Constructive Bio
Grant in 2025
Constructive Bio is a biotechnology company focused on genome rewriting to advance bioprocesses and biopharmaceuticals. By transforming living cells into biofactories, it aims to develop sustainable materials and therapeutics. The company possesses the capability to create virus-resistant organisms and utilizes its proprietary technology to biosynthesize various classes of enzymes, pharmaceuticals, and biomaterials. This innovative approach allows clients to reprogram the genetic code, enabling the production of natural molecules and exploring chemical spaces that are not accessible through traditional biological methods. Constructive Bio's work positions it at the forefront of biotechnology, paving the way for the next generation of sustainable solutions in the life sciences sector.
Lant Medical
Seed Round in 2025
Lant Medical is a health technology company specializing in the development of non-antibiotic treatments for Helicobacter pylori (H. pylori) infections. Their innovative therapy targets the root cause of the infection and its associated symptoms, providing an effective monotherapy or complement to existing treatments. This enables healthcare professionals to manage H. pylori infections more efficiently.
Lant Medical
Grant in 2025
Lant Medical is a health technology company specializing in the development of non-antibiotic treatments for Helicobacter pylori (H. pylori) infections. Their innovative therapy targets the root cause of the infection and its associated symptoms, providing an effective monotherapy or complement to existing treatments. This enables healthcare professionals to manage H. pylori infections more efficiently.
Sequential Skin is a diagnostic platform focused on skin longevity and aging, leveraging expertise in genetics, epigenetics, and the skin microbiome. The company specializes in clinical microbiome testing for skin, scalp, and female health. Its primary offering is a skin health test that employs quantitative real-time PCR (qPCR) technology to analyze specific markers within the skin microbiome. This analysis provides individuals with a detailed understanding of their skin profile, helping them identify their unique skincare needs. By delivering personalized insights, Sequential Skin empowers individuals to make informed decisions about their skincare routines.
Esox Biologics
Grant in 2025
Esox Biologics provides innovative and sustainable solutions for aquatic veterinary medicine. The company offers a disease prediction platform called eForesee, which uses data-driven predictions unique to individual farms. Regular monitoring of the aquatic environment and livestock health is a key component of their services. Esox Biologics utilizes extensive knowledge of the aquatic microbiome to prevent the spread of infectious diseases among aquatic animals by collecting environmental DNA and employing next-generation sequencing technologies.
Dia Beta Labs
Grant in 2024
Dia Beta Labs is a biotechnology company dedicated to improving the lives of individuals with metabolic diseases. It operates from Ulster, where it has access to advanced facilities and a network of experts. The company's focus is on developing therapeutic agents to address the decline of pancreatic health in patients, with the goal of achieving more sustainable and effective weight loss than current options. Its discovery platform uses industry-standard methodologies and models to identify and advance lead molecules for animal research.
Keltic Pharma Therapeutics
Grant in 2024
Keltic Pharma Therapeutics enhances drug discovery through innovative scientific research, resulting in a healthier future.
ChromaTwist is a developer of innovative ultraviolet fluorescent dyes designed for applications in bio-sensing and bio-imaging diagnostic tests. The company's proprietary technology platform utilizes shifted organic fluorescent dyes, which emit visible light upon UV irradiation. These dyes are composed of aromatic organic materials featuring donor and acceptor groups, allowing them to absorb UV light and emit across the full visible spectrum. ChromaTwist's modular and scalable chemistry enables the continuous advancement of their fluorophores, thereby expanding their potential applications in the healthcare sector, particularly in areas like flow cytometry and multiphoton microscopy.
Concert Bio is a technology company that assists businesses in enhancing their microbial communities' productivity through its proprietary full-stack platform. This platform integrates monitoring, analytics, and intervention strategies to manipulate microbiomes, empowering clients to optimize these communities for improved performance.
Epitopea is a transatlantic biotechnology company focused on developing innovative immunotherapies for cancer treatment by targeting a novel class of tumor-specific antigens. The company utilizes a proprietary technique that integrates immunopeptidomics, mass spectrometry, genomics, and bioinformatics to identify conserved, aberrantly expressed tumor-specific antigens hidden within cancer's genetic material. This approach, developed through research conducted by Drs. Claude Perreault and Pierre Thibault at the Institute for Research in Immunology and Cancer at Université de Montréal, aims to create therapies that selectively eliminate malignant cells while preserving healthy tissue. By targeting antigens that are broadly shared among patients with the same cancer type, Epitopea seeks to enhance treatment efficacy while minimizing side effects and providing durable benefits.
Lentitek is a cell and gene therapy company focused on developing innovative treatments for cancer patients. The company is dedicated to making advanced therapeutics more accessible by enhancing the production of lentiviral vectors, which are essential for gene therapies. Lentitek employs a proprietary method that utilizes a novel promoter and a triple transfection production process to significantly increase viral yields by tenfold or more. This approach not only improves the efficiency of lentiviral production but also aims to lower production costs for healthcare providers, thereby broadening the availability of its therapies to a larger patient population.
BoobyBiome is a company focused on enhancing infant health through the development of probiotic supplements specifically designed for babies with compromised microbiomes. By leveraging specialized expertise and research, BoobyBiome aims to recreate the beneficial bacteria associated with breast milk, particularly for infants born prematurely or those who rely on formula feeding. Their products are formulated to closely mimic the properties of breast milk, providing essential support for gut health and immune system development in infants. Through these innovative probiotic solutions, BoobyBiome seeks to promote healthy growth and development during a critical stage of life.
SynaptixBio is a biotechnology company focused on developing innovative therapies for severe leukodystrophies, particularly targeting TUBB4a Leukodystrophy. By addressing the root causes of these conditions, SynaptixBio aims to provide potential curative treatments that could significantly disrupt existing treatment practices. The company is dedicated to translating groundbreaking research into transformative therapeutic options, specifically by altering the expression of a mutated gene responsible for the disease. Through its efforts, SynaptixBio seeks to deliver lifesaving solutions to those affected by this acute subset of leukodystrophies.
Awen Oncology
Grant in 2024
Awen Oncology is a pre-clinical stage pharmaceutical company focused on developing novel cancer therapies. It specializes in targeting 'developmentally-silent oncogenic drivers', which are genes that contribute to cancer growth but are not typically targeted by existing treatments. The company's approach combines expertise in cell and molecular biology with advanced structural biology and in-silico drug screening to rapidly and efficiently identify and develop effective cancer treatments.
MedAnnex Limited is a biotechnology company based in Edinburgh, United Kingdom, that focuses on developing innovative treatments for patients with autoimmune diseases and cancers. Founded in 2009, the company is dedicated to creating first-in-class antibody therapies, particularly its lead product, annexuzlimab, a monoclonal antibody designed to target and inhibit annexin-A1. This approach aims to modulate both the innate and adaptive immune systems, thereby enhancing treatment options for healthcare providers and improving patient outcomes. Through its specialized research and development efforts, MedAnnex seeks to address significant unmet medical needs in the field of immunotherapy.
ThirtyFiveBio
Grant in 2024
ThirtyFiveBio is a biotechnology company focused on developing innovative protein modulators aimed at treating severe gastrointestinal diseases, an area marked by significant unmet clinical needs. The company specializes in genetically and pharmacologically validated modulators that facilitate a comprehensive drug discovery program. This program is designed to identify contemporary small-molecule modulators of specific proteins, particularly targeting GPR35 signaling pathways. By addressing the challenges associated with digestive system malignancies, ThirtyFiveBio aims to offer therapeutic solutions that could help prevent tumor growth and improve patient outcomes.
Nuclera is a biotechnology company specializing in an automated protein prototyping system aimed at enhancing drug discovery processes. Its eProtein Discovery system enables researchers to rapidly produce and test high-quality, soluble, and active proteins, significantly accelerating protein projects. By integrating technology such as cell-free protein synthesis and digital microfluidics, Nuclera provides a high-throughput platform for automated protein access. This innovative approach allows scientists to obtain reliable proteins within a short timeframe, facilitating faster progress in their research and contributing to more efficient drug development efforts.
LIfT BioSciences
Grant in 2024
LIfT BioSciences is a biotechnology company based in London, established in 2016, that specializes in advanced innate immuno-cell therapies. It has developed a unique platform known as Neutrophil Only Leukocyte Infusion Therapy (N-LIfT), which enables the production of Immunomodulatory Alpha Neutrophils (IMANs) from induced pluripotent stem cells (iPSCs). This technology aims to address the limitations of existing therapies for solid tumors by utilizing CAR neutrophil cell therapy. The IMANs can alter the tumor microenvironment, enhancing the immune response and enabling a more effective attack on tumors. By leveraging proprietary enhancement media and genetic engineering, LIfT BioSciences seeks to significantly increase the cancer-fighting capabilities of these cells, offering patients the potential for improved outcomes and lasting immunity against cancer.
Monument Therapeutics
Grant in 2024
Monument Therapeutics is a biotechnology company focused on developing innovative drugs for serious diseases affecting the central nervous system. The company employs proprietary digital biomarkers to reduce variability in patient populations and identify individuals with similar underlying neurobiology. This targeted approach aims to enhance the research and development of neuroscience drugs in areas with significant unmet medical needs, ultimately advancing treatment options for these complex conditions.
BSF Enterprise
Grant in 2024
BSF Enterprise is focused on advancing biotechnology solutions through an acquisition-led growth strategy. The company specializes in the development of lab-grown tissues, leveraging cell-based tissue engineering to produce cultured meat, lab-grown leather, human corneas, collagen, and skin substitutes. By integrating innovative technologies, BSF Enterprise aims to transform sustainable practices across various sectors. Additionally, the company seeks investment opportunities in the biotechnology, marketing, and e-commerce sectors in the United Kingdom, positioning itself as a key player in the evolving landscape of biotech solutions.
Presymptom Health
Grant in 2024
Presymptom Health is a medical technology company dedicated to advancing healthcare through the development of pre-symptomatic diagnostic tests and clinical decision support algorithms. The company focuses on creating innovative blood tests designed to detect illnesses at an early stage, particularly aiming to predict the onset of sepsis up to three days before symptoms manifest. By enabling earlier intervention, Presymptom Health seeks to improve critical care outcomes and enhance patient management, ultimately contributing to better survival rates and healthcare efficiency.
Neobe Therapeutics
Grant in 2024
Neobe Therapeutics provides immunotherapies, clinical trials, research, and tumor-colonizing bacteria engineering services.
SökerData is a biotechnology company that specializes in research and data analysis solutions focused on disease-related datasets. The company has developed a data visualization platform designed to analyze biomarkers in clinical outcomes across various demographics. This platform provides researchers with essential features and tools for interpreting large datasets, facilitating early drug discovery. By enabling researchers to better understand the impact of biomarkers on different populations, SökerData supports informed decision-making and enhances the comprehension of disease outcomes in diverse demographic groups.
Aelius Biotech
Grant in 2024
Aelius Biotech specializes in developing advanced models of the mucosal surfaces of the human body, including the gastrointestinal tract and airways. The company is actively working on creating model systems for the eye and cervico-vaginal tract. Aelius Biotech provides a comprehensive range of in vitro and in vivo testing services, including simple lab assays, routine testing, and rheology. Their integrated model gut system allows healthcare industry participants to simulate key processes such as digestion, mucus permeation, and epithelial absorption in one cohesive platform. By conducting human trials and offering detailed insights, Aelius Biotech aids healthcare companies in making informed, data-driven decisions to enhance and de-risk the development of orally delivered products.
AMPLY Discovery
Grant in 2024
AMPLY Discovery is a biotechnology company focused on drug discovery, utilizing machine learning and synthetic biology to explore vast biological datasets for novel drug and nutraceutical candidates. The company operates a proprietary platform that integrates in silico and in vitro approaches to identify first-in-class molecules, addressing significant health challenges such as cancer, metabolic diseases, and multidrug-resistant infections. By digitizing life's natural diversity, AMPLY enhances the predictability and cost-effectiveness of discovering new therapeutics, enabling research entities to identify promising drug candidates based on their functional properties.
PulmoBioMed is a company focused on providing innovative solutions for clinicians and researchers through non-invasive sampling of fluids. The firm has developed a passive fluid aerosol sampler designed to capture exhaled breath condensate and aerosol samples. This product effectively segregates exhaled and environmental particles by size, addressing critical challenges such as sample contamination and loss. PulmoBioMed's technology aims to generate highly reproducible data with precise digital molecular analysis, facilitating the study of biological agents and supporting metabolomic profiling. Through its advancements, the company seeks to enhance research capabilities and improve patient outcomes in the field of respiratory health.
Mesenbio is a preclinical biopharmaceutical company based at the University of York, specializing in cell-derived therapies. It has developed a unique technique known as Cell Line Extracellular Vesicle Release (CLEVR), which aims to enhance the treatment pipeline by addressing significant challenges in extracellular vesicle therapy. The company focuses on creating innovative treatments, including a novel therapy for arthritis derived from engineered human stem cells. By unlocking the potential of extracellular vesicles, Mesenbio seeks to transform medical approaches to musculoskeletal diseases, thereby providing more effective therapeutic options.
CellRev is a biotechnology company that specializes in advancing cell manufacturing processes through innovative bioprocessing technology. The company focuses on enabling the transition from traditional batch processing to continuous processing for adherent cells, which enhances yield and reduces both operating costs and capital expenditure. By addressing critical challenges such as aggregation, clumping, and cell detachment, CellRev offers unique solutions for developers in the fields of cultured meat, cell therapy, and biologics. Its proprietary cell detachment process, combined with a specially designed bioprocess, positions CellRev as a leader in improving the efficiency of manufacturing processes for cell-based vaccines, therapies, and drugs. This disruptive approach aims to eliminate the need for serum in production, thereby streamlining operations for clients in the biomanufacturing landscape.
SynaptixBio is a biotechnology company focused on developing innovative therapies for severe leukodystrophies, particularly targeting TUBB4a Leukodystrophy. By addressing the root causes of these conditions, SynaptixBio aims to provide potential curative treatments that could significantly disrupt existing treatment practices. The company is dedicated to translating groundbreaking research into transformative therapeutic options, specifically by altering the expression of a mutated gene responsible for the disease. Through its efforts, SynaptixBio seeks to deliver lifesaving solutions to those affected by this acute subset of leukodystrophies.
Laverock Therapeutics
Grant in 2023
Laverock Therapeutics is focused on advancing a gene silencing platform that facilitates the development of programmable, allogeneic cell therapies. This innovative platform allows for the engineering of next-generation cell therapies that are both adaptive and capable of responding to various intra- and extra-cellular environmental cues. By enhancing the functionality of these therapies, Laverock Therapeutics aims to improve the efficacy, safety, and accessibility of iPSC-derived products, addressing significant limitations associated with current therapeutic approaches. The company's work is positioned to benefit medical and biotechnology institutions seeking to leverage advanced cell therapy solutions.
Beta Bugs
Venture Round in 2023
Beta Bugs is an insect genetics company specializing in the development and distribution of high-performance Black Soldier Fly breeds aimed at enhancing productivity in the insect protein sector. The company operates a breeding program called HiPer-Fly® and maintains a dedicated egg production site known as The Multiplier®, supplying its breeds to both UK and international markets. By focusing on biotechnology and breeding techniques, Beta Bugs aims to create a sustainable protein source that can effectively replace traditional feed ingredients such as fishmeal and soymeal in livestock, aquaculture, and pet feed. Headquartered at the Easter Bush Campus, a recognized center for animal genetics, Beta Bugs collaborates closely with the Roslin Institute, noted for its pioneering work in animal genetics.
Pathios Therapeutics
Grant in 2023
Pathios Therapeutics is an early-stage biotech company based in Oxford, United Kingdom, focused on developing therapies for autoimmune diseases and cancer. Founded in 2017, the company specializes in creating small molecule inhibitors that target the pH-sensing G protein-coupled receptor GPR65. These inhibitors are designed to counteract the immunosuppressive effects of immune cells, such as tumor-associated macrophages, which are influenced by the acidic environment often found in tumors. By leveraging a deep scientific approach and human genetic insights, Pathios Therapeutics aims to generate novel therapeutics for advanced solid tumors and other unmet medical needs.
ThirtyFiveBio
Grant in 2023
ThirtyFiveBio is a biotechnology company focused on developing innovative protein modulators aimed at treating severe gastrointestinal diseases, an area marked by significant unmet clinical needs. The company specializes in genetically and pharmacologically validated modulators that facilitate a comprehensive drug discovery program. This program is designed to identify contemporary small-molecule modulators of specific proteins, particularly targeting GPR35 signaling pathways. By addressing the challenges associated with digestive system malignancies, ThirtyFiveBio aims to offer therapeutic solutions that could help prevent tumor growth and improve patient outcomes.
AstronauTx is a biotechnology company focused on developing innovative treatments for Alzheimer's disease and other neurodegenerative conditions. The company specializes in restoring the normal function of astrocytes, which are crucial for supporting neuronal activity and maintaining brain health. In healthy individuals, astrocytes play a vital role in metabolism and the integrity of the blood-brain barrier; however, in neurodegenerative diseases, their dysfunction can contribute to neurotoxicity. By targeting these processes, AstronauTx aims to enable healthcare professionals to more effectively address the challenges posed by dementias, ultimately improving patient outcomes.
TherageniX specializes in gene therapy for tissue regeneration, focusing on orthopedic applications. The company's patented technology uses a non-viral delivery system to introduce specific genes, such as VEGF and BMP, into autologous bone marrow cells, enhancing their regenerative capacity. This process aids in tissue repair and regeneration, improving functional outcomes and reducing donor site trauma for patients with diseases, injuries, or age-related tissue damage.
ZiO Health is a biotechnology company focused on enhancing patient outcomes through its innovative pocket-sized laboratory testing technology. The company has developed proprietary biosensor devices that utilize machine learning algorithms to provide real-time results tailored to individual patient profiles. These multi-functional electronic devices are designed for measuring, testing, and detecting the molecular composition of various chemical and biological substances, enabling users to assess the presence, absence, or quantity of specific target molecules. By delivering quality home diagnostics and personalized testing solutions, ZiO Health aims to empower individuals to optimize their health and prevent illness.
Concert Bio is a technology company that assists businesses in enhancing their microbial communities' productivity through its proprietary full-stack platform. This platform integrates monitoring, analytics, and intervention strategies to manipulate microbiomes, empowering clients to optimize these communities for improved performance.
FourPlus Immersive
Grant in 2023
FourPlus Immersive offer immersive software solutions for the life sciences sector, including skills & facility mapping & recruitment tools.
Ramanomics extracts microorganisms and their antimicrobial profiles from clinical specimens.
Peptimatrix
Pre Seed Round in 2023
Peptimatrix is a biotechnology company specializing in the development of an innovative, animal-free 3D cell culture platform. Utilizing a peptide hydrogel technology, the company aims to reduce and replace the use of animals and animal-derived products in drug development and research. By combining expertise from matrix biologists, cancer scientists, toxicologists, and biomaterial engineers, Peptimatrix offers a more reproducible, reliable, and ethical alternative to traditional cell culture methods. The company's mission is to provide researchers with a better way to model development and disease.
SMi Systems is a biomedical research and medical equipment manufacturing organization that specializes in developing advanced discovery and diagnostic tools. Its flagship product, SMi Drug Discovery, is a high-performance diagnostic device capable of detecting diseases within the first 24 hours of infection. This innovative device can simultaneously identify multiple diseases and process numerous patient samples in a matter of minutes. By facilitating the detection of individual disease-associated molecules, SMi Systems' automated and high-throughput diagnostic tools enable scientists to measure critical molecular interactions essential for understanding therapeutic mechanisms. This capability allows researchers to observe a vast diversity of molecular interactions across various disease areas and monitor drug binding to their targets, thereby advancing scientific research and clinical diagnostics.
SMi Systems is a biomedical research and medical equipment manufacturing organization that specializes in developing advanced discovery and diagnostic tools. Its flagship product, SMi Drug Discovery, is a high-performance diagnostic device capable of detecting diseases within the first 24 hours of infection. This innovative device can simultaneously identify multiple diseases and process numerous patient samples in a matter of minutes. By facilitating the detection of individual disease-associated molecules, SMi Systems' automated and high-throughput diagnostic tools enable scientists to measure critical molecular interactions essential for understanding therapeutic mechanisms. This capability allows researchers to observe a vast diversity of molecular interactions across various disease areas and monitor drug binding to their targets, thereby advancing scientific research and clinical diagnostics.
CGT Catapult
Grant in 2023
CGT Catapult is a UK-based centre of excellence dedicated to advancing the cell and gene therapy sector globally. Supported by Innovate UK, it aims to facilitate the translation of early-stage research into commercially viable therapies. Based in central London with over 120 experts and state-of-the-art laboratories, CGT Catapult offers a comprehensive platform for product development, clinical trials, manufacturing, regulatory support, health economics, and market access expertise. Additionally, they are constructing a £55 million large-scale GMP manufacturing centre to accelerate the delivery of cell and gene therapies to patients worldwide.
Lindus Health
Grant in 2023
Lindus Health is a clinical research organization that specializes in managing end-to-end clinical trials for healthcare and biotechnology companies. The company offers services such as ethics and IRB submissions, trial monitoring, data management, biostatistics, regulatory affairs, and payor relations. Lindus Health employs an in-house team of clinicians and researchers to accelerate the clinical trial process using its proprietary software platform, Curebase OS, which automates workflows and reduces manual inefficiencies. The company also leverages real-world patient data for precise participant recruitment and smarter trial design, aiming to make clinical trials faster and more cost-effective while improving patient treatment outcomes.
Senisca is a senotherapeutics company established in 2020, focused on developing anti-aging oligonucleotide therapeutics. The company aims to provide innovative pharmaceutical treatments for age-related chronic diseases by creating a new generation of oligonucleotide-based interventions. These therapeutics target the underlying mechanisms of aging, restoring the ability of cells to regulate gene expression effectively. By rejuvenating aged cells, Senisca seeks to improve healthspan and address both the diseases and aesthetic manifestations of aging, ultimately enabling individuals to live healthier for longer periods.
LightOx is a biotechnology company focused on developing innovative molecular tools and light-activated therapeutics for cancer treatment. The company offers a unique range of fluorescent probes that are smaller than existing commercial options, allowing for versatile use in imaging, therapeutics, and assay development. These probes can function as freely-moving agents within cells or be coupled with flexible linkers to provide specificity for various research applications. LightOx is dedicated to improving patient outcomes by creating targeted drug compounds that selectively eliminate tumor cells while minimizing damage to surrounding healthy tissues. This approach aims to enhance the efficiency of cancer treatment and contribute to better long-term health for patients.
EnsiliTech
Pre Seed Round in 2023
EnsiliTech is a biopharmaceuticals company focused on preserving the integrity of vaccines and other biological materials. The company has developed a novel ensilication technology that utilizes protective silica nanoshells to shield vaccine components from environmental degradation. This innovative approach aims to prevent vaccine spoilage, thereby enhancing the shelf-life of these critical biological products. By improving the stability and accessibility of vaccines, EnsiliTech seeks to reduce waste and contribute to global vaccination efforts, ensuring that more people can benefit from life-saving immunizations.
EnsiliTech is a biopharmaceuticals company focused on preserving the integrity of vaccines and other biological materials. The company has developed a novel ensilication technology that utilizes protective silica nanoshells to shield vaccine components from environmental degradation. This innovative approach aims to prevent vaccine spoilage, thereby enhancing the shelf-life of these critical biological products. By improving the stability and accessibility of vaccines, EnsiliTech seeks to reduce waste and contribute to global vaccination efforts, ensuring that more people can benefit from life-saving immunizations.
Concert Bio is a technology company that assists businesses in enhancing their microbial communities' productivity through its proprietary full-stack platform. This platform integrates monitoring, analytics, and intervention strategies to manipulate microbiomes, empowering clients to optimize these communities for improved performance.
National Biofilms Innovation Centre
Grant in 2022
The National Biofilms Innovation Centre (NBIC) serves as a collaborative hub uniting academia, industry, government, and public policy to address the challenges posed by biofilms, which significantly impact global economic activity across sectors such as food, health, shipping, clean water, and energy. Supported by funding from the BBSRC, Innovate UK, and Hartree Centre, NBIC's mission focuses on fostering a network for research and innovation that catalyzes partnerships with industry to drive breakthrough innovations. The Centre facilitates the exploration of unmet needs and the exchange of ideas through various initiatives, including roadmaps, workshops, and conferences. Additionally, NBIC is dedicated to nurturing the next generation of scientists through PhD and Post-Doc programs, alongside entrepreneurial training, aimed at enhancing their expertise and understanding of the commercial landscape while promoting the creation of new start-ups.
52 North Health is a medical technology company focused on enhancing healthcare outcomes for cancer patients. It specializes in an AI-driven, portable finger prick blood test that measures neutrophil count and C-reactive protein (CRP) levels at home. This enables early detection of neutropenic sepsis risk during chemotherapy, improving patient safety and quality of life. The device facilitates timely management of the condition, offering a reliable and cost-effective solution for both patients and healthcare providers.
LabGenius Ltd is a biopharmaceutical company based in London, United Kingdom, focused on discovering and developing new protein therapeutics to address unmet medical needs, including conditions like Inflammatory Bowel Disease. Founded in 2012, the company utilizes a machine learning-driven evolution engine and a robotic platform known as EVA, which is capable of designing, conducting, and learning from its own experiments. This innovative approach integrates advanced technologies from synthetic biology, robotics, and machine learning, enabling the engineering of protein drugs with enhanced properties such as protease stability and tissue penetration. By leveraging these cutting-edge methodologies, LabGenius aims to provide physicians with access to novel protein therapeutics that are developed through automation and intelligent design.
Metallo Bio's focus is on the development of two lead chemicals that represent a pioneering new class of antibiotics, with the goal of addressing the rising issue of antimicrobial resistance.
AMPLY Discovery
Grant in 2022
AMPLY Discovery is a biotechnology company focused on drug discovery, utilizing machine learning and synthetic biology to explore vast biological datasets for novel drug and nutraceutical candidates. The company operates a proprietary platform that integrates in silico and in vitro approaches to identify first-in-class molecules, addressing significant health challenges such as cancer, metabolic diseases, and multidrug-resistant infections. By digitizing life's natural diversity, AMPLY enhances the predictability and cost-effectiveness of discovering new therapeutics, enabling research entities to identify promising drug candidates based on their functional properties.
aTen Therapeutics
Grant in 2022
aTen Therapeutics is a biotechnology company focused on developing innovative therapeutic antibodies aimed at treating major diseases, particularly cancer. The company employs novel antibody approaches to target crucial control pathways that play a significant role in cancer cell growth, invasion, and metastasis. By utilizing anti-cancer agents, aTen Therapeutics' products have the potential to inhibit cancer cell proliferation and improve treatment outcomes for patients. Their commitment to advancing biopharmaceutical solutions reflects a goal of enhancing the quality of life for individuals affected by cancer and preventing the progression of the disease. With a management team experienced in the biopharmaceutical industry, aTen Therapeutics is well-positioned to contribute to the development of effective therapies that can significantly impact patient care.
BoobyBiome is a company focused on enhancing infant health through the development of probiotic supplements specifically designed for babies with compromised microbiomes. By leveraging specialized expertise and research, BoobyBiome aims to recreate the beneficial bacteria associated with breast milk, particularly for infants born prematurely or those who rely on formula feeding. Their products are formulated to closely mimic the properties of breast milk, providing essential support for gut health and immune system development in infants. Through these innovative probiotic solutions, BoobyBiome seeks to promote healthy growth and development during a critical stage of life.
BoobyBiome
Pre Seed Round in 2022
BoobyBiome is a company focused on enhancing infant health through the development of probiotic supplements specifically designed for babies with compromised microbiomes. By leveraging specialized expertise and research, BoobyBiome aims to recreate the beneficial bacteria associated with breast milk, particularly for infants born prematurely or those who rely on formula feeding. Their products are formulated to closely mimic the properties of breast milk, providing essential support for gut health and immune system development in infants. Through these innovative probiotic solutions, BoobyBiome seeks to promote healthy growth and development during a critical stage of life.
Stemnovate Limited is a biotechnology company based in Cambridge, United Kingdom, that specializes in developing innovative tools and technologies for drug screening and safety testing. Established in 2016, the company offers a range of products including induced pluripotent stem cells, primary human and multispecies cells, and a comprehensive cell culture and analysis package. Stemnovate employs advanced devices such as micro physiological systems and microfluidic technologies to facilitate research and development. One of its notable projects, the "Liver on chip," focuses on liver toxicity testing and integrates cellular reprogramming, stem cell research, and organ-on-chip technology. The company also provides services in cell reprogramming, differentiation, and application development, catering to a diverse clientele that includes pharmacists, contract research organizations, small to medium enterprises, and academic institutions.
Eleven Therapeutics
Seed Round in 2022
Eleven Therapeutics is a biotechnology company leveraging artificial intelligence to advance medicinal nucleic acids, particularly focusing on RNAi therapies and mRNA therapeutics. The company employs AI-driven parallel functional testing and combinatorial chemistry to develop programmable molecules called SCSI-RNAs, which can target specific diseases or biological targets. Additionally, Eleven Therapeutics is pioneering extended durability mRNA therapeutics designed to address unmet medical needs in metabolic, endocrinologic, and infectious diseases. Their proprietary high-throughput AI-enabled screening platforms enhance the stability and targeted delivery of these nucleic acid molecules, ensuring superior durability and specificity.
Awakn Life Sciences
Grant in 2022
Awakn Life Sciences is a clinical-stage biotechnology company dedicated to developing and delivering innovative psychedelic medicine aimed at treating addiction, with a primary focus on Alcohol Use Disorder (AUD). The company comprises a multidisciplinary team of chemists, scientists, psychiatrists, and psychologists who are working to create the next generation of psychedelic drugs and therapies, as well as the technologies that enable their use. Recognizing the inadequacies of current treatment options for AUD, Awakn aims to provide breakthrough therapeutics for individuals suffering from addiction, addressing a significant medical need both in the United States and internationally.
Sequential Skin is a diagnostic platform focused on skin longevity and aging, leveraging expertise in genetics, epigenetics, and the skin microbiome. The company specializes in clinical microbiome testing for skin, scalp, and female health. Its primary offering is a skin health test that employs quantitative real-time PCR (qPCR) technology to analyze specific markers within the skin microbiome. This analysis provides individuals with a detailed understanding of their skin profile, helping them identify their unique skincare needs. By delivering personalized insights, Sequential Skin empowers individuals to make informed decisions about their skincare routines.
Metallo Bio
Pre Seed Round in 2022
Metallo Bio's focus is on the development of two lead chemicals that represent a pioneering new class of antibiotics, with the goal of addressing the rising issue of antimicrobial resistance.
Senisca is a senotherapeutics company established in 2020, focused on developing anti-aging oligonucleotide therapeutics. The company aims to provide innovative pharmaceutical treatments for age-related chronic diseases by creating a new generation of oligonucleotide-based interventions. These therapeutics target the underlying mechanisms of aging, restoring the ability of cells to regulate gene expression effectively. By rejuvenating aged cells, Senisca seeks to improve healthspan and address both the diseases and aesthetic manifestations of aging, ultimately enabling individuals to live healthier for longer periods.
Biotangents
Debt Financing in 2022
Biotangents Ltd. is a biotechnology company based in Glasgow, United Kingdom, specializing in the design and construction of biological pathways to produce desirable natural materials. Founded in 2015, Biotangents utilizes its proprietary Leapfrog Assembly platform to create complex genetic constructs from multiple DNA components. The company has developed notable technologies such as Short Sequence Randomisation and Moduleic Sensing, the latter of which focuses on modular cell-free nucleic acid detection. Biotangents is also engaged in creating a veterinary diagnostic device aimed at detecting various infectious diseases in livestock. This device utilizes isothermal amplification technology, allowing for precise molecular detection without extensive technical requirements, and can be swiftly adapted to target new pathogens. Through its innovations, Biotangents strives to mitigate the impact of infectious diseases in livestock, enabling more efficient production of animal protein.
STORM Therapeutics
Grant in 2022
Storm Therapeutics Limited is a biotechnology company based in Cambridge, United Kingdom, focused on discovering and developing small molecule drugs that target RNA-modifying enzymes for cancer treatment and other immune diseases. Incorporated in 2015 and previously known as Iceni Therapeutics Limited, the company utilizes its drug discovery and RNA analytics platform to modulate RNA modifying enzymes, identifying novel targets and first-in-class drug candidates. Storm Therapeutics aims to provide innovative therapies against RNA epigenetic targets, addressing various conditions including oncology, inflammation, viral infections, and central nervous system diseases.
BoobyBiome is a company focused on enhancing infant health through the development of probiotic supplements specifically designed for babies with compromised microbiomes. By leveraging specialized expertise and research, BoobyBiome aims to recreate the beneficial bacteria associated with breast milk, particularly for infants born prematurely or those who rely on formula feeding. Their products are formulated to closely mimic the properties of breast milk, providing essential support for gut health and immune system development in infants. Through these innovative probiotic solutions, BoobyBiome seeks to promote healthy growth and development during a critical stage of life.
Five Alarm Bio
Grant in 2022
Five Alarm Bio is a drug discovery company based in Cambridge, United Kingdom, founded in 2016. The company specializes in researching and developing anti-aging therapies aimed at reducing age-related illnesses and limitations. Five Alarm Bio employs a small molecule strategy to enhance the body's defenses against damage that accumulates with aging, with the goal of extending the lifespan of healthy cells and mitigating the development and progression of diseases associated with aging.
Eleven Therapeutics
Grant in 2021
Eleven Therapeutics is a biotechnology company leveraging artificial intelligence to advance medicinal nucleic acids, particularly focusing on RNAi therapies and mRNA therapeutics. The company employs AI-driven parallel functional testing and combinatorial chemistry to develop programmable molecules called SCSI-RNAs, which can target specific diseases or biological targets. Additionally, Eleven Therapeutics is pioneering extended durability mRNA therapeutics designed to address unmet medical needs in metabolic, endocrinologic, and infectious diseases. Their proprietary high-throughput AI-enabled screening platforms enhance the stability and targeted delivery of these nucleic acid molecules, ensuring superior durability and specificity.
Cytochroma manufacture genetically diverse stem cell-derived models to predict the safety and effect of drugs in a global population. Cytochroma’s automated cell manufacture, physiologically relevant models and rapid screening platform makes preclinical testing faster, safer and smarter.
Rinri Therapeutics
Grant in 2021
Rinri Therapeutics Limited is a biotechnology company based in Sheffield, United Kingdom, focused on developing regenerative stem cell-based therapies aimed at treating hearing loss. Founded in 2018, the company's innovative technology targets sensorineural hearing loss by replacing damaged or dead sensory cells in the inner ear, allowing for the potential restoration of hearing in affected patients. Through its advancements in cell therapy, Rinri Therapeutics seeks to provide effective solutions for individuals suffering from hearing impairments.
CryoLogyx is an early-stage biotechnology company focused on developing innovative cryopreservation technology that enhances the freezing, storage, and transportation of cells. By utilizing advanced cryoprotectants, CryoLogyx ensures that cells remain viable and ready for use in drug discovery, diagnostics, and cell therapy applications. The company's proprietary technology facilitates the delivery of frozen, ready-to-use cells, allowing healthcare researchers to access and utilize these vital resources in their preferred formats, thereby transforming the landscape of cell storage and transportation.
ChromaTwist
Seed Round in 2021
ChromaTwist is a developer of innovative ultraviolet fluorescent dyes designed for applications in bio-sensing and bio-imaging diagnostic tests. The company's proprietary technology platform utilizes shifted organic fluorescent dyes, which emit visible light upon UV irradiation. These dyes are composed of aromatic organic materials featuring donor and acceptor groups, allowing them to absorb UV light and emit across the full visible spectrum. ChromaTwist's modular and scalable chemistry enables the continuous advancement of their fluorophores, thereby expanding their potential applications in the healthcare sector, particularly in areas like flow cytometry and multiphoton microscopy.
Senisca is a senotherapeutics company established in 2020, focused on developing anti-aging oligonucleotide therapeutics. The company aims to provide innovative pharmaceutical treatments for age-related chronic diseases by creating a new generation of oligonucleotide-based interventions. These therapeutics target the underlying mechanisms of aging, restoring the ability of cells to regulate gene expression effectively. By rejuvenating aged cells, Senisca seeks to improve healthspan and address both the diseases and aesthetic manifestations of aging, ultimately enabling individuals to live healthier for longer periods.
CN Bio Innovations Ltd, established in 2008 and headquartered in Cambridge, UK, specializes in developing and providing Organ-on-Chip devices to pharmaceutical and biotech companies. These devices enable more accurate preclinical drug testing by replicating the physiological functions of human organs. CN Bio's offerings include microphysiological systems and consumables, used by various industries to analyze novel compounds, assess toxicity and safety, and support research scientists in investigating biological processes. The company's flagship product, the LiverChip platform, features a full viral lifecycle model of hepatitis B, currently employed in drug discovery collaborations with leading pharma and biotech firms. CN Bio, part of Hong Kong-based CN Innovations Holdings Limited, works closely with academic experts and is backed by prestigious grants, aiming to accelerate the development of transformative therapies worldwide.
Aramune Technologies is a biotechnology company focused on developing plant-derived feed materials that serve as sustainable alternatives to antimicrobial agents used in animal feeds. Their technology involves isolating natural compounds from plants, which are then mixed with standard animal feeds to promote growth and prevent infections without harming the environment. This approach aims to benefit both farmers and consumers by enabling disease prevention in livestock while minimizing environmental impact.
4D Biomaterials
Grant in 2020
4D Medicine specializes in creating innovative solutions for the targeted and controlled regeneration of human tissue through the development of degradable, implantable medical devices. Utilizing novel photopolymer materials, the company is advancing a range of products that are currently undergoing regulatory clearance with the Food and Drug Administration. These resorbable medical devices aim to enhance patient outcomes in various applications, including musculoskeletal surgery, soft tissue repair, and drug delivery. By focusing on regulatory approval and effective medical applications, 4D Medicine seeks to provide valuable options for medical device suppliers and healthcare providers.
Lumino
Pre Seed Round in 2020
Lumino is focused on enhancing mental health outcomes through the development of digital therapeutic programs. These programs specifically address various mental health concerns and incorporate techniques such as cognitive behavioral therapy (CBT) to help individuals manage their symptoms effectively. Supported by Innovate UK and the Oxford Academic Health Science Network, Lumino aims to leverage digital technology to deliver scalable mental health services, ultimately promoting healthier and happier lives for users.
SilviBio is a company focused on advancing sustainable tree growth through innovative seed enhancement technology. It develops products aimed at reducing seed losses that hinder forestry organizations from achieving government tree planting goals. SilviBio's technology involves coating seeds to improve their ability to absorb and retain moisture, which enhances germination rates, particularly in dry conditions. By improving yield results, the company supports both the forestry and agriculture sectors in their efforts to grow trees more sustainably.
NovaBiotics Ltd. is a clinical-stage biotechnology company based in Aberdeen, United Kingdom, with a location in Raleigh, North Carolina. Founded in 2004, the company specializes in the design, development, and manufacture of innovative anti-infective drugs aimed at treating medically unmet diseases. Its product portfolio includes Novexatin, a cationic antifungal peptide targeting fungal nail infections; Lynovex, an oral and inhaled therapy for cystic fibrosis-related lung conditions; Novamycin, an antifungal peptide for various invasive fungal infections; and Novarifyn, an antibacterial peptide for bacterial infections. NovaBiotics is committed to advancing its proprietary antimicrobial peptide platform, which is pivotal in creating new antifungal and antibacterial agents. The company's robust pipeline addresses challenging therapeutic needs, particularly in the realm of difficult-to-treat infections caused by emerging drug-resistant pathogens.
BioFab is developing innovative new products for healthcare diagnostics with a particular focus on point-of-care testing (POCT) applications. Our vision is to create a truly universal diagnostic platform that can bring the clinical lab to the patient. Our innovative approach will enable this vision by offering a diverse range of test cartridges which can run on a single, universal reader device. It will not need any user training and will simply require the addition of the patient sample. Fully automated processing will then take place in a totally enclosed cartridge and will then deliver laboratory grade results without risk of cross-contamination. We are developing a test for Covid-19 with the support of an Innovate UK Smart award and will expand the product range to cover cardio-vascular disease, respiratory/gastric infections, blood infections (sepsis), STDs, Cancer and other conditions. We also have the ability to access the rapidly expanding Chinese market and have route-to-market and manufacturing base via established partners in China.
DIOSynVax is a vaccine antigen design company focused on enhancing vaccine development through innovative technology. The company specializes in digitally designing, immune-optimized selecting, and synthesizing vaccines to improve protection against both emerging and re-emerging pathogens, including influenza, COVID-19, and viral hemorrhagic fevers. By leveraging its advanced technology, DIOSynVax aims to expedite the vaccine development process, ultimately enabling healthcare providers to treat patients more effectively and facilitate quicker recovery from various diseases. Through its efforts, DIOSynVax seeks to make significant advancements in public health by addressing the challenges posed by existing and future viruses.
Neuronostics
Grant in 2020
Neuronostics Ltd is a spin-out from the University of Exeter in the UK, dedicated to developing and commercializing innovative technology for assessing seizure susceptibility. The company has created a novel platform that focuses on diagnosing and prognosticating neurological conditions, specifically targeting epilepsy. Utilizing a patented seizure risk score derived from routine electroencephalogram (EEG) recordings, Neuronostics' technology aims to facilitate early diagnosis and prognosis of epilepsy. This advancement is designed to empower clinicians to enhance patient care and improve the quality of life for individuals living with this neurological condition.
Neuronostics
Grant in 2020
Neuronostics Ltd is a spin-out from the University of Exeter in the UK, dedicated to developing and commercializing innovative technology for assessing seizure susceptibility. The company has created a novel platform that focuses on diagnosing and prognosticating neurological conditions, specifically targeting epilepsy. Utilizing a patented seizure risk score derived from routine electroencephalogram (EEG) recordings, Neuronostics' technology aims to facilitate early diagnosis and prognosis of epilepsy. This advancement is designed to empower clinicians to enhance patient care and improve the quality of life for individuals living with this neurological condition.
Mosaic Therapeutics
Grant in 2020
Mosaic Therapeutics is reshaping the interface of computational and experimental medicine to power new medicines for patients.
ExplantLab is a research organization based in Newcastle upon Tyne, United Kingdom. It focuses on investigating the connections between patients' genetics and the design, manufacturing, and performance of medical devices. The company aims to enhance the lives of patients by developing innovative medical solutions tailored to individual genetic profiles.
Symbiosis Pharmaceutical Services
Grant in 2019
Symbiosis Pharmaceutical Services Limited is a contract manufacturer specializing in sterile pharmaceuticals for clinical trials, established in 2011 in Stirling, United Kingdom. The company addresses the growing global demand for niche sterile manufacturing by providing filling and finishing services tailored to the needs of biotech and specialty pharmaceutical companies. Its purpose-built facility is designed to accommodate both biologic and small molecule production, focusing on small-scale injectable products. Symbiosis distinguishes itself by offering rapid access to manufacturing slots and quick release of drug products, enabling clients to meet tight timelines effectively. With a commitment to maintaining regulatory compliance, Symbiosis supports its clients in navigating the complexities of drug product development and supply.
CellRev
Pre Seed Round in 2019
CellRev is a biotechnology company that specializes in advancing cell manufacturing processes through innovative bioprocessing technology. The company focuses on enabling the transition from traditional batch processing to continuous processing for adherent cells, which enhances yield and reduces both operating costs and capital expenditure. By addressing critical challenges such as aggregation, clumping, and cell detachment, CellRev offers unique solutions for developers in the fields of cultured meat, cell therapy, and biologics. Its proprietary cell detachment process, combined with a specially designed bioprocess, positions CellRev as a leader in improving the efficiency of manufacturing processes for cell-based vaccines, therapies, and drugs. This disruptive approach aims to eliminate the need for serum in production, thereby streamlining operations for clients in the biomanufacturing landscape.
Ixaka is a private UK-based cell and gene therapy company with additional operations in Spain and France. The company focuses on harnessing the body's natural ability to cure diseases through its proprietary technologies. This includes concentrated multi-cell therapies and targeted nanoparticles, which aim to enhance the therapeutic efficacy of cells. Ixaka’s innovations are geared towards addressing a wide array of serious medical conditions, such as cancers, cardiovascular issues, neurological disorders, ocular diseases, and genetic conditions. By aiming to deliver curative cells directly to disease sites and modifying cells within the body, Ixaka seeks to provide advanced cell-based therapeutics that improve patient outcomes and quality of life.
Freeline Therapeutics
Grant in 2019
Freeline Therapeutics, established in 2015 and based in Stevenage, UK, is a clinical-stage biotechnology company specializing in the development of systemic adeno-associated virus (AAV) vector-mediated gene therapies. The company focuses on treating inherited, debilitating diseases by delivering functional copies of therapeutic genes into human liver cells, enabling the production of functional proteins in the bloodstream. Freeline's pipeline includes FLT180a for hemophilia B, FLT190 for Fabry disease, and FLT201 for Gaucher disease Type 1, all in various stages of clinical trials. Additionally, the company offers expertise in CMC process development, analytics, and AAV technologies.
Symbiosis Pharmaceutical Services
Grant in 2019
Symbiosis Pharmaceutical Services Limited is a contract manufacturer specializing in sterile pharmaceuticals for clinical trials, established in 2011 in Stirling, United Kingdom. The company addresses the growing global demand for niche sterile manufacturing by providing filling and finishing services tailored to the needs of biotech and specialty pharmaceutical companies. Its purpose-built facility is designed to accommodate both biologic and small molecule production, focusing on small-scale injectable products. Symbiosis distinguishes itself by offering rapid access to manufacturing slots and quick release of drug products, enabling clients to meet tight timelines effectively. With a commitment to maintaining regulatory compliance, Symbiosis supports its clients in navigating the complexities of drug product development and supply.
CGT Catapult
Grant in 2019
CGT Catapult is a UK-based centre of excellence dedicated to advancing the cell and gene therapy sector globally. Supported by Innovate UK, it aims to facilitate the translation of early-stage research into commercially viable therapies. Based in central London with over 120 experts and state-of-the-art laboratories, CGT Catapult offers a comprehensive platform for product development, clinical trials, manufacturing, regulatory support, health economics, and market access expertise. Additionally, they are constructing a £55 million large-scale GMP manufacturing centre to accelerate the delivery of cell and gene therapies to patients worldwide.
Aglaris specializes in the development of automated cell culture bioreactors aimed at enhancing the mass production of human stem cells. The company focuses on simplifying and streamlining cell and tissue culture processes, ensuring they are efficient and reliable. By automating these processes, Aglaris significantly reduces the need for human intervention, which in turn minimizes contamination risks associated with cell handling. The technology behind Aglaris's bioreactors is innovative and protected by international patents, positioning the company to play a crucial role in advancing regenerative medicine and cell therapies.
Nanna Therapeutics
Grant in 2019
Nanna Therapeutics Limited, established in 2012 and headquartered in Cambridge, UK, is a biotechnology company focused on developing drugs for age-related diseases such as mitochondrial, neurodegenerative, cardiovascular/metabolic, joint/tissue diseases, and cancer. As of April 2020, the company operates as a subsidiary of Astellas Pharma Europe Ltd. Nanna Therapeutics employs a unique approach by targeting fundamental cellular processes to create innovative treatments for these conditions, with a particular emphasis on mitochondria, the energy source in every cell. The company's proprietary drug discovery platform, TIME (Totally Integrated Medicines Engine), combines advanced technologies like microfluidics and artificial intelligence to accelerate drug development and disrupt traditional methods of creating new medicines.
Epsilogen Ltd is an immuno-oncology company based in London, United Kingdom, founded in 2016. The company specializes in developing immunoglobulin E (IgE) antibodies aimed at treating cancer. Epsilogen offers a portfolio of IgE candidates that specifically target cancer antigens such as HER2, EGFR, and PD-L1. Its innovative IgE platform supports the development and validation of novel antibodies, allowing for enhanced potency, improved tumor access, and a prolonged presence in tissue. This focus on IgE-based therapies positions Epsilogen to provide effective treatment options for patients with solid tumors.
MediSieve Ltd. is a London-based medical device company specializing in Magnetic Blood Filtration (MBF) technology aimed at treating blood-borne diseases. Founded in 2014, the company has developed a system that utilizes a magnetic filter to physically remove infected blood cells from a patient's bloodstream. The process involves circulating blood through an external loop where targeted magnetic particles are infused, binding to disease-relevant targets. This filtered blood then passes through a magnetic filter that captures the particles and bound targets, allowing the unaffected blood to return to the patient without the particles entering their body. MediSieve's innovative approach is applicable to various conditions, including malaria, leukaemia, sepsis, and other blood-borne diseases, enhancing the efficacy and safety of existing therapies. The company operates out of the Imperial Incubator in White City, London, where it conducts product development and validation in its dedicated laboratory facilities.
Bionema Limited is a Swansea-based company founded in 2012 that specializes in the research, development, and commercialization of biopesticides and related products for the horticulture, turf and landscape, and forestry sectors. The company focuses on creating innovative, chemical-free solutions for crop protection, using environmentally-friendly microorganisms to develop natural biopesticides, biostimulants, and biofertilizers. By reducing reliance on synthetic pesticides, Bionema aims to enhance food security and increase crop yields while promoting sustainable agricultural practices. In addition to its product offerings, Bionema provides training to users to maximize the efficacy of its bio-control products, thereby supporting farmers and businesses in achieving agricultural sustainability and environmental longevity.
Orbit Discovery
Grant in 2018
Orbit Discovery Ltd. is a biotechnology company based in Oxford, United Kingdom, that specializes in peptide display technology for the identification of peptide drugs aimed at treating chronic diseases. Established in 2015, the company utilizes an innovative in vitro display platform that links randomized peptide sequences to their encoding DNA on small beads, facilitating the screening of potential peptide therapeutics. This approach allows for the discovery of peptides that can offer the specificity and efficacy of larger biologic molecules while maintaining the advantages of smaller molecules, such as reduced dosage and lower manufacturing costs. Orbit Discovery's technology enhances the drug development process by enabling high-throughput screening of peptide candidates, thus supporting both internal drug discovery initiatives and collaborative research efforts.
STORM Therapeutics
Grant in 2018
Storm Therapeutics Limited is a biotechnology company based in Cambridge, United Kingdom, focused on discovering and developing small molecule drugs that target RNA-modifying enzymes for cancer treatment and other immune diseases. Incorporated in 2015 and previously known as Iceni Therapeutics Limited, the company utilizes its drug discovery and RNA analytics platform to modulate RNA modifying enzymes, identifying novel targets and first-in-class drug candidates. Storm Therapeutics aims to provide innovative therapies against RNA epigenetic targets, addressing various conditions including oncology, inflammation, viral infections, and central nervous system diseases.
Neuronostics
Grant in 2018
Neuronostics Ltd is a spin-out from the University of Exeter in the UK, dedicated to developing and commercializing innovative technology for assessing seizure susceptibility. The company has created a novel platform that focuses on diagnosing and prognosticating neurological conditions, specifically targeting epilepsy. Utilizing a patented seizure risk score derived from routine electroencephalogram (EEG) recordings, Neuronostics' technology aims to facilitate early diagnosis and prognosis of epilepsy. This advancement is designed to empower clinicians to enhance patient care and improve the quality of life for individuals living with this neurological condition.
Metrion Biosciences
Grant in 2018
Metrion Biosciences Ltd is a contract research organization based in Cambridge, United Kingdom, specializing in drug discovery services. Founded in 2015, the company provides a range of preclinical screening services, with a particular focus on ion channel testing. Its offerings include cardiac safety screening, neuroscience assays, and translational assays, aimed at supporting pharmaceutical and bioscience clients globally. Metrion Biosciences employs highly skilled electrophysiology techniques and offers flexible business models, including fee-for-service and collaborative options. This versatility allows the company to cater to various medicinal chemistry optimization programs, ensuring comprehensive support throughout the drug discovery process.