Lumira Ventures

Puzzle Medical Devices develops innovative heart pump solutions to treat advanced heart failure. Its flagship product, ModulHeart, is a modular percutaneous device designed to reduce cardiac afterload and improve renal perfusion. The device's unique design enables safe percutaneous implantation, supporting both renal and cardiac function with low risk of complications. Puzzle Medical has successfully completed its first-in-human study, demonstrating improvements in cardiac and kidney function.

Axonis Therapeutics is a biotechnology company focused on neurological disorders. It develops medicines targeting KCC2, a critical mediator of inhibition within the brain, using a proprietary neuron-specific K-Cl cotransporter (KCC2) discovery engine. The company aims to improve lives by treating conditions such as epilepsy and pain.

Alpha9 Theranostics is a biopharma company that focuses on radiotherapeutics for the treatment of solid and hematologic malignancies. The company is creating a strong pipeline of radiopharmaceuticals to target solid and hematologic malignancies. Its systematic approach to radiotherapeutic design is fueled by a toolbox of technologies and chemistries, which offers broad potential for expansion into a multitude of oncology targets. Alpha9 Theranostics was founded in 2019 and is headquartered in Vancouver, Canada.

AmacaThera Inc. is a clinical-stage biotechnology company based in Toronto, Canada, founded in 2016. The company is focused on developing an innovative injectable hydrogel platform technology designed to enhance drug delivery and improve patient outcomes in various medical applications, particularly in post-surgical pain management, cancer treatment, and other challenging therapeutic areas. AmacaThera's technology features a unique fast-gelling material that liquefies under mechanical force, consisting of a reversible blend of hyaluronan and methylcellulose. This approach allows for localized and sustained drug delivery, potentially reducing postoperative pain and addressing other medical needs effectively.

AmacaThera Inc. is a clinical-stage biotechnology company based in Toronto, Canada, founded in 2016. The company is focused on developing an innovative injectable hydrogel platform technology designed to enhance drug delivery and improve patient outcomes in various medical applications, particularly in post-surgical pain management, cancer treatment, and other challenging therapeutic areas. AmacaThera's technology features a unique fast-gelling material that liquefies under mechanical force, consisting of a reversible blend of hyaluronan and methylcellulose. This approach allows for localized and sustained drug delivery, potentially reducing postoperative pain and addressing other medical needs effectively.

Iterion Therapeutics, Inc. is a clinical-stage biotechnology company based in Houston, Texas, focused on developing innovative therapeutics for cancer treatment. Established in 2010, the company specializes in targeted cancer therapies, with its lead product, Tegavivint, serving as a potent and selective inhibitor of the Wnt/b-catenin signaling pathway. This pathway is known to play a critical role in various cancer-related processes, including cell proliferation and immune evasion. Tegavivint has demonstrated pre-clinical efficacy in several cancer models, such as desmoid tumors, acute myeloid leukemia, osteosarcoma, and various solid tumors. Iterion Therapeutics is actively enrolling patients in a Phase I clinical study of Tegavivint for desmoid tumors at multiple clinical centers across the United States and Canada.

Notch Therapeutics is a Toronto-based company developing immune cell therapies using induced pluripotent stem cell technology to create gene-edited allogeneic T cells. Its platform enables precise control of Notch signaling during T-cell development, enabling scalable manufacture of a uniform supply of therapeutic T cells for cancer indications such as non-Hodgkin lymphoma, leukemia, and multiple myeloma. The approach aims to overcome bottlenecks in cell therapy development by integrating advanced product design with commercially compatible processes, supporting a next-generation pipeline of cell therapies.

IMV Inc., headquartered in Dartmouth, Canada, is a clinical-stage biopharmaceutical company focused on developing cancer immunotherapies and vaccines against infectious diseases. Founded in 2000, the company utilizes its proprietary delivery platform (DPX) to directly program immune cells within the body, enhancing their ability to target and eliminate specific threats. IMV's lead drug candidate, DPX-Survivac, is a targeted T cell therapy that has shown promising results in late-stage ovarian cancer and relapsed/refractory DLBCL, with multiple Phase 2 clinical trials ongoing across six cancer indications. Additionally, the company is developing a DPX-based vaccine candidate against COVID-19 and DPX-RSV, targeting the respiratory syncytial virus strain A. IMV collaborates with infectious disease experts and has partnerships in the animal health sector, including an agreement with Pfizer Animal Health.

IMV Inc., headquartered in Dartmouth, Canada, is a clinical-stage biopharmaceutical company focused on developing cancer immunotherapies and vaccines against infectious diseases. Founded in 2000, the company utilizes its proprietary delivery platform (DPX) to directly program immune cells within the body, enhancing their ability to target and eliminate specific threats. IMV's lead drug candidate, DPX-Survivac, is a targeted T cell therapy that has shown promising results in late-stage ovarian cancer and relapsed/refractory DLBCL, with multiple Phase 2 clinical trials ongoing across six cancer indications. Additionally, the company is developing a DPX-based vaccine candidate against COVID-19 and DPX-RSV, targeting the respiratory syncytial virus strain A. IMV collaborates with infectious disease experts and has partnerships in the animal health sector, including an agreement with Pfizer Animal Health.

AmacaThera Inc. is a clinical-stage biotechnology company based in Toronto, Canada, founded in 2016. The company is focused on developing an innovative injectable hydrogel platform technology designed to enhance drug delivery and improve patient outcomes in various medical applications, particularly in post-surgical pain management, cancer treatment, and other challenging therapeutic areas. AmacaThera's technology features a unique fast-gelling material that liquefies under mechanical force, consisting of a reversible blend of hyaluronan and methylcellulose. This approach allows for localized and sustained drug delivery, potentially reducing postoperative pain and addressing other medical needs effectively.

Founded in 2003, Exact Imaging specializes in developing high-resolution micro-ultrasound systems for real-time imaging and guided biopsies, primarily focused on the urological market for prostate cancer detection. Its flagship product, ExactVu™, operates at 29 MHz, offering unmatched resolution for visualizing and targeting suspicious regions, while also facilitating systematic TRUS biopsies.

Gladius Pharmaceuticals Inc. is a biotechnology firm based in Montréal that focuses on developing innovative antibiotics to address life-threatening, multi-drug-resistant bacterial infections. The company is dedicated to creating novel drug candidates that demonstrate broad-spectrum efficacy against gram-negative pathogens. Gladius's antibiotics aim to assist in the empiric treatment of these infections and have the potential to replace older generation cephalosporins, thereby providing physicians with effective treatment options for challenging bacterial infections.

Medexus Pharmaceuticals is a specialty pharmaceutical company focused on the North American market. It develops, markets, and distributes a portfolio of therapies addressing rare diseases, autoimmune conditions, pediatric needs, oncology, and allergy. The company’s products include Rasuvo and Metoject (methotrexate) for rheumatoid arthritis and other autoimmune diseases; IXINITY for Hemophilia B; Rupall for seasonal and perennial allergic rhinitis and chronic spontaneous urticaria; Cuvposa for sialorrhea in children with neurologic conditions; Gliolan for intraoperative visualization of brain tumors; and Treosulfan as a conditioning agent before stem cell transplantation. Its operations span Canada and the United States, supported by a North American commercial platform that sells to wholesalers, distributors, healthcare facilities, and specialty pharmacies. Originally known as Pediapharm, the company rebranded as Medexus in 2018 and is based in Verdun, Canada.

KalGene Pharmaceuticals Inc. is a private biotechnology company based in Candiac, Canada, focused on developing precision medicine for the treatment of Alzheimer’s disease. Established in 2006, KalGene collaborates with leading clinician-scientists and academic institutions across North America and Europe. The company specializes in creating targeted therapeutics and companion diagnostics aimed at enhancing clinical outcomes and survival rates. Through personalized medicine, KalGene seeks to predict patient responses to specific therapies before treatment begins, enabling physicians to tailor interventions based on individual biological signatures and needs.

Founded in 2003, Exact Imaging specializes in developing high-resolution micro-ultrasound systems for real-time imaging and guided biopsies, primarily focused on the urological market for prostate cancer detection. Its flagship product, ExactVu™, operates at 29 MHz, offering unmatched resolution for visualizing and targeting suspicious regions, while also facilitating systematic TRUS biopsies.

Founded in 2003, Exact Imaging specializes in developing high-resolution micro-ultrasound systems for real-time imaging and guided biopsies, primarily focused on the urological market for prostate cancer detection. Its flagship product, ExactVu™, operates at 29 MHz, offering unmatched resolution for visualizing and targeting suspicious regions, while also facilitating systematic TRUS biopsies.

KalGene Pharmaceuticals Inc. is a private biotechnology company based in Candiac, Canada, focused on developing precision medicine for the treatment of Alzheimer’s disease. Established in 2006, KalGene collaborates with leading clinician-scientists and academic institutions across North America and Europe. The company specializes in creating targeted therapeutics and companion diagnostics aimed at enhancing clinical outcomes and survival rates. Through personalized medicine, KalGene seeks to predict patient responses to specific therapies before treatment begins, enabling physicians to tailor interventions based on individual biological signatures and needs.

Founded in 2003, Exact Imaging specializes in developing high-resolution micro-ultrasound systems for real-time imaging and guided biopsies, primarily focused on the urological market for prostate cancer detection. Its flagship product, ExactVu™, operates at 29 MHz, offering unmatched resolution for visualizing and targeting suspicious regions, while also facilitating systematic TRUS biopsies.

Opsens Inc. is a Canadian company that specializes in developing, manufacturing, and selling fiber optic sensors for various applications, primarily in interventional cardiology and industrial markets. It operates in two main segments: Medical and Industrial. The Medical segment focuses on physiological measurements, including Fractional Flow Reserve (FFR) and Diastolic Pressure Ratio (dPR), and offers products such as the OptoWire, an advanced optical pressure guidewire, and miniature optical sensors for pressure and temperature measurement. These sensors are designed for integration into medical devices, catering to needs in areas like transcatheter aortic valve replacement. The Industrial segment provides fiber optic sensing solutions for diverse applications, including life sciences, energy, and civil engineering. Opsens markets its products through a direct sales force and distributors across the United States, Japan, Canada, and internationally, with its headquarters located in Québec, Canada.

Zymeworks is a biotechnology company focused on optimizing protein-based therapeutics, particularly for cancer treatment. It uses proprietary computational methods to engineer differentiated product candidates, with its lead asset zanidatamab in multiple clinical trials targeting HER2-expressing solid tumors.

This national mobile wellness rewards initiative harnesses the public’s affinity for popular loyalty points, the convenience of smart phone technology and Canadians’ natural desire to lead healthier lives. It is this unique combination that results in such a powerful “nudge” platform – in support of a healthier

Gladius Pharmaceuticals Inc. is a biotechnology firm based in Montréal that focuses on developing innovative antibiotics to address life-threatening, multi-drug-resistant bacterial infections. The company is dedicated to creating novel drug candidates that demonstrate broad-spectrum efficacy against gram-negative pathogens. Gladius's antibiotics aim to assist in the empiric treatment of these infections and have the potential to replace older generation cephalosporins, thereby providing physicians with effective treatment options for challenging bacterial infections.

Aurinia Pharmaceuticals is a biopharmaceutical company dedicated to developing and delivering therapies for patients with serious autoimmune diseases, particularly those with high unmet medical needs. Its lead product, LUPKYNIS (voclosporin), is the first FDA-approved oral therapy for treating active lupus nephritis.

Aptose Biosciences is a clinical-stage biotechnology company focused on discovering and developing personalized cancer therapies. Its pipeline includes small molecule drugs designed for single-agent efficacy and to enhance the effectiveness of other anti-cancer treatments, without overlapping toxicities.

Aurinia Pharmaceuticals is a biopharmaceutical company dedicated to developing and delivering therapies for patients with serious autoimmune diseases, particularly those with high unmet medical needs. Its lead product, LUPKYNIS (voclosporin), is the first FDA-approved oral therapy for treating active lupus nephritis.

Vendorlink.ca is a provider of web-based vendor management solutions specifically designed for the healthcare sector. The company offers a platform that enables hospitals to enforce their policies while ensuring patient safety and privacy through effective vendor training and monitoring. Its comprehensive tools facilitate the management of vendor credentials, activities, and behaviors, allowing healthcare facilities to maintain high standards. Additionally, Vendorlink.ca employs a dedicated team to verify each vendor's credentials before they are published on the vendor's profile, ensuring accuracy and reliability. For vendors, the platform functions as a third-party credentialing system, granting hospitals instant access to essential credentials at all times.