film solar technology developed at MIT. Its core business involves creating flexible, lightweight solar panels that can be seamlessly integrated into everyday materials and surfaces, revolutionizing the conventional energy sector. The company's innovative manufacturing approach significantly reduces production costs, making solar power more accessible and affordable. This technology presents a transformational opportunity for semiconductor and electronics manufacturing, driving down costs for both module production and installation. By enabling virtually any surface to generate power, Active Surfaces aims to accelerate the transition to a cleaner, more sustainable future.

Adhesion Technologies is a bio-adhesive producer offers an alternative to toxic furniture glues, promoting to reduce chemical exposure.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

Dottir Labs specializes in developing spectroscopy sensor technology tailored for aqueous environments. This technology detects and measures nutrients, metabolic markers, and both organic and non-organic waste products in real-time, empowering clients to achieve sustainability through data-driven insights.

ThermoBionics is a manufacturer specializing in wearable cooling products that leverage innovative technology to enhance cooling efficiency while minimizing weight. The company focuses on developing apparel that utilizes its proprietary, patent-pending technology to artificially regulate the body's thermoregulatory functions. This allows users to reduce perspiration and promote moisture evaporation, ensuring comfort in various outdoor temperature and humidity conditions.

Benchmark Labs is a San Francisco-based company specializing in AI-driven weather forecasting systems tailored for the agricultural sector and other industries. The firm provides asset-specific weather information that enhances operational efficiency and infrastructure reliability amidst changing weather conditions. By utilizing IoT sensor technology, Benchmark Labs delivers accurate forecasts that are essential for optimizing renewable energy generation and managing water resources. Its innovative platform enables clients to navigate weather variability effectively, ensuring smoother operations across various applications.

MacroCycle Technologies is a company developing a chemical recycling process to convert polyethylene terephthalate (PET) and polyester-fiber waste into virgin-grade plastics. Their proprietary technology, based on synthesizing cyclic macromolecules, enables the production of recycled PET with lower energy use than traditional methods. This process offers a sustainable, zero-carbon, and cost-competitive solution for plastic upcycling, contributing to a circular economy.

Blaze Power operates as a lithium-ion battery materials manufacturer. It innovates and commercializes iron-based cathode materials to enable mass-market electrification in transportation and energy storage. The company is driven to industrialize these cathodes in purpose-built inflation reduction act-compliant facilities.

Western New England University, located in Springfield, Massachusetts, is a small institution known for its close-knit academic environment, where students can build meaningful relationships with faculty and peers. The university offers a range of undergraduate and graduate programs, with particular strengths in Pharmacy, Engineering, and Law. Its undergraduate offerings include disciplines from the Arts and Sciences, Business, and Engineering departments, along with a Pre-Pharmacy major that leads to its highly regarded graduate Pharmaceutical Sciences program. The campus life is vibrant, featuring a variety of cultural events and activities, such as music festivals and seasonal celebrations, fostering community engagement. Students can participate in performing arts groups, a school newspaper, and literary publications, in addition to enjoying organized campus gatherings and regional trips. Admission to undergraduate programs requires the submission of standardized applications, while graduate program applicants must meet specific departmental criteria. Scholarships and financial aid options are available, contributing to accessibility for prospective students.

River Otter Renewables is a recycling comany that produced biocrude oil from plant and waste as well as sewage and plastic waste.

Feon develops new-molecule-based liquid electrolytes for lithium-ion and lithium-metal batteries.

Kanda Industries designs and manufactures the custom furnitures for homes and Offices.

Seia Bio is a biotechnology company that specializes in the development and production of non-model microbes. These are beneficial microorganisms that are not typically studied in laboratories but play crucial roles in various industries, such as agriculture. Seia Bio's core business involves enhancing the shelf-life and temperature stability of these non-model microbes through a proprietary coating technology. This process protects the microbes from harsh environmental conditions, ensuring their viability and effectiveness. By doing so, Seia Bio aims to improve the yield and sustainability of crops, ultimately benefiting farmers and the agricultural industry.

Reveal Pharmaceuticals is a developer of innovative MRI contrast agents that aim to provide a safer, gadolinium-free alternative to traditional Gadolinium-Based Contrast Agents (GBCAs). The company's focus is on creating precision imaging agents that enhance diagnostic capabilities in areas such as pulmonary embolism and cancer. By leveraging its patented RVP platform, Reveal Pharmaceuticals integrates targeted molecular probes into its imaging solutions, allowing for safer scans without the need for biopsies. This approach supports the growing emphasis on personalized medicine and targeted therapeutics, ensuring that patients receive crucial medical imaging with reduced risk.

Advanced Silicon Group is a nanotechnology company founded in 2015, focused on commercializing innovative silicon nanotechnology developed by its employees. The company specializes in measuring host cell proteins in biomanufacturing, utilizing its advanced technology to enhance various applications, including photovoltaics, lithium-ion batteries, microfluidics, and micro-electromechanical systems (MEMS). Advanced Silicon Group is also engaged in the development of next-generation biosensors, leveraging silicon to enable multiplexed measurements that allow for the simultaneous detection of multiple protein concentrations. This capability aids clients in improving performance and reducing costs by integrating silicon nanowire arrays into their products.

Founded in 2020, Irradiant Technologies specializes in developing advanced lithography techniques for high-throughput microfabrication. Headquartered in Cambridge, Massachusetts, the company's core technology enables ultrafast three-dimensional assembly of diverse materials with nanoscale precision, facilitating innovation in photonic and optical components for telecommunications, computation, and sensing.

Founded in 2017 and headquartered in Boston, Southie Autonomy develops robot software that enables industrial robots to be repurposed and redeployed by users without specialized skills. Its system aims to reduce time, cost, and skill barriers for applications like kitting, palletizing, and simple assembly.

AI platform producing compostable and biodegradable plastic alternatives

Gel4Med LLC is a Boston-based medical technology company founded in 2015, specializing in the development of innovative biomaterials for tissue treatment and regeneration. The company focuses on creating an antimicrobial tissue-scaffolding matrix that addresses the challenge of antibiotic-resistant bacteria while facilitating tissue regeneration. Utilizing bioinspired and engineering approaches, Gel4Med's technology aims to improve patient outcomes in various therapeutic areas, particularly in wound care and tissue regeneration. Their leading asset features a self-assembling peptide technology that acts as both an antibacterial barrier and a promoter of tissue regeneration, enabling patients to prevent infections during surgical procedures.

Osmoses specializes in decarbonizing gas separations using innovative membrane technology. Its solution efficiently purifies gas molecules, reducing energy consumption and capital requirements while integrating seamlessly into existing industrial processes. This enables energy producers to achieve cleaner and more sustainable operations.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Founded in Boston in 1995, AmberGen specializes in innovative photonic technology for therapeutics and diagnostics. The company's core expertise lies in proteomics and light-based control of biomolecules, aiming to advance medical research and diagnosis through high-resolution, multiplexed analysis of biomarkers.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

Northeastern University, founded in 1898, is a private, research-intensive university located in Boston, Massachusetts. It offers a wide range of undergraduate and graduate programs, including doctorate degrees, across nine colleges and schools. Additionally, it provides select advanced degrees at graduate campuses in Charlotte, North Carolina, and Seattle. The university is renowned for its experiential learning approach, integrating real-world experience into its academic curriculum.

Rendever offers a virtual reality and shared experiences platform designed to reduce social isolation by fostering personal connections among seniors in living communities and hospitals. The platform enables group sessions where participants can check off bucket list items, revisit meaningful places, share stories, and stay engaged with family, helping improve mental well-being and quality of life. It is used by major senior living operators such as Revera, Benchmark, and SRG, and by healthcare systems including UCHealth and Cleveland Clinic, with NIH and NIA-funded research and partnerships with organizations like AARP and Verizon.

Haystack Ag supports growers and global carbon markets with tools for high-accuracy, cost-effective soil carbon measurement.

Stitch3D offers a cloud-based platform for hosting, viewing, analyzing, and sharing complex 3D files. It employs AI and machine learning algorithms to simplify the translation of spatial data into actionable insights.

Fourier is a thermal management solutions ranging from high power density electronics to renewable energy to space applications.

Phoenix Tailings specializes in recycling mining tailings, specifically Bauxite Residue ('Red Mud'), to extract strategic materials for industries such as aerospace, automotive, electronics, and biotechnology. Founded in 2019 with a mission to revolutionize the mining industry sustainably and economically.

Notch Inc., located in Cambridge, Massachusetts, specializes in developing advanced metamaterial solutions that enhance antenna technology. The company's innovations enable electronically controlled beamforming, which improves communication ranges and performance. Additionally, Notch Inc. incorporates features that bolster cybersecurity, ensuring that their solutions not only optimize connectivity but also protect against potential threats. Through its cutting-edge technology, Notch Inc. aims to address the evolving needs of modern communication systems.

Aclarity, LLC is a United States-based manufacturer specializing in innovative water purification devices for residential use. Founded in 2017, the company develops advanced electrochemical water treatment systems that effectively eliminate contaminants such as pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. Aclarity's patented technology aims to provide cost-effective, low-maintenance solutions for comprehensive water treatment, catering to the growing need for clean water and addressing pollution challenges in both water and wastewater systems. As a venture capital-backed cleantech startup, Aclarity is focused on revolutionizing the water treatment industry with its cutting-edge approach.

Loop CO2 specializes in transforming carbon dioxide into valuable products like cosmetic oils, adhesives, and thermoplastic elastomers. This innovative process enables clients to minimize their environmental impact by adopting eco-friendly alternatives.

Electrified Thermal Solutions, founded in 2021 and based in Medford, Massachusetts, develops innovative energy storage technology. The company converts intermittent renewable electricity into constant heat using low-cost conductive ceramic blocks, enabling industrial sectors to replace fossil fuels with zero-carbon heat.

PathMaker Neurosystems is a clinical-stage neurotechnology company that develops neuromodulation therapies for neuromotor disorders, including amyotrophic lateral sclerosis. The company focuses on non-invasive, multi-site direct current stimulation to modulate neural pathways and spinal motor neurons involved in disease processes. Its approach aims to reduce protein aggregation and motor neuron hyperexcitability, with the goal of improving motor function and potentially extending survival for ALS patients.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

Florrent develops bio-based materials and high-energy-density supercapacitors derived from agricultural waste streams to address bottlenecks in decarbonization and electrification of transportation and buildings. Its technology aims to improve power quality and reliability while offering lower upfront and lifetime costs than conventional batteries, enabling commercial, industrial, and grid operators to enhance performance and support economic inclusion in underrepresented communities.

The University of Massachusetts Amherst is a public research and land-grant university that offers undergraduate, master's, and doctoral programs. It serves as the flagship campus of the University of Massachusetts system. The university has multiple academic departments and research facilities that support a range of disciplines.

Carbix develops weathering technologies that convert CO2 emissions into building materials. It uses a bioreactor to capture CO2 from industrial plant flue gas and combines it with mineral inputs and energy from renewable sources or energy-from-waste to accelerate sequestration and form carbonates that serve as raw materials for construction products and other industrial applications.

Arrakis Materials converts CO₂ into carbon-negative minerals, enabling carbon storage and utilization.

Lithios is a technology company that uses electrochemistry for advanced lithium extraction from complex mixtures and untapped brine resources, applying electrochemical methods to capture and release lithium and enable low-cost, selective extraction for industries pursuing a sustainable, electrified future.

Aloft Systems specializes in maritime transportation through the development of innovative wind propulsion technology. This technology aims to reduce emissions and save fuel on existing vessels by utilizing direct wind propulsion. The company offers self-contained wind propulsion units that can be integrated into various ships, along with software that operates these units autonomously. This enables shipping companies to transport cargo efficiently along point-to-point routes, enhancing delivery reliability while significantly cutting emissions and eliminating fuel costs. Aloft Systems' commitment to zero-emission propulsion makes its solutions accessible to a wide range of vessels, positioning it as a leader in sustainable maritime transportation.

Prisere LLC specializes in enhancing business resilience against global disasters and disruptions. It offers consulting services that include risk communications, mapping, and software applications, along with training and technical advisory services. The company collaborates with institutions to provide expertise in disaster risk reduction, using technology to improve risk management and facilitate access to affordable insurance. This enables businesses to bolster long-term profitability and stability, particularly in regions underserved by traditional risk mapping and modeling tools.

Stepwise specializes in home electrification services. They offer smart devices that monitor energy consumption, manage electric loads like EV chargers, facilitate heat pump installations, and ensure compliance with safety standards and utility programs.

AeroShield specializes in the production of super-insulating, nanoporous glass materials designed for energy-efficient windows. Utilizing silica aerogel, AeroShield's products offer optical clarity akin to traditional glass while delivering superior insulation, making them 50% more effective than conventional double-pane windows. This innovative approach not only enhances thermal comfort but also significantly improves energy performance, allowing window manufacturers to meet sustainability and compliance objectives. Additionally, the payback period for AeroShield's materials is up to five times faster than that of similarly performing windows, making them a compelling choice for the modern market.

EnVision Endoscopy specializes in developing innovative medical devices aimed at enhancing endoscopic surgical procedures. Their flagship product is an image-guided suturing system designed to be attached to flexible endoscopes, making it accessible to a wide range of gastroenterologists and surgeons. This biodegradable, single-use device facilitates easier completion of procedures by enabling tissue approximation during surgeries. The company's solutions are intended to reduce procedure time and mortality rates in hospitals, addressing critical clinical needs for policymakers, insurers, clinicians, and patients alike.

The principal mission of the Company is to provide technology and technology services to industry and public sector agencies for enhanced productivity, improved safety, and reduced costs.

Pison Technology, Inc., established in 2016 and headquartered in Boston, Massachusetts, specializes in developing and marketing wearable devices. These devices are designed to capture and filter signals sent to the nervous system, primarily serving individuals with amyotrophic lateral sclerosis (ALS). Pison's innovative, non-invasive electroneurography (ENG) algorithms and sensor array technology aim to optimize cognitive and physiological capabilities through gesture control, with applications in cognitive enhancement, disease diagnosis, management, and improving overall quality of life.

Founded in Boston in 1995, AmberGen specializes in innovative photonic technology for therapeutics and diagnostics. The company's core expertise lies in proteomics and light-based control of biomolecules, aiming to advance medical research and diagnosis through high-resolution, multiplexed analysis of biomarkers.

Kinto.Care is an online platform designed to enhance communication and support for caregivers, particularly those caring for loved ones with dementia. The platform offers user-generated content and digital tools that facilitate care team collaboration, medication management, and tracking of health data. By providing practical advice, care planning, and group learning opportunities, Kinto.Care aims to empower family members to effectively coordinate care and manage their loved ones' medical needs through a unified interface.

Founded in 2018 by Drs. Veronika Stelmakh and Walker Chan, Mesodyne is a pioneering engineering and manufacturing company specializing in innovative electricity generation methods. Their patented LightCell technology converts any fuel to electricity via light, providing rugged, long-lasting, portable power for military and commercial users.

Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in the development of healthcare equipment. The company's primary product, PointCheck, is a non-invasive device designed to monitor and count white blood cells. This innovative technology allows for more frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, enhancing their quality of life and clinical outcomes. The device is particularly beneficial as it eliminates the need for invasive blood draws and laboratory infrastructure, making it more accessible and convenient for patients.

Founded in 2018, Radical Plastics develops a proprietary catalyst that renders plastic compounds biodegradable in natural environments. Its primary product is soil degradable compounds for agricultural film.

Reveal Pharmaceuticals is a developer of innovative MRI contrast agents that aim to provide a safer, gadolinium-free alternative to traditional Gadolinium-Based Contrast Agents (GBCAs). The company's focus is on creating precision imaging agents that enhance diagnostic capabilities in areas such as pulmonary embolism and cancer. By leveraging its patented RVP platform, Reveal Pharmaceuticals integrates targeted molecular probes into its imaging solutions, allowing for safer scans without the need for biopsies. This approach supports the growing emphasis on personalized medicine and targeted therapeutics, ensuring that patients receive crucial medical imaging with reduced risk.

ActivSignal, established in 2016 and based in Natick, Massachusetts, specializes in biotechnology. The company focuses on developing innovative protein profiling technologies, primarily serving the proteomics research sector. Their tools enable scientists to analyze multiple signaling pathways simultaneously, providing insights into cellular pathway activation or inhibition profiles.

Extend Biosciences Inc. is an emerging biotechnology company developing a novel drug delivery platform technology that improves the pharmacokinetic properties of peptides and proteins. Peptides have been particularly challenging to bring to market because they are removed from circulation prior to administering therapeutic value. Their proprietary platform technology significantly improves the circulating half-life and bioavailability of peptides and proteins, enabling the scientific community to truly develop potent and specific drugs. Their mission is to revolutionize drug delivery and give patients a better quality of life.

Jaxon.AI develops an artificial intelligence platform that guides data science teams through the research, design, and build phases. It leverages technologies such as ChatGPT to address domain- and use-case-specific problems and creates blueprints to keep users on the optimal path. The platform features a proprietary reasoning engine that simulates model performance to compare tradeoffs and identify effective approaches for each problem. It also targets reducing AI hallucinations by enabling an automated design cycle with formal methods, helping teams improve reliability and consistency in AI projects.

Gradient is a developer of secure software that addresses fundamental issues of trust and authenticity in the digital landscape. The company's solutions focus on redefining identity and data authentication, providing a framework for establishing trust and facilitating the sharing of provable statements while ensuring privacy and security. This enables users to collaborate openly without sacrificing digital security or integrity. Gradient's infrastructure is designed to foster decentralized trust, contributing to safer and more reliable digital interactions.

Eden is focused on developing a sustainable platform for natural resource recovery, aiming to create a carbon-neutral future. The company has introduced a novel method known as Pulsed Electrical Well Stimulation (PEWS), which is a patent-pending technology designed to replace traditional hydraulic fracturing. This innovative approach eliminates the need for water injection and addresses the logistical challenges and environmental risks associated with conventional fracking methods. By utilizing high-voltage electricity and proprietary modeling techniques, Eden enhances rock permeability with precision, facilitating effective resource extraction across various geological settings. This technology not only reduces costs but also minimizes the negative impacts typically associated with hydraulic fracturing, positioning Eden as a leader in environmentally responsible resource recovery.

Aclarity, LLC is a United States-based manufacturer specializing in innovative water purification devices for residential use. Founded in 2017, the company develops advanced electrochemical water treatment systems that effectively eliminate contaminants such as pathogens, metals, volatile organic compounds (VOCs), per- and polyfluoroalkyl substances (PFAS), and ammonia from water. Aclarity's patented technology aims to provide cost-effective, low-maintenance solutions for comprehensive water treatment, catering to the growing need for clean water and addressing pollution challenges in both water and wastewater systems. As a venture capital-backed cleantech startup, Aclarity is focused on revolutionizing the water treatment industry with its cutting-edge approach.

PathMaker Neurosystems is a clinical-stage neurotechnology company that develops neuromodulation therapies for neuromotor disorders, including amyotrophic lateral sclerosis. The company focuses on non-invasive, multi-site direct current stimulation to modulate neural pathways and spinal motor neurons involved in disease processes. Its approach aims to reduce protein aggregation and motor neuron hyperexcitability, with the goal of improving motor function and potentially extending survival for ALS patients.

Prezerv Technologies is a provider of GPR technologies and services, offering scalable solutions for businesses of all sizes.

Harmony Desalting is an innovative company specializing in advanced desalination technology aimed at improving access to clean water. Utilizing a reverse osmosis batch process, Harmony Desalting enhances the efficiency of water treatment through the integration of new technologies, membranes, and valuable insights. This approach allows clients to significantly lower the costs associated with seawater desalination while simultaneously increasing plant productivity and minimizing the size of seawater intakes. By focusing on these key areas, Harmony Desalting is well-positioned to address the growing global demand for sustainable water solutions.

SilarTek is a technology company established in 2020 and located in Leominster, Massachusetts. The company specializes in developing innovative solar silicon technology aimed at making solar panels more affordable and accessible to a broader audience. SilarTek's unique approach involves utilizing molten salt electrolysis combined with an advanced molten salt composition, which enables the production of low-cost solar-grade silicon. This technology is designed to benefit both consumers and businesses by providing an efficient solution for solar panel manufacturing.

Worcester Polytechnic Institute (WPI), located in Worcester, Massachusetts, is a prestigious technological university founded in 1865. Renowned for its commitment to project-based learning, WPI emphasizes practical application of theoretical knowledge to address real-world challenges. The university boasts a distinguished faculty and state-of-the-art research facilities, fostering an environment rich in innovation and collaboration. WPI attracts ambitious students eager to engage in hands-on experiences that prepare them to make meaningful contributions to society. With a strong focus on developing skills that are crucial in today’s dynamic landscape, WPI positions itself as a leader in education and research, dedicated to empowering its students and faculty to achieve excellence.

Zero Homes operates a home electrification marketplace that enables homeowners to plan, purchase, and schedule electrification projects. The platform offers electrification guidance through virtual home energy assessments, decarbonization roadmaps tailored to each residence, and scoped, priced projects designed to deliver all-electric upgrades without on-site visits. By combining planning tools, transparent pricing, and scheduling capabilities in a single digital platform, Zero Homes helps homeowners access retrofits that improve comfort, reduce emissions, and simplify the transition to electric systems.

Western New England University, located in Springfield, Massachusetts, is a small institution known for its close-knit academic environment, where students can build meaningful relationships with faculty and peers. The university offers a range of undergraduate and graduate programs, with particular strengths in Pharmacy, Engineering, and Law. Its undergraduate offerings include disciplines from the Arts and Sciences, Business, and Engineering departments, along with a Pre-Pharmacy major that leads to its highly regarded graduate Pharmaceutical Sciences program. The campus life is vibrant, featuring a variety of cultural events and activities, such as music festivals and seasonal celebrations, fostering community engagement. Students can participate in performing arts groups, a school newspaper, and literary publications, in addition to enjoying organized campus gatherings and regional trips. Admission to undergraduate programs requires the submission of standardized applications, while graduate program applicants must meet specific departmental criteria. Scholarships and financial aid options are available, contributing to accessibility for prospective students.

The University of Massachusetts (UMass) Dartmouth is known for its rigorous academic programs, especially in the areas of engineering, law, marine science, and Portuguese studies.

Volta Energy developing technology to decarbonize energy generation.

SpadXTech employs microbial fermentation techniques and proprietary biotechnology to produce sustainable materials. Their products aim to mitigate climate change, reduce air and water pollution, and tackle plastic waste.

M2 Thermal Solutions is a company focused on developing innovative air conditioning technology that addresses significant engineering challenges related to energy efficiency. Their groundbreaking thermodynamic mechanism enables independent control of both dry-bulb temperature and humidity within residential spaces. By utilizing a two-stage process to sensibly cool and dehumidify air without relying on traditional vapor-compression systems, M2 Thermal Solutions' devices can adapt to varying indoor and outdoor temperature and humidity conditions. This approach not only enhances user comfort but also contributes to reduced energy consumption and mitigates the impact of climate change.

GenH is a Boston-based company founded in 2017 that specializes in advanced hydroelectric technologies for urban environments. The company focuses on developing modular hydropower systems that enhance and optimize energy generation at non-powered dams and canal heads. By providing resilient and deployable hydropower solutions, GenH enables clients to electrify these sites without the need for significant construction or investment in fixed infrastructure. This innovative approach aims to help clients achieve economic parity with traditional fossil fuel systems, thereby promoting sustainable energy generation while minimizing reliance on subsidies.

UMass Lowell is a research university that offers bachelor, master, and doctoral degree programs.

Allium Engineering specializes in developing and manufacturing corrosion-resistant steel rebar, utilizing innovative coating technology. This enhances concrete infrastructure durability, minimizes maintenance needs, reduces carbon emissions, and benefits construction sites.

Tufts University is a moderately sized institution that integrates the characteristics of a research university with those of a liberal arts college, fostering an environment of curiosity and creativity. Established with a commitment to student-centered education, Tufts emphasizes the creation and application of knowledge across a diverse range of disciplines. The university offers various programs, including degrees in public health and health informatics through its School of Medicine, and is home to the Tufts Center for the Study of Drug Development, an independent nonprofit organization that enhances the quality and efficiency of pharmaceutical development. Tufts aims to provide transformational experiences for students and faculty in an inclusive and collaborative setting, encouraging innovative thinking and active engagement in addressing complex global challenges.

Bootbox Labs is a manufacturing company that provides refrigerant-free and climate-neutral heat pumps for the HVAC industry.

Curbhub employs decentralized couriers and advanced technology to optimize logistics, transforming linear processes into parallel, efficient ones.

SeaDeep employs AI to revolutionize underwater imaging. Its platform enhances real-time assessment of marine environments and structures, offering unprecedented fidelity.

PowerHouse is a company dedicated to combating climate change by providing innovative solar energy solutions. It specializes in developing a solar energy system that overcomes the limitations of traditional deployment methods, offering versatile and aesthetically pleasing options for residential, commercial, and off-grid applications. The company's platform aims to expand the reach of renewable energy, making it more accessible and desirable for clients.

Reveal Pharmaceuticals is a developer of innovative MRI contrast agents that aim to provide a safer, gadolinium-free alternative to traditional Gadolinium-Based Contrast Agents (GBCAs). The company's focus is on creating precision imaging agents that enhance diagnostic capabilities in areas such as pulmonary embolism and cancer. By leveraging its patented RVP platform, Reveal Pharmaceuticals integrates targeted molecular probes into its imaging solutions, allowing for safer scans without the need for biopsies. This approach supports the growing emphasis on personalized medicine and targeted therapeutics, ensuring that patients receive crucial medical imaging with reduced risk.

NanoView Diagnostics develops the ExoView platform for characterizing extracellular vesicles through specific binding and detection on an affinity microarray. Its products include ExoView R100, ExoView Tetraspanin kits, custom assays, sample services, and support.

DynamiCare Health offers a digital platform that assists individuals in monitoring and reducing their use of drugs, opioids, alcohol, and tobacco. The platform enables users to perform substance tests via an app and tracks treatment attendance using GPS. Healthcare providers can access data on participants' progress through the DynamicCare Analytics portal, which sends real-time risk alerts when clients are at risk.

Leuko Labs, Inc., established in 2017 and headquartered in Boston, Massachusetts, specializes in the development of healthcare equipment. The company's primary product, PointCheck, is a non-invasive device designed to monitor and count white blood cells. This innovative technology allows for more frequent testing of immunosuppressed patients, such as those undergoing chemotherapy, enhancing their quality of life and clinical outcomes. The device is particularly beneficial as it eliminates the need for invasive blood draws and laboratory infrastructure, making it more accessible and convenient for patients.

Transaera is a company focused on developing advanced air conditioning solutions that prioritize energy efficiency and environmental sustainability. By utilizing a novel desiccant material, Transaera's cooling systems effectively remove moisture from the air prior to the cooling process, significantly reducing energy consumption and greenhouse gas emissions. These innovative systems are designed for both residential and commercial applications, providing affordable and environmentally friendly cooling options that enhance indoor comfort while minimizing the impact on global climate and local grid infrastructure. Through its technology, Transaera aims to improve productivity and comfort in indoor environments while contributing to a more sustainable future.