ARCH Venture Partners

Be Biopharma, Inc. is focused on developing innovative therapeutics derived from engineered B-cells to address various diseases, including cancer, autoimmune disorders, and infectious diseases. Founded in 2020 and based in Cambridge, Massachusetts, the company aims to overcome significant challenges associated with traditional cell and gene therapies, such as the limitations of dosing, unpredictable reactions in patients, and the necessity of pre-treatment chemotherapy. By leveraging precision genome editing, Be Biopharma creates durable and effective cell therapies that can be administered without toxic conditioning, thereby improving treatment options for conditions like Hemophilia B and enhancing overall patient outcomes.

Be Biopharma, Inc. is focused on developing innovative therapeutics derived from engineered B-cells to address various diseases, including cancer, autoimmune disorders, and infectious diseases. Founded in 2020 and based in Cambridge, Massachusetts, the company aims to overcome significant challenges associated with traditional cell and gene therapies, such as the limitations of dosing, unpredictable reactions in patients, and the necessity of pre-treatment chemotherapy. By leveraging precision genome editing, Be Biopharma creates durable and effective cell therapies that can be administered without toxic conditioning, thereby improving treatment options for conditions like Hemophilia B and enhancing overall patient outcomes.

Vizgen, Inc. is a biotechnology company focused on developing advanced tools for spatially resolved transcriptomic profiling, which enhances understanding of biological systems related to human health and disease. The company's primary offering, MERFISH, is a multiplexed single-molecule imaging technology that allows for the simultaneous measurement of RNA species' copy number and spatial distribution within individual cells. This technology facilitates single-cell gene expression profiling in intact tissue slices, providing valuable insights for research in fields such as oncology, immunology, neuroscience, infectious diseases, and regenerative medicine. Founded in 2019 and based in Cambridge, Massachusetts, Vizgen aims to empower medical researchers to explore complex biological questions on a systems scale through its innovative profiling solutions.

Egenesis Inc. is a biotechnology company focused on gene editing and genome engineering to create human transplantable organs, tissues, and cells. Established in 2015 and headquartered in Cambridge, Massachusetts, with an additional office in New York City, Egenesis aims to address the global organ shortage by developing solid organs and therapeutic cell transplantation solutions for various diseases. The company utilizes a gene editing platform that incorporates techniques such as single-cell cloning and somatic cell nuclear transfer, which are essential for creating human-compatible organ tissues and cells. Egenesis is particularly engaged in advancing programs related to kidney and islet cell transplantation, striving to provide alternative treatment options for patients with life-threatening conditions.

Areteia Therapeutics is a biotechnology company committed to putting asthma patients in better control of their disease. The company was spun out of Pennsylvania-based Knopp, which published results from its phase 2 clinical trial last year that showed its oral drug candidate could reduce the count of blood eosinophil, which is an indication of improving lung function and is found in several asthma-related treatments.

Remix Therapeutics Inc. is a biotechnology company focused on the research and development of innovative small-molecule therapies that target RNA processing to address various diseases. Established in 2018 and based in Cambridge, Massachusetts, the company employs its proprietary biology platform to identify and prioritize therapeutic targets within RNA processing. Through its REMseq platform, Remix Therapeutics validates potential drug targets and optimizes chemical compounds for therapeutic use. The company's approach aims to reprogram RNA processing to control gene expression, thereby correcting, enhancing, or eliminating problematic gene messages. This enables healthcare providers to tackle the underlying causes of diseases, offering novel solutions to previously undruggable conditions.

Generate Biomedicines, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies through its unique platform. The company specializes in Generative Biology, a machine learning-driven approach that analyzes known proteins to understand the relationship between genetic sequences, protein structure, and function. This enables the creation of novel therapeutic proteins, including antibodies, enzymes, and receptors, which are designed to interact specifically and effectively with various therapeutic targets. Founded in 2018 and rebranded from Generate Biologics in 2020, Generate Biomedicines aims to streamline the drug discovery process by generating new biological molecules with significant therapeutic potential.

Volastra Therapeutics, Inc. is a biotechnology company based in New York that focuses on developing therapies for metastatic cancers. Founded in 2019, the company utilizes a library of organoids derived from metastatic cancer samples to understand tumor spread and create targeted therapeutic strategies aimed at chromosomal instability. By integrating artificial intelligence, bioinformatics, and proprietary imaging techniques, Volastra identifies cancers at higher risk of metastasis, allowing healthcare professionals to select appropriate patients for therapy and improve treatment outcomes. Through its innovative approach, Volastra seeks to advance the understanding and management of metastatic diseases.

IngredientWerks is a molecular farming company founded in 2022 and based in Woburn, Massachusetts. The company focuses on improving the taste and experience of plant-based foods by enhancing the protein content in plants. This innovative approach allows IngredientWerks to sustainably design and produce food ingredients, catering to the growing demand for alternative proteins. By offering enhanced taste and quality at reduced costs, the company aims to provide sustainable solutions for clients in the rapidly expanding alternative protein market.

Treeline Biosciences is a biotechnology company established in 2021 and based in Stamford, Connecticut. The company focuses on developing transformative precision medicines aimed at treating cancer and other serious health conditions. Utilizing a comprehensive drug discovery platform, Treeline combines mechanistic biology, medicinal chemistry, computational science, structural biology, and protein science to create innovative therapeutic solutions. Through its research and development efforts, Treeline aims to provide effective treatments to improve patient outcomes in oncology and beyond.

Areteia Therapeutics is a biotechnology company committed to putting asthma patients in better control of their disease. The company was spun out of Pennsylvania-based Knopp, which published results from its phase 2 clinical trial last year that showed its oral drug candidate could reduce the count of blood eosinophil, which is an indication of improving lung function and is found in several asthma-related treatments.

Vizgen, Inc. is a biotechnology company focused on developing advanced tools for spatially resolved transcriptomic profiling, which enhances understanding of biological systems related to human health and disease. The company's primary offering, MERFISH, is a multiplexed single-molecule imaging technology that allows for the simultaneous measurement of RNA species' copy number and spatial distribution within individual cells. This technology facilitates single-cell gene expression profiling in intact tissue slices, providing valuable insights for research in fields such as oncology, immunology, neuroscience, infectious diseases, and regenerative medicine. Founded in 2019 and based in Cambridge, Massachusetts, Vizgen aims to empower medical researchers to explore complex biological questions on a systems scale through its innovative profiling solutions.

Remix Therapeutics Inc. is a biotechnology company focused on the research and development of innovative small-molecule therapies that target RNA processing to address various diseases. Established in 2018 and based in Cambridge, Massachusetts, the company employs its proprietary biology platform to identify and prioritize therapeutic targets within RNA processing. Through its REMseq platform, Remix Therapeutics validates potential drug targets and optimizes chemical compounds for therapeutic use. The company's approach aims to reprogram RNA processing to control gene expression, thereby correcting, enhancing, or eliminating problematic gene messages. This enables healthcare providers to tackle the underlying causes of diseases, offering novel solutions to previously undruggable conditions.

Be Biopharma, Inc. is focused on developing innovative therapeutics derived from engineered B-cells to address various diseases, including cancer, autoimmune disorders, and infectious diseases. Founded in 2020 and based in Cambridge, Massachusetts, the company aims to overcome significant challenges associated with traditional cell and gene therapies, such as the limitations of dosing, unpredictable reactions in patients, and the necessity of pre-treatment chemotherapy. By leveraging precision genome editing, Be Biopharma creates durable and effective cell therapies that can be administered without toxic conditioning, thereby improving treatment options for conditions like Hemophilia B and enhancing overall patient outcomes.

LifeMine Therapeutics, Inc. is a biotechnology company focused on discovering new drug modalities from eukaryotic microbes, particularly fungi. Founded in 2016 and headquartered in Cambridge, Massachusetts, with an additional office in New York, the company employs an integrated platform that combines genomics, artificial intelligence, and synthetic biology. This innovative Avatar-Rx platform utilizes high-throughput microbiology, data science, machine learning, genome engineering, and automation to explore the fungal biosphere for novel genetically encoded molecules with specific biological functions. By integrating chemoinformatic-assisted drug optimization and advanced chemical synthesis with biotransformation, LifeMine Therapeutics aims to advance a pipeline of new medicines into development.

Feelmore Labs is a health and wellness technology company based in New York City, specializing in the development of non-invasive wearable devices that aim to enhance emotional well-being. By focusing on the modulation of the insula, a deep brain region responsible for emotional responses, Feelmore Labs' devices help users achieve a sense of calm, reduce stress and anxiety, and improve sleep patterns. This innovative approach positions the company at the forefront of a new category of medical and consumer devices designed to positively impact individuals' lives.

Generate Biomedicines, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies through its unique platform. The company specializes in Generative Biology, a machine learning-driven approach that analyzes known proteins to understand the relationship between genetic sequences, protein structure, and function. This enables the creation of novel therapeutic proteins, including antibodies, enzymes, and receptors, which are designed to interact specifically and effectively with various therapeutic targets. Founded in 2018 and rebranded from Generate Biologics in 2020, Generate Biomedicines aims to streamline the drug discovery process by generating new biological molecules with significant therapeutic potential.

ROME Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies for cancer and autoimmune diseases. Established in 2019, the company utilizes the repeatome—a previously overlooked segment of genetic material—to create novel treatment options. By identifying multiple drug targets and advancing several discovery programs, ROME Therapeutics aims to tap into this unexplored area of biology. The organization has assembled a team of experts in oncology, immunology, virology, and machine learning to lead its research and development efforts, which are designed to provide healthcare professionals with effective new treatments for patients suffering from these conditions.

HiberCell, Inc. is a biotechnology company established in 2019 and located in New York. The company focuses on developing innovative therapeutics aimed at preventing cancer relapse and metastasis, which are significant contributors to cancer-related mortality. HiberCell's therapeutic pipeline targets adaptive stress pathways and immune modulation to address the mechanisms of treatment resistance. By employing artificial intelligence and machine learning, the company integrates multi-omic and phenotypic profiles of tumors to generate insights that link these characteristics to clinical outcomes. This approach aims to enhance patient outcomes, enabling individuals to lead longer, cancer-free lives.

Ultivue, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in the development and manufacture of reagents for marker multiplexing detection and analysis in the life sciences and biomedical fields. Founded in 2015, Ultivue focuses on tissue imaging and diagnostics, offering innovative technologies such as DNA-PAINT and DNA-Exchange. These technologies enable researchers to capture high-resolution microscopic images, facilitating a deeper understanding of biological processes and medical diagnostics. Ultivue's products are designed for use in fluorescent microscopy-based research, with the potential for significant applications in clinical diagnostics. The company's multiplex biomarker assays aid in tissue phenotyping and digital pathology, integrating validated antibodies and advanced analytics to support personalized medicine and enhance research discoveries related to complex tumor microenvironments.

Treeline Biosciences is a biotechnology company established in 2021 and based in Stamford, Connecticut. The company focuses on developing transformative precision medicines aimed at treating cancer and other serious health conditions. Utilizing a comprehensive drug discovery platform, Treeline combines mechanistic biology, medicinal chemistry, computational science, structural biology, and protein science to create innovative therapeutic solutions. Through its research and development efforts, Treeline aims to provide effective treatments to improve patient outcomes in oncology and beyond.

Vizgen, Inc. is a biotechnology company focused on developing advanced tools for spatially resolved transcriptomic profiling, which enhances understanding of biological systems related to human health and disease. The company's primary offering, MERFISH, is a multiplexed single-molecule imaging technology that allows for the simultaneous measurement of RNA species' copy number and spatial distribution within individual cells. This technology facilitates single-cell gene expression profiling in intact tissue slices, providing valuable insights for research in fields such as oncology, immunology, neuroscience, infectious diseases, and regenerative medicine. Founded in 2019 and based in Cambridge, Massachusetts, Vizgen aims to empower medical researchers to explore complex biological questions on a systems scale through its innovative profiling solutions.

Excision BioTherapeutics Inc. is a life science company based in Philadelphia, Pennsylvania, established in 2015. The company specializes in developing gene editing therapeutics aimed at treating life-threatening diseases caused by neurotropic viruses. Utilizing CRISPR-based technology, Excision BioTherapeutics focuses on creating advanced gene-editing medicines that can eradicate or disrupt viral genes in human patients. The company is committed to advancing these therapeutics to ensure they are safe and effective, with the goal of significantly improving the lives of individuals affected by viral infections worldwide.

EQRx, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on transforming the drug discovery and delivery process to address the rising costs of medicines. Founded in 2019, EQRx aims to provide a market-based solution by leveraging advances in science and technology while collaborating with various healthcare stakeholders. The company has over ten programs in its pipeline targeting oncology and immune-inflammatory conditions, which include clinical and preclinical stages, as well as drug engineering initiatives. Among its key programs are Aumolertinib, Lerociclib, Sugemalimab, and Nofazinlimab. Through its innovative approach, EQRx seeks to develop high-quality, patent-protected medicines more efficiently and cost-effectively than traditional pharmaceutical methods.

LifeMine Therapeutics, Inc. is a biotechnology company focused on discovering new drug modalities from eukaryotic microbes, particularly fungi. Founded in 2016 and headquartered in Cambridge, Massachusetts, with an additional office in New York, the company employs an integrated platform that combines genomics, artificial intelligence, and synthetic biology. This innovative Avatar-Rx platform utilizes high-throughput microbiology, data science, machine learning, genome engineering, and automation to explore the fungal biosphere for novel genetically encoded molecules with specific biological functions. By integrating chemoinformatic-assisted drug optimization and advanced chemical synthesis with biotransformation, LifeMine Therapeutics aims to advance a pipeline of new medicines into development.

Altos Labs is a biotechnology company focused on cellular rejuvenation programming to restore cell health and resilience, with the goal of reversing disease to transform medicine. The company comprises a community of leading scientists, clinicians, and leaders from both academia and industry working together towards this common mission. Altos has operations in the San Francisco Bay Area and San Diego, and in Cambridge, UK, with significant collaborations in Japan.

Remix Therapeutics Inc. is a biotechnology company focused on the research and development of innovative small-molecule therapies that target RNA processing to address various diseases. Established in 2018 and based in Cambridge, Massachusetts, the company employs its proprietary biology platform to identify and prioritize therapeutic targets within RNA processing. Through its REMseq platform, Remix Therapeutics validates potential drug targets and optimizes chemical compounds for therapeutic use. The company's approach aims to reprogram RNA processing to control gene expression, thereby correcting, enhancing, or eliminating problematic gene messages. This enables healthcare providers to tackle the underlying causes of diseases, offering novel solutions to previously undruggable conditions.

Dewpoint Therapeutics is a Boston-based biotech company focused on the research and development of treatments targeting biomolecular condensates to address various diseases, including cancer, neurodegenerative disorders, and immunological conditions. Founded in 2018, the company employs an innovative drug platform that utilizes machine-learning-based image analysis for visualizing condensates. This technology supports an engine of engineered cell lines designed to track and mitigate harmful protein sequestration. By leveraging its proprietary platform, Dewpoint seeks to facilitate drug discovery across a wide range of medical indications and collaborates with leading academic and pharmaceutical partners to enhance the accessibility of new therapies for unmet healthcare needs.

Glympse Bio, Inc. is a diagnostic company based in Cambridge, Massachusetts, that focuses on developing modular nanoparticle sensors for noninvasive disease monitoring. Founded in 2015, the company creates engineered diagnostic agents designed to interrogate the body for specific disease states, subsequently conveying this information through urine analysis. This innovative approach facilitates the monitoring of various conditions, including fibrosis, cancer, immunology, and infectious diseases, while also assessing drug responses. Glympse Bio's flagship product, Glympse Inside, serves as a pan-disease platform aimed at revolutionizing how diseases are monitored and treated. The technology was initially developed at MIT and is supported by a team of experts in nanomedicine and biomedical engineering.

Sana Biotechnology is a biotechnology company based in Seattle, Washington, with additional offices in South San Francisco, California, and Cambridge, Massachusetts. Founded in 2018, the company specializes in developing engineered cells as medicines to treat a variety of diseases. Sana Biotechnology focuses on reprogramming cells in the body and replacing damaged cells and tissues, leveraging recent scientific advancements to create new therapeutic options. The company's research spans multiple therapeutic areas with significant unmet needs, including oncology, diabetes, B-cell-mediated autoimmune disorders, and central nervous system conditions. Its pipeline includes various product candidates aimed at addressing these challenges through innovative cell engineering programs.

Verve Therapeutics, Inc. is a genetic medicines company focused on innovative treatments for cardiovascular disease through gene editing. Founded in 2018 and based in Cambridge, Massachusetts, with a research facility in Philadelphia, the company aims to shift the management of cardiovascular conditions from chronic treatments to single-course gene editing therapies. Its initial programs concentrate on the PCSK9 and ANGPTL3 genes, which are known to significantly impact blood lipid levels, a major factor in cardiovascular disease. Verve Therapeutics collaborates with partners such as Beam Therapeutics and Verily to enhance its gene editing delivery technologies. The company is staffed by a team of experts in cardiovascular medicine, human genetics, and drug development, positioning itself to address the challenges of cardiovascular health effectively.

ROME Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative therapies for cancer and autoimmune diseases. Established in 2019, the company utilizes the repeatome—a previously overlooked segment of genetic material—to create novel treatment options. By identifying multiple drug targets and advancing several discovery programs, ROME Therapeutics aims to tap into this unexplored area of biology. The organization has assembled a team of experts in oncology, immunology, virology, and machine learning to lead its research and development efforts, which are designed to provide healthcare professionals with effective new treatments for patients suffering from these conditions.

Volastra Therapeutics, Inc. is a biotechnology company based in New York that focuses on developing therapies for metastatic cancers. Founded in 2019, the company utilizes a library of organoids derived from metastatic cancer samples to understand tumor spread and create targeted therapeutic strategies aimed at chromosomal instability. By integrating artificial intelligence, bioinformatics, and proprietary imaging techniques, Volastra identifies cancers at higher risk of metastasis, allowing healthcare professionals to select appropriate patients for therapy and improve treatment outcomes. Through its innovative approach, Volastra seeks to advance the understanding and management of metastatic diseases.

Vizgen, Inc. is a biotechnology company focused on developing advanced tools for spatially resolved transcriptomic profiling, which enhances understanding of biological systems related to human health and disease. The company's primary offering, MERFISH, is a multiplexed single-molecule imaging technology that allows for the simultaneous measurement of RNA species' copy number and spatial distribution within individual cells. This technology facilitates single-cell gene expression profiling in intact tissue slices, providing valuable insights for research in fields such as oncology, immunology, neuroscience, infectious diseases, and regenerative medicine. Founded in 2019 and based in Cambridge, Massachusetts, Vizgen aims to empower medical researchers to explore complex biological questions on a systems scale through its innovative profiling solutions.

EQRx, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on transforming the drug discovery and delivery process to address the rising costs of medicines. Founded in 2019, EQRx aims to provide a market-based solution by leveraging advances in science and technology while collaborating with various healthcare stakeholders. The company has over ten programs in its pipeline targeting oncology and immune-inflammatory conditions, which include clinical and preclinical stages, as well as drug engineering initiatives. Among its key programs are Aumolertinib, Lerociclib, Sugemalimab, and Nofazinlimab. Through its innovative approach, EQRx seeks to develop high-quality, patent-protected medicines more efficiently and cost-effectively than traditional pharmaceutical methods.

Egenesis Inc. is a biotechnology company focused on gene editing and genome engineering to create human transplantable organs, tissues, and cells. Established in 2015 and headquartered in Cambridge, Massachusetts, with an additional office in New York City, Egenesis aims to address the global organ shortage by developing solid organs and therapeutic cell transplantation solutions for various diseases. The company utilizes a gene editing platform that incorporates techniques such as single-cell cloning and somatic cell nuclear transfer, which are essential for creating human-compatible organ tissues and cells. Egenesis is particularly engaged in advancing programs related to kidney and islet cell transplantation, striving to provide alternative treatment options for patients with life-threatening conditions.

Voxel8 Inc. is a technology company based in Somerville, Massachusetts, that specializes in the design and manufacture of electronic devices and advanced 3D printing solutions. Established in 2013, Voxel8 has developed a unique digital 3D printing technology that allows for the zonal tuning of mechanical properties in various textiles, making it applicable in sectors such as footwear, apparel, and medical devices. Their systems enable the customization of each print, enhancing both performance and aesthetics while minimizing waste through an additive manufacturing process. Additionally, Voxel8 offers Project Wire, a cloud-based software tool that facilitates the design of 3D printable electronic devices compatible with their printers. With a focus on sustainability, the company has created a range of bio-based materials aimed at reducing the carbon footprint associated with textile production. This innovative approach not only improves functional performance—such as abrasion resistance and cushioning—but also allows for the integration of 3D embellishments and color, significantly transforming the landscape of footwear and athletic apparel manufacturing.

Feelmore Labs is a health and wellness technology company based in New York City, specializing in the development of non-invasive wearable devices that aim to enhance emotional well-being. By focusing on the modulation of the insula, a deep brain region responsible for emotional responses, Feelmore Labs' devices help users achieve a sense of calm, reduce stress and anxiety, and improve sleep patterns. This innovative approach positions the company at the forefront of a new category of medical and consumer devices designed to positively impact individuals' lives.

Ultivue, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in the development and manufacture of reagents for marker multiplexing detection and analysis in the life sciences and biomedical fields. Founded in 2015, Ultivue focuses on tissue imaging and diagnostics, offering innovative technologies such as DNA-PAINT and DNA-Exchange. These technologies enable researchers to capture high-resolution microscopic images, facilitating a deeper understanding of biological processes and medical diagnostics. Ultivue's products are designed for use in fluorescent microscopy-based research, with the potential for significant applications in clinical diagnostics. The company's multiplex biomarker assays aid in tissue phenotyping and digital pathology, integrating validated antibodies and advanced analytics to support personalized medicine and enhance research discoveries related to complex tumor microenvironments.

Karuna Therapeutics is a clinical-stage biopharmaceutical company based in Boston, Massachusetts, dedicated to developing innovative therapies for neuropsychiatric disorders and pain. Its lead product candidate, KarXT, is an oral modulator that has completed a Phase II clinical trial for treating acute psychosis in schizophrenia patients and is undergoing a Phase Ib clinical trial for various central nervous system disorders, including cognitive and negative symptoms of schizophrenia, Alzheimer’s, and dementia-related psychosis. The company is also developing additional muscarinic-targeted drug candidates to address unmet medical needs in these areas. Founded in 2009, Karuna Therapeutics has established partnerships with organizations such as Eli Lilly and Company and PureTech Health LLC, focusing on advancing its drug discovery efforts through collaborations with Charles River Laboratories and PsychoGenics Inc.

Beam Therapeutics Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing precision genetic medicines using its innovative base editing technology. Founded in 2017, the company aims to provide lifelong cures for patients with serious diseases. Its therapeutic portfolio includes treatments for sickle cell disease, beta-thalassemia, pediatric T-cell acute lymphoblastic leukemia, pediatric acute myeloid leukemia, alpha-1 antitrypsin deficiency, and glycogen storage disorder 1A, as well as therapies for ocular and central nervous system disorders. Beam's base editing technology allows for targeted modifications at a single base in the genome without creating double-stranded breaks in DNA, positioning it as a pioneer in the field of genetic medicine. The company's pipeline includes several programs, such as BEAM-101, ESCAPE, BEAM-302, BEAM-301, and BEAM-201, reflecting its commitment to advancing genetic therapies.

HiberCell, Inc. is a biotechnology company established in 2019 and located in New York. The company focuses on developing innovative therapeutics aimed at preventing cancer relapse and metastasis, which are significant contributors to cancer-related mortality. HiberCell's therapeutic pipeline targets adaptive stress pathways and immune modulation to address the mechanisms of treatment resistance. By employing artificial intelligence and machine learning, the company integrates multi-omic and phenotypic profiles of tumors to generate insights that link these characteristics to clinical outcomes. This approach aims to enhance patient outcomes, enabling individuals to lead longer, cancer-free lives.

Sana Biotechnology is a biotechnology company based in Seattle, Washington, with additional offices in South San Francisco, California, and Cambridge, Massachusetts. Founded in 2018, the company specializes in developing engineered cells as medicines to treat a variety of diseases. Sana Biotechnology focuses on reprogramming cells in the body and replacing damaged cells and tissues, leveraging recent scientific advancements to create new therapeutic options. The company's research spans multiple therapeutic areas with significant unmet needs, including oncology, diabetes, B-cell-mediated autoimmune disorders, and central nervous system conditions. Its pipeline includes various product candidates aimed at addressing these challenges through innovative cell engineering programs.

Glympse Bio, Inc. is a diagnostic company based in Cambridge, Massachusetts, that focuses on developing modular nanoparticle sensors for noninvasive disease monitoring. Founded in 2015, the company creates engineered diagnostic agents designed to interrogate the body for specific disease states, subsequently conveying this information through urine analysis. This innovative approach facilitates the monitoring of various conditions, including fibrosis, cancer, immunology, and infectious diseases, while also assessing drug responses. Glympse Bio's flagship product, Glympse Inside, serves as a pan-disease platform aimed at revolutionizing how diseases are monitored and treated. The technology was initially developed at MIT and is supported by a team of experts in nanomedicine and biomedical engineering.

KSQ Therapeutics, based in Cambridge, Massachusetts, specializes in precision functional genomics to discover innovative drug therapies. Founded in 2015, the company employs its proprietary CRISPRomics™ drug discovery engine to gain insights into the role of human genes across various diseases. This comprehensive understanding of disease biology allows KSQ to identify and validate high-confidence, patient-specific drug targets, enhancing the drug development process by focusing on candidates with the greatest therapeutic potential. The company has initiated several preclinical discovery programs aimed at developing novel medications that could significantly improve patient outcomes.

Magnolia Neurosciences aims to discover and develop proprietary, selective, and drug-like small molecule therapeutics for the prevention of neuronal cell death, thereby providing novel treatment options for patients suffering from neurodegeneration and related conditions. Magnolia Neurosciences Corporation, created to pursue technologies developed at The University of Texas MD Anderson Cancer Center’s Therapeutics Discovery Division and the Neurodegeneration Consortium (NDC), is a New York-based Accelerator Life Science Partner portfolio company.

Cytrellis Biosystems, Inc. is a clinical stage medical technology company that focuses on the design and development of devices for dermatology, scar reduction, and aesthetic medicine. Founded in 2011 and headquartered in Sherborn, Massachusetts, the company aims to address age-related skin issues by offering non-surgical solutions to remove sagging skin without causing scarring. Its innovative devices provide aesthetic practitioners with advanced tools to enhance skin appearance, thereby improving patient outcomes in the field of aesthetic medicine.

Beam Therapeutics Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing precision genetic medicines using its innovative base editing technology. Founded in 2017, the company aims to provide lifelong cures for patients with serious diseases. Its therapeutic portfolio includes treatments for sickle cell disease, beta-thalassemia, pediatric T-cell acute lymphoblastic leukemia, pediatric acute myeloid leukemia, alpha-1 antitrypsin deficiency, and glycogen storage disorder 1A, as well as therapies for ocular and central nervous system disorders. Beam's base editing technology allows for targeted modifications at a single base in the genome without creating double-stranded breaks in DNA, positioning it as a pioneer in the field of genetic medicine. The company's pipeline includes several programs, such as BEAM-101, ESCAPE, BEAM-302, BEAM-301, and BEAM-201, reflecting its commitment to advancing genetic therapies.

Ultivue, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in the development and manufacture of reagents for marker multiplexing detection and analysis in the life sciences and biomedical fields. Founded in 2015, Ultivue focuses on tissue imaging and diagnostics, offering innovative technologies such as DNA-PAINT and DNA-Exchange. These technologies enable researchers to capture high-resolution microscopic images, facilitating a deeper understanding of biological processes and medical diagnostics. Ultivue's products are designed for use in fluorescent microscopy-based research, with the potential for significant applications in clinical diagnostics. The company's multiplex biomarker assays aid in tissue phenotyping and digital pathology, integrating validated antibodies and advanced analytics to support personalized medicine and enhance research discoveries related to complex tumor microenvironments.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, who typically rely on insulin injections. The company was founded based on groundbreaking research by Professor Douglas Melton, which enabled the generation of functional, insulin-producing beta cells in the laboratory. This technology has been exclusively licensed to Semma Therapeutics, and the company aims to combine these proprietary cells with advanced devices to create a functional replacement for the missing beta cells without the need for immunosuppression. Headquartered in Cambridge, Massachusetts, with an additional office in Boston, Semma Therapeutics operates as a subsidiary of Vertex Pharmaceuticals and is dedicated to advancing this new therapeutic option to improve the lives of diabetes patients.

Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics, a new class of medicines with the potential to transform the treatment of a wide spectrum of diseases with high unmet medical need. By leveraging the biology of exosomes as natural intercellular transfer mechanisms, Codiak has developed its proprietary engEx Platform to expand upon the innate properties of exosomes to design, engineer and manufacture novel exosome therapeutic candidates. Codiak has utilized its engEx Platform to generate a deep pipeline of engineered exosomes aimed at treating a broad range of disease areas, spanning oncology, neuro-oncology, neurology, neuromuscular disease and infectious disease.

ImmusanT is a biotechnology company that develops diagnostics and therapeutics for the diagnosis and treatment of celiac disease. The company focuses on restoring tolerance to gluten in celiac disease by harnessing new discoveries in immunology that improve diagnosis and treatment. It develops Nexvax2, a therapeutic vaccine for treating, preventing, and diagnosing celiac disease. The company also develops a functional T-cell test to diagnose and monitor the maintenance of immune tolerance with peptide based therapy. ImmusanT was incorporated in 2010 and is based in Cambridge, Massachusetts.

KSQ Therapeutics, based in Cambridge, Massachusetts, specializes in precision functional genomics to discover innovative drug therapies. Founded in 2015, the company employs its proprietary CRISPRomics™ drug discovery engine to gain insights into the role of human genes across various diseases. This comprehensive understanding of disease biology allows KSQ to identify and validate high-confidence, patient-specific drug targets, enhancing the drug development process by focusing on candidates with the greatest therapeutic potential. The company has initiated several preclinical discovery programs aimed at developing novel medications that could significantly improve patient outcomes.

LifeMine Therapeutics, Inc. is a biotechnology company focused on discovering new drug modalities from eukaryotic microbes, particularly fungi. Founded in 2016 and headquartered in Cambridge, Massachusetts, with an additional office in New York, the company employs an integrated platform that combines genomics, artificial intelligence, and synthetic biology. This innovative Avatar-Rx platform utilizes high-throughput microbiology, data science, machine learning, genome engineering, and automation to explore the fungal biosphere for novel genetically encoded molecules with specific biological functions. By integrating chemoinformatic-assisted drug optimization and advanced chemical synthesis with biotransformation, LifeMine Therapeutics aims to advance a pipeline of new medicines into development.

Arbor Biotechnologies, Inc., founded in 2016 and based in Cambridge, Massachusetts, operates within the biotechnology sector, focusing on bio-discovery and human diagnostic development. The company utilizes a range of advanced technologies, including artificial intelligence, genome sequencing, gene synthesis, and high-throughput screening, to facilitate the discovery of proteins aimed at enhancing human health and sustainability. Arbor's proprietary genomic tools leverage AI and machine learning to analyze genomic sequence data, thereby improving the efficiency of developing curative treatments for genetic diseases. These innovations enable drug developers to replace entire genes and precisely correct mutations, ultimately addressing previously untreatable genetic conditions.

Egenesis Inc. is a biotechnology company focused on gene editing and genome engineering to create human transplantable organs, tissues, and cells. Established in 2015 and headquartered in Cambridge, Massachusetts, with an additional office in New York City, Egenesis aims to address the global organ shortage by developing solid organs and therapeutic cell transplantation solutions for various diseases. The company utilizes a gene editing platform that incorporates techniques such as single-cell cloning and somatic cell nuclear transfer, which are essential for creating human-compatible organ tissues and cells. Egenesis is particularly engaged in advancing programs related to kidney and islet cell transplantation, striving to provide alternative treatment options for patients with life-threatening conditions.

908 Devices Inc. is a Boston-based company that specializes in the development and sale of handheld and desktop measurement devices for chemical and biochemical analysis. Founded in 2012, the company leverages mass spectrometry technology to create portable tools designed for immediate application in various fields, including life sciences research, bioprocessing, industrial biotechnology, and forensics. Its product lineup includes the MX908, a battery-powered, handheld mass spectrometry device capable of rapid analysis of unknown gas, liquid, and solid materials; the Rebel, a desktop analyzer offering real-time data on bioprocess environments; and the ZipChip, a high-resolution separation platform that enhances mass spectrometry sample analysis. 908 Devices aims to provide reliable and actionable insights in challenging environments, meeting the needs of professionals who require efficient solutions for complex analytical tasks.

VBI Vaccines Inc. is a biopharmaceutical company focused on developing and commercializing vaccines for infectious diseases and immuno-oncology, operating in Israel, the United States, and internationally. The company’s flagship product, Sci-B-Vac, is a commercial-stage hepatitis B vaccine that effectively mimics all three viral surface antigens, providing rapid protection and high antibody levels with lower dosing requirements compared to traditional vaccines. VBI's innovative enveloped virus-like particle (eVLP) platform technology facilitates the creation of vaccines that closely resemble target viruses, enhancing immune responses. The company is advancing several clinical programs, including VBI-1901, an immunotherapeutic candidate for glioblastoma, and VBI-1501, a prophylactic vaccine for cytomegalovirus. VBI collaborates with various organizations, including Brii Biosciences and GlaxoSmithKline, and partners with the National Research Council of Canada to develop a pan-coronavirus vaccine. Headquartered in Cambridge, Massachusetts, VBI Vaccines Inc. aims to address unmet medical needs through its innovative vaccine solutions.

Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics, a new class of medicines with the potential to transform the treatment of a wide spectrum of diseases with high unmet medical need. By leveraging the biology of exosomes as natural intercellular transfer mechanisms, Codiak has developed its proprietary engEx Platform to expand upon the innate properties of exosomes to design, engineer and manufacture novel exosome therapeutic candidates. Codiak has utilized its engEx Platform to generate a deep pipeline of engineered exosomes aimed at treating a broad range of disease areas, spanning oncology, neuro-oncology, neurology, neuromuscular disease and infectious disease.

Lodo Therapeutics Corporation is a drug discovery and development company focused on the creation of naturally derived novel therapeutics that will have a dramatic impact human health on a global basis. Lodo seeks to work in partnership with global pharmaceutical companies and world leading Non-Governmental Organizations (NGO’s) to tackle some of the greatest challenges in human health: resistant infectious disease and cancers. Lodo Therapeutics was created to pursue the scientific vision of Dr. Sean Brady at Rockefeller University. Dr. Brady and his laboratory have developed a genome-based, culture-independent platform for the discovery, biosynthesis, and characterization of small molecules from microbial sources present in soil samples. Lodo believes that the potential cures for a number of deadly and/or debilitating diseases literally lie at our feet. By combining the advancements in DNA sequencing and bioinformatics, this innovative discovery platform exploits the power of microbial evolution for the identification of therapeutically valuable pharmaceutical products derived from natural sources. Lodo Therapeutics, an Accelerator Corporation-backed entity, is headquartered in New York City. The company’s lab and offices are located in the Alexandria Center for Life Science, New York City’s first and only premier life science park.

Petra Pharma Corporation is a clinical-stage pharmaceutical company based in New York that focuses on discovering and developing therapies targeting phosphoinositide (PI) signaling pathways. Established in 2015, the company aims to create novel small molecules that address serious medical conditions, particularly cancer and metabolic diseases. By honing in on unique enzyme targets involved in critical cellular processes such as cell division, growth, trafficking, and signaling, Petra Pharma seeks to develop innovative treatments that can enhance human health and provide new options for healthcare providers.

Scholar Rock is a biotechnology company focused on discovering and developing innovative therapies that target dysregulated growth factors within disease microenvironments. Founded in 2012 and based in Cambridge, Massachusetts, the company employs a proprietary platform to create monoclonal antibodies that selectively modulate the activation of these signaling proteins. This approach aims to avoid traditional challenges associated with growth factor inhibition while facilitating efficient drug development. Scholar Rock's lead product, SRK-015, is designed as a first-in-class inhibitor of myostatin activation, targeting conditions such as spinal muscular atrophy. The company's pipeline includes additional candidates, such as SRK-181, which inhibits latent transforming growth factor beta-1 for cancer treatment. Scholar Rock's research focuses on serious diseases, including neuromuscular disorders, cancer, fibrosis, and autoimmune diseases, reflecting its commitment to transforming patient outcomes through targeted therapies.

Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics, a new class of medicines with the potential to transform the treatment of a wide spectrum of diseases with high unmet medical need. By leveraging the biology of exosomes as natural intercellular transfer mechanisms, Codiak has developed its proprietary engEx Platform to expand upon the innate properties of exosomes to design, engineer and manufacture novel exosome therapeutic candidates. Codiak has utilized its engEx Platform to generate a deep pipeline of engineered exosomes aimed at treating a broad range of disease areas, spanning oncology, neuro-oncology, neurology, neuromuscular disease and infectious disease.

Ultivue, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in the development and manufacture of reagents for marker multiplexing detection and analysis in the life sciences and biomedical fields. Founded in 2015, Ultivue focuses on tissue imaging and diagnostics, offering innovative technologies such as DNA-PAINT and DNA-Exchange. These technologies enable researchers to capture high-resolution microscopic images, facilitating a deeper understanding of biological processes and medical diagnostics. Ultivue's products are designed for use in fluorescent microscopy-based research, with the potential for significant applications in clinical diagnostics. The company's multiplex biomarker assays aid in tissue phenotyping and digital pathology, integrating validated antibodies and advanced analytics to support personalized medicine and enhance research discoveries related to complex tumor microenvironments.

PRIME Coalition is a not-for-profit venture capital firm established in 2014 and based in Cambridge, Massachusetts. As a 501(c)(3) public charity, it focuses on making minority early-stage investments in companies, particularly in the cleantech, business services, and energy services sectors within the United States. The organization aims to support innovative ventures that are positioned to address pressing environmental challenges and promote sustainable practices. Through its investments, PRIME Coalition seeks to foster the development of technologies and services that can contribute to a more sustainable future.

Pulmatrix, Inc. is a clinical-stage biopharmaceutical company based in Lexington, Massachusetts, specializing in the development of inhaled therapies for serious pulmonary diseases. Utilizing its proprietary iSPERSE technology, Pulmatrix focuses on creating innovative dry powder delivery systems to enhance therapeutic delivery to the lungs. The company's product pipeline includes Pulmazole, an inhaled anti-fungal treatment for patients with allergic bronchopulmonary aspergillosis, and PUR1800, a narrow-spectrum kinase inhibitor aimed at treating obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. Pulmatrix has established partnerships with RespiVert Ltd. for the development of kinase inhibitors and with Cipla Technologies LLC to commercialize Pulmazole. Founded in 2003, Pulmatrix aims to address significant unmet medical needs in respiratory health through its advanced therapeutic solutions.

908 Devices Inc. is a Boston-based company that specializes in the development and sale of handheld and desktop measurement devices for chemical and biochemical analysis. Founded in 2012, the company leverages mass spectrometry technology to create portable tools designed for immediate application in various fields, including life sciences research, bioprocessing, industrial biotechnology, and forensics. Its product lineup includes the MX908, a battery-powered, handheld mass spectrometry device capable of rapid analysis of unknown gas, liquid, and solid materials; the Rebel, a desktop analyzer offering real-time data on bioprocess environments; and the ZipChip, a high-resolution separation platform that enhances mass spectrometry sample analysis. 908 Devices aims to provide reliable and actionable insights in challenging environments, meeting the needs of professionals who require efficient solutions for complex analytical tasks.

Semma Therapeutics, Inc. is focused on developing innovative cell therapies for patients with Type 1 diabetes, who typically rely on insulin injections. The company was founded based on groundbreaking research by Professor Douglas Melton, which enabled the generation of functional, insulin-producing beta cells in the laboratory. This technology has been exclusively licensed to Semma Therapeutics, and the company aims to combine these proprietary cells with advanced devices to create a functional replacement for the missing beta cells without the need for immunosuppression. Headquartered in Cambridge, Massachusetts, with an additional office in Boston, Semma Therapeutics operates as a subsidiary of Vertex Pharmaceuticals and is dedicated to advancing this new therapeutic option to improve the lives of diabetes patients.

Chiasma, Inc. is a late-stage biopharmaceutical company based in Needham, Massachusetts, that specializes in developing oral medications for rare and serious chronic diseases. Utilizing its proprietary Transient Permeability Enhancer technology, Chiasma aims to transform injectable drugs into oral formulations, enhancing their absorption and potentially enabling new therapeutic indications. The company is currently focused on MYCAPSSA, an oral octreotide capsule designed for adult patients with acromegaly, a condition characterized by excessive growth hormone production. MYCAPSSA is undergoing Phase III clinical trials in the United States and is also in the process of seeking regulatory approval in the European Union. Founded in 2001, Chiasma is dedicated to improving treatment options for patients with debilitating conditions through innovative drug delivery methods.

Cytrellis Biosystems, Inc. is a clinical stage medical technology company that focuses on the design and development of devices for dermatology, scar reduction, and aesthetic medicine. Founded in 2011 and headquartered in Sherborn, Massachusetts, the company aims to address age-related skin issues by offering non-surgical solutions to remove sagging skin without causing scarring. Its innovative devices provide aesthetic practitioners with advanced tools to enhance skin appearance, thereby improving patient outcomes in the field of aesthetic medicine.

Scholar Rock is a biotechnology company focused on discovering and developing innovative therapies that target dysregulated growth factors within disease microenvironments. Founded in 2012 and based in Cambridge, Massachusetts, the company employs a proprietary platform to create monoclonal antibodies that selectively modulate the activation of these signaling proteins. This approach aims to avoid traditional challenges associated with growth factor inhibition while facilitating efficient drug development. Scholar Rock's lead product, SRK-015, is designed as a first-in-class inhibitor of myostatin activation, targeting conditions such as spinal muscular atrophy. The company's pipeline includes additional candidates, such as SRK-181, which inhibits latent transforming growth factor beta-1 for cancer treatment. Scholar Rock's research focuses on serious diseases, including neuromuscular disorders, cancer, fibrosis, and autoimmune diseases, reflecting its commitment to transforming patient outcomes through targeted therapies.

Juno is a clinical-stage company that brings together three of the world’s leading cancer centers – Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and Seattle Children’s Research Institute – in unique partnership to advance a broad pipeline of breakthrough immunotherapies. With one of the largest ever Series A investments for a biotech startup, Juno will build on the foundation of novel immunotherapies to develop two distinct and complementary platforms – CARs and TCRs.

SAGE Therapeutics is a biopharmaceutical company focused on developing innovative treatments for central nervous system (CNS) disorders. The company's lead product is ZULRESSO, an intravenous formulation of brexanolone designed for treating postpartum depression. SAGE's pipeline includes several advanced candidates, such as SAGE-217, currently in Phase III trials for various depressive disorders and anxiety, and SAGE-324, which is in Phase II trials for essential tremors. Additionally, SAGE-718 is being explored for multiple conditions, including depression and Alzheimer's disease, having completed its Phase I trials. The company has established strategic collaborations with Shionogi & Co., Ltd. and Biogen Inc. to enhance the development and commercialization of its therapies. Founded in 2010 and headquartered in Cambridge, Massachusetts, SAGE Therapeutics aims to address significant unmet needs in brain health through its scientific innovations and partnerships.

Bellerophon Therapeutics, Inc. is a clinical-stage therapeutics company based in Warren, New Jersey, focused on developing innovative treatments for cardiopulmonary diseases. The company's primary product is INOpulse, a proprietary pulsatile nitric oxide delivery platform designed to address various forms of pulmonary hypertension. Currently, INOpulse is undergoing multiple Phase 2 clinical trials, targeting pulmonary hypertension associated with interstitial lung disease, chronic obstructive pulmonary disease, sarcoidosis, chronic thromboembolic pulmonary hypertension, and pulmonary hypertension related to high altitude sickness and COVID-19. In addition to INOpulse, Bellerophon is also developing a bioabsorbable cardiac matrix (BCM), an injectable device aimed at preventing cardiac remodeling and congestive heart failure following myocardial infarction. Bellerophon was established in 2009 and previously operated as Ikaria Development LLC before rebranding in 2014.

Juno is a clinical-stage company that brings together three of the world’s leading cancer centers – Fred Hutchinson Cancer Research Center, Memorial Sloan-Kettering Cancer Center and Seattle Children’s Research Institute – in unique partnership to advance a broad pipeline of breakthrough immunotherapies. With one of the largest ever Series A investments for a biotech startup, Juno will build on the foundation of novel immunotherapies to develop two distinct and complementary platforms – CARs and TCRs.

908 Devices Inc. is a Boston-based company that specializes in the development and sale of handheld and desktop measurement devices for chemical and biochemical analysis. Founded in 2012, the company leverages mass spectrometry technology to create portable tools designed for immediate application in various fields, including life sciences research, bioprocessing, industrial biotechnology, and forensics. Its product lineup includes the MX908, a battery-powered, handheld mass spectrometry device capable of rapid analysis of unknown gas, liquid, and solid materials; the Rebel, a desktop analyzer offering real-time data on bioprocess environments; and the ZipChip, a high-resolution separation platform that enhances mass spectrometry sample analysis. 908 Devices aims to provide reliable and actionable insights in challenging environments, meeting the needs of professionals who require efficient solutions for complex analytical tasks.

908 Devices Inc. is a Boston-based company that specializes in the development and sale of handheld and desktop measurement devices for chemical and biochemical analysis. Founded in 2012, the company leverages mass spectrometry technology to create portable tools designed for immediate application in various fields, including life sciences research, bioprocessing, industrial biotechnology, and forensics. Its product lineup includes the MX908, a battery-powered, handheld mass spectrometry device capable of rapid analysis of unknown gas, liquid, and solid materials; the Rebel, a desktop analyzer offering real-time data on bioprocess environments; and the ZipChip, a high-resolution separation platform that enhances mass spectrometry sample analysis. 908 Devices aims to provide reliable and actionable insights in challenging environments, meeting the needs of professionals who require efficient solutions for complex analytical tasks.

Bluebird Bio is a biotechnology company focused on the research, development, and commercialization of innovative gene therapies for severe genetic diseases and cancer. Its gene therapy programs include LentiGlobin, aimed at treating β-thalassemia and sickle cell disease, and Lenti-D, for cerebral adrenoleukodystrophy. In oncology, Bluebird Bio is developing chimeric antigen receptor T (CAR T) cell therapies, specifically bb2121 and bb21217, for multiple myeloma. The company collaborates with several partners, including Bristol-Myers Squibb and Regeneron Pharmaceuticals, to discover and commercialize disease-altering therapies. Additional collaborations with organizations such as Medigene AG and Gritstone Oncology focus on developing T cell receptor product candidates for cancer treatment. Founded in 1992 and headquartered in Cambridge, Massachusetts, Bluebird Bio aims to fundamentally address the genetic basis of diseases through its proprietary lentiviral vector gene addition platform. Revenue is generated from collaboration agreements, research fees, license fees, and grants.

Chiasma, Inc. is a late-stage biopharmaceutical company based in Needham, Massachusetts, that specializes in developing oral medications for rare and serious chronic diseases. Utilizing its proprietary Transient Permeability Enhancer technology, Chiasma aims to transform injectable drugs into oral formulations, enhancing their absorption and potentially enabling new therapeutic indications. The company is currently focused on MYCAPSSA, an oral octreotide capsule designed for adult patients with acromegaly, a condition characterized by excessive growth hormone production. MYCAPSSA is undergoing Phase III clinical trials in the United States and is also in the process of seeking regulatory approval in the European Union. Founded in 2001, Chiasma is dedicated to improving treatment options for patients with debilitating conditions through innovative drug delivery methods.

Agios Pharmaceuticals is a biopharmaceutical company based in Cambridge, Massachusetts, specializing in the discovery and development of medicines targeting cellular metabolism and related areas, including hematologic malignancies, solid tumors, and rare genetic diseases. The company offers TIBSOVO, an oral targeted inhibitor for treating relapsed or refractory acute myeloid leukemia (AML) in adult patients, and IDHIFA, which is also aimed at AML patients with specific mutations. Agios is advancing several drug candidates through various stages of clinical trials, including TIBSOVO for frontline AML and cholangiocarcinoma, mitapivat for pyruvate kinase deficiency and thalassemia, and vorasidenib for solid tumors. The company emphasizes a precision medicine approach, focusing on genetically or biomarker-defined patient populations to enhance the potential for early proof of concept and accelerated approval. Agios Pharmaceuticals was established in 2007 and has evolved from its original name, Cancer Metabolism Therapeutics, to its current identity.

Pulmatrix, Inc. is a clinical-stage biopharmaceutical company based in Lexington, Massachusetts, specializing in the development of inhaled therapies for serious pulmonary diseases. Utilizing its proprietary iSPERSE technology, Pulmatrix focuses on creating innovative dry powder delivery systems to enhance therapeutic delivery to the lungs. The company's product pipeline includes Pulmazole, an inhaled anti-fungal treatment for patients with allergic bronchopulmonary aspergillosis, and PUR1800, a narrow-spectrum kinase inhibitor aimed at treating obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. Pulmatrix has established partnerships with RespiVert Ltd. for the development of kinase inhibitors and with Cipla Technologies LLC to commercialize Pulmazole. Founded in 2003, Pulmatrix aims to address significant unmet medical needs in respiratory health through its advanced therapeutic solutions.

Bluebird Bio is a biotechnology company focused on the research, development, and commercialization of innovative gene therapies for severe genetic diseases and cancer. Its gene therapy programs include LentiGlobin, aimed at treating β-thalassemia and sickle cell disease, and Lenti-D, for cerebral adrenoleukodystrophy. In oncology, Bluebird Bio is developing chimeric antigen receptor T (CAR T) cell therapies, specifically bb2121 and bb21217, for multiple myeloma. The company collaborates with several partners, including Bristol-Myers Squibb and Regeneron Pharmaceuticals, to discover and commercialize disease-altering therapies. Additional collaborations with organizations such as Medigene AG and Gritstone Oncology focus on developing T cell receptor product candidates for cancer treatment. Founded in 1992 and headquartered in Cambridge, Massachusetts, Bluebird Bio aims to fundamentally address the genetic basis of diseases through its proprietary lentiviral vector gene addition platform. Revenue is generated from collaboration agreements, research fees, license fees, and grants.

Kilimanjaro Energy, Inc., a research and development company, engages in the demonstration, commercialization, and promulgation of the air-capture technology for the capture of carbon dioxide (CO2) from the atmosphere. It focuses on the development of ACCESS, an atmospheric carbon capture system. The company was formerly known as Global Research Technologies, LLC. Kilimanjaro Energy was founded in 2004 and is based in Waukesha, Wisconsin with a development and business presence in New York, New York, as well as administrative offices, a research laboratory, and a prototype development and demonstration area in Tucson, Arizona.

Pulmatrix, Inc. is a clinical-stage biopharmaceutical company based in Lexington, Massachusetts, specializing in the development of inhaled therapies for serious pulmonary diseases. Utilizing its proprietary iSPERSE technology, Pulmatrix focuses on creating innovative dry powder delivery systems to enhance therapeutic delivery to the lungs. The company's product pipeline includes Pulmazole, an inhaled anti-fungal treatment for patients with allergic bronchopulmonary aspergillosis, and PUR1800, a narrow-spectrum kinase inhibitor aimed at treating obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. Pulmatrix has established partnerships with RespiVert Ltd. for the development of kinase inhibitors and with Cipla Technologies LLC to commercialize Pulmazole. Founded in 2003, Pulmatrix aims to address significant unmet medical needs in respiratory health through its advanced therapeutic solutions.

Agios Pharmaceuticals is a biopharmaceutical company based in Cambridge, Massachusetts, specializing in the discovery and development of medicines targeting cellular metabolism and related areas, including hematologic malignancies, solid tumors, and rare genetic diseases. The company offers TIBSOVO, an oral targeted inhibitor for treating relapsed or refractory acute myeloid leukemia (AML) in adult patients, and IDHIFA, which is also aimed at AML patients with specific mutations. Agios is advancing several drug candidates through various stages of clinical trials, including TIBSOVO for frontline AML and cholangiocarcinoma, mitapivat for pyruvate kinase deficiency and thalassemia, and vorasidenib for solid tumors. The company emphasizes a precision medicine approach, focusing on genetically or biomarker-defined patient populations to enhance the potential for early proof of concept and accelerated approval. Agios Pharmaceuticals was established in 2007 and has evolved from its original name, Cancer Metabolism Therapeutics, to its current identity.

VBI Vaccines Inc. is a biopharmaceutical company focused on developing and commercializing vaccines for infectious diseases and immuno-oncology, operating in Israel, the United States, and internationally. The company’s flagship product, Sci-B-Vac, is a commercial-stage hepatitis B vaccine that effectively mimics all three viral surface antigens, providing rapid protection and high antibody levels with lower dosing requirements compared to traditional vaccines. VBI's innovative enveloped virus-like particle (eVLP) platform technology facilitates the creation of vaccines that closely resemble target viruses, enhancing immune responses. The company is advancing several clinical programs, including VBI-1901, an immunotherapeutic candidate for glioblastoma, and VBI-1501, a prophylactic vaccine for cytomegalovirus. VBI collaborates with various organizations, including Brii Biosciences and GlaxoSmithKline, and partners with the National Research Council of Canada to develop a pan-coronavirus vaccine. Headquartered in Cambridge, Massachusetts, VBI Vaccines Inc. aims to address unmet medical needs through its innovative vaccine solutions.

Chiasma, Inc. is a late-stage biopharmaceutical company based in Needham, Massachusetts, that specializes in developing oral medications for rare and serious chronic diseases. Utilizing its proprietary Transient Permeability Enhancer technology, Chiasma aims to transform injectable drugs into oral formulations, enhancing their absorption and potentially enabling new therapeutic indications. The company is currently focused on MYCAPSSA, an oral octreotide capsule designed for adult patients with acromegaly, a condition characterized by excessive growth hormone production. MYCAPSSA is undergoing Phase III clinical trials in the United States and is also in the process of seeking regulatory approval in the European Union. Founded in 2001, Chiasma is dedicated to improving treatment options for patients with debilitating conditions through innovative drug delivery methods.

Magen BioSciences is a biotechnology company based in Waltham, Massachusetts, focused on developing pharmaceutical products aimed at enhancing human skin health. Utilizing a science-driven approach, the company leverages its comprehensive understanding of both normal and diseased skin biology to create solutions that improve the health and appearance of the skin.

AmberWave, Inc. is a research and development company specializing in photovoltaic technology solutions and semiconductor manufacturing, aimed at serving commercial and industrial sectors, as well as unmanned aerial vehicles. Founded in 1998 and headquartered in Ipswich, Massachusetts, the company focuses on advanced substrate engineering for integrated circuits, semiconductor lighting, and photovoltaics. AmberWave’s notable technologies include Strained Silicon, which enhances microchip performance while reducing power consumption, and Aspect Ratio Trapping, utilized in the production of silicon-based photonics and photovoltaic cells. Previously known as AmberWave Systems Corporation, the company rebranded in 2010 and continues to develop high-value materials for emerging markets and applications.

SilverStorm Technologies provides networking and clustered interconnect solutions for high performance business computing markets. It designs and manufactures an InfiniBand based set of solutions for the performance and I/O requirements of data center environments that utilize clustered topologies. The company markets its products through direct sales, and channel and technology partners globally. SilverStorm Technologies, Inc. was founded as InfiniCon Systems, Inc. in 2000 and changed its name to SilverStorm Technologies, Inc. in 2005. The company is headquartered in King of Prussia, Pennsylvania. As of November 01, 2006, SilverStorm Technologies, Inc. operates as a subsidiary of QLogic Corp.

AmberWave, Inc. is a research and development company specializing in photovoltaic technology solutions and semiconductor manufacturing, aimed at serving commercial and industrial sectors, as well as unmanned aerial vehicles. Founded in 1998 and headquartered in Ipswich, Massachusetts, the company focuses on advanced substrate engineering for integrated circuits, semiconductor lighting, and photovoltaics. AmberWave’s notable technologies include Strained Silicon, which enhances microchip performance while reducing power consumption, and Aspect Ratio Trapping, utilized in the production of silicon-based photonics and photovoltaic cells. Previously known as AmberWave Systems Corporation, the company rebranded in 2010 and continues to develop high-value materials for emerging markets and applications.

Ensemble Therapeutics Corporation is engaged in the discovery and development of small molecule therapies aimed at treating cancer and other serious diseases. The company focuses on creating innovative therapies, particularly in the field of immuno-oncology, targeting mechanisms such as Indoleamine 2, 3-dioxygenase 1 (IDO-1) and components of the ubiquitin proteasome system. Its pipeline includes treatments that inhibit apoptosis-promoting proteins, which can prevent tumor cell death, as well as targeting Cyclophilins that aid in protein folding. Founded in 2002 and based in Cambridge, Massachusetts, Ensemble Therapeutics aims to provide safe and effective treatment options by addressing previously inaccessible drug targets. The company changed its name from Ensemble Discovery Corporation in June 2010.

As of December 2007, Reef Point Systems, Inc. was acquired by NextPoint Networks, Inc. Reef Point Systems, Inc. provides security solutions for converged wireless and wireline networks in the United States. Its iQ product portfolio enables fixed/mobile convergence security, secure mobile access, network infrastructure protection, and managed security services. It enables operators to secure voice over the Internet protocol, Internet protocol television, and voice, video, and data services from a converged Internet protocol infrastructure. The company’s iQ family lets wireless service providers protect the wireless network infrastructure and deliver multimedia services for mobile users over unlicensed mobile access and Internet protocol multimedia subsystem infrastructure. Its products also enable service providers to offer various security services, including virtual private networks, firewalls, denial of service attack prevention, content filtering, and remote access. The company, formerly known as Quarry Technologies, Inc., was founded in 1998 and is headquartered in Burlington, Massachusetts.

Alnylam Pharmaceuticals is a biopharmaceutical company that specializes in the discovery, development, and commercialization of RNA interference (RNAi) therapeutics. The company focuses on addressing rare genetic disorders and diseases affecting the cardiovascular, hepatic, and central nervous systems. Its marketed products include ONPATTRO, which treats hereditary transthyretin-mediated amyloidosis, and GIVLAARI, aimed at adults with acute hepatic porphyria. Additionally, Alnylam is advancing several investigational therapies, such as givosiran for acute hepatic porphyria, lumasiran for primary hyperoxaluria type 1, and vutrisiran for transthyretin amyloidosis. The company has established strategic alliances with organizations such as Sanofi Genzyme and Regeneron Pharmaceuticals to further its RNAi therapeutic developments. Founded in 2002 and headquartered in Cambridge, Massachusetts, Alnylam Pharmaceuticals is recognized as a leader in the RNAi therapeutic field, leveraging Nobel Prize-winning science to create innovative medicines for severe diseases.

SilverStorm Technologies provides networking and clustered interconnect solutions for high performance business computing markets. It designs and manufactures an InfiniBand based set of solutions for the performance and I/O requirements of data center environments that utilize clustered topologies. The company markets its products through direct sales, and channel and technology partners globally. SilverStorm Technologies, Inc. was founded as InfiniCon Systems, Inc. in 2000 and changed its name to SilverStorm Technologies, Inc. in 2005. The company is headquartered in King of Prussia, Pennsylvania. As of November 01, 2006, SilverStorm Technologies, Inc. operates as a subsidiary of QLogic Corp.

AmberWave, Inc. is a research and development company specializing in photovoltaic technology solutions and semiconductor manufacturing, aimed at serving commercial and industrial sectors, as well as unmanned aerial vehicles. Founded in 1998 and headquartered in Ipswich, Massachusetts, the company focuses on advanced substrate engineering for integrated circuits, semiconductor lighting, and photovoltaics. AmberWave’s notable technologies include Strained Silicon, which enhances microchip performance while reducing power consumption, and Aspect Ratio Trapping, utilized in the production of silicon-based photonics and photovoltaic cells. Previously known as AmberWave Systems Corporation, the company rebranded in 2010 and continues to develop high-value materials for emerging markets and applications.

AmberWave, Inc. is a research and development company specializing in photovoltaic technology solutions and semiconductor manufacturing, aimed at serving commercial and industrial sectors, as well as unmanned aerial vehicles. Founded in 1998 and headquartered in Ipswich, Massachusetts, the company focuses on advanced substrate engineering for integrated circuits, semiconductor lighting, and photovoltaics. AmberWave’s notable technologies include Strained Silicon, which enhances microchip performance while reducing power consumption, and Aspect Ratio Trapping, utilized in the production of silicon-based photonics and photovoltaic cells. Previously known as AmberWave Systems Corporation, the company rebranded in 2010 and continues to develop high-value materials for emerging markets and applications.

As of December 2007, Reef Point Systems, Inc. was acquired by NextPoint Networks, Inc. Reef Point Systems, Inc. provides security solutions for converged wireless and wireline networks in the United States. Its iQ product portfolio enables fixed/mobile convergence security, secure mobile access, network infrastructure protection, and managed security services. It enables operators to secure voice over the Internet protocol, Internet protocol television, and voice, video, and data services from a converged Internet protocol infrastructure. The company’s iQ family lets wireless service providers protect the wireless network infrastructure and deliver multimedia services for mobile users over unlicensed mobile access and Internet protocol multimedia subsystem infrastructure. Its products also enable service providers to offer various security services, including virtual private networks, firewalls, denial of service attack prevention, content filtering, and remote access. The company, formerly known as Quarry Technologies, Inc., was founded in 1998 and is headquartered in Burlington, Massachusetts.