Battelle Ventures

Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis, focusing on structural variation detection in DNA. The company develops the Saphyr system, which offers ultra-sensitive and specific detection of structural variations—such as insertions, deletions, inversions, and translocations—linked to various genetic disorders, including cancer. Utilizing optical genome mapping technology, the Saphyr system enables the direct visualization of long DNA molecules and their structural variations without the need for sequencing. This capability is crucial for researchers and clinicians aiming to gain insights into disease mechanisms and genetic disorders, ultimately aiding in the development of personalized treatment strategies. Bionano Genomics markets its products primarily to academic and governmental laboratories, as well as pharmaceutical and biotechnology companies across multiple regions, including North America, Europe, and Asia. Headquartered in San Diego, California, the company was founded in 2003 and was previously known as BioNano Genomics, Inc. until its name change in July 2018.

Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis, focusing on structural variation detection in DNA. The company develops the Saphyr system, which offers ultra-sensitive and specific detection of structural variations—such as insertions, deletions, inversions, and translocations—linked to various genetic disorders, including cancer. Utilizing optical genome mapping technology, the Saphyr system enables the direct visualization of long DNA molecules and their structural variations without the need for sequencing. This capability is crucial for researchers and clinicians aiming to gain insights into disease mechanisms and genetic disorders, ultimately aiding in the development of personalized treatment strategies. Bionano Genomics markets its products primarily to academic and governmental laboratories, as well as pharmaceutical and biotechnology companies across multiple regions, including North America, Europe, and Asia. Headquartered in San Diego, California, the company was founded in 2003 and was previously known as BioNano Genomics, Inc. until its name change in July 2018.

Micro Interventional Devices, Inc. is a medical device company focused on developing disruptive technologies for percutaneous and minimally invasive structural heart repair procedures. Founded in 2010 and based in Newtown, Pennsylvania, the company offers a range of innovative products, including the Permaseal device for transapical access and closure, Minimally Invasive Annuloplasty for tricuspid and mitral repair, the Endovalve for percutaneous mitral valve replacement, and the Permavalve, which features active fixation. Their proprietary technology leverages a breakthrough in soft-tissue anchoring and delivery systems, allowing for off-pump procedures that transform traditional open surgical techniques into less invasive transcatheter approaches.

Proterro, Inc. is a biotechnology company based in Princeton, New Jersey, founded in 2008. It specializes in the production and marketing of sugar feedstock, specifically a fortified sucrose product known as PROTOSE. Unlike traditional methods that involve extracting sucrose from crops or breaking down cellulosic materials, Proterro utilizes patented microorganisms that synthesize sucrose directly. This innovative approach allows the company to produce a non-crop-based, fermentation-ready sugar feedstock, which mitigates the price volatility typically associated with corn and other agricultural feedstocks. By focusing on this unique production method, Proterro aims to provide a cost-effective and scalable solution for the commercial production of biofuels and biobased chemicals.

Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis, focusing on structural variation detection in DNA. The company develops the Saphyr system, which offers ultra-sensitive and specific detection of structural variations—such as insertions, deletions, inversions, and translocations—linked to various genetic disorders, including cancer. Utilizing optical genome mapping technology, the Saphyr system enables the direct visualization of long DNA molecules and their structural variations without the need for sequencing. This capability is crucial for researchers and clinicians aiming to gain insights into disease mechanisms and genetic disorders, ultimately aiding in the development of personalized treatment strategies. Bionano Genomics markets its products primarily to academic and governmental laboratories, as well as pharmaceutical and biotechnology companies across multiple regions, including North America, Europe, and Asia. Headquartered in San Diego, California, the company was founded in 2003 and was previously known as BioNano Genomics, Inc. until its name change in July 2018.

Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis, focusing on structural variation detection in DNA. The company develops the Saphyr system, which offers ultra-sensitive and specific detection of structural variations—such as insertions, deletions, inversions, and translocations—linked to various genetic disorders, including cancer. Utilizing optical genome mapping technology, the Saphyr system enables the direct visualization of long DNA molecules and their structural variations without the need for sequencing. This capability is crucial for researchers and clinicians aiming to gain insights into disease mechanisms and genetic disorders, ultimately aiding in the development of personalized treatment strategies. Bionano Genomics markets its products primarily to academic and governmental laboratories, as well as pharmaceutical and biotechnology companies across multiple regions, including North America, Europe, and Asia. Headquartered in San Diego, California, the company was founded in 2003 and was previously known as BioNano Genomics, Inc. until its name change in July 2018.

Nistica, Inc. specializes in the development and manufacturing of optical networking modules designed to enhance the delivery of high-bandwidth applications. The company offers a range of products, including reconfigurable optical add/drop multiplexer (ROADM) subsystems, low port-count wavelength selective switch modules, wave blocker arrays with optical programmability, and high port-count series products. Its FLEXBOX, a disaggregated ROADM node, is tailored for software-defined networks, while the company's ROADM linecards support various optical networking needs. Founded in 2005 and based in Bridgewater, New Jersey, Nistica serves optical system original equipment manufacturers (OEMs) both domestically and internationally, aiming to automate and simplify the optical network infrastructure. In 2012, Nistica was acquired by Molex Optical Solutions Group.

GRIDSMART Technologies, Inc. specializes in developing advanced traffic management systems for municipal clients both in the United States and internationally. The company offers a comprehensive suite of products under the GRIDSMART brand, which includes various camera-based solutions for traffic monitoring and data collection. Notable products include the GRIDSMART Bell Camera for intersection management, the GRIDSMART Engine for tracking and counting vehicles, motorcycles, and bicycles, and a variety of software modules that provide real-time data and alerts. GRIDSMART Technologies also offers traditional zoom and thermal imaging cameras, enhancing its traffic monitoring capabilities. The company markets its products through distributors and direct sales teams across several countries, including Canada, Australia, Oman, and Ireland. Founded in 2006 and headquartered in Knoxville, Tennessee, GRIDSMART Technologies was previously known as Aldis, Inc. and became a subsidiary of Cubic Transportation Systems in 2019.

Nistica, Inc. specializes in the development and manufacturing of optical networking modules designed to enhance the delivery of high-bandwidth applications. The company offers a range of products, including reconfigurable optical add/drop multiplexer (ROADM) subsystems, low port-count wavelength selective switch modules, wave blocker arrays with optical programmability, and high port-count series products. Its FLEXBOX, a disaggregated ROADM node, is tailored for software-defined networks, while the company's ROADM linecards support various optical networking needs. Founded in 2005 and based in Bridgewater, New Jersey, Nistica serves optical system original equipment manufacturers (OEMs) both domestically and internationally, aiming to automate and simplify the optical network infrastructure. In 2012, Nistica was acquired by Molex Optical Solutions Group.

Hepregen Corporation specializes in bio-engineering technology with a focus on developing its microliver platform, which is designed for applications in acute and chronic toxicity assessment and drug metabolism. This innovative platform supports the pharmaceutical industry in various areas, including drug discovery, disease modeling, and toxicogenomics. By collaborating with industry partners, Hepregen aims to validate its technology across a broad spectrum of applications, enhancing safety assessments and drug development processes. The potential market for the microliver platform is significant, estimated at around one billion dollars annually, reflecting its importance in improving pharmaceutical products for clinical use.

Hepregen Corporation specializes in bio-engineering technology with a focus on developing its microliver platform, which is designed for applications in acute and chronic toxicity assessment and drug metabolism. This innovative platform supports the pharmaceutical industry in various areas, including drug discovery, disease modeling, and toxicogenomics. By collaborating with industry partners, Hepregen aims to validate its technology across a broad spectrum of applications, enhancing safety assessments and drug development processes. The potential market for the microliver platform is significant, estimated at around one billion dollars annually, reflecting its importance in improving pharmaceutical products for clinical use.

NuPathe Inc. is a specialty pharmaceutical company focused on innovative neuroscience solutions for diseases of the central nervous system including neurological and psychiatric disorders. NuPathe's lead product candidate, NP101, is an active, single-use, transdermal sumatriptan patch being developed for the treatment of migraine. In addition to NP101, NuPathe has two proprietary product candidates based on its LAD™, or Long-Acting Delivery, biodegradable implant technology that allows delivery of therapeutic levels of medication over a period of months with a single dose. NP201, for the continuous symptomatic treatment of Parkinson's disease, utilizes a leading FDA-approved dopamine agonist, ropinirole, and is being developed to provide up to two months of continuous delivery. NP202, for the long-term treatment of schizophrenia and bipolar disorder, is being developed to address the long-standing problem of patient noncompliance by providing three months of continuous delivery of risperidone, an atypical antipsychotic. NuPathe is actively seeking partnerships to maximize the commercial potential for its product candidates in the U.S. and territories throughout the world.

RemoteReality is the designer and manufacturer of ultra wide-angle computational cameras and video systems. Using their unique patented optics, the latest in image sensors, and their own advanced video processing, their solutions deliver high resolution real time, low latency video for a variety of cutting edge applications. Their video solutions are available in both day and night configurations, spanning the visible, LWIR and MWIR spectra.

NellOne Therapeutics, Inc. is a regenerative medicine company based in Oak Ridge, Tennessee, focused on developing and commercializing protein therapeutics aimed at restoring cardiac muscle mass and function in patients recovering from myocardial infarctions and congestive heart failure. The company was established as a spin-off from the U.S. Department of Energy's Oak Ridge National Laboratory, where research on the Nell1 gene's pathway was conducted, revealing its role in the formation of critical mammalian tissues and organs. Founded by Battelle Ventures, NellOne is dedicated to translating this scientific discovery into effective clinical applications for heart recovery.

Bionano Genomics is a biotechnology company that specializes in genome mapping and analysis, focusing on structural variation detection in DNA. The company develops the Saphyr system, which offers ultra-sensitive and specific detection of structural variations—such as insertions, deletions, inversions, and translocations—linked to various genetic disorders, including cancer. Utilizing optical genome mapping technology, the Saphyr system enables the direct visualization of long DNA molecules and their structural variations without the need for sequencing. This capability is crucial for researchers and clinicians aiming to gain insights into disease mechanisms and genetic disorders, ultimately aiding in the development of personalized treatment strategies. Bionano Genomics markets its products primarily to academic and governmental laboratories, as well as pharmaceutical and biotechnology companies across multiple regions, including North America, Europe, and Asia. Headquartered in San Diego, California, the company was founded in 2003 and was previously known as BioNano Genomics, Inc. until its name change in July 2018.

Nistica, Inc. specializes in the development and manufacturing of optical networking modules designed to enhance the delivery of high-bandwidth applications. The company offers a range of products, including reconfigurable optical add/drop multiplexer (ROADM) subsystems, low port-count wavelength selective switch modules, wave blocker arrays with optical programmability, and high port-count series products. Its FLEXBOX, a disaggregated ROADM node, is tailored for software-defined networks, while the company's ROADM linecards support various optical networking needs. Founded in 2005 and based in Bridgewater, New Jersey, Nistica serves optical system original equipment manufacturers (OEMs) both domestically and internationally, aiming to automate and simplify the optical network infrastructure. In 2012, Nistica was acquired by Molex Optical Solutions Group.

Hi-G-Tek is the developer of a new active-RFID platform for real-time monitoring and control of critical physical assets. Their company is commercializing patented technology that enables low power, cost-effective wireless solutions for monitoring, assessing and protecting high-value physical assets and sensitive materials. Their unique solutions provide unprecedented levels of real-time security and “sensing” of key assets, whether stationary or in transit, indoors or outdoors.

CDI Bioscience has developed an innovative technology for increased yield of bioproducts, manufactured in cellular systems. Genetic engineering technology is used to control the metabolism of cells, thus shifting the cell from replicative to production mode (RP Shift®). In particular, this technology has been designed for use in mammalian cells, unlocking their potential to produce proteins, peptides and enzymes. The current design of the technology can be readily translated to bacterial and yeast cellular systems for the production of commercial grade bioproducts.

GRIDSMART Technologies, Inc. specializes in developing advanced traffic management systems for municipal clients both in the United States and internationally. The company offers a comprehensive suite of products under the GRIDSMART brand, which includes various camera-based solutions for traffic monitoring and data collection. Notable products include the GRIDSMART Bell Camera for intersection management, the GRIDSMART Engine for tracking and counting vehicles, motorcycles, and bicycles, and a variety of software modules that provide real-time data and alerts. GRIDSMART Technologies also offers traditional zoom and thermal imaging cameras, enhancing its traffic monitoring capabilities. The company markets its products through distributors and direct sales teams across several countries, including Canada, Australia, Oman, and Ireland. Founded in 2006 and headquartered in Knoxville, Tennessee, GRIDSMART Technologies was previously known as Aldis, Inc. and became a subsidiary of Cubic Transportation Systems in 2019.

ypherlink, Inc. operates as an information-management-software company. It offers Harvester that automates a significant amount of the data discovery and mapping process, as well as enables organizations to understand what information is available and where field-level relationships exist between multiple data sources; Exploratory Warehouse, which provides prototyping of the data warehouse; and Integrity that enhances ongoing data quality processes. The company’s Harvester Integrator component provides data movement capabilities, including extracting, transforming, and loading (ETL) data into target applications. It serves organizations, government agencies, and systems integrators and application/tool providers. Sypherlink, Inc. was founded in 2001 and is headquartered in Dublin, Ohio.

Metatomix was founded in 2000 and describes themselves as the "semantic integration provider." Metatomix' solutions aim to link data from "existing disparate systems to create a common semantic understanding of your information across the enterprise, providing you a 360° view of your business information. As a result, business applications can leverage information that comes not just from a single product system or data store, but from across all data sources."

Superprotonic is an energy technology company established to market and commercialize the innovative solid acid fuel cell (SAFC) technology developed and patented by the company's founders at the California Institute of Technology. Solid acid fuel cells offer significant cost and performance advantages compared to other fuel cell technologies currently under development.

Endovalve develops percutaneous valve-replacement systems to treat mitral regurgitation. The company was founded by Tracy S. Warren and is based in Princeton, New Jersey.

Hi-G-Tek is the developer of a new active-RFID platform for real-time monitoring and control of critical physical assets. Their company is commercializing patented technology that enables low power, cost-effective wireless solutions for monitoring, assessing and protecting high-value physical assets and sensitive materials. Their unique solutions provide unprecedented levels of real-time security and “sensing” of key assets, whether stationary or in transit, indoors or outdoors.

Rajant Corporation has developed wireless broadband systems and components that have multiple applications in homeland security, public safety, security and enterprise networking sectors. Rajant Corporation's wireless LAN systems are portable, mobile, battery powered, self-integrating, self-meshing, self-healing, secure, 802.11 access points.

BioVigilant Systems invented instantaneous microbial detection technology to address environmental monitoring needs in pharmaceutical, biotechnology, healthcare, and environmental applications. BioVigilant’s IMD systems detect—instantaneously and in real time—particulate count, size, and biological status. Unlike other rapid microbial methods, BioVigilant’s optically-based systems require no staining, no reagents, no waiting period, and little human intervention.

Metatomix was founded in 2000 and describes themselves as the "semantic integration provider." Metatomix' solutions aim to link data from "existing disparate systems to create a common semantic understanding of your information across the enterprise, providing you a 360° view of your business information. As a result, business applications can leverage information that comes not just from a single product system or data store, but from across all data sources."

Endovalve develops percutaneous valve-replacement systems to treat mitral regurgitation. The company was founded by Tracy S. Warren and is based in Princeton, New Jersey.

Multispectral Imaging, Inc. designs, develops, manufactures, and supplies infrared imaging detectors and arrays. The company provides technologies for night vision and thermal-imaging products. Its solutions include infrared imaging array detector modules that use microelectromechanical sensor and ROIC technologies to produce detectors with sensitivities; and microcantilever detector technologies, which enable detector sensitivities to the infrared detection approach. The company was founded in 2003 and is based in Parsippany, New Jersey with a branch office in Oak Ridge, Tennessee. As of April 4, 2008, Multispectral Imaging, Inc. operates as a subsidiary of Agiltron, Inc.

SmartSynch is a technology company specializing in smart grid solutions that enable utilities to communicate with devices on the grid through public wireless networks. By utilizing existing cellular infrastructure, SmartSynch simplifies the deployment of smart metering technology for over 100 North American electric utilities. Their innovations facilitate the two-way delivery of real-time energy usage data, allowing for improved monitoring, control, and efficiency in energy distribution. SmartSynch's solutions help identify and mitigate energy losses, optimize power factors, and provide essential feedback for managing energy loads during peak demand. With the potential benefits of smart grid technologies projected to reach significant financial savings over the next two decades, SmartSynch aims to create substantial value for its clients by enhancing the capabilities of the electricity grid through its advanced infrastructure solutions.

Ventaira Pharmaceuticals is an emerging specialty pharmaceutical company focused on the development of new inhalation products by utilizing its novel proprietary electrohydrodynamic (EHD) aerosolization and formulation technologies.

SafeView, Inc. is a provider of homeland security technology services, specializing in advanced security screening systems. The company focuses on commercializing patented holographic imaging technology developed by the Pacific Northwest National Laboratory. Its flagship product, the Guardian 100, utilizes active millimeter wave technology to safely and clearly detect hidden items, including metal, plastic, and ceramic, without the use of ionizing radiation. This innovative approach offers a significant improvement over traditional methods such as metal detectors and pat-down searches, enhancing safety in public spaces. SafeView aims to address security needs in various environments, including passenger terminals, cargo facilities, and border security applications.