Big Brain Holdings

Founded in 2021, Big Brain Holdings is a venture capital firm based in Los Angeles, California. It focuses on investing in early-stage companies operating in the blockchain, fintech, and web3 sectors.
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Jorge Cantera

Investor

River Fields

Analyst

Thomas Helm

Venture Partner

Sam Kim

General Partner

Kavita Singh

Analyst

Tom Weber

Analyst

Jonathan Wong

Analyst

Past deals in Smart Contracts

Vest

Venture Round in 2025
Vest Labs is in the process of developing an advanced financial exchange specifically designed for digital assets.

Essential

Series A in 2024
Essential develops intent-based infrastructure and tools aimed at facilitating the shift from value extraction to intent satisfaction. Its platform focuses on creating core components that support composability across ecosystems, minimizing extractive behaviors while maximizing user satisfaction.

Eywa

Seed Round in 2024
Eywa is a decentralized cross-chain protocol designed to facilitate the transfer of liquidity and data across various blockchains that support smart contracts. By addressing interoperability challenges, Eywa aims to create a seamless ecosystem for decentralized finance (DeFi) applications. The protocol serves as a middle layer, enabling developers to build cross-chain decentralized applications and engage in cross-chain farming. This functionality allows users to easily perform cross-chain swaps and bridge assets across different DeFi platforms. Eywa's approach enhances the accessibility and utility of existing DeFi blockchains, fostering innovation and collaboration within the cryptocurrency space.

Mitosis

Seed Round in 2024
Mitosis develops a cross-chain liquidity protocol facilitating interoperability and enhanced composability in decentralized finance.

Obscuro Labs

Venture Round in 2024
Obscuro Labs develops TEN, a Layer 2 rollup that scales and encrypts Ethereum, allowing smart contracts to contain both public and private elements without changing the user or developer experience. The TEN protocol operates contracts at larger scale and supports on-chain gaming, smart contract sharing, sealed token auctions, data encryption, and the deployment of tokenized rewards, while also enabling components such as artificial intelligence agents to function within the ecosystem.

Zeus Network

Seed Round in 2024
Zeus Network is a cutting-edge and permissionless communication layer platform that connects connects Solana and Bitcoin.

Initia Labs

Seed Round in 2024
Initia is a network for 0-to-1 omnichain rollups built by fusing a novel L1 with an interwoven application-specific L2 infrastructure system. The Initia Platform provides product ready rollups that enables teams to build scalable and sovereign systems while eliminating the UX complexities end users face when interacting with a modular multi-chain universe. Initia’s ownership of the full tech stack allows for a suite of chain-level mechanisms that align the economic interests across users, developers, L2 app chains, and the L1. Initia's initial launch products include an all-in-one portal for accessing core tools of the ecosystem, a Omnitia-ecosystem focused wallet for navigating between the L2s, a block explorer that supports InitiaVM transactions and developer tooling, and a Market Minitia that allows users to trade NFTs and create AI-generated NFT collections through prompts.

Saturn

Pre Seed Round in 2023
Saturn is a decentralized Bitcoin exchange that enhances peer-to-peer non-custodial orderbooks and provides a secure trading experience.

Cube Group

Seed Round in 2023
Cube Group is a hybrid CEX-DEX digital asset marketplace that addresses the challenges of traditional centralized exchanges and decentralized finance platforms. The company provides a user-centric design, radical transparency, safety, and liquidity, with features like multi-party compute, on-chain settlement, proof-of-reserves, and multi-chain support. Its vaults represent users' balances on their respective layer-one blockchains, offering transparent liquidation standards and criteria for derivatives and margin trading. The platform also standardizes market data and order sessions, allowing seamless onboarding for market participants through web interfaces for trading.

Drip Labs

Seed Round in 2023
Drip Labs is a technology company that facilitates the creation, distribution, and monetization of digital content, such as art, music, and videos, on a Web3 content distribution network. It empowers creators by simplifying the process of minting, selling, and managing digital assets, while providing fans with unique ways to support and engage with their favorite artists.

Lumina

Seed Round in 2023
Lumina is a zero-knowledge, KYC-enabled, enterprise-ready DEX on Mina.

Artela

Seed Round in 2023
Artela is a technology company that develops an extensible blockchain network, enabling developers to create feature-rich decentralized applications (dApps). Its platform includes an extension layer, allowing users to add custom, native extensions, enhancing programmability while maintaining compatibility with existing smart contracts. This modular approach empowers developers to customize their applications and drive faster innovations in the Web3 space.

XPLA

Seed Round in 2023
XPLA is a Layer 1 blockchain designed to serve as a central hub for digital media content, encompassing Web3 games, a blockchain gaming platform, an NFT marketplace, and metaverse applications. With a focus on creating a sustainable ecosystem, XPLA employs a developer-friendly environment supported by its native SDK and middleware. The platform promotes a "Play to Own" principle, ensuring that gamers' ownership and contributions are recognized and valued. Utilizing the Cosmos SDK for its Mainnet, XPLA emphasizes interoperability with various chains through Cosmos IBC, and it supports smart contracts via EVM compatibility. The ecosystem includes a diverse array of games and decentralized applications (DApps), continuously evolving with partnerships involving renowned intellectual properties like The Walking Dead: All-Stars and Summoners War: Chronicles. By fostering collaboration among experts in technology, security, and content, XPLA positions itself as a pivotal player in the blockchain gaming industry, delivering a comprehensive suite of services.

zkLink

Seed Round in 2023
zkLink is a blockchain infrastructure company offering a multi-chain trading platform that unifies blockchain networks and addresses Ethereum fragmentation through aggregated rollups. Its solutions use zero-knowledge proofs to enable secure cross-chain transactions and to aggregate liquidity from isolated networks, supporting high-throughput decentralized applications. The platform provides customizable rollup architectures, including app-specific options, to unify tokens and liquidity across Ethereum Layer 2s and to give developers cost- and performance-efficient interoperability.

Ferris Labs

Pre Seed Round in 2023
Ferris Labs is a technology firm focused on revolutionizing digital interactions through blockchain, Web3, and peer-to-peer (P2P) transactions. The company specializes in creating decentralized solutions that enhance security and transparency in digital transactions. By leveraging blockchain technology, Ferris Labs develops secure digital ledgers that foster trust and accountability. Their platform supports decentralized applications and smart contracts, empowering users with greater control over their data. Additionally, Ferris Labs offers a unique gaming platform designed to enhance crypto-based rewards within games, promoting a sustainable Web3 gaming ecosystem where participants can build value. The firm aims to transform various sectors, including finance, e-commerce, and gaming, by enabling direct, cost-effective value exchanges that eliminate intermediaries. Through its innovative approach, Ferris Labs is committed to reshaping the digital landscape and enhancing connectivity for both businesses and individuals.

HERE Wallet

Pre Seed Round in 2022
HERE Wallet offers a self-custodial wallet service for the NEAR Protocol, integrating a built-in decentralized exchange (DEX) aggregator, support for non-fungible tokens (NFTs), non-blocking staking, and weekly airdrops.

Layerswap Labs

Seed Round in 2022
Layerswap Labs is developer of permissionless and trustless bridging protocol. This protocol handles millions of dollars in transactions every day across multiple networks. We ensure quick, reliable, and affordable crypto transfers, giving the freedom to move crypto anywhere.

Decaf

Seed Round in 2022
Decaf is a digital payment platform that facilitates secure and transparent transactions using blockchain technology. It enables users to send and receive money instantly, with each transaction recorded immutably on the blockchain.

SithSwap

Seed Round in 2022
SithSwap is a company that operates an advanced Automated Market Maker (AMM) on the StarkNet platform. It specializes in providing instant swaps for both volatile and stable assets with minimal slippage and near-zero fees. The company's services are designed to offer trading pairs similar to Uniswap V2, with configurable trading fees and no administrative fees. Additionally, SithSwap incorporates built-in flash loan capabilities and leverages the full security of Ethereum, allowing traders to earn incentives for participating in governance decisions regarding future protocol emissions.

Nimblr

Pre Seed Round in 2022
Nimblr is an insurance company focused on creating a decentralized insurance platform that leverages blockchain technology. The platform aims to facilitate a community-driven approach to insurance, allowing various stakeholders—including insureds, underwriters, actuaries, and assessors—to operate anonymously and autonomously. By providing digital asset and smart contract risk coverage, Nimblr enables users to establish efficient and profitable risk pools, contributing to the development of a decentralized insurance industry. The company also offers traditional insurance services, including actuaries, claims assessors, and appraisers, accessible through an online inquiry form on its website.

Gora

Seed Round in 2022
Gora operates a decentralized oracle network platform that connects the Algorand blockchain with real-world data. Its infrastructure accelerates decentralized application development by securely integrating off-chain data with smart contracts.

IndexZoo

Seed Round in 2022
IndexZoo operates a multi-chain ecosystem offering precise index and leveraged tokens. It aims to provide high leverage and low-cost trading options across various blockchains.

Yanda

Convertible Note in 2022
Yanda develops an automated cryptocurrency trading platform that aims to empower users with financial control while reducing overhead. The platform features a simple interface for configuring and customizing trading strategies alongside built-in trading facilities, enabling users to tailor cryptocurrency trading to respond efficiently to market trends.

CyberBox

Seed Round in 2022
CyberBox is the first NFT Marketplace with ReFi integration on the Celo blockchain. Our vision is to build a marketplace to support every NFT collection and every ReFi project that looks to create impact with NFTs and build their communities around them and promote the value of sustainability and climate protection.

Eywa

Seed Round in 2022
Eywa is a decentralized cross-chain protocol designed to facilitate the transfer of liquidity and data across various blockchains that support smart contracts. By addressing interoperability challenges, Eywa aims to create a seamless ecosystem for decentralized finance (DeFi) applications. The protocol serves as a middle layer, enabling developers to build cross-chain decentralized applications and engage in cross-chain farming. This functionality allows users to easily perform cross-chain swaps and bridge assets across different DeFi platforms. Eywa's approach enhances the accessibility and utility of existing DeFi blockchains, fostering innovation and collaboration within the cryptocurrency space.

DeFiHelper

Pre Seed Round in 2022
DeFiHelper is an innovative platform designed to manage and automate decentralized finance (DeFi) investments. Its core offerings include no-code automation for portfolio management, auto-staking, real-time tracking of portfolios, and notifications on market-related events.

Sidechain

Pre Seed Round in 2022
Sidechain is a technology company that develops blockchain-based software, specifically leveraging the Solana blockchain. Its platform enables creators to build authentic communities, reward audiences, and integrate on-chain commerce, allowing them to engage and monetize their content within decentralized ecosystems.

Collector

Seed Round in 2022
Collector modernizes the collectibles industry by creating a secure, blockchain-based digital marketplace. It enables users to digitize, trade, collateralize, and securely market their collectibles, reducing time waste, fraud risk, and transaction fees compared to traditional methods.

Entangle Protocol

Venture Round in 2022
Entangle is a developer of a cross-chain decentralized finance (DeFi) protocol that focuses on enhancing liquidity provision and yield access through the use of synthetic assets. The platform enables connections between Ethereum virtual machine and non-Ethereum virtual machine chains, facilitating seamless interactions across different blockchain ecosystems. By employing a messaging layer to replicate states, Entangle aims to improve liquidity retention through various utility mechanisms. This allows users to borrow against their synthetic collateral in native stablecoins, thereby increasing the overall efficiency and accessibility of liquidity in the DeFi space.

Apillon

Pre Seed Round in 2021
Apillon is a Web3 development platform designed for developers and businesses entering the Web3 ecosystem. It simplifies blockchain development with an intuitive UI, seamless API integration, and unified pricing, enabling swift dapp creation. With nearly 150,000 users onboarded, Apillon is rapidly becoming the go-to platform in the Web3 space.

AlgoBlocks

Seed Round in 2021
AlgoBlocks is a blockchain technology company focused on enhancing user experience in decentralized finance (DeFi). Its platform addresses the challenges faced by cryptocurrency users in discovering relevant decentralized applications (Dapps) based on their wallet holdings and other criteria. By simplifying complex DeFi investment actions through advanced smart contracts, AlgoBlocks enables users to navigate the DeFi landscape with ease. Key features of the platform include a comprehensive dashboard that supports over 35 chains and 3,000 tokens, a history of investments that is agnostic to chains and actions, an NFT gallery for consolidated asset management, and personalized recommendations for DeFi products based on wallet contents. The platform also introduces Dapps to users and offers automation tools like Zap and Super Zap to facilitate seamless investments, making the transition to DeFi smoother and more accessible.

Ludex

Pre Seed Round in 2018
Ludex is a developer of a web3 gaming protocol that enables video game developers to integrate on-chain token transactions and smart contracts into games using APIs and SDKs, without requiring blockchain expertise. The platform also facilitates creating, organizing, and participating in tournaments and matches where prizes can be won, thereby making blockchain-based contract functionality accessible to gamers.
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